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동국대학경주병원에서 분리된 각종 병원성 세균 및 항생제 감수성 양상
하경임,고은하,전창호,정병욱,안우섭,김우택,배정수,어경윤 동국대학교 경주대학 1993 東國論集 Vol.12 No.-
We investigated characteristics of bacterial infection and antimicrobial suscerptibility patterns of clinical specimens in Dong Guk University Kyong Ju Hospital from october 1991 to december 1992. The types of clinical specimens requested for culture were as follows ; pus(34.2%), urine(29.6%), sputum(25.2%), blood(9.2%), etc. The most frequently isolated organisms were E. coli(17.6%), Pseudomonas(12.7%), S. aureus(12.2%), and CNS(11.2%), orderly. Predominant organisms from pus, urine and sputum were S.aureus, E. coli and Pseudomonas. Blood culture was requested 1,244 samples from 614 patients, 91 pathogeni organisms were isolated(14.8% from patient and 7.3% from requested clinical samples). E. coli was most frequently isolated(29.7%) and Salmonella typhi was noted 8.8% from the requested samples. The patterns of isolated organisms according to departments were as follows ; E.coli and Klebsiella were frequently isolated in internal medicine and general surgery, E.coli and Pseudomas in Neurosurgery, S. aureus and Pseudomonas in orthopedic surgery. In ICU, Pseudomonas was predominatly isolated and the rate of mixed infection was also high(16.4%). Most of gram-negative bacilli revealed relatively high susceptibility to Chlorampenicol, Amikacin, Tobramycin and Carbenicillin, but Acinetobacter were only susceptible to Carbenicillin and Tetrecyclin, and Serratia were to Carbenicillin and Amikacin while Salmonella were susceptible to all tested first drugs. The proportions of multi-drug resistant bacteria were 34.9% of Acinetobacter, 21.1% of Serratia, 20.0% of Pseudomonas and 15.4% of Citrobacter but Aztreonam was highly susceptible(84∼100%) except Acinetobacter. S. aureus and CNS were susceptible to Chlorampenicol, Oxacillin, Cephalothin and Vancomycin, especially, 100% susceptible to Vancomycin. But Methicillin reistant Staphylococcus aureus were very high(49%) inspite of new constructed hospital. Pneumococcus and Streptococcus species were relatively high susceptible to all tested drugs.
( Soo-kyung Park ),( Hae Lim Baek ),( Junghee Yu ),( Ji Yeon Kim ),( Hyo-joon Yang ),( Yoon Suk Jung ),( Kyu Yong Choi ),( Hungdai Kim ),( Hyung Ook Kim ),( Kyung Uk Jeong ),( Ho-kyung Chun ),( Kyunge 대한장연구학회 2017 Intestinal Research Vol.15 No.4
Background/Aims: Colorectal cancer (CRC) screening using stool DNA was recently found to yield good detection rates. A multi-target stool DNA test (Cologuard<sup>®</sup>, Exact Sciences), including methylated genes has been recently approved by the U.S. Food and Drug Administration. The aim of this study was to validate these aberrantly methylated genes as stool-based DNA markers for detecting CRC and colorectal advanced adenoma (AA) in the Korean population. Methods: A single-center study was conducted in 36 patients with AA; 35 patients with CRC; and 40 endoscopically diagnosed healthy controls using CRC screening colonoscopy. The methylation status of the SFRP2, TFPI2, NDRG4, and BMP3 promoters was investigated blindly using bisulfate-modified stool DNA obtained from 111 participants. Methylation status was investigated by methylation-specific polymerase chain reaction. Results: Methylated SFRP2, TFPI2, NDRG4, and BMP3 promoters were detected in 60.0%, 31.4%, 68.8%, and 40.0% of CRC samples and in 27.8%, 27.8%, 27.8%, and 33.3% of AA samples, respectively. The sensitivities obtained using 4 markers to detect CRC and AA were 94.3% and 72.2%, respectively. The specificity was 55.0%. Conclusions: Our results demonstrate that the SFRP2, TFPI2, NDRG4, and BMP3 promoter methylation analysis of stool sample DNA showed high sensitivity but low specificity for detecting CRC and AA. Because of the low specificity, 4 methylated markers might not be sufficient for CRC screening in the Korean population. Further large-scale studies are required to validate the methylation of these markers in the Asian population and to find new markers for the Asian population. (Intest Res 2017;15:495-501)
Field Cancerization in Sporadic Colon Cancer
( Soo-kyung Park ),( Chang Seok Song ),( Hyo-joon Yang ),( Yoon Suk Jung ),( Kyu Yong Choi ),( Dong Hoe Koo ),( Kyung Eun Kim ),( Kyung Uk Jeong ),( Hyung Ook Kim ),( Hungdai Kim ),( Ho-kyung Chun ),( 대한소화기학회 2016 Gut and Liver Vol.10 No.5
Background/Aims: Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2), N-Myc downstream-regulated gene 4 (NDRG4) and bone morphogenic protein 3 (BMP3), have previously been shown to be hypermethylated in colorectal cancer (CRC). We aim to examine field cancerization in CRC based on the presence of aberrant DNA methylation in normal-appearing tissue from CRC patients. Methods: We investigated promoter methylation in 34 CRC patients and five individuals with normal colonoscopy results. CRC patients were divided into three tissue groups: tumor tissue, adjacent and nonadjacent normal-appearing tissue. The methylation status (positive: methylation level >20%) of SFRP2, TFPI2, NDRG4, and BMP3 promoters was investigated using methylation-specific PCR. Results: The methylation frequencies of the SFRP2, TFPI2, NDRG4 and BMP3 promoters in tumor/adjacent/nonadjacent normal-appearing tissue were 79.4%/63.0%/70.4%, 82.4%/53.6%/60.7%, 76.5%/61.5%/69.2%, 41.2%/35.7%/50.0%, respectively. The methylation levels of the SFRP, TFPI2, NDRG4 and BMP3 promoters in tumor tissues were significantly higher than those in normal-appearing tissue (SFRP2, p=0.013; TFPI2, p<0.001; NDRG4, p=0.003; BMP3, p=0.001). No significant correlation was observed between the methylation levels of the promoters and the clinicopathological variables. Conclusions: The field effect is present in CRC and affects both the adjacent and nonadjacent normal-appearing mucosa. (Gut Liver 2016;10:773-780)
Microsatellite Instability Status of Interval Colorectal Cancers in a Korean Population
( Kil Woo Lee ),( Soo-kyung Park ),( Hyo-joon Yang ),( Yoon Suk Jung ),( Kyu Yong Choi ),( Kyung Eun Kim ),( Kyung Uk Jung ),( Hyung Ook Kim ),( Hungdai Kim ),( Ho-kyung Chun ),( Dong Il Park ) 대한간학회 2016 Gut and Liver Vol.10 No.5
Background/Aims: A subset of patients may develop colorectal cancer after a colonoscopy that is negative for malignancy. These missed or de novo lesions are referred to as interval cancers. The aim of this study was to determine whether interval colon cancers are more likely to result from the loss of function of mismatch repair genes than sporadic cancers and to demonstrate microsatellite instability (MSI). Methods: Interval cancer was defined as a cancer that was diagnosed within 5 years of a negative colonoscopy. Among the patients who underwent an operation for colorectal cancer from January 2013 to December 2014, archived cancer specimens were evaluated for MSI by sequencing microsatellite loci. Results: Of the 286 colon cancers diagnosed during the study period, 25 (8.7%) represented interval cancer. MSI was found in eight of the 25 patients (32%) that presented interval cancers compared with 22 of the 261 patients (8.4%) that presented sporadic cancers (p=0.002). In the multivariable logistic regression model, MSI was associated with interval cancer (OR, 3.91; 95% confidence interval, 1.38 to 11.05). Conclusions: Interval cancers were approximately four times more likely to show high MSI than sporadic cancers. Our findings indicate that certain interval cancers may occur because of distinct biological features. (Gut Liver 2016;10:781-785)
A DLL based clock generator for low-power mobile SoCs
Kyung Ho Ryu,Dong Hun Jung,Seong-Ook Jung IEEE 2010 IEEE transactions on consumer electronics Vol.56 No.3
<P>In this paper, a delay locked loop (DLL) based clock generator is proposed. In this DLL, a dual edge triggered phase detector (DET-PD) with a high phase detector gain, a wide phase capture range, and a reduced reset time is proposed in order to achieve fast lock speed without degrading the loop stability. To resolve the static phase offset problem of previous DET-PDs, a feedback based duty cycle controller is proposed. A high speed frequency multiplier is also proposed in order to achieve a high operating frequency and a wide operating range. The proposed DET-PD shows a 4.19 ps static phase offset at a typical corner, which is 10.5 times better than that of the conventional DET-PD based DLL, and shows a 2.36 - 2.51 times improved lock speed compared with a single edge triggered phase detector (SET-PD) based DLL. Also, the proposed clock generator achieves an operating range of 150 MHz - 2 GHz and frequency multiplication factor of x1 - x8.</P>
Kyung Uk Jung,Hyung Ook Kim,Hungdai Kim,Donghyoun Lee,Chinock Cheong 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6
The standard treatments for locally advanced rectal cancer typically involved neoadjuvant therapy with either short-course radiation or long-course chemoradiation, followed by radical surgery and adjuvant chemotherapy. While the advancement of surgical techniques and the adoption of multimodal therapy have greatly contributed to reducing local failure, there has been limited improvement in overall survival, primarily due to the stagnation in systemic failure. In response to this challenge, a new strategy known as total neoadjuvant therapy (TNT) has emerged, involving the administration of both full-dose chemotherapy and radiation before surgery. It has shown promise in reducing systemic failure, enhancing tumor regression, and improving treatment adherence, ushering in a new era in the standard treatment of locally advanced rectal cancer. This review aims to summarize the evolution of multimodal treatments for locally advanced rectal cancer, ultimately converging into the current TNT strategy, and provides an assessment of the benefits and limitations of TNT based on available evidence, serving as a foundation for selecting the best treatment option.
자궁경부 세포진 검사에서 미확정 편평세포의 임상적 의의와 적절한 처치
윤정묵(Jung Mook Yoon),이상은(Sang Eun Lee),황태율(Tae Yul Hwang),송경민(Kyung Min Song),홍표(Pyo Hong),민수기(Soo Kee Min),황성욱(Seong Ook Hwang),김준미(Joon Mee Kim),고승권(Seung Kwon Koh),조숙(Sook Cho),이우영(Woo Young Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : To evaluate the clinical significance and the optimal management of atypical squamous cells of undetermined significance (ASCUS) in Papanicolaou cervical smears. Method : This study included 25380 cases of cervical Pap smears received from January 1995 to June 2000 by the Department of Obstetrics & Gynecology, Inha Hospital, Medical College, the Inha University. Retrospective review was done on 384 cases of ASCUS. Result : ASCUS and squamous intraepithelial lesions (SIL) were diagnosed in 384 cases (1.5%), and 311 cases (1.1%), respectively. The ratio of ASCUS to SIL was 1.2. Colposcopic directed biopsies revealed 14 cases (14.1%) of low grade SIL (LSIL), 21 cases (21.2%) of high grade SIL (HSIL), and 2 cases (2.0%) of squamous cell carcinoma. Conclusion : The immediate colposcopy with biopsy in women with ASCUS may decrease follow-up visits for Pap testing, reduce patient anxiety, minimize the loss of high risk cases during follow-up and lower medicolegal litigation. The early colposcopy may be the method of choice for follow-up in women with ASCUS in Korea.