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비유기중의 소유방염에 대한 항균펩타이드(Buforin Ⅱb)의 효능실험
김인송,권성균,임형준,이완규 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3
Recently, a novel antimicrobial peptide including Buforin II has been emphasized to kill multi-drug resistant bacteria and avoid promoting multi-drug resistance. This study evaluated the efficacy of an antimicrobial peptide (Buforin IIb) on bovine mastitis. Based on the Minimum inhibitory concentration(MIC, 4 g/ml) of Buforin IIb, syringes were made five concentration(MIC×10, ×50, ×100, ×300, and ×500). Thirty three cows(38 quarters) with bovine mastitis were selected using California mastitis test and grouped in dependant on drug concentration and treatment duration. Each group treated by intramammary infusion twice a day for 3 5 days. The milk samples of 5 groups were aseptically collected from quarters at 0, 3, 7 and 14 days, and 2 groups were collected at 0, 5, 9 and 14 days after first treatment. Collected samples were used for bacterial culture and somatic cell count. Bacterial number(log_(10) mean CFU/ml) was decreased in dependant on drug concentration and extending treatment duration. In group D(MIC×300), bacterial number was decreased from 4.59±0.10(day 0) to 2.89±1.37(day 3), 4.04±0.33(day 7), and 4.19 ± 0.10(day 14), respectively(p 0.05). Bacterial number of B2(MIC×50, 5 days treated) is decreased, approximately 10%, than group B1(MIC×50, 3 days treated). Somatic cell count of group D was slightly decreased from 11,100(×10³)(day 0), to 7,386(×10³)(3 day), 6,886(×10³)(day 7), and 9,661(×10³)(day 14). Staphylococcus spp., was the most common isolate, was bacteriologically cured 100% by Buforin IIb treatment. Overall results indicate that Buforin IIb could have possibility to cure bovine mastitis, if higher concentration over experimental concentration were treated with extending treatment duration.
위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구
박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3
Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.
林大銑,宋圭鉉,朴敬浩,朴暎緖,李玩永 中央醫學社 1963 中央醫學 Vol.5 No.4
A case of secondary aspergillosis of the left maxillary sinus following chronic sinusitis in a 42 year old male coal miner specialist is reported. His chief complaints were nasal obstruction and postnasal drip of several years duration. Roentgenogram revealed marked and moderate shadow in the left and right maxillary sinuses respectively. Significant operative findings included almost paper-thin bony walls of the left maxillary sinus, and small amount of yellow greenish purulent material was drained, followed by yellowish brown semisolid tissue on further curettage. The latter specimen was found to be essentially mass of fungi, showing numerous distinctly septate, branching hyphae on the Papanicolaou stain of the direct smears of the cut surface of the specimen, and Hematoxylin-Eosin and Periodic Acid Schiff stains of paraffin sections. Pertinent aspects of clinical and pathological differential diagnosis between aspergillosis - and mucormycosis, are described. Aspergillosis presents usually benign course, with insignificant chief complaints as our case, whereas mucormycosis is most frequently associated with uncontrollable diabetics, and run usually acutely fatal course. There are three main types of ucormycosis-cerebral, pulmonary and intestinal. The characteristic broad nonseptate branching hyphae of mucor, and marked affinity to the blood vessels,, penetrating the tough walls of arteries, with thromboses and infarction, readily differentiate aspergillosis from mucormycosis.
RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향
박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-
TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.
내시경적 식도정맥류 결찰술 시행시 안전하고도 간편한 Overtube 삽입법
송인성,정현채,이효석,김정룡,최규완,한철주,윤용범 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.4
Endoscopic variceal ligation (EVL) is effective for the management of bleeding esophageal varices, and its use is widespread now. EVL necessitates the use of overtubes. Two primary techniques have been used for overtube placement; one is with endoscope, and the other is with bougie dilator. Overtube placement with endoseope is not without risk. There are reportd of esophageal or pharyngeal laceration or perforation. Overtube placement with bougie dilator circumvents this risk, but it is rather cumbersome to use. The authors devised a safe and easy method for overtube placement, and applied it to a number of patients to test its safety and convenience. First, overtube-dilator assembly was prepared as follows. A Rigiflex achalasia dilator (balloon 30mm OD, 10cm length; Microvasive Co) was lubricated and inserted into the overtube. A tenth of the balloon tip was protruded out of the overtube, then the balloon was insufflated with air at 10-15 psi. Second, standard endoscopy was performed, followed by placement of guide wire in the stomach. Overtube-dilator assembly was lubricated and introduced over the wire as a rail. Once the overtube was properly positioned, the balloon was deflated, and the balloon and wire were removed as a whole, which completed overtube placement. For 65 patients with esophageal variceal bleeding, 82 procedures of EVL were performed using the new technique. Overtube-dilator assembly was easy to prepare and handle. This technique added little time to the procedure and minimizes patients discomfort. No patient suffered major complications such as bleeding, laceration or perforation. This novel method for overtube placement was safe and convenient for use in EVL. It can also be applied to other procedures using overtube such as endoscopic foreign body removal. (Kor J Gastrointest Endosc 15: 659-663, 1995)