Cytoprotective Effect of Hispidin Against Hyperglycemia Induced Oxidative Cell Damage on Mouse Insulin Producing Cells(MIN6)

Jae Soon Jang,Min Kyoung Min,Eock Kee Hong 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.10

사회인지론에 근거한 낮병원 정신질환 입원환자 대상비만 예방 및 관리를 위한 영양교육 효과평가

한민지,이지연,이해연,한은경,최경순,김희선 순천향대학교 기초과학연구소 2021 순천향자연과학연구 논문집 Vol.27 No.1.2

Mental illness such as schizophrenia, bipolar disorder and depression have shown high prevalence of obesity. According to the previous studies, nutrition education has therapeutic effects on patients, however mentally ill patients rarely have opportunities of long term nutrition education. In this study, nutrition education based on the social cognitive theory was conducted. Patients with mental illness received education program once a month during 18 months in a day hospital. Fifteen patients were included and divided into two groups according to the attendance rate. Results showed that the group attended the education more than 10 times showed weight loss, while the group less than 10 times showed weight gain. Five long-term hospitalized patients gained weight during one year prior to the nutrition education, but showed weight loss during one year with the nutrition education. Regardless of the number of attendance, the group of BMI≥30kg/m2 showed weight loss. Although this study has several limitations and did not obtain a statistically significant results, it confirmed the necessity of providing clinical nutrition services including nutrition education for mentally ill patients.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

장애인 수행능력향상을 위한 보조공학기기 제공과 인간공학적 접근의 필요성

정민예,김정란,민경철,구인순 한국장애인고용촉진공단 고용개발원 2006 장애와 고용 Vol.16 No.2

장애인의 기능을 향상시킬 수 있는 방법 중 하나는 보조공학기기의 제공이다. 보조공학기기의 제공은 감각, 지각, 인지, 운동능력 등을 전문적으로 평가할 수 있는 전문가에 의해 선택, 적용, 훈련되는 것이 중요하다. 또한 근골격계 질환을 예방하기 위한 인간공학적 접근에 대한 이해와 작업분석, 직무조정이 가능한 전문가에 의해 보조공학기기가 제공된다면 잔존기능의 향상 뿐 아니라 업무동안 바람직하지 못한 자세를 유지함으로써 발병할 수 있는 근골격계 질환 예방까지 기대할 수 있을 것이다. 본 연구에서는 보조공학기기의 이론적 배경과 인간공학적 접근의 이론적 배경을 소개하였고, 적절한 보조도구를 제공한 장애 근로자에 대해 근골격계 질환 위험요인을 측정하였으며, 이를 통한 자세보완이 장애 근로자의 작업 기능을 향상시킬 수 있음을 객관적으로 밝히는 평가결과를 제시하였다. 따라서 장애인의 직업능력을 향상시키려면 다양한 전문가들의 팀 어프로치가 필요하며 체계적인 서비스가 마련되어야 할 것이다. One of the methods to improve functions of the disabled person is to supply assistive devices. It is important for the disabled person that the devices should be supplied by an expert, who is capable of evaluating their sensory, perception, cognition and motor function. Moreover if the expert have knowledge about ergonomlcs, he or she will also prevent the musculo-skeletal disease which may be happen in work place. In this paper, we introduced the theoretical background of the assistive devices and ergonomic approach, and evaluate the risk factors of the musculo-skeletal disease of the disabled worker who was equipped a proper assistive device, and presented objective experimental results that posture intervention by using assistive device can be useful to improve work function of the disabled worker.

Microabrasive로 처리한 상아질표면에 대한 복합레진의 결합강도에 관한 연구

최경규,민병순 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.1

제2형 당뇨병 환자에서 우연히 발견된 기종성 방광염 1례

박보민,김윤정,이영태,노정현,권수경,김동준,고경수,이병두,임경호,이순희,박정현 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Emphysematous cystitis is an uncommon disease in which bacterias produce gas within the bladder wall and surrounding tissue. Patients with diabetes, neurogenic bladder and chronic urinary tract infection are predisposed to the disease. It is usually caused by E.coli and Klebsiella. Severity of illness ranges from an asymtomatic condition to life threatening cystitis. Succesful management depends on early diagnosis with correction of underlying causes, administration of appropriate antibiotics, establishment of adequate bladder drainage and surgical excision of involved tissue when required. We report a case of 52-year-old woman who did not compain of symtoms of cystitis but epigastric pain, nausea, and vomitting. Emphysematous cystitis was revealed on the abdominal X-ray series incidentally. CT scans of the pelvis showed mottled gas bubble within the bladder. After treatment, the symtoms subsided and plain abdominal film showed no evidence of gas shadow in the pelvic cavity.

Shield Disk 상의 Ag-Cu 공정계 합금 도금기술 개발

윤경도,차동관,심기종,민봉기,최순돈,이상기 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.1

The composition and the microstructure of the Ag-Cu alloy electrodeposits electroplated in Succinimide bath were investigated varying the electrolysis conditions such as bath composition, current density and additive agents etc. The cathode overpotential increased with the increase of Succinimide concentration and current density ratio in the bath. The Ag content of the alloy deposits decreased with the increase of current density and pH and temperature in the bath. The optimum condition for 78wt.%Ag-22wt.%Cu code position alloy is an follows : pH10(adjusted by NH_4OH), 0.03M AgNO_3, 0.27M Cu(NO_3)_2 3H_2O, 0.5M Succinimide in bath and 3.5A/dm^2∼5.5A/dm^2 current density.

치과용 가시광선중합형 복합레진의 잔류단량체 정량분석에 관한 연구

최경규,민병순 大韓齒科保存學會 1992 Restorative Dentistry & Endodontics Vol.17 No.1

The purpose of this study was to estimate the contents of the resicual monoers, such as Bis-GMA and TEGDMA. In this study, materials used were six kinds of anterior and posterior visible lightpcured resins. Resins were placed in disk- shaped Teflon mold (8.5mm in diameter, 2.0mm in thickness), and cured for 20 seconds with visible light soruce attached wide diameter lightguide. The specimens were immersed in 10ml ethanol and stored for 5 days at 37℃. The concentration of residual monomers in eluate solution was analysed by HPLC, and the following results are obtained. 1. The residual Bis-GMA and TEGDMA were detected in all materials used, and the ranges of quantly of the residual Bis-GMA was 0.101-1.346 wt% and that of TEGDMA was 0.230-5.794wt%. 2. The contents of residual TEGDMA was detected higher than that of residualBis-GMA(P<0.01). 3. The content of residual monomers was detected to be highest in Bis-Fil M as microfilled type. 4. In most of the materials used, there was no significant difference in the contents of residual monomers between anterior and posterior light-cured resins.

식품 위해 요소중점 관리 기준에 대한 서울지역 사업체 급식관리자의 위생관리평가

이헌옥,심재영,김영경,조민호,최호순,엄애선 한국조리과학회 2001 한국식품조리과학회지 Vol.17 No.6

Hazard Analysis Critical Control Point(HACCP) is becoming an important component of food safety worldwide. The aim of this study was to investigate comprehensively the education and knowledge level of food service managers on HACCP as well as applying HACCP system to industrial foodservice. Total 247 foodservice managers participated in the survey and 159 responses were used for analysis. The results were as follows; 1) 89% of foodservice managers were educated about HACCP, and 40.9% felt they did fully understand HACCP and 47.8% did half. 2) The score for the implementation of HACCP was in the order of apparatus and facility sanitation, personal sanitation, and time-temperature/etc. sanitation. 3) Foodservice managers who were taught HACCP kept a deep attention to food and personal sanitation, compared with those without education(p<0.05). However, the education time on HACCP affected conducting safety management. The results suggest that education and understanding of HACCP are positively related, and understanding of HACCP has a positive influence on conducting safety management.