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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
A Study on the Transition and Classification of Somatotyping
Wan Suk Choi,Ok Kon Moon,Jung Hyun Choi,Bo Kyoung Kim,Joong San Wang,Hong Rae Kim,Joo Hyun Park,Young Hwa Song,Hyun Sook Hwang,Soon Hee Kim 국제물리치료학회 2013 Journal of International Academy of Physical Ther Vol.4 No.1
Experts of medicine, philosophy and psychology found that human somatotypes were related to personality or physical characteristics and classified somatotypes into various forms. This study explored the changes and types of somatotyping methods from Before Christ to present day and identified the status of studies of somatotypes in the area of physical therapy. This study covered the methods applied in various majors with a focus on those provided in books and papers of Heath BH. and Carter JEL. Based on the results, there are officially twelve assessment methods. Currently, the method of Heath & Carter is most widely applied. Somatotypes are studied in many areas. It is actively explored in the area of pain physical therapy, thermotherapy and integumentary physical therapy. Also, the soft tissue physical therapy area seeks interdisciplinary studies. This study found that there were various assessment methods in diverse areas. It is likely that continuous studies will develop new assessment methods. It is hoped that in the area of physical therapy, somatotypes shall be applied more amply.
Jeong Joon Ahn,Kyoung San Choi,Sang Woog Kho 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Climate change can affect major changes to the dynamics of individual insect. The increase of surface temperature would cause multivoltine species to increase the number of generations (i.e. voltinism) per year. Determining the voltinism was based on the climate data and biological parameters. The soybean bug, Riptortus pedestris (Fabricius) (Hemiptera: Alydidae) is one of major pests of soybean and has multi host plants. To estimate the voltinism of R. pedestris, the climate data were obtained from the web site of the Korea Meterological Administration(KMA) from 1966 or 1973 to 2015 at 77 locations, respectively. We used the lower developmental threshold (15.0°C) and thermal constant (312.5DD) for R. pedestris from egg to adult emergence. Degree-days were calculated by using simple cutoff method and cumulating degree-days (CDD) were obtained by summing calculated degree-days. The voltinism of R. pedestris was calculated by dividing CDD per specific period by the thermal constant requirement of R. pedestris development from egg to adult emergence. The number of generations varied depending on the season, with the lowest in February and the highest in August at each location. At least one generation per month would be possible from July to August. The average voltinism from 1966 to 2015 was highest at Seoguipo, and was followed by Daegu, Jejusi, Gwangju and Jeonju. The average voltinism from 1966 to 2015 was lowest at Ulreundo. The voltinism of R. pedestris observed the last 50 years was attributable to human activities at some locations.
A Study on the Transition and Classification of Somatotyping
Choi, Wan Suk,Moon, Ok Kon,Choi, Jung Hyun,Kim, Bo Kyoung,Wang, Joong San,Kim, Hong Rae,Park, Joo Hyun,Song, Young Hwa,Hwang, Hyun Sook,Kim, Soon Hee International Academy of Physical Therapy Research 2013 Journal of International Academy of Physical Ther Vol.4 No.1
Experts of medicine, philosophy and psychology found that human somatotypes were related to personality or physical characteristics and classified somatotypes into various forms. This study explored the changes and types of somatotyping methods from Before Christ to present day and identified the status of studies of somatotypes in the area of physical therapy. This study covered the methods applied in various majors with a focus on those provided in books and papers of Heath BH. and Carter JEL. Based on the results, there are officially twelve assessment methods. Currently, the method of Heath & Carter is most widely applied. Somatotypes are studied in many areas. It is actively explored in the area of pain physical therapy, thermotherapy and integumentary physical therapy. Also, the soft tissue physical therapy area seeks interdisciplinary studies. This study found that there were various assessment methods in diverse areas. It is likely that continuous studies will develop new assessment methods. It is hoped that in the area of physical therapy, somatotypes shall be applied more amply.
대형할인점 리모델링 프로젝트의 CM at Risk 적용 타당성에 관한 연구
최규산,이호경,박영호,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
Remodeling projects are on a increasing trend because of the old buildings built in 1960-70's, the preference for energy saving and the changes of social demands and government policies, etc. And also discount-store projects, which are rapidly increasing, are characterized by the fact that they are repetitive and have analogous scale and structure. Therefore, it is necessary to develop the concept discount-store model and apply the appropriate project delivery system for a successful execution of the projects. The purpose of this study is to analyze the characteristics of the discount-store remodeling projects and propose CM at Risk for the optimum delivery system of those projects.
Joong San Wang,Si Eun Park,Hee Joon Shin,Wan Suk Choi,Hong Rae Kim,Bo Kyoung Kim,Joo Hyun Park,Joon Hee Lee,Kyung Ok Min 국제물리치료학회 2015 Journal of International Academy of Physical Ther Vol.6 No.1
Juvenile soccer players, Flexi-bar, Trunk muscles strength, Body composition The purpose of this study is to verify a correlation between flexi-bar exercise and improvement of trunk strength and body composition in juvenile soccer players. The subjects were 11 teenager juvenile soccer players who conducted flexi-bar exercise half an hour daily three times a week for eight weeks. They were tested for trunk muscles strength, body composition and correlation. The result showed that trunk muscles strength improved significantly( p<.01) and weight, Rt. arm muscle mass, Rt. leg muscle mass, and Lt. leg muscle mass(p<.05), Lt. arm muscle mass, trunk muscle mass, and body muscle mass(p<.01) improved significantly as well while Lt. arm fat mass, Rt. leg fat mass, and Lt. leg fat mass decreased significantly(p<.05). In the correlation analysis, the more trunk muscle mass and trunk muscles strength increased, the more muscle mass of body regions increased, which was a positive correlation whereas fat mass of body regions decreased, which was a negative correlation. It was verified that there was a correlation between flexi-bar exercise and improvement of trunk muscles strength and body composition for juvenile soccer players.
급성췌장염 마우스 모델에서 지실과 지각 추출물의 보호효과
박경철 ( Kyoung Chel Park ),배기상 ( Gi Sang Bae ),최선복 ( Sun Bok Choi ),조일주 ( Il Joo Jo ),곽태신 ( Tae Sin Gwak ),이금산 ( Guem San Lee ),박성주 ( Sung Joo Park ),송호준 ( Ho Joon Song ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.5
Objective : We investigated the effect of Poncirus trifoliata and Citrus aurantium extract in mice with cerulein-induced acute pancreatitis (AP) model. Methods : AP was induced via intraperitoneal injection of cerulein (50 ㎍/kg) given every hour for 6h. Poncirus trifoliata (PT: 200 or 400 ㎎/kg) and Citrus aurantium (CA: 200 or 400 ㎎/kg) extract were injected 1 h before in mice with cerulein-induced AP. Mice were sacrificed at 6 h after last injection of cerulein. Blood samples were taken to determine serum amylase and lipase levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay. Results : PT pre-treatment significantly protected the pancreas and lung damages and reduced the MPO activity and serum amylase in cerulein-induced AP. However, CA pre-treatment did not significantly protected the pancreas and lung inflammation in cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP.