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난치성 양극성 장애의 약물치료 : 새로운 항경련제와 칼슘통로 차단제
김영훈,이정구,이상경 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.1
Most psychiatrists are familiar with the traditional anticonvulsants, carbamazepine and valproic acid, in the treatment of the patients with bipolar disorders. Lamotrigine, a new anticonvulsant, may have antidepressant and mood-stabilizing effects probably by inhibition of pathological glutamate release on the presynaptic membrane, especially in the treatment-refractory bipolar disorders. Treating depression in bipolar disorder can be difficult because of the limited antidepressant effects of the standard mood stabilizers and the tendency of antideressants to induce mania or decrease cycle length. Lamotrigine, a drug that has both mood stabilizing and antidepresasant effects, woud have an important role in the treatment of refractory bipolar disorders. The efficacy of verapamil in the treatment of mania has been examined in several small open trials and at least 7 double-blind trials, and that of nimodipine in a double-blind trial. Although preliminary data suggest that verapamil may have antimanic or mood-stabilizing properties, any conclusion about the efficacy of verapamil in the treatment of the lithiun-refractory or rapid cycling bipolar patients could not be drawn till now.
신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구
權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-
In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.
도경훈,정의윤,조정복 東西大學校 2000 동서논문집 Vol.6 No.-
Objects-based coding algorithms segment image contents into set of objects or regions according to a given model and estimate their parameters like motion, shape, and color. It is known that object-based coding is more efficient coding method in videophone image sequence. It is difficult to detect moving object only using motion information. Chromaticity distribution of skin color is similar region independent of human race. This paper presents efficient image analysis method using both skin color and motion. The proposed algorithm is composed of facial region detection using skin color and region detection using motion information.
위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구
노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.
裵鍾淳,權正烈,沈勇勳,盧潤炅 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-
Vertical deformation and lateral flow can occur as a result of the construction of nearby embankments on a soft ground. This paper considered the behavior from a model test that situated pressure berms on the soft ground by trapezodial load., as varied the height and width of the pressure berm and height(H) of the load. But width(B) of the load is equal to all tests. The test results are as follows : 1. Maximum settlement occur at the center of the embankment and ending settlement is to the depth about 1.8B from the ground surface. 2. Maximum uplift location is about 0.3B ∼ 0.4B from the toe of the pressure berm and maximum uplift deformation occur with its height at H/2 without any influence from its width. 3. The width and height of the pressure berm for mimimum uplift deformation is 2H and H/3. 4. Maximum lateral flow occur to the depth at D/3 from the ground surface without any influence from its height and width.
신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2
As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.
Kyeong Hoon Jung,Kang Yi 한국정보과학회 2018 Journal of Computing Science and Engineering Vol.12 No.3
Blind spot monitoring (BSM) is one of the essential functions of Advanced Driver Assistance Systems (ADAS). In this paper, we propose a vision-based monitoring algorithm to detect vehicles in a blind-spot area using a rear-view camera. Instead of moving around the whole image to search for a vehicle, we use well-defined detection windows with fixed position and size. And we used histogram of oriented gradients (HOG) and the support vector machine (SVM) to detect a vehicle in each detection window. When a vehicle is detected, we compute the motion vector of the vehicle to determine if it approaches the ego vehicle or not. The alarm signal is finally generated based on history of events. To evaluate performance of the BSM algorithm, we captured various kinds of sequences by using a rear-view camera. Experimental results reveal precision higher than 98% and recall higher than 99%. We also develop high-speed methods to improve processing speed while keeping performance degradation as minimal as possible. Implementation of this fast algorithm on a commercial embedded device validated real-time characteristics of the proposed BSM algorithm.
Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum
Jung, Suk-Kyeong,Jeong, Dae Gwin,Lee, Mi Sook,Lee, Jung-Kee,Kim, Hyung-Kwoun,Ryu, Seong Eon,Park, Byoung Chul,Kim, Jae Hoon,Kim, Seung Jun Wiley Subscription Services, Inc., A Wiley Company 2008 Proteins Vol.71 No.1
<P>The M37 lipase from Photobacterium lipolyticum shows an extremely low activation energy and strong activity at low temperatures, with optimum activity seen at 298 K and more than 75% of the optimum activity retained down to 278 K. Though the M37 lipase is most closely related to the filamentous fungal lipase, Rhizomucor miehei lipase (RML) at the primary structure level, their activity characteristics are completely different. In an effort to identify structural components of cold adaptation in lipases, we determined the crystal structure of the M37 lipase at 2.2 Å resolution and compared it to that of nonadapted RML. Structural analysis revealed that M37 lipase adopted a folding pattern similar to that observed for other lipase structures. However, comparison with RML revealed that the region beneath the lid of the M37 lipase included a significant and unique cavity that would be occupied by a lid helix upon substrate binding. In addition, the oxyanion hole was much wider in M37 lipase than RML. We propose that these distinct structural characteristics of M37 lipase may facilitate the lateral movement of the helical lid and subsequent substrate hydrolysis, which might explain its low activation energy and high activity at low temperatures. Proteins 2008. © 2008 Wiley-Liss, Inc.</P>
CASE REPORT : Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome
( Jung Hoon Kim ),( Won Jun Song ),( Ji Eun Jun ),( Duck Hyun Ryu ),( Ji Eun Lee ),( Ho Jung Jeong ),( Suk Hyeon Jeong ),( Hyung Koo Kang ),( Jung Soo Kim ),( Hyun Lee ),( Hae Ri Chon ),( Kyeong Man J 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3
Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient’s condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.