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Efficacy and Tolerability of Aripiprazole: A 26-Week Switching Study from Oral Antipsychotics
JungSun Lee,Seockhoon Chung,JoonNoh Lee,JunSoo Kwon,DoHoon Kim,ChulEung Kim,KangSeob Oh,YangWhan Jeon,MinSoo Lee,MyungHo Lim,HyeRyein Chang,ChangYoon Kim 대한신경정신의학회 2010 PSYCHIATRY INVESTIGATION Vol.7 No.3
Objective-To determine if the maintenance effectiveness and tolerability of aripiprazole demonstrated in a 12-week study were maintained in an extension phase (up to 26 weeks). Methods-This study was the extension of our switching study from other antipsychotics to aripiprazole in symptomatically stable patients with schizophrenia or schizoaffective disorder. All the patients were randomly assigned to the aripiprazole group or the non-aripiprazole group. The effectiveness analysis consisted of the comparison of the upper bound of the 95% confidence interval (CI) of the mean Clinical Global Impression-Improvement (CGI-I) score to 4 (no change) at the end of the study. Results-At the baseline, the aripiprazole group (n=135) and the non-aripiprazole group (n=31) were comparable with respect to their mean ages, gender distribution, baseline Positive and Negative Syndrome Scale scores, and Clinical Global Impression-Severity (CGI-S) scores. The study showed that the mean CGI-I score was 2.92 (95% CI: 2.72-3.12) in the aripiprazole group and 2.81 (95% CI: 2.35-3.26) in the non-aripiprazole group at 26 weeks. In the aripiprazole group, the remission rates at 12 and 26 weeks were 74.8% and 72.6%, respectively, and 80.2% of the patients with remission at 12 weeks maintained their remission state until the end of the study. About one-fourth of the patients in the aripiprazole group reported one or more spontaneous treatment-emergent adverse events, such as insomnia, headache, and nausea. Conclusion-This study suggested that most clinically stable outpatients with schizophrenia maintain their remission states after being switched to aripiprazole, without serious symptom aggravation and adverse events over a course of 26 weeks.
JungSun Lee,JunSoo Kwon,Daeho Kim,SungWan Kim,JaeJin Kim,JongHoon Kim,HeeJung Nam,Seunghyong Ryu,IlHo Park,SukKyoon An,HongSeok Oh,Seunghee Won,Kanguk Lee,KyuYoung Lee,SeungHwan Lee,YuSang Lee,JungSeo 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. Methods-This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men). Results-The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine. Conclusion-The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.
실시간 온라인 수업에 대한 교수자의 인식 및 만족도 연구 : D대학교 한국어 교육기관의 사례를 중심으로
최정선(Choi, Jungsun),권미경(Kwon, Meekyung),최은경(Choi, Eun-Kyung) 동악어문학회 2020 동악어문학 Vol.81 No.-
본고의 목적은 실시간 온라인 수업을 실시한 기관의 교수자가 온라인 수업에 대해 가지는 인식과 만족도를 분석하여 실시간 온라인 수업의 내실화와 활성화 방안을 제안하는 것이다. 이를 위해 D대학교 한국어 교육기관의 교수자 68명을 대상으로 설문조사를 실시하였다. 연구 결과를 통해 익숙하지 않은 실시간 온라인 수업 방식도 사전에 충분한 교육을 받으면 교수자와 학습자 모두에게 만족스러운 교수법이 될 수 있음을 알 수 있었다. 문제점으로는 프로그램 오류, 필기와 자료 공유의 불편함, 발표와 토론, 과제 피드백 등이 제기되었고, 교수자들은 학생들의 실력 향상이나 효과에 긍정적인 반응을 보이지 않았다. 또한 상호작용, 학생의 동기유발, 참여 등의 측면에서도 부정적이었다. 교수자들은 실시간 온라인 수업에 비해서 대면수업이 더 효과적이라고 인식하고 있었으나. 향후 유사한 프로그램의 기술이 더욱 고도화될 것으로 전망됨에 따라 실시간 온라인 수업은 더욱 확대될 것이다. 연구 결과를 통해 대면수업과 실시간 온라인 수업의 객관적 성취도 결과 비교 연구, 학습자의 인식과 만족도 연구, 교사와 학습자의 인식 비교 연구의 필요성을 제안하였다. The purpose of this study is to analyze the instructors" perceptions and satisfaction levels about real-time online classes that their institutions have conducted and propose ways of enhancing and activating the classes. To this end, a survey was conducted on 68 instructors of the Korean language education program at D University. Through the survey results, we found that teaching methods that have not been dealt with before can be satisfactory for both instructors and learners if they have sufficient training in advance to master the methods. The instructors raised problems in the online classes such as Webex program errors and the inconvenience of writing on the screen and data sharing, presentations, discussions, and task feedback. They didn"t respond positively to the improvement or learning effectiveness of most learners and they were also negative about various interactions and learners" motivation and participation in the classes. As a result, they were perceiving that face-to-face instruction is more effective than real-time online one, but the online classes will be further expanded as the technology of similar programs is expected to become more advanced in the future. Based on the results of the study, this paper suggested a comparative study of objective achievement results in face-to-face classes and real-time online classes, a study on learner"s perceptions and satisfaction levels, and a study on comparison between instructor and learner"s perception.
Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?
Soon-Chan Kwon,Inah Kim,Jaechul Song,Jungsun Park 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-
Background: The South Korean criteria for occupational diseases were amended in July 2013. These criteria included formaldehyde as a newly defined occupational carcinogen, based on cases of “leukemia or nasopharyngeal cancer caused by formaldehyde exposure”. This inclusion was based on the Internal Agency for Research on Cancer classification, which classified formaldehyde as definite human carcinogen for nasopharyngeal cancer in 2004 and leukemia in 2012. Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related. Results: Previous reports regarding excess mortality from nasopharyngeal cancer caused by formaldehyde exposure seemed to be influenced by excess mortality from a single plant. The recent meta-risk for nasopharyngeal cancer was significantly increased in case-control studies, but was null for cohort studies (excluding unexplained clusters of nasopharyngeal cancers). A recent analysis of the largest industrial cohort revealed elevated risks of both leukemia and Hodgkin lymphoma at the peak formaldehyde exposure, and both cancers exhibited significant dose-response relationships. A nested case-control study of embalmers revealed that mortality from myeloid leukemia increased significantly with increasing numbers of embalms and with increasing formaldehyde exposure. The recent metarisks for all leukemia and myeloid leukemia increased significantly. In South Korea, a few cases were considered occupational cancers as a result of mixed exposures to various chemicals (e.g., benzene), although no cases were compensated for formaldehyde exposure. The peak formaldehyde exposure levels in Korea were 2.70–14.8 ppm in a small number of specialized studies, which considered anatomy students, endoscopy employees who handled biopsy specimens, and manufacturing workers who were exposed to high temperatures. Conclusion: Additional evidence is needed to confirm the relationship between formaldehyde exposure and nasopharyngeal cancer. All lymphohematopoietic malignancies, including leukemia, should be considered in cases with occupational formaldehyde exposure.
황정선,정재권,현영오,Hwang, Jungsun,Jung, Jae-Kwon,Hyun, Young-O 항공우주시스템공학회 2013 항공우주시스템공학회지 Vol.7 No.2
Crashworthiness design concept in the helicopter development is still under evolutionary stage. Survivability in the event of a crash was remarkably improved and this fact can be recognized by the analysis results on the AH-64 Apache and UH-60 Black Hawk crash accidents. Those two models are the first ones in which the crashworthiness design concept was applied with a full-scale requirement. Here we need to notice that under-design of the system results in unexpected injuries and deaths while over-design of the crashworthy elements result in unnecessary weight and costs. If landing gear system would be verified to have enough energy absorption capability in the specified vertical velocity interval, then design requirements of the airframe, fuel system and seats could be modified positively. In this paper, the right and systematic crashworthiness design concept is reviewed on the assumption that design requirements of some crashworthy elements could be partially tailored.
Hong, Hyun Sook,Lee, Jungsun,Lee, EunAh,Kwon, Young Sam,Lee, Eunkyung,Ahn, Woosung,Jiang, Mei Hua,Kim, Jae Chan,Son, Youngsook Nature Publishing Group 2009 Nature medicine Vol.15 No.4
Tissue injury may create a specific microenvironment for inducing the systemic participation of stromal-like cells in the repair process. Here we show that substance P is an injury-inducible factor that acts early in the wound healing process to induce CD29<SUP>+</SUP> stromal-like cell mobilization. Likewise, mobilization of such cells also occurs in uninjured mice, rats and rabbits if substance P is intravenously injected. Upon further characterization these substance P–mobilized CD29<SUP>+</SUP> cells were found to be similar to stromal cells from a number of connective tissues, including bone marrow (that is, bone marrow stromal cells, or BMSCs). Both substance P injection and transfusion of autologously derived substance P–mobilized CD29<SUP>+</SUP> cells from uninjured rabbits accelerated wound healing in an alkali burn model. Also, epithelial engraftment of the transfused cells into the injured tissue occurred during the wound healing. Finally, using human BMSCs as a test population, we show that substance P stimulates transmigration, cell proliferation, activation of the extracellular signal–related kinases (Erk) 1 and 2 and nuclear translocation of β-catenin in vitro. This finding highlights a previously undescribed function of substance P as a systemically acting messenger of injury and a mobilizer of CD29<SUP>+</SUP> stromal-like cells to participate in wound healing.