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A Comparison of Two Brands of Clopidogrel in Patients With Drug-Eluting Stent Implantation
박예민,안태훈,이경훈,Kwen-Chul Shin,정을식,Dong Su Shin,Myeong Gun Kim,강웅철,한승환,최인석,신익균 대한심장학회 2012 Korean Circulation Journal Vol.42 No.7
Background and Objectives: Although generic clopidogrel is widely used, clinical efficacy and safety between generic and original clopi-dogrel had not been well evaluated. The aim of this study was to evaluate the clinical outcomes of 2 oral formulations of clopidogrel 75 mg tablets in patients with coronary artery disease (CAD) undergoing drug-eluting stent (DES) implantation. Subjects and Methods: Between July 2006 and February 2009, 428 patients that underwent implantation with DES for CAD and com-pleted >1 year of clinical follow-up were enrolled in this study. Patients were divided into the following 2 groups based on treatment for-mulation, Platless® (test formulation, n=211) or Plavix® (reference formulation, n=217). The incidence of 1-year major adverse cardiovas-cular and cerebrovascular event (MACCE) and stent thrombosis (ST) were retrospectively reviewed. Results: The baseline demographic and procedural characteristics were not significantly different between two treatment groups. The in -cidence of 1-year MACCEs was 8.5% {19/211, 2 deaths, 4 myocardial infarctions (MIs), 2 strokes, and 11 target vessel revascularizations (TVRs)} in Platless® group vs. 7.4% (16/217, 4 deaths, 1 MI, 2 strokes, and 9 TVRs) in Plavix® group (p=0.66). The incidence of 1-year ST was 0.5% (1 definite and subacute ST) in Platless® group vs. 0% in Plavix® group (p=0.49). Conclusion: In this study, the 2 tablet preparations of clopidogrel showed similar rates of MACCEs, but additional prospective random-ized studies with pharmacodynamics and platelet reactivity are needed to conclude whether generic clopidgrel may replace original clopi-dogrel.
허남일(Nam-il Her),김병철(Byung-chul Kim),홍권희(Kwen-hi Hong),김근홍(Geun-hong Kim),신훈(Hoon Shin),박경호(Kyung-ho Park),박주식(Joo-shik Bak) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.11
KSTAR cryostat is a 8.8 m diameter vacuum vessel that provides the necessary thermal barrier between the ambient temperature test cell and the supercritical helium cooled superconducting magnet providing the base pressure of 1 x 10-3 Pa. The cryostat is a single walled vessel consisting of central cylindrical section and two end closures, a flat base structure with external reinforcements and a dome-shaped lid structure. The base structure has 8 equally spaced support legs anchored on the concrete base. The cryostat vessel design was executed to satisfy the performance and operation requirements. The major loads considered in the structural analysis were vacuum pressure, dead weight, electromagnetic load driven by plasma disruption, and seismic load. Based on the fabrication and inspection procedures for the vessel, cryostat vessel was fabricated and inspected. It was confirmed that the inspection results were acceptable.
김민정 ( Min Joung Kim ),이연정 ( Youn Jeoung Lee ),권인 ( In Kwen ),허수영 ( Soo Young Hur ),이귀세라 ( Gui Sera Lee ),신종철 ( Jong Chul Shin ),김은중 ( Eun Joung Kim ),임현욱 ( Hyun Wook Lim ),김사진 ( Sa Jin Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
목적 : 난소 난관 농양의 진단에 있어, 수술적 조직학적으로 확진된 환자들에 있어 전산화 단층 촬영을 시행함에 있어 임상적, 초음파적 소견과 그에 따른 전산화 단층 촬영의 적응증 및 연관성을 알아보고자 하였다. 연구 방법 : 1993년 1월부터 2003년 1월까지 가톨릭대학교 부속 성가병원 산부인과에서 수술 후 병리학적으로 확진된 79명의 난소 난관 농양 환자들을 후향적으로 조사하였다. 79명의 환자들은 입원시 모두 초음파를 시행하였고, 15명은 치료 Objective : The purpose of this study was to identify retrospectively the different computed tomography markers and sonography in a series of surgically and pathologically proven cases of tubo-ovarian abscesses in order to achieve correct preoperative dia
Prolonged Extreme Thrombocytosis in a Postsplenectomy Patient with Hereditary Spherocytosis
Yae Min Park,Yunjeong Jo,Sei-Hyun Kim,Kwen-Chul Shin,In Sik Won,Sun Jin Sym,조은경,신동복,Jae Hoon Lee,박진희 대한혈액학회 2009 Blood Research Vol.44 No.4
We report a case of prolonged extreme reactive thrombocytosis in a post-splenectomy patient with hereditary spherocytosis. A 29-year-old female patient presented with gall stones detected incidentally by abdominal ultrasonography. Her laboratory findings showed hemolytic anemia with spherocytosis on the peripheral blood smear and increased osmotic fragility. She was diagnosed with hereditary spherocytosis and underwent a laparoscopic cholecystectomy and splenectomy. After undergoing surgery, the hemolytic anemia was resolved but thrombocytosis was newly detected. Nineteen months after the splenectomy, the thrombocytosis was still persistent and extremely high. To our knowledge, this is the first report of a prolonged extreme reactive thrombocytosis after a splenectomy in Korea.
호두까기 증후군에서 정맥신우조영술로 진단된 요관주위 정맥류
김형수 ( Hyung Soo Kim ),박진웅 ( Jin Woong Park ),원인식 ( In Sik Won ),신권철 ( Kwen Chul Shin ),김세중 ( Se Joong Kim ),양재석 ( Jae Seok Yang ),이현희 ( Hyun Hee Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.2
Renal pelvic and periureteral varices are rare cause of hematuria. On the intravenous pyelography, periureteral varices show a scalloped corkscrew-like appearance to the ureter without evidence of proximal obstruction. The cause of these varices includes renal vein thrombosis, obstruction of the inferior vena cava, congenital anomalies of the inferior vena cava or renal veins, infection, malignancy and nutcracker syndrome. We report a case of Periureteral Varices Diagnosed by Intravenous Pyelography caused by nutcracker syndrome.