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문광덕(Kwang-Deok Moon),신승렬(Seung-Ryeul Shin) 한국식품영양과학회 1996 한국식품영양과학회지 Vol.25 No.2
토마토 과실의 연화현상의 주 원인으로 판단되는 세포벽의 형태적 변화를 조사하기 위하여 성숙 단계별로 취하여 과실의 경도, 세포벽 구성 성분의 변화 및 세포벽의 변화를 조사하였다. 과육의 경도는 적숙기 이후부터 급격한 감소를 나타내었다. 세포벽 함량은 성숙 중에 감소하였고 가용성 펙틴의 증가와 불용성 펙틴의 감소는 적숙기와 식용 적기 사이에서 가장 현저했으며, 총 펙틴의 함량은 다소 감소하는 경향을 나타내었다. 성숙에 따른 토마토 과육의 세포 및 세포벽의 형태적 변화를 현미경으로 관찰한 결과, 수확까지의 토마토에서는 middle lamella와 세포내 기관들이 잘 관찰되었으나, 연화가 진행됨에 따라 식용 적기의 토마토에는 middle lamella를 관찰할 수 없었으며 과숙기에서는 middle lamella의 가용화와 함께 세포벽의 부분적인 분해와 세포분리현상이 관찰되었다. This study was conducted to understand the characteristics of fruit softening during maturation which causes considerable losses in quality of horticultural products during storage and marketing process after harvest. The changes in the cell wall contents and structure of tomatoes during maturation were characterized. The hardness of fruit was decreased rapidly between mature and pink stage tomatoes. Contents of cell wall and insoluble pectin was decreased during maturation, but soluble pectin was increased. Microscopic observations of cell wall of tomato fruits during maturation showed the degradation of middle lamella in pink stage tomato fruits. Partial degradation of cell wall and cell separation were observed in red stage tomato fruits.
폐암의 병기결정에 있어서 컴퓨터 단층촬영(CT)과 감마 카메라를 이용한 양전자방출 단층촬영(PET)의 민감도와 특이도의 비교연구
문광덕,이철주,김영진,최호,김정태,강준규,홍준화,박찬희,윤석남 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1
A retrospective study was undertaken to compare sensitivities and speciticities of computed tomography (CT) scan and radiolabeled glucose analog ^(18)F-fluoro-2-deoxy-D-glucose (FDG) camera based positron emission tomography (PET). Nine patients with lung cancer who underwent preoperative CT and ^(18)F-FDG coincidence PET scanning were evaluated retrospectively. Imaging studies were read prospecdvely and blinded to the surgical and pathologic data. The final diagnosis was established by histopathologic examination at thoracotomy. CT was accurate in 7 patients (77.8%), with understaging in 1 patient and overstaging in 1 patient. In detection of locally advanced disease (N2/N3), the sensitivity, specificity, positive predictive value and negative predictive value were 50%, 85.7%, 50% and 85.7%, respectively. On the other hand, ^(18)F-FDG-PET was accurate in 8 patients (88.9%), with overstaging in 1 patient and without any understaging. In detection of locally advanced disease (N2/N3), the sensitivity, specificity, positive predictive value and negative predictive value were 100%, 85.7%, 66.7% and 100%, respectively. ^(18)F-FDG-PET was significantly more accurate than CT in lymph node staging of lung cancer. The high negative predictive value of FDG-PET could reduce a need for invasive surgical staging (ISS).
Kwang-Min Park,Sung-Gyu Lee,Kyoung-Yeon Hwang,Young-In Yoon,Shin Hwang,Tae-Yong Ha,Chul-Soo Ahn,Ki-Hun Kim,Deok-Bog Moon,Gi-Won Song,Dong-Hwan Jung,Young-Joo Lee 한국간담췌외과학회 2015 한국간담췌외과학회지 Vol.19 No.1
Backgrounds/Aims: According to 7th AJCC TNM staging system, gallbladder carcinoma (GBC) with lymph node (LN) metastasis is classified as N1 or N2; thus making the stage IIIB (N1) or IVB (N2). Stage IIIB consists of N1 status with wide coverage of T1-3, but T3N1 group often showed poorer outcomes than T1-2N1 groups. This study intended to assess post-resection prognosis of T3N1 versus other stage III subgroups. Methods: We selected 103 patients from our institutional database of GBC who underwent R0 resection between July 1996 and June 2009 and whose GBC was confined to stage T3N0, T1-3N1 or T1-3N2. These patients were stratified into five groups, namely, T3N0 (n=26), T1N1 (n=13), T2N1 (n=35), T3N1 (n=20) and T1-3N2 (n=9), and were followed for ≥5 years or until death. Results: Surgical procedures were minor liver resection (n=53), minor liver resection with bile duct resection (n=23), major liver resection (n=12), major liver resection with bile duct resection (n=5), and hepatopancreatoduodenectomy (n=12). Mean follow-up period was 57.2±68.5 months. Overall 5-year survival rate based on all-cause death and cancer-associated death, respectively, was 57.7% and 60.6% in T3N0, 15.4% and 15.4% in T1N1 (n=13), 28.6% and 28.6% in T2N1 (n=35), 5.0% and 5.7% in T3N1 (n=20), and 22.2% and 22.2% in T1-3N2. The survival outcome of T3N1 group was the poorest among the four stage III groups and was comparable to that of stage IVB (p=0.53). Conclusions: The prognosis of T3N1 GBC is unusually poor even after R0 resection, thus we suggest extensive LN dissection may be necessary in patients with T3 tumors for accurate prognostic evaluation and radical removal of potential nodal micrometastasis. Further validation of this result is necessary in large patient populations from multiple centers.