Effects of Instructional Treatments with Learning Conditions and Tasks on Learning of Simple and Complex Grammatical Rules

Mi-Sook Ko 한국영어어문교육학회 2008 영어어문교육 Vol.14 No.4

This study is a subsequent experiment of Ko’s (2006), which investigated the effects of learning conditions and task types respectively. Based on the findings of Ko’s (2006), the present study examined which combination of instructional treatments combining two learning conditions with two task types could be more effective than the other combinations on the learning of different grammatical rules. 130 Korean college freshmen with low proficiency were assigned to four experimental groups: EC (explicit condition and comprehension task), EP (explicit condition and production task), IC (implicit condition and comprehension task), and IP (implicit condition and production task). After two week instructions, post-test data through grammaticality judgment test and controlled written test were analyzed by the two-way Multiple Analysis of Covariance (MANCOVA). The findings of the study are as follows: (a) for the comprehension of a simple rule, there is no significant difference; (b) for the production of a simple and a complex rule, the EP can be the most effective; and (c) for the comprehension of a complex rule, the EP and the IP can be more effective than the EC and the IC. Overall, the effect of the combination with an explicit condition and a production task is more evident than the others. The results are expected to give empirical evidence and suggestions for more effective ways of promoting learning of formal linguistic features and leading L2 learners to develop their interlanguage.

韓國社會에 있어서 姑婦葛藤에 관한 硏究

高貞子,金甲淑 東亞大學校 1988 東亞論叢 Vol.25 No.1

This is a preliminary study of changing relationship between mother and daughter-in-law in the Ko-rean society. Surveys were longitudinally carried out on 1974 and 1985. This thesis was made by an experimental research. Data were collected from 146 mothers-in-law and 141 daughters-in-law in Pusan. The collected data were analysed by statistical methods such as percentages and chi-square. The results of this study were as follows. The chief dissatisfaction toward daughter-in-law were doing without consultation and no affection and respect also. The lack of communication of mother-in-law and daughter-in-law is the cause of conflict. There were some tendencies of decresing "inwardly-conflict-resolving", which means more frequent appealing to other relevant consultants, such as daughter by mother and husband by daughter-in-law. Though employment of daughter-in-law outside domestic work increases during the period, traditional attitude of mother against to involvement in the occupational activities by the former did not changed according so far. The conflict between mother-in-law and daughter-in-law play negative effects on the intimacy. As compremiser, in the case of mother-in-law, daughter-in-law respects mother-in-law and gives her the role.

지방자치단쳬 민원행정서비스의 질적 제고를 위한 정책 방향

고숙희,라휘문 세명대학교 2000 世明論叢 Vol.8 No.-

There have been the changes of Civil Affairs Administration after the inauguration of elected governors. The source of reforms in local public service after the election was the initiative of the governors of each local government. Therefore the type of local public services during 1995-1999 can be defined as 'Customer Care', which was characterized by high customer orientation and no shift in the power balance. As the reforms of the same period have been oriented to the customer as service recipients, the responsiveness of service delivery in local government has been enhanced. But the efficiency and effectiveness has been ignored relatively. The implication of this study is that local governments have to be concerned of the customer as tax payer as well as service recipients when delivering the civil affairs service.

지방소득세의 도입모형

고숙희,라휘문 世明大學校 1998 世明論叢 Vol.7 No.-

There are few studies for the tax assignment and revenue sharing of subnational level. This paper discusses these important issues and tries to provide relevnt policy recommendations for Korea's redesign of intergovernmental assignment of revenue sources. More specifically, this paper is to empirically study developing the local income tax. This paper argued that the current structure of korean local tax system has been designed to support the national development planning policy prevailed in the 60s and 70s. A salient feature of such system is that the tax base of the national and local governments are strictly separated so that the national government takes precedence over major over major tax base such as income. This paper argues that such system lacks flexibility in handling problems faced by diversified and independent local governments in the 90s. As a solution, it is suggested that the national and local governments share the income tax base. The organization of this paper is summarized as follows; The reserch issues is addressed in the first chapter with introductory statements. Chapter 2 deals with the theoretical background including possibilities of developing the local income tax(Types, Tax Sources, Tax Rates, Criteria and Results of Distribution) are discussed in Chapter 3. Chapter 4 contains the model and recommendation of the local income tax.

과량의 방사선에 머리부분이 노출된 흰쥐 망막의 속핵층과 신경절세포의 미세구조변화

고정식,최숙경,양남길,안의태,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

이 실험은 머리부분이 많은 양이 방사선에 노출되었을 때, 망막 속핵층과 신경세포의 미세구조적 반응을 관찰하기 위하여 시행하였다. 실험동물로는 체중200-250g의 흰쥐를 사용하였으며, 마취상태에서 머리부분에만 방사선을 조사였다. 방사선조사는 선형가속기(Mitsubishi Linear Accelerator, ML-4MV)를 이용하였으며 1분당 200rad씩 연속 조사하여 3,000rad 또는 6,000rad를 조사한 후 6시간, 2일, 6일에 희생시켰다. 각 동물은 1% glutaradehyde- 1% paraformaldehyde액으로 관류고정한 다음, 안구를 적출하여 톱니둘레를 따라 절단한 후 망막의 일정부위에서 조직을 떼어내었다. 떼어낸 조직은 2.5% glutaradehyde- 1.5% paraformaldehyde 액에 일차고정한 다음 1% osmium tetroxide액에 이차 고정하였다. 고정된 조직은 수세와 탈수과정을 거쳐 araldite혼합액에 포매한 다음 얇은 절편을 작성하여 uranyl acetate와 lead citrate로 염색한 후 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. 무축삭신경원은 세포질의 전자밀도가 높은 어두운 세포(type 3)와 전자밀도가 낮은 밝은 세포로 구분되었으며, 밝은 세포는 핵의 윤곽이 매끄럽고 둥근 세포(type 1)와 핵막의 함입현상이 뚜렷한 세포(type 2)로 구분되었다. 2. 3,000rad의 X-선을 조사한 후 6시간군의 경우, 속핵층을 구성하는 세포들과 신경절세포에서는 속핵층을 구성하는 세포들과 신경절세포에서는 사립체와 세포막이 파괴되는 모습이 관찰되었는데 2일군의 경우 그 경향이 가장 심했다. 3. 3,000rad의 X-선을 조사한 후 6일군의 경우, 부챗살아교세포의 영역이 넓어져서 전체적인 모습이 2일군의 것에 비하여 많이 회복되어 보였다. 4. 6,000rad의 X-선을 조사한 후 6일군의 경우, 속핵층을 구성하는 세포들이 기저복합체 근처에서 관찰되었다. 5. 6,000rad의 X-선을 조사한 후 6시간부터, 부챗살아교세포는 미세사가 많고 전자밀도가 높은 변성된 세포들이 자주 관찰되었다. 이상의 결과를 고찰해 보면 머리부분이 3,000rad의 X-선에 노출되면 망막의 속핵층을 구성하는 세포들과 신경절세포는 처음에는 새포질소기관들과 세포막이 손상을 받으나, 6일 후에는 부챗살아교세포의 영역이 넓어져서 전체적인 구조가 많이 회복된다. 그러나 6,000rad정도의 방사선에 노출되면 부챗살아교세포도 변성되어 속핵층과 신경절세포층의 구조가 변성된다고 생각된다. This experiment was performed to study the morphological responses of the cell of the inner nuclear layer and the ganglion cell of the rat retina following X-ray irradiation. Male rats were divided into normal and experimental groups. The heads of the rats, under sodium thiopental anesthesia, were exposed to 3,000rads or 6,000rads of radiation in a single dose, respectively. The source was a Mitsubishi linear accelerator ML-4MV. The target to skin distance was 80cm, and the dose rate was 200 rads/min. The experimental groups were sacrificed on 6hour, 2 and 6 days after X-ray irradiations. Under anesthesia, 1% glutaraldehyde-1% paraformaldehye solution was perfused through the heart. Pieces of the tissue taken from the posterior region of the retina were fixed in 2.5% glutaraldehyde-1.5% paraformaldehyde, and in 1% osmium tetroxide, and embedded in araldite mixture. Ultrathin sections were stained with uranyl acetate and lead citrate solutions and were observed with JEM 100CX-II electron microscope. The results were as follow: 1. Three type of amacrine cells were found, according to their electron densities and nuclear shape, i,e,dark amacrine cell with invaginated nucleus(type 3), light amacrine cell with round nucleus(type 1) and light amacrine cell wit invaginated nucleus(type 2). 2. Six hours after exposure to 3,000 rads of X-ray, morphological changes were observed in cytoplasm of the cells of the inner nuclear layer and the ganglion cell: i.e., edematous changes, fragmentation of mitochondria, breakdown of the plasma membrane, etc. 3. Six days after exposure to 3,000rads of X-ray, many of the malformations were seen to be repaired, except the territory of activated Muller cell. 4. Six days after exposure to 6.000 rads of X-ray, cells of the inner nuclear layer were observed near the Bruch's membrane. 5. Six days after exposure to 6.000 rads of X-ray, darkly degenerated Muller cells were frequently observed. From the above results it wluded that 3,000rads of head-irradiation induces damages to the cell organelles in the cells of the inner nuclear layer and the ganglion cell during the first few days, but many of the malformations can be repaired within six days. And 6,000rads of head irradiation leads to renaturation of the inner nuclear layer and the ganglion cell layer of the retina, since the most of the Muller cells are degenerated within a few days following irradiation.

국내 5개 3차 병원의 β-lactam계 항생제 사용 실태 및 Klebsiella pneumoniae의 항생제 내성과의 상관 관계

정숙인,박경화,권기태,고관수,오원섭,정두련,백경란,염준섭,장현하,김신우,손준성,송재훈 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Background : This study was performed to evaluate the prescribing pattern of β-lactam antibiotics and the relationship between antimicrobial resistance and antimicrobial use in 5 tertiary care hospitals in Korea. Materials and Methods : Data on annual patient-days and annual consumption (defined daily dose (DDD) per 100 patient-days) of β-lactam antibiotics from 2003 to 2005 in 5 tertiary hospitals were analyzed. To determine the antimicrobial resistance in K. pneumoniae, broth microdilution test and double disk synergy were performed according to the CLSI performance standards. Spearman's correlation coeffient was used to determine the relationship between antibiotic consumption and resistance. Results : The prescription of β-lactam antibiotics in 5 tertiary hospitals markedly varied. In two hospitals, increase in consumption of β-lactam antibiotics was more than 30% during recent 3 years. The higher consumption of β-lactam antibiotics significantly correlated with the higher rate of antibiotic-resistant K. pneumoniae in 5 tertiary care hospitals. Conclusion : Continuous surveillance of antibiotic use is needed to encourage appropriate prescribing of antibiotics and to reduce antibiotic resistance. 목적 : 항생제의 오남용으로 인한 내성균의 발현 및 급속한 확산이 전세계적으로 문제시 되고 있다. 특히 병원은 항생제 내성의 중심점에 있는 것으로 여겨진다. 본 연구에서는 최근 3년간 국내 5개 3차 병원의 β-lactam계 항생제의 사용량을 조사하고, 각 병원별 항생제 사용량과 K. pneumoniae의 항생제 내성률과의 상관관계를 알아보고자 하였다. 재료 및 방법 : 국내 5개 3차 병원에서 2003년 1월부터 2005년 12월까지 병원 입원 환자를 대상으로 연도별 재원연인원수와 각 β-lactam계 항생제의 총사용량을 수집하여 DDD (defined daily dose) per 100 patient-days로 환산하여 비교하였다. 2005년 6월부터 8월까지 각 병원의 임상검체에서 동정된 K. pneumoniae를 수집하여 액체배지미량희석법으로 항생제 감수성 검사를 시행하였고 ESBL(extended-spectrum β-lactamase) 생성 여부는 double disk synergy test를 시행하였다. 항생제 사용량과 내성의 상관관계는 Spearman 상관관계 분석을 시행하였다. 결과 : 5개 병원 중 3개 병원에서는 연도별 β-lactam계 항생제 사용량이 비슷하게 유지되었으나, 2개 병원에서는 2003년에 비해 2005년에 항생제 사용량이 30% 이상 증가하였다. β-lactam계 항생제 중 제제별 비율은 각 병원마다 차이가 있었으나, 3세대 cephaosporin의 사용이 가장 많았고 2세대 ceaphlosporin, β-lactam/β-lactamase inhibitor, 1세대 cephalosporin 순이었다. 경구용 β-1actam계 항생제의 사용량(r=0.900, P<0.037)과 2세대 cephalosporin의 사용량(r=0.900, P<0.037)은 각각 K. pneumoniae의 ESBL 생성과 양의 상관관계가 있었다. Ceftazidime의 사용량은 K. pneumoniae의 ceftazidime 내성률과 양의 상관관계가 있었다(r=0.900, P<0.037). 반면 imipenem의 사용량은 piperacillin/tazobactam 내성과 음의 상관관계가 있었다(r=-0.900, P<0.037). 결론 : 최근 3개년간 항생제 사용량은 병원별로 차이가 있으나 일부 병원에서는 증가하였다. β-lactam계 항생제의 사용량은 K. pneumoniae의 항생제 내성과 상관관계가 있었다. 항생제 사용을 줄임으로써 항생제 내성을 감소시킬 수 있을 것으로 기대되며, 병원별로 항생제 사용에 대한 지속적인 감시가 필요할 것이다.

폐렴구균 감염증에서 항생제 내성의 임상적 의미 : Asian Network for Surveillance of Resistant Pathogens(ANSORP) Study

정숙인,기현균,손준성,고관수,김나영,장현하,오원섭,백경란,이남용,김신우,이혁,--,송재훈 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : 전 세계적으로 폐렴구균의 페니실린을 포함한 β-lactam과 마크로라이드 및 퀴놀론 계열의 항생제에 대한 내성이 급격히 증가하여 임상적으로 문제가 되고 있으나, 시험관내 내성이 실제 임상적 예후에 미치는 영향에 대해서는 아직까지 논란이 되고 있다. 본 연구는 폐렴구균의 항생제 내성률이 높은 아시아 지역에서 항생제 내성이 폐렴구균 감염증의 임상경과에 미치는 영향을 평가하기 위하여 시행되었다. 방법 : ANSORP에서 주관한 전향적 임상 연구로서 1999년 11월부터 2001년 8월까지 아시아 지역 11개국의 14개 기관에서 진단된 침습성 폐럼구균 감염증 환자를 대상으로 내성 균주 감염의 위험요인, 임상양상, 예후 등의 임상적 분석을 시행하였다. 결과 : 총 646명 환자의 평균연령은 30.1세(6일-89세)였고, 이전 3개월 내에 항생제 사용력이 있는 환자는 159명(32.4%)이었다. 질환별로는 폐렴이 377예(58.4%)로 가장 많았고, 중이염 67예, 뇌수막염 66예(10.2%), 일차성 균혈증 65예(10.1%)였다. 총 646균주 중 347균주(53.7%)가 페니실린 비감수성(중등도 내성 23.1%, 고도 내성 23.1%)이었고, 페니실린에 대한 MIC_(90)은 0.03㎍/mL에서 4㎍/mL까지의 분포를 보였다. 페니실린 비감수성 균주에 의한 감염증과 차이가 없었다. 페니실린 내성 폐렴구균 폐렴에 의한 사망률은 페니실린 감수성 폐렴구균 폐렴에 의한 사망률과 차이가 없었다(p=0.846). Erythromycin에 대한 고도 내성을 보이는 균주의 비율이 매우 높았으나, 실제 임상상이나 치사율에는 영향을 미치지 않았다(p=0.092). 페니실린 비감수성 폐렴구균에 의한 뇌수막염의 치사률도 감수성 균주에 의한 사망률과 차이가 없었다(p=0.059). 결론 : 본 연구의 결과 페니실린 및 베타 락탐 제제에 대한 시험관 내성은 폐렴구균 폐렴이나 뇌수막염의 임상상이나 치사율에 영향을 미치지 않는 것으로 확인되었다. 이는 내성의 정도와 연관될 것으로 생각되므로, 향후 고도 내성 균주가 증가할 때 추가 검증을 요한다. 아울러 macrolide 및 퀴놀론계 항생제 내성의 임상적 의미에 대한 후속 연구가 필요할 것으로 사료된다. Background : Despite the widespread emergence of antimicrobial resistance among pneumococcal strains worldwide, clinical implications of in vitro resistance still remain an open question. To evaluate the clinical impact of pneumococcal resistance in Asian countries where the prevalence of pneumococcal resistance was reported to be highest in the world, ANSORP has performed a prospective, multinational surveillance study with cases with invasive pneumococcal diseases in Asian countries. Methods : In vitro susceptibility of pneumococcal isolates was determined by broth microdilution tests with 16 antimicrobial agents. All enrolled cases of pneumococcal infections were analyzed with regard to demographic data, clinical features, risk factors and mortality. Results : A total of 646 patients with pneumococcal infections were enrolled from 14 centers in 12 countries between the period from November 1999 to August 2001. Pneumonia (58.4%) was the most common clinical disease followed by bacteremia (33.4%), otitis media (10.4%), and meningitis (10.2%). Among 646 isolates, 347 (53.7%) were penicillin non-susceptible (intermediate 23.1%, resistant 30.7%). MIG_(90)s for penicillin ranged from 0.03 (India) to 4.0 ㎍/mL (Korea, Taiwan, Vietnam, and Hong Kong). Overall mortality from pneumococcal diseases by penicillin non-susceptible strains was not different from that by susceptible strains. Pneumococcal pneumonia caused by penicillin- or erythromycin-resistant strains showed similar mortality, severity of illness, or complications to that by susceptible strains. Mortality from pneumococcal meningitis caused by penicillin non-susceptible strains was also similar to that by susceptible strains. Conclusion : Data suggest that current situation of in vitro resistance to penicillin or macrolides may not affect the mortality from pneumococal pneumonia or meningitis caused by antibiotic-resistant strains.

국내에서 발생하고 있는 사람 브루셀라증의 임상적 특성

김연숙,최영실,오원섭,권기태,이혁,이선희,손준성,김신우,장현하,정숙인,고관수,박미연,백경란,송재훈 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : 2002년 내국인에서의 첫 사람 브루셀라증의 증례 보고 이후 국내에서 사람 브루셀라증이 빠른 증가를 보이고 있다. 이에 연구자들은 국내에서 발생하는 브루셀라증의 임상적 특성을 연구하고자 하였다. 방법 : 2003년부터 2006년 7월까지 7개 대학병원에 내원한 환자들을 대상으로 WHO의 진단기준에 의하여 확진된 브루셀라증 환자들의 의무기록을 후향적으로 조사분석 하였다. 배양된 균은 삼성서울병원에 의뢰하여 16S rRNA 유전자 분석방법을 이용하여 종을 확인하였고, 표준시험관응집검사는 국립보건원에 의뢰하여 시행하였다. 결과 : 34예의 환자들이 브루셀라증으로 확진되었고, 31명이 남자였다. 혈액에서 B. abortus가 증명된 경우가 8예, 표준시험관 응집검사상 의미 있는 항체가 상승을 보인경우가 26예이었다. 환자들은 대부분 축산업관련 종사자였고, 추후 브루셀라증으로 확진된 소와의 직접 접촉을 통해 감염된 것으로 여겨진다. 국내 사람 브루셀라증의 가장 흔한 증상은 발열이었고, 위장관계 합병증이 가장 흔히 동반되었다. 치료로는 doxycycline/rifampicin이 24예의 환자에서 doxycycline/aminoglycoside (streptomycin 혹은 gentamicin)이 10예의 환자에서 6주 이상의 기간 동안 투여되었다. 치료에 반응을 보이지 않는 환자는 없었고, 재발이 1예 있었다. 결론 : 국내에서 발생하는 사람 브루셀라증의 원인균으로 현재까지 분리 동정된 것은 B. abortus이며, 소 브루셀라증의 증가로 인해 인체감염사례가 함께 증가하는 것으로 사료된다. 위험 직업군 종사자들에서 감염된 소와의 직접 접촉을 통해 주로 발생하고 있는 브루셀라증의 임상종상은 국외에서 발생하는 경우와 유사한 양상을 보이고 있으며 치료에 대한 반응은 비교적 좋은 편이긴 하나, 추후 보다 많은 환자들을 대상으로 한 연구가 필요하리라 사료된다. 사람 브루셀라증의 조절을 위해서는 소 브루셀라증의 조절이 필수적이며, 브루셀라증의 조절에 성공한 선진국의 사례를 적극적으로 도입해야 할 것으로 생각된다. Background : Since the first Korean case of human brucellosis was reported in 2002, the incidence of human brucellosis has been rapidly increasing. We performed this study to evaluate the clinical characteristics of human brucellosis occurring in South Korea. Materials and Methods : Demographic features, clinical manifestations, and therapeutic outcomes of cases confirmed as brucellosis according to WHO diagnostic criteria were evaluated. Species of Brucella isolates were identified with 16S rRNA gene sequencing method. Serologic diagnosis was performed with standard tube agglutination test (STA). Results : A total of 34 cases were enrolled from 2003 to 2006 in six hospitals. Eight cases were confirmed with the isolation of Brucella from blood and 26 cases were confirmed with titer of antibodies ≥1:160 by STA. Male (31) was predominant and most of the patients were cattle farmers. The most common transmission route was direct contact with infected or their cattle byproducts. Fever was the most prominent symptom and fatigue followed. Gastrointestinal and musculoskeletal systems were commonly complicated. Patients were treated with doxycycline and rifampin or aminoglycosides for more than 6 weeks. All patients responded well to the therapeutic regimens, but one patient relapsed 10 months after treatment. Conclusion : Brucellosis occurring in Korea has been caused by B. abortus, whose preferred natural host animals are cattle. Korean patients were infected through direct contact with bovine brucellosis. Clinical manifestations of brucellosis were similar to those occurring worldwide. Therapeutic outcomes were good among patients with brucellosis in Korea. In order to prevent human brucellosis, measures to eradicate bovine brucellosis should precede.

有機物 施用에 의한 病害蟲 發生 및 벼 收量性

김용재,고숙주,이인,김도익 全南大學校 農業科學技術硏究所 1996 農業科學技術硏究 Vol.31 No.-

This study was conducted to find out the occurrence of pests and yield performance of rice by pesticide spray or non-saray and application of organic matter, such as rice straw compost, fowl dung compost, rice straw + SEMIP(super effective micro-organism in plantation), organic fertilizer and milk vetch. The contents of 0.M and C.E.C were increased a little in soil applied with organic matter. At the one panicle formation stage the contents of T-N of rice leaf blade and leaf sheath in conventional plot were lower than that in applied organic matter plot. The occurrence of pests in pesticide non-spray was much more than that in pesticide spray. Rice plant was damaged by sheath blight in every kinds of organic matter of pesticide non-spray plot. Therefore sheath blight must be applied by chemicals. The damage of rice stern borer was high in plots of fowl dung compost, organic fertilizer and milk vetch of pesticide non-spray plot. The contents of protein in conventional plot were 5.18-5.24%, but 5.41-5.89% in applied organic matter plot. Percentage of ripened grain in pesticide non-spray(83.6-86.9%) was lower than that in pesticide spray (88.0-89.7%). The yield of brown rice in pesticide non-spray was 13% lower than that in pesticide spray.

다발성 말초신경증이 동반된 불명열로 발현한 혈관내 림프종증

박병배,김갑현,손준성,기현균,정숙인,오원섭,백경란,정철원,송재훈,고영혜 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

불명열의 원인에는 감염, 신생물, 교원섬유혈관질환 등의 여러 가지 질환이 속한다. 불명열 환자를 접하게 되면 그 원인을 밝히기 위한 검사를 시행하게 되는데, 수많은 검사를 시행하고도 그 원인 질환이 진단 안 되는 경우가 5-15% 정도 된다. 불명열의 원인으로서 이전까지 진단이 어려웠던 농양이나 종양은 현대의 방사선적 영상기술 발달로 조기 진단이 가능하게 되었지만, 악성 혈액질환처럼 종괴를 형성하지 않는 질환들의 정확하고 신속한 진단은 여전히 어려운 실정이다. 혈관내림프종증은 림프절 병변을 거의 형성하지 않기 때문에 진단이 매우 어려운 질환이다. 병의 경과가 빨리 진행하여 예후가 좋지 않으므로 신속한 진단이 절실히 요구되는 질환이다. 저자들은 말초신경증이 동반된 불명열을 주소로 내원한 환자에서 흉강내시경 폐생검을 시행하여 혈관내림프종증을 조기 진단할 수 있었기에 이를 문헌 고찰과 함께 보고 하는 바이다. Fever of unknown origin (FUO) is caused by infections (30-40%), neoplasms (20-30%), collagen vascular diseases (10-20%), and numerous miscellaneous diseases (15-20%). The literatures also reveal that 5-15% of FUO cases defy diagnosis, despite extensive studies. Diagnostic advances continuously modify the spectrum of FUO-causing diseases. Modern imaging techniques (e.g., ultrasound, CT scan, MRI) enable early detection of abscesses and solid tumors that used to be difficult to diagnose. But the correct diagnosis can be delayed because the tumor, such as rare hematologic malignancy, is difficult to be detected by various imaging studies. Intravascular lymphomatosis (IVL) is a rare form of non-Hodgkin's lymphoma and generally fatal disease characterized by extensive proliferation of neoplastic mononuclear cells within the lumina of blood vessels. The prognosis is usually extremely poor, with rapid death despite chemotherapy. The diagnosis is most frequently made after biopsy of skin or brain but is often established post mortem. Most patients with IVL present with FUO and nonspecific cutaneous and neurologic manifestations. Peripheral nerve system or pulmonary involvements are not common as initial menifestations. We report a case of intravascular lymphomatosis, presenting as FUO with peripheral polyneuropathy. We made early diagnosis of IVL by video-assisted thoracoscopic lung biopsy. She is improving with good performance after the 4th cycle of chemotherapy till now.