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- 저자 : Kimberly O’Brien (검색결과 1 건)
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Ethnic Differences in Iron Absorption and Its Relevance to Personalized Nutrition
Kimberly O’Brien 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
An individual’s genetic background may influence their biological responses to nutrients and their risk of subsequent adverse health outcomes that are linked to nutritional status. Identifying genes that are associated with nutrient utilization has great potential to improve human health and personalize nutritional intakes. Personalized nutrition approaches are highly relevant to iron homeostasis as both iron deficiency and excess impact risk of chronic disease and adverse health outcomes. Large screening studies have evaluated risk of elevated body iron stores as a function of ancestry and have found that individuals of Asian, particularly East Asian ancestry have the highest risk of elevated body iron stores. This finding is surprising given that the most common genetic mutations associated with iron overload (C282Y and H63D) are nearly absent among Asian individuals. Individuals of East Asian ancestry may also develop iron overload-related diseases such as diabetes at a lower body mass index than typically observed among other ancestry groups. Iron balance is controlled at the level of the enterocyte as humans have no regulatable means of excreting excess iron once absorbed into the body. We recently determined that Asian females absorb significantly more non-heme iron than White females even when controlling for body iron stores. Characterizing ethnic differences in iron absorption and identifying variations in genes that are associated with iron absorption may help target iron supplementation to individuals that will benefit most from these practices and optimize dietary iron intake recommendations. This is particularly important for iron given that prophylactic iron supplementation is often recommended to large subsets of the population during vulnerable life stages. One such example is universal prenatal iron supplementation. While this practice is beneficial in preventing maternal anemia in iron deficient women it may place those with certain genotypes at increased risk of excess body iron stores at maturity.
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