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Neurolymphomatosis in patients with mantle cell lymphoma diagnosed by FDG PET-CT
Sooyoung Kim,Hakyeu An,Yoon Seok Choi,Kee Hong Park,Eun Hee Sohn 대한임상신경생리학회 2020 Annals of Clinical Neurophysiology Vol.22 No.1
Neurolymphomatosis (NL) is characterized by the infiltration of malignant lymphoma cells into peripheral nerves, nerve roots, plexuses, or cranial nerves. This is a very rare complication of mantle-cell lymphoma. Diagnosing NL is made difficult by cerebrospinal fluid cytology and bone-marrow biopsy results often being negative. NL can appear as the only sign of recurrence in a patient with a previous diagnosis of lymphoma. Here we present two cases of NL in patients with mantle-cell lymphoma diagnosed by positron emission tomography with deoxy-fluoro-D-glucose integrated with computed tomography.
Kim, Jeongah,Jang, Sangwon,Choi, Mijung,Chung, Sooyoung,Choe, Youngshik,Choe, Han Kyoung,Son, Gi Hoon,Rhee, Kunsoo,Kim, Kyungjin Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.8
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that $REV-ERB{\alpha}$, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that $REV-ERB{\alpha}$ may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of $REV-ERB{\alpha}$ affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. $REV-ERB{\alpha}$ deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The $REV-erb{\alpha}$ knockout mice showed prolonged microglial activation in the SN along with the over-production of interleukin $1{\beta}$, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of $REV-ERB{\alpha}$ can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.
Evaluation of Cooperative Diversity Techniques Using STC for Future S-DMB Services
KIM, Sooyoung,PARK, Unhee,KIM, Hee-Wook,AHN, Do-Seob The Institute of Electronics, Information and Comm 2009 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.92 No.11
<P>This paper presents an evaluation of various cooperative diversity techniques applied to future satellite digital multimedia broadcasting (S-DMB) systems. The increasing importance of hybrid and/or integrated satellite and terrestrial networks is associated with the utilization of spatial diversity techniques such as antenna diversity using space-time coding. The space-time coding schemes can be expected to result in more diversity gain as the number of transmit antennas are increased. However, we cannot design a rate-1 scheme that achieves full diversity for more than two transmit antennas. To overcome this limitation, quasi-orthogonal schemes were proposed, at the expense of the decoder complexity and diversity gain. In this paper, we introduce an efficient quasi-orthogonal space time coding scheme, and evaluate various aspects associated with the application of the proposed scheme to satellite systems. The proposed scheme in this paper provides the full rate as well as maximum-likelihood decoding via simple linear detection.</P>
Control-oriented modeling and torque estimations for vehicle driveline with dual-clutch transmission
Kim, Sooyoung,Choi, Seibum Elsevier 2018 Mechanism and machine theory Vol.121 No.-
<P><B>Abstract</B></P> <P>Over the years, dual-clutch transmission (DCT) has demonstrated its higher efficiency and superior shift performances over other types of transmissions, and has been increasingly used in modern mass-produced vehicles. However, due to the absence of the smoothing effects of torque converters, vehicles with DCT are easily exposed to driveline oscillations that lead to poor driving quality, especially during gear shifts. Therefore, torque transfer through the driveline should be controlled with great care by two clutches and engine to achieve the DCT's outstanding performance. The main obstacle to the accurate torque control is its lack of adequate sensors in production vehicles. Thus, the objectives of this paper are two-fold. First, a control-oriented model with practical concerns is implemented for DCT drivelines, aiming to accurately describe the powertrain oscillations that should be suppressed by the torque control. Secondly, a real-time torque monitoring strategy based on the proposed model is suggested to deal with the absence of torque sensors. The primary task of the torque estimator is to concurrently estimate the torque transmitted through both clutches and drive shaft by using only readily available data from production cars. The developed torque estimator is verified through multiple experiments under various driving conditions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A control-oriented model for a vehicle driveline with DCT is developed with practical aspects. </LI> <LI> A torque observer is designed to estimate torque through both clutches and the drive shaft in a DCT. </LI> <LI> The observer is based on the control-oriented model and uses data available on production cars. </LI> <LI> The effectiveness of the developed model and the torque observer is demonstrated by experiments. </LI> <LI> The proposed methods of modeling and torque estimation are useful for accurate powertrain controls. </LI> </UL> </P>
Ovarian tissue cryopreservation and transplantation in patients with cancer
( Sooyoung Kim ),( Younji Lee ),( Sanghoon Lee ),( Tak Kim ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4
Chemotherapy and radiotherapy improved survival rates of patients with cancer. However, they can cause ovarian failure and infertility in women of reproductive age. Infertility following cancer treatment is considered a major quality of life issue. Ovarian tissue cryopreservation and transplantation is an important option for fertility preservation in adult patients with cancer who need immediate chemotherapy or do not want to undergo ovarian stimulation. Ovarian tissue freezing is the only option for preserving the fertility of prepubertal patients with cancer. In a recent review, it was reported that frozen-thawed ovarian transplantation has lead to about 90 live births and the conception rate was about 30%. Endocrine function recovery was observed in 92.9% between 3.5 and 6.5 months after transplantation. Based on our review, ovarian tissue cryopreservation and transplantation may be carefully considered before cancer treatment in order to preserve fertility and endocrine function in young cancer survivors.
Implications of Circadian Rhythm in Dopamine and Mood Regulation
Kim, Jeongah,Jang, Sangwon,Choe, Han Kyoung,Chung, Sooyoung,Son, Gi Hoon,Kim, Kyungjin Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.7
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-$erb{\alpha}$ induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.
( Sooyoung Moon ),( Junghee Kim ),( Eunkyoung Kim ),( Sunyoung Kim ) 한국유아교육학회 2021 정기학술대회 논문집 Vol.2021 No.1
Educational implications of “Learning Community” through this study are as follows. The collaboration of professor-teacher for learning was realized when they faced with each other as emotional supporters beyond providing the lesson of reproduction of knowledge. The professionalism of teachers was manifested as the power of execution to attempt new changes as similar concerns and different environment between teachers were shared.