EEG signal to Image Transformation for Emotion Recognition

Hung,Aran Oh(오아란),Soo-Hyung Kim(김수형) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

Inundation Analysis of Coastal Area Considering Climate Change

Kim, Kyungtae,Kim, Yonsoo,Kim, Soojun,Choi, Changhyun,Kim, Hung Soo 한국방재학회 2015 한국방재학회 학술발표대회논문집 Vol.14 No.-

Future climate change is expected to raise the mean sea level of Korea by about 0.85m-1.29m. Consequently, flood damage in the coastal area would likewise increase and the scale of damage would also become much larger. Various researches have been conducted to efficiently respond to natural disasters caused by climate change. However, there haven’t been many researches related to the analysis and evaluation of coastal area flood vulnerability caused by the rise in sea level. Hence, this study selected Gilsan River basin, a branch of Geum River as the subject matter and tried to evaluate the effect of sea level rise caused by climate change on the coastal area and adjacent rivers. This study also calculated the change in water quantity in the coastal area by considering the sea level rise as well as the future precipitation according to climate change. It also prepared/compared the relevant flood inundation map. The study result showed that the overall flood level increased as the elevation of the water surface rose due to the rise in sea level. In addition, the extent of increase in flood level caused by sea level rise was greater at a location nearer the outlet and it was smaller at a place farther from the outlet. Based on this result, it could be verified that in coastal rivers, climate change can have an effect not only on the precipitation increase but also on the flood water level and flood inundation due to the rise in sea level. The result of this study could be used as basic data for creating technology that would assess the flood vulnerability of coastal urban regions and evaluate preventive measures for coastal disaster risks.

Population Pharmacokinetic Analysis of Meropenem After Intravenous Infusion in Korean Patients With Acute Infections

Kim, Yong Kyun,Lee, Dong-Hwan,Jeon, Jaehyun,Jang, Hang-Jea,Kim, Hyeon-Kuk,Jin, Kyubok,Lim, Sung-Nam,Lee, Sung Sook,Park, Bong Soo,Kim, Yang Wook,Shin, Jae-Gook,Kiem, Sungmin Elsevier 2018 Clinical therapeutics Vol.40 No.8

<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>The aim of this study was to investigate the population pharmacokinetic (PK) profile of meropenem in Korean patients with acute infections.</P> <P><B>Methods</B></P> <P>The study included 37 patients with a creatinine clearance ≤50 or >50 mL/min who received a 500- or 1000-mg dose of meropenem, respectively, infused intravenously over 1 hour every 8 hours. Blood samples were collected before and at 1, 1.5, and 5 hours after the start of the fourth infusion. The population PK analysis was conducted by using nonlinear mixed effect modeling software (NONMEM). Monte-Carlo simulations were performed to identify optimal dosing regimens.</P> <P><B>Findings</B></P> <P>Thirty-seven subjects completed the study. Meropenem PK variables were well described by using a one-compartment model. The typical values (relative SE) for weight-normalized clearance (CL) and V<SUB>d</SUB> were 0.266 L/h/kg (12.29%) and 0.489 L/kg (11.01%), respectively. Meropenem CL was significantly influenced by the serum creatinine level, which explained 11% of the interindividual CK variability. The proposed equation to estimate meropenem CL in Korean patients was as follows: CL (L/h) = 0.266 × weight × [serum creatinine/0.74]<SUP>–1.017</SUP> <SUB>.</SUB> The simulation results indicate that the current meropenem dosing regimen may be suboptimal in patients infected with normal or augmented renal function.</P> <P><B>Implications</B></P> <P>Prolonged infusions of meropenem over at least 2 hours should be considered, especially in patients with augmented renal function and those infected with pathogens for which the minimum inhibitory meropenem concentration is >1 μg/mL. Our results suggest an individualized meropenem dosing regimen for patients with abnormal renal function and those infected with pathogens with decreased in vitro susceptibility.</P>

Introduction of Main/Sub focuses in Science and Technology process

Hung Soo Kim 한국방재학회 2015 한국방재학회 학술발표대회논문집 Vol.14 No.-

The Science and Technology process focuses on a number of areas where science and technology development provides a major opportunity to innovate water resources management. A number of areas have been carefully selected and are described below. Main focus 1: Efficient water management Today’s water management continues to be highly inefficient in many respects, seriously hampering the sustainable management of water resources, delivery of services and the protection of human health and the environment. In the years to come, major efforts will need to be made to improve water efficiency as a means to secure water resources, adapt to climate change, or operate water services systems at lower costs. Sub Focus: Urban water efficiency, Agricultural water efficiency, Industrial water efficiency, Energy efficiency in water and waste water systems Main focus 2: Resource recovery from water and waste-water systems Increasingly, water and waste-water systems are recognized as potential sources of recovering water, energy, nutrients and other materials. At the same time, the re-use of waste water in agricultural, industrial and urban applications is gaining momentum. The development of re-use and recycling within the water and waste-water sectors provides major opportunities for improving environmental performance, creating climate benefits and reducing costs. Sub Focus: Water re-use and recycling technologies, Energy recovery and production from water and waste water cycles, Nutrients recovery from waste water Main focus 3: Water and Natural disasters As the devastating impact of recent natural disasters such as the flood occurred in Thailand in 2011, indicates, mankind is vulnerable to extreme weather events in developing and even in developed countries. Clearly, such extreme events have always been part of our life and may be caused by climate change. This makes water related problems, especially, such as floods and droughts, more difficult to analyze and predict. Climate change is predicted to have a range of serious consequences, some of which will have impact over the longer term, like droughts, while some have immediate and obvious impacts, such as intense rain and flooding. Floods and droughts are major natural disasters involving loss of life and the destruction of property. So, we may need advanced technologies and measures in order to cope with natural disasters. Sub Focus: Climate change : impact assessment and adaptation, Drought analysis and management, Urban floods and damage reduction studies, RS and GIS applications for natural hazards Main focus 4: Smart technology for Water Water management is increasingly influenced by developments in Smart Technology(ST). Better use of this ST in measuring, monitoring and distributing water can lead to a significant contribution in overcoming water management challenges in the 21st century. Bridging the ‘divide’ between the water and ST sectors will be important in the development and (wide-scale) application of new smart technologies in the water sector. Sub Focus: Urban and Irrigation water management and ST, Integrated and intelligent river basin water management and ST, Design and implementation of smart water grid, Water resources management and Big Data Main focus 5: Understanding and managing ecosystem services for water Ecosystems provide valuable services underpinning water security and the sustainable management of water resources. In recent years, major advances have been made in understanding the role of ecosystems in, for example, reducing floods, recharging aquifers, or protecting and improving water quality. Sub Focus: The science and technology of natural and green infrastructure management, The economic valuation of ecosystem services for water, The payment for ecosystem services for water quality and delivery

Effects of platelet-rich plasma on the expression of Hoxa 1 0 and UF in the uterine endometrium of rats

( Hang Yong Jang ),( Soo Min Myoung ),( Jeong Min Choe ),( Tak Kim ),( Hyun Tae Park ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

A Topological View of Chaos : ( II ) Independence and Noise Cancellation

( Hung Soo Kim ) 고려대학교 공학기술연구소 1997 공학기술연구소보 Vol.4 No.-

<i>Rudaeicoccus suwonensis</i> gen. nov., sp. nov., an actinobacterium isolated from the epidermal tissue of a root of a <i>Phalaenopsis</i> orchid

Kim, Soo-Jin,Jang, Yun-Hee,Ahn, Jae-Hyung,Weon, Hang-Yeon,Schumann, Peter,Chun, Se-Chul,Kwon, Soon-Wo,Kim, Wan-Gyu International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.4

<P>A bacterial strain, designated HOR6-4<SUP>T</SUP>, was isolated from the epidermal tissue of a root of a <I>Phalaenopsis</I> orchid. Strain HOR6-4<SUP>T</SUP> was characterized using a polyphasic approach. The cells were aerobic, Gram-stain-positive, non-motile coccoids. Phylogenetic analysis of its 16S rRNA gene sequence revealed a clear affiliation with the family <I>Dermacoccaceae</I>. Strain HOR6-4<SUP>T</SUP> showed relatively low 16S rRNA gene sequence similarity (below 95.9 %) to type strains of species with validly published names, showing the highest sequence similarities to the type strains of <I>Flexivirga alba</I> (95.8 %) and <I>Yimella lutea</I> (95.5 %). The DNA G+C content of strain HOR6-4<SUP>T</SUP> was 64.7 mol%. Strain HOR6-4<SUP>T</SUP> had anteiso-C<SUB>17 : 0</SUB> (19.3 %), 10-methyl C<SUB>18 : 0</SUB> (tuberculostearic acid; 13.5 %) and 10-methyl C<SUB>17 : 0</SUB> (11.7 %) as the major fatty acids and contained MK-8(H<SUB>4</SUB>) and MK-8(H<SUB>6</SUB>) as the predominant quinones. Polar lipids were diphosphatidylglycerol, phosphatidylinositol, three aminophospholipids, two phospholipids and an aminolipid. The peptidoglycan type was A4α, with an <SMALL>l</SMALL>-Lys–<SMALL>l</SMALL>-Thr–<SMALL>d</SMALL>-Glu interpeptide bridge with a glycine residue bound to the alpha-carboxyl group of <SMALL>d</SMALL>-Glu in position 2 of the peptide subunit. Mycolic acids were not present. On the basis of comparative analysis of phenotypic and phylogenetic traits, strain HOR6-4<SUP>T</SUP> is considered to represent a novel species in a new genus in the family <I>Dermacoccaceae</I>, for which the name <I>Rudaeicoccus suwonensis</I> gen. nov., sp. nov. is proposed. The type strain of <I>Rudaeicoccus suwonensis</I> is HOR6-4<SUP>T</SUP> ( = KACC 12637<SUP>T</SUP>  = DSM 19560<SUP>T</SUP>).</P>

Effect of Aggregation on Chaotic Time Series

Hung Soo Kim,Yong Nam Yoon,Gyu-Sei Yi,Taegyun Kim 대한토목학회 2000 KSCE journal of civil engineering Vol.4 No.4

<i>Roseomonas aerophila</i> sp. nov., isolated from air

Kim, Soo-Jin,Weon, Hang-Yeon,Ahn, Jae-Hyung,Hong, Seung-Beom,Seok, Soon-Ja,Whang, Kyung-Sook,Kwon, Soon-Wo International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.6

<P>An aerobic, Gram-stain-negative, motile, mesophilic bacterium, designated strain 7515T-07<SUP>T</SUP>, was isolated from an air sample in the Taean region, Republic of Korea. The strain grew at 4–40 °C (optimum, 30 °C) and pH 5.0–9.0 (optimum, pH 7.0). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain 7515T-07<SUP>T</SUP> was related to members of the genus <I>Roseomonas</I> and had highest 16S rRNA gene sequence similarity with <I>Roseomonas ludipueritiae</I> 170/96<SUP>T</SUP> (96.7 %). 16S RNA gene sequence similarity between strain 7515T-07<SUP>T</SUP> and <I>Roseomonas gilardii</I> ATCC 49956<SUP>T</SUP> (the type species of the genus <I>Roseomonas</I>) was 93.4 %. Strain 7515T-07<SUP>T</SUP> contained Q-10 as the ubiquinone and C<SUB>18 : 1</SUB>ω7<I>c</I> and C<SUB>19 : 0</SUB> cyclo ω8<I>c</I> as the dominant fatty acids (>10 %). The polar lipid profile contained diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine and two unidentified aminolipids. The DNA G+C content was 73.0 mol%. Combined data from phenotypic, phylogenetic and chemotaxonomic studies demonstrated that strain 7515T-07<SUP>T</SUP> is a representative of a novel species of the genus <I>Roseomonas</I>, for which the name <I>Roseomonas aerophila</I> sp. nov. is proposed. The type strain is 7515T-07<SUP>T</SUP> ( = KACC 16529<SUP>T</SUP> = NBRC 108923<SUP>T</SUP>).</P>

Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation.

Kim, Sun Mi,Kwon, Oh-Joon,Hong, Yun Kyoung,Kim, Joo Hang,Solca, Flavio,Ha, Sang-Jun,Soo, Ross A,Christensen, James G,Lee, Ji Hyun,Cho, Byoung Chul American Association for Cancer Research, Inc 2012 Molecular Cancer Therapeutics Vol.11 No.10

<P>The secondary T790M mutation in epidermal growth factor receptor (EGFR) is the major mechanism of acquired resistance to EGFR tyrosine kinase inhibitors (TKI) in non-small cell lung cancer (NSCLC). Although irreversible EGFR TKIs, such as afatinib or dacomitinib, have been introduced to overcome the acquired resistance, they showed a limited efficacy in NSCLC with T790M. Herein, we identified the novel de novo resistance mechanism to irreversible EGFR TKIs in H1975 and PC9-GR cells, which are NSCLC cells with EGFR T790M. Afatinib activated interleukin-6 receptor (IL-6R)/JAK1/STAT3 signaling via autocrine IL-6 secretion in both cells. Inhibition of IL-6R/JAK1/STAT3 signaling pathway increased the sensitivity to afatinib. Cancer cells showed stronger STAT3 activation and enhanced resistance to afatinib in the presence of MRC5 lung fibroblasts. Blockade of IL-6R/JAK1 significantly increased the sensitivity to afatinib through inhibition of afatinib-induced STAT3 activation augmented by the interaction with fibroblasts, suggesting a critical role of paracrine IL-6R/JAK1/STAT3 loop between fibroblasts and cancer cells in the development of drug resistance. The enhancement of afatinib sensitivity by inhibition of IL-6R/JAK1/STAT3 signaling was confirmed in in vivo PC9-GR xenograft model. Similar to afatinib, de novo resistance to dacomitinib in H1975 and PC9-GR cells was also mediated by dacomitinib-induced JAK1/STAT3 activation. Taken together, these findings suggest that IL-6R/JAK1/STAT3 signaling can be a potential therapeutic target to enhance the efficacy of irreversible EGFR TKIs in patients with EGFR T790M.</P>