위전절제술 후 Kim 's Tie 부근 공장에 국소 재발한 위암환자 1예

배병구,서병조,유항종,강윤경,김진복,Bae Byung-Gu,Suh Byoung-Jo,Yu Hang-Jong,Kang Yun-Kyung,Kim Jin-Pok 대한위암학회 2005 대한위암학회지 Vol.5 No.1

위암은 국내에서 발생 빈도가 가장 높은 암으로서 근치적 절제술 및 확대 영역 림프절 절제술의 도입과 더불어 술후 보조 항암화학요법 및 면역요법 등의 이용으로 최근 치료성적의 향상을 보이고 있다. 그러나 수술적 치료를 포함한 치료법의 발전에도 불구하고 다양한 형태의 재발을 경험하게 되고, 대부분의 재발은 3년 이내에 일어난다. 재발양상으로는 크게 국소재발, 원격재발, 복막재발 등이 있으며, 여러 가지 재발양상이 한꺼번에 보이는 경우도 있다. 이 중 국소재발의 호발 부위로는 림프절($48\%$), 문합부($32\%$, 잔존 위($20\%$)의 순으로 보고되고 있다. 증례: 51세의 여자 환자로 1999년 10월 진행성 위암으로 근치적 위전절제술을 시행 받았고, 당시 병기는 T3N1M0(IIIa,AJCC 1997)이었다. 수술 후 10회의 보조적 정맥 주사용 항암화학요법 및 경구용 항암화학요법을 2년간 실시하였고, 외래를 통한 추적검사상 약 5년간 재발을 보이지 않았으나 2004년 9월 시행한 내시경상 Kim's tie 부근공장에서 궤양성 병변을 발견하고 조직검사를 시행, 병리학적으로 낮은 분화도를 보이는 인환 세포암종 형태의 위선암 재발로 진단하고 수술을 시행하였다. 수술 방법은 Kim's tie 위치를 포함해 근위부 6.5 cm, 원위부 4 cm의 절제연을 두고 공장부분 절제술을 시행하였다. 수술 당시 다른 복부장기로 전이는 없었으며 전이성 복수도 없었다. 수술 후 별다른 합병증 없이 회복하였으며 보조 항암화학요법 제제로써 TS-1을 사용하며 외래 통한 추적검사 중이다. Despite improvements in the surgical treatment of gastric adenocarcinomas, the recurrence rates remain high in patients with advanced-stage disease. Most of the recurrence occurs within 3 years of the surgical resection, and nearly $90\%$ of the patients with recurrence die within 2 years of the diagnosis of recurrence. A recent study analyzed recurrence patterns for patients who had undergone a potentially curative gastrectomy. For those patients, $33\%$ of the recurrences involved locoregional sites, $44\%$ the peritoneum, and $38\%$ distant sites. A 51-year-old female patient was diagnosed with stomach cancer and underwent a total gastrectomy with D2 lymph node dissection during Oct. 1999. The pathologic report indicated a T3N1M0 tumor. We performed immunochemotherapy for 2 years with regular follow up. A gastrofiberscopic examination done during sep. 2004, cancer recurrence was found at the Kim's tie site of the jejunual loop. We did an abdominal exploration and a segmental resection of cancer site with pathologically negative resection margins. After the operation, we started secondary chemotherapy with TS-1.

양지면 전원주택단지 프로젝트 계획

김신원,정유홍,노희곤,도의성,최기왕 경희대학교 디자인연구원 2006 예술· 디자인학연구 Vol.9 No.2

This plan of rural housing-development is to present a new orientation for the residential culture that can meet the shifting demands of modern people as their attitudes toward naturalistic life. In this plan, sites of possible, a new housing complex is designed to supplement the site partition problem of existing housing complex by using attractiveness that the site has as a residence environment in housing planning. The conclusion can be summarized as follows. 1. Currently, most residential developments on slopes are planned with excessive slope cutting or filling on existing natural slopes rather than utilizing existing contours. In consideration of this, this proposed plan uses the existing contours of the slope to the maximum capacity in site planning. 2. The majority of the home site buyers are between the ages 30's to 50's of middle to high level incomes. Reflecting the financial needs of these families, home construction was planned by using building methods that require lower costs. 3. Reflected open-space furtherance maximum at design of community equipment for party's offer to sale in lots persons, from site purchase recognition of construction to in package sale in lots way select. 4. Considered to preserve existing natural-food life in way financial world stroke maximum, and accomplish creation with existing vegetation. Also, did planting considering privacy, and considered vegetation's environment adaptation degree because using midland style vegetation. 5. Garden wished to offer an opportunity that can make by oneself directly depending on each fondness and character to tenants. If is this intuition, wished to design, and maintained spur of housing development because housing development uses maximum natural history style comparing with other power jars all. Also, because considering people who move in housing-development, designed, and tried to make housing-development that want to live most offering the convenience.

光陵의 蝶相 : 特히 季節的 消長에 대하여

金憲奎,申裕垣 이화여자대학교 한국문화연구원 1959 韓國文化硏究院 論叢 Vol.1 No.-

1. Sixty-five species were known from this area by 1932 with no additional species being reported to date. 2. In order to clarify the fauna, the authors made one full year's collection from October, 1958 to October, 1959. Thirty-two species are added to the fauna of Kwangnung, raising the number of species to ninety-seven. 3. Weekly collections were made by the authors along several preset courses in order to cover the area adequately as shown on the map. Collections were made as recorded in the following table: 1958 1959 month Oct Apr May June July Aug Sept Oct date 24 12, 1819, 25 2, 9, 1512,28,30 12, 1320, 28 5, 1125 2, 1624, 30 13, 2027 4, 25 4. The species were grouped in four categories according to the number of specimens appearing in our collections. The following table presents the numbers of species in each categories: A=most abundant - 22 species B=common - 16 ˝ C=rare - 15 ˝ D=very rare - 38 ˝ 5. The greatest numbers for most species were collected in June, with fewer in May, August, and July respectively.

서비스 주체의 상호 협력 관계를 제공하는 멀티미디어 Qos 프레임워크

김태윤,장경아,유항재 高麗大學校附設 컴퓨터科學技術硏究所 1999 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.2 No.-

인터넷 사용자의 급속한 증가와 전자 상거래의 발달로 신뢰성, 보안성, 확장성, 유연성 등의 기본적인 요구 사항 뿐 아니라 멀티미디어 응용 서비스에 대한 필요성이 제기되고 있다. 멀티미디어 컴퓨팅과 커뮤니케이션은 네트워크, 통신망, 오퍼레이팅 시스템에서 다양한 메커니즘을 필요로 한다. 대규모 분산 환경에서 QoS는 Video-on-Demand, News-On-Demand 등의 단일 매체에 대한 서비스와는 다르게 응용 매체에 대한 우선 순위 부여 및 상호 협력 구조적 서비스 및 MPEG 비디오 서비스와 같은 멀티미디어 응용 서비스에 대한 지원 능력을 요구하고 있다. 본 논문에서는 인터넷을 기반으로 대단위 분산 시스템 환경에서 QoS를 지원하기 위한 통합적 QoS 프레임워크로 E-QoS 모델을 설계하였으며, 향후 이를 바탕으로 한 세부 메커니즘의 설계 방향을 제시하였다. The huge Internet and electronic commerce shall be provided not only basic requirements of reliability, security extendibility, flexibility but also adaptive application service of multimedia data. There are required a lot of mechanism for network, operating system in multimedia computing and communication. In large distributed computing, QoS shall be provided a priority allocation service and an interactive infrastructure service as like not single media service of Video-on-Demand, and News-on-Demand but multimedia application service of MPEG video service. In this paper, supporting large distributed computing based on Internet, we propose a E-QoS Model as Integrated QoS Framework, and propose a direction of design for specific mechanism in the future works.

中學 科學敎育의 探究學習에 대한 評價問項 開發(Ⅰ)

奇宇恒,權炳奎,朴德圭,이병교,鄭遠佑,金裕漢 경북대학교 과학교육연구소 1984 科學敎育硏究誌 Vol.8 No.-

The purpose of this study is to achieve the individualized inquiring learning which is centered on students by improving the method of the evaluation of the inquiry learning in the science class in a multi-student class. Therefore the author made the table of specification for scientific achievements of the abilities of inquiring by analyzing the abilities of inquiring according to the content of science and five basic experiments of each unit inthe first grade of of middle school, ant then made the paper and pencil and performance test items for the evaluation of the abilities of inquiring. The paper and pencil test was taken after the experimental and observational class, and performance test was taken in the way of the students' self evaluation, peer evaluation and Tester evaluation. The results are as follows: 1) In operation of the inquiry learning by two experiments, performance test items and 13 the paper and pencil test items made for evaluation of the abilities of inquiring could be applied usefully. 2) Correlation coefficient between paper and pencil test and performance test is .362 and it is very low. Therefore it is desirable that performance test be used for the evaluation for the abilities of inquiring which cannot be evaluated by paper and pencil test. 3) In evaluation of the abilities of inquiring by performance test on five basic experiments, it is more desirable that 'the use of microscope' is presented in the way of peer evaluation or peer and Tester evaluation, 'the observation on epidermis of onion cell' in the way of peer evaluation, and self-evaluation. 4) Skill of the abilities of inquiring in experimental and observational class can be evaluated correctly through performance test.

마우스에 있어서 Isoniazid와 Rifampicin의 免疫毒性에 對한 酒精 및 高麗人蔘의 影響

안영근,김정훈,유항묵,강영세 圓光大學校 1988 論文集 Vol.22 No.2

結核의 一般的인 藥物療法으로 利用되고 있는 Isonicotinic acid hydrazide(INAH)와 Rifampicin의 倂用投與는 結核의 治療效果를 改善시킬 수 있는 反面에 INAH와 Rifampicin의 長期 倂用投與가 肝毒性과 免疫抑制作用을 出現시킨다고 報告된 바 있다. 한편 酒精의 長期間 暴露는 肝毒性과 T-lymphocyte 機能抑制 및 體液性 免疫에 손상을 가져 온다고 알려진 바 있고 高麗人蔘은 細胞性 및 體液性 免疫 修飾作用이 있으며 特히 石油 ether 分劃은 그 作用이 强하여 細胞性 및 體液性 免疫 macrophage의 活性 등을 현저하게 亢進시킨다고 本人 等이 밝힌 바 있다. 本 硏究의 結果 INAH와 Rifampicin 倂用投與時 이들 藥物에 의한 免疫 毒性에 對하여 酒精및 高麗人蔘을 倂用하였을 때 INAH와 Rifampicin은 細胞性 및 體液性 免疫을 低下시켰으며 酒精의 倂用投與는 免疫 毒性을 增加하였으나 高麗人蔘의 倂用投與는 細胞性 및 體液性 免疫과 大食細胞의 活性을 增加시킴을 밝혔다. 1. Rifampicin and INAH exposure decreased relative spleen weight, humoral and cellular immune responses and macrophage activity. 2. Alcohol combined administration significantly increased the cellular immunotoxicity of Rifampicin and INAH. Especially, 4% alcohol combined administration significantly suppressed the cellular immune response and macrophage activity. 3. Generally, Korean ginseng extracts reduced or removed the decline of humoral and cellular immune responses and macrophage activity by immunotoxicity of Rifampicin and INAH.

마우스에 있어서 Isoniazid와 Rifampicin의 免疫毒性에 대한 酒淸 및 高麗人蔘의 影響

안영근,김정훈,유항묵,강영세 원광대학교 식품약품안전성연구소 1987 食品藥品安全性硏究 Vol.1 No.-

結核의 一般的인 藥物療法으로 利用되고 있는 Isonicotinic acid hydrazide(INAH)와 Rifampicin의 倂用投與는 結核의 治療效果를 改善시킬 수 있는 反面에 INAH와 Rifampicin의 長期 倂用投與가 肝毒性과 免疫抑制作用을 出現시킨다고 新告된 바 있다. 한편 酒精의 長期間 暴露는 肝毒性과 T-Iymphocyte機能抑制 및 體液性 免疫에 손상을 가져 온다고 알려진 바 있고 高麗人蔘은 細胞性 및 體液性 免疫 修飾作用이 있으며 特히 石油 ether 分劃은 그 作用이 强하여 細胞性 및 體液性 免疫 macrophage의 活性 등을 현저하게 亢進시킨다고 本人 等이 밝힌 바 있다. 本 硏究의 結果 INAH와 Rifampicin倂用與時 이들 藥物에 의한 免疫 毒性에 對하여 酒精 및 高麗人蔘을 倂用하였을 때 INAH와 Rifampicin은 細胞性 및 體液性 免疫을 低下시켰으며 酒精의 倂用投餘는 免疫 毒性을 增加하였으나 高麗人蔘의 倂用投與는 細胞性 및 體液性 免疫과 大食細胞의 活性을 增加시킴을 밝혔다. 1. Rifampicin and INAH exposure decreased relative spleen weight, humoral and cellular immune responses and macrophage activity. 2. Alcohol combined administration significantly increased the cellular immunotoxicity of Rifampicin and INAH. Especially, 4% alcohol combined administration significantly suppressed the cellular immune response and macrophage activity. 3. Generally, Korean giseng extracts reduced of removed the decline of humoral and cellular immune responses and macrophage activity by immunotoxicity of Rifampicin and INAH.

The Effect of ZD 1839 (Iressa) in the Treatment of RefractoryNon Small Cell Lung Cancer

Yong Tai Kim,Chul Kim,Joo Hyuk Sohn,So Young Park,Soo Young Park,Nae Choon Yu,Young Sam Kim,Se Kyu Kim,Joon Chang,Kil Dong Kim,Kyung Young Chung,Joo Hang Kim 대한암학회 2003 Cancer Research and Treatment Vol.35 No.6

Purpose: The aim of this study was to evaluate theefficacy and the safety of ZD 1839 (Iressa) as a 3rd or4th line chemotherapy regimen in NSCLC patients whoare refractory to a previous chemotherapy regimen.Materials and Methods: Twenty-five patients who wererefractory to previous chemotherapy were selected forthis study. The eligible patients had an ECOG performancestatus of 0 to 2, and an appropriate end organfunction. ZD 1839 (Iressa) 250 mg/d was orally administereduntil the patients experienced disease progressionor unacceptable toxicity.Results: Twenty-five patients were analyzed. The medianage of the patients was 57 years. The response ratewas 12.0% with partial responses in 3 patients. Fourteenpatients (56%) remained in the stable disease state and8 patients progressed. The median overall survival was9.0 months (95% CI 6.7~11.2). The median progressionfree survival was 3 months (95% CI 2.2~3.8). Hematologicaltoxicities of grade 3 or 4 neutropenia, anemia andthrombocytopenia were absent. Non-hematological toxicitieswere grade 2 or 3 skin rashes in 10 (40.0%) patientsand 1 (4.0%) patient and grade 3 nausea in 3 (12.0%) patients.No patient failed to continue chemotherapy due toany drug-related adverse events.Conclusion: The results suggest that ZD 1839 (Iressa)monotherapy is effective and tolerable as a 3rd or 4th linesalvage treatment for NSCLC patients refractory to previouschemotherapy regimens. (Cancer ResTreat. 2003;35:502-506)

The Analysis of Vitamin C Concentration in Organs of $Gulo^{-/-}$ Mice Upon Vitamin C Withdrawal

Kim, Hye-Min,Bae, Se-Yeon,Yu, Yeon-Sil,Kim, Ye-Jin,Kim, Hang-Rae,Hwang, Young-Il,Kang, Jae-Seung,Lee, Wang-Jae The Korean Association of Immunobiologists 2012 Immune Network Vol.12 No.1

Background: Vitamin C is an essential nutrient for maintaining human life. Vitamin C insufficiency in the plasma is closely related with the development of scurvy. However, in vivo kinetics of vitamin C regarding its storage and consumption is still largely unknown. Methods: We used $Gulo^{-/-}$ mice, which cannot synthesize vitamin C like human. Vitamin C level in plasma and organs from $Gulo^{-/-}$ mice was examined, and it compared with the level of wild-type mice during 5 weeks. Results: The significant weight loss of $Gulo^{-/-}$ mice was shown at 3 weeks after vitamin C withdrawal. However, there was no differences between wild-type and vitamin C-supplemented $Gulo^{-/-}$ mice (3.3 g/L in drinking water). The concentration of vitamin C in plasma and organs was significantly decreased at 1 week after vitamin C withdrawal. Vitamin C is preferentially deposited in adrenal gland, lymph node, lung, and brain. There were no significant changes in the numbers and CD4/CD8 ratio of splenocytes in $Gulo^{-/-}$ mice with vitamin C withdrawal for 4 weeks. And the architecture of spleen in $Gulo^{-/-}$ mice was disrupted at 5 weeks after vitamin C withdrawal. Conclusion: The vitamin C level of $Gulo^{-/-}$ mice was considerably decreased from 1 week after vitamin C withdrawal. Vitamin C is preferentially stored in some organs such as brain, adrenal gland and lung.

The Analysis of Vitamin C Concentration in Organs of Gulo^-/- Mice Upon Vitamin C Withdrawal

Kim, Hye-Min,Bae, Se-Yeon,Yu, Yeon-Sil,Kim, Ye-Jin,Kim, Hang-Rae,Hwang, Young-Il,Kang, Jae-Seung,Lee, Wang-Jae 대한면역학회 2012 Immune Network Vol.12 No.1

Vitamin C is an essential nutrient for maintaining human life. Vitamin C insufficiency in the plasma is closely related with the development of scurvy. However, in vivo kinetics of vitamin C regarding its storage and consumption is still largely unknown. Methods: We used GUlo^-/- mice, which cannot synthesize vitamin C like human. Vitamin C level in plasma and organs from GUlo^-/- mice was examined, and it compared with the level of wild-type mice during 5 weeks. Results: The significant weight loss of GUlo^-/- mice was shown at 3 weeks after vitamin C withdrawal. However, there was no differences between wild-type and vitamin C-supplemented GUlo^-/- mice (3.3 g/L in drinking water). The concentration of vitamin C in plasma and organs was significantly decreased at 1 week after vitamin C withdrawal. Vitamin C is preferentially deposited in adrenal gland, lymph node, lung, and brain. There were no significant changes in the numbers and CD4/CD8 ratio of splenocytes in GUlo^-/- mice with vitamin C withdrawal for 4 weeks. And the architecture of spleen in GUlo^-/- mice was disrupted at 5 weeks after vitamin C withdrawal. Conclusion: The vitamin C level of GUlo^-/- mice was considerably decreased from 1 week after vitamin C withdrawal. Vitamin C is preferentially stored in some organs such as brain, adrenal gland and lung.