지베렐린과 에세폰의 葉面撒布가 '美白' 복숭아의 熟期와 品質에 미치는 影響

김영호,윤철구,임상철,김학현,이철희,최관순,김선규 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

In order to obtain the basic data for artificial maturity control of 'Mibaek' peach, GA and ethephon were foliar sprayed 4 weeks prior to harvest, and their effects on fruit maturity and quality were examined. GA and ethephon tended to decrease the fruit weight except 100mg ㆍ L-1 GA+50 to 100mg · L-1 ethephon treatment. GA increased the fruit firmness, and ethephon at higher concentration increased the fruit drop. Harvest date was advanced for 7 to 8 days by ethephon while was delayed for 6 to 8 days by GA treatment, regardless of concentration.

과수 조류피해 방지에 관한 연구

김영호,윤철구,임상철,손인창,박재혁,김동환,김선규 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 2002 연구보고서 Vol.6 No.-

새로운 저비용 고효율 조류 피해 방지법의 개발을 위한 기초자료를 얻기 위하여, 현재 사과, 배 과수원에서 사용되고 있는 조류피해 방지 방법들의 정확한 효과를 서로 비교 검토하고, 아울러 충북지역 과수 재배 농가들을 대상으로 유해조류에 의한 피해 실태와 경제성 있는 조류 피해방지 방법에 대한 설문조사를 병행 실시한 결과는 다음과 같다. 1. 조류피해는 방조망 설치에 의해서만 완전히 방지할 수 있었으며, 조류 피해율별 손익계산 결과를 참고하여 이익이 있을 때는 표준방조망을 설치하고, 그렇지 않을 경우에는 설치비가 저렴하며 농가에서 간단히 시공할 수 있는 간이방조망 설치가 더 경제적인 것으로 판단되었다. 도내 과수 농가의 조류피해는 지역 간에 큰 차이가 있었으며, 음향적 방제인 버드가드와 보호봉지인 망사봉지에 의한 방제가 가장 효과적이었다. 그러나 버드가드는 높은 설치비용이 문제되므로, 퇴치 효과가 비슷하거나 더 우수하면서 저렴한 한국식 음향 기구를 개발할 필요가 있는 것으로 판단되었다. 보호봉지인 UV 봉지와 플라스틱 보호캡 및 망사봉지 처리는 품종에 관계없이 피해를 현저하게 감소시켰으나, 과실의 착색 등 품질에 미치는 영향에 대해서 추가적인 연구와 검토가 필요한 것으로 생각되었다. To obtain basic data for low cost-high efficiency control methods for bird damage, the available control methods currently in use mostly in Chungbuk Province were tested on site, and the control efficiency was compared. Also, a comprehensive survey of actual bird damage and the control methods on model apple and pear growers in Chungbuk Province was conducted. The results are summarized as follows. The perfect control for bird damage was possible only through bird net, it was recommended that profit-and loss account must be considered before installing bird net, and when the 'standard bird net' does not come up to break-even point, more economic and convenient 'simplified bird net' should be a alternative. Actual extent of bird damage varied according to the locality, and imported acoustic apparatus BirdGard^R, development of our own system with superior or same quality and reasonable price is necessary. Fruit bags such as UV bags, plastic protective caps, and net bags were highly effective for bird damage control, irrespective of fruit species and cultivar, but further study to resolve some problems such as poor coloration caused by bagging is necessary.

내측연수경색에서 관찰된 안구의 반대편 측방돌진

김지수,문소영,정선미,한문구,박성호 대한평형의학회 2003 Research in Vestibular Science Vol.2 No.2

7분 선별검사(7 Minute Screen Test) 각 하위 척도의 임상적 유용성

구형모,김지혜,고선규,고혜정,이형석,김상윤,김도관 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : We aimed to provide standard data of the individual tests in 7MS that could generalized for Korean elderly accor-ding to age and education. We also evaluated diagnostic efFicacy of each test in 7MS. Methods : Data on demographic characteristics of 311 normals were gathered for comparison. We also assessed two differences between normal and dementia group in individual tests of 7MS. Results : All individual tests of 7MS showed significant differences in sex, age, and education, except for ECR. But there were no significant differences in sex controlling age and education. As a result of ROC curve, the ability of the ECR test to discriminate between AD and normal subject appeared superior. The scores of the individual tests of 7MS among CDR 0.5 and 1 group and normal group were compared. It was also found that the ECR test stands out among 7MS tests. Conclusion : The 7MS, Particularly ECR, had the highest sensitivity and specificity for diagnosis of AD as well as early de-mentia. It suggests that the individual tests of 7MS are useful to predict early dementia, without using the complex logistic re-gression equation.

2,4-D 處理가 'Harcot' 살구와 '美白' 복숭아의 果實 成熟과 品質에 미치는 影響

윤철구,김영호,임상철,김학현,이철희,최관순,김선규 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

Effect of 2,4- D application on the fruit maturity and quality of 'Harcot' apricot and 'Mibaek' peach was examined. Leaf area of 'Harcot' apricot was not affected by 2,4-D while that of 'Mibaek' peach was increased by 35mg · L-1 2,4-D. Application of 2,4-D at 35mgㆍL-1 increased the fruit weight of both species, and that of 'Harcot' was doubled. Soluble solids content of 'Harcot' was decreased by 2,4-D while that of 'Mibaek' was not affected. Fruit maturity of 'Harcot' and 'Mibaek' was enhanced for respective 4 and 1 day by 2,4-D application. Percent fruit cracking of 'Harcot' apricot was decreased by 35mg · L-1 2,4-D.

한우에 있어서 GnRH와 PGF_2α에 의한 발정동기화 연구

강한석,김선구 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

This study was conducted to get some information for the timed insemination program development of Korean native cows. Korean native cows that didn't show estrus behavior up to 60days after calving were used. Estrus synchtonization was induced by injection of PGF2α and GnRH. The estrus synchronization rate was 40.0% in treatment of PGF2α- PGF2α and 93.3% in treatment of GnRH- PGF2α -GnRH. All synchronization cows ovulated between 26 and 32hrs after the 2nd injection of GnRH and the highest ovulation rate was shown at 28hrs after the 2nd injection of GnRH. The highest pregnancy rate was shown in case of artificial insemination at 24hrs after the 2nd injection of GnRH. The pregnancy rate was 50.7% in treatment of PGF2α - PGF2α and 76.9% in treatment of GnRH- PGF2α -GnRH.

Prognostic Factors for Recurrence and Progression in Korean Non-Muscle-Invasive Bladder Cancer Patients: A Retrospective, Multi-Institutional Study

Kim, Hyung Suk,Ku, Ja Hyeon,Kim, Se Joong,Hong, Sung Joon,Hong, Sung Hoo,Kim, Hong Sup,Kwon, Tae Gyun,Cho, Jin Seon,Jeon, Seong Soo,Joo, Kwan Joong,Ahn, Han Jong,Park, Hong Seok,Seong, Do Hwan,Kwon, D Yonsei University College of Medicine 2016 Yonsei medical journal Vol.57 No.4

<P><B>Purpose</B></P><P>To identify the prognostic factors related to tumor recurrence and progression in Korean patients with non-muscle-invasive bladder cancer (NMIBC).</P><P><B>Materials and Methods</B></P><P>Data were collected and analyzed for 2412 NMIBC patients from 15 centers who were initially diagnosed after transurethral resection of bladder tumor (TURBT) from January 2006 to December 2010. Using univariable and multivariable Cox proportional hazards models, the prognostic value of each variable was evaluated for the time to first recurrence and progression.</P><P><B>Results</B></P><P>With a median follow-up duration of 37 months, 866 patients (35.9%) experienced recurrence, and 137 (5.7%) experienced progression. Patients with recurrence had a median time to the first recurrence of 10 months. Multivariable analysis conducted in all patients revealed that preoperative positive urine cytology (PUC) was independently associated with worse recurrence-free survival [RFS; hazard ratio (HR) 1.56; <I>p</I><0.001], and progression-free survival (PFS; HR 1.56; <I>p</I>=0.037). In particular, on multivariable analysis conducted for the high-risk group (T1 tumor/high-grade Ta tumor/carcinoma <I>in situ</I>), preoperative PUC was an independent predictor of worse RFS (HR 1.73; <I>p</I><0.001) and PFS (HR 1.96; <I>p</I>=0.006). On multivariable analysis in patients with T1 high-grade (T1HG) cancer (n=684), better RFS (HR 0.75; <I>p</I>=0.033) and PFS (HR 0.33; <I>p</I><0.001) were observed in association with the administration of intravesical Bacillus Calmette-Guérin (BCG) induction therapy.</P><P><B>Conclusion</B></P><P>A preoperative PUC result may adversely affect RFS and PFS, particularly in high-risk NMIBC patients. Of particular note, intravesical BCG induction therapy should be administered as an adjunct to TURBT in order to improve RFS and PFS in patients with T1HG cancer.</P>

Guided Tissue Regeneration of the Mixture of Human Tooth-Ash and Plaster of Paris in Dogs

Ku, Ha Ra,Jang, Hyun Seon,Kim, S.G.,Jeong, Moon Jin,Park, Joo Cheol,Kim, Heung Joong,Kwon, Young Sun,Kim, Chong Kwan,Kim, Byung Ock Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.330-332 No.1

<P>This study evaluated the efficacy of periodontal tissue regeneration using guided tissue regeneration (GTR) with a mixture of tooth ash and plaster as a bone substitute material in the treatment of class II furcation defects in dogs. GTR was performed at the site of a surgically formed mandibular premolar bifurcation area in dogs. Four adult dogs were used in the animal study. The animals were in a good periodontal state without any systemic disease. A resorbable membrane (Bio-Gide®, Swiss) and bone graft material using a mixture of tooth ash and plaster were used to examine the biological activity. The defect in the control group was filled a Bio-Gide® only. For the experimental group, the defects were filled with a mixture of tooth ash and plaster and covered by a Bio-Gide®. Oral rinsing with 0.12% chlorhexidine was performed twice a day for 2 weeks. In control group, new bone formation was observed adjacent to the preexisting bone. Soft tissue ingrowth was also noted. In experimental group, new lamellar type trabecular bone formation as well as centum and PDL regeneration was observed in the base of the infrabony pocket. More bone regeneration would be expected when GTR is performed using a mixture of human tooth-ash and plaster of Paris as a bone graft material.</P>

Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma

Kim, Junhyung,Yoon, Seon Jin,Moon, Ju Hyung,Ku, Cheol Ryong,Kim, Se Hoon,Lee, Eun Jig,Kim, Sun Ho,Kim, Eui Hyun The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.1

Objective : Silent corticotroph adenomas (SCA) are endocrine-inactive pituitary adenomas with positive immunohistochemistry staining for adrenocorticotropic hormone (ACTH). We investigated whether SCA-associated clinical profiles were more aggressive than hormonally negative adenomas (HNA). Methods : Among 627 patients with pathologically proven endocrine-inactive pituitary adenomas between 2004 and 2013, positive immunohistochemistry revealed 55 SCAs and 411 HNAs. Surgical outcomes and radiological and endocrinological characteristics were compared. Results : Strong female predominance was observed in the SCA group (p<0.001). Cavernous sinus invasion was identified in 22 (40%) SCA patients and 72 (17.6%) HNA patients (p<0.001). There were no differences in ACTH or cortisol levels between the two groups. The incidence of preoperative hypopituitarism and postoperative hormonal outcome did not differ between two groups. Total resection was achieved in 35 patients (63.7%) with SCA and 332 patients (80.8%) with HNA (p=0.007). When tumors were completely removed, recurrence rates were not statistically different between two groups (p=0.60). When complete resection was not achieved, tumors regrew from these remnants in seven patients (35.0%) with SCA and 12 patients (15.2%) with HNA (p=0.05). Conclusion : Total surgical resection for SCA is often challenging as these tumors frequently invade a cavernous sinus. Early remnant tumor intervention is justified, because untreated residual pituitary tumors regrow when patients were followed up for a long time. Prophylactic radiotherapy is not warranted for completely resected SCAs as tumor recurrence is uncommon.

Clostridium difficile에 의한 설사의 예후인자

김준형,김희정,구남수,김영근,최준용,신소연,박윤선,김연아,김명수,정수진,최희경,송영구,이경원,김준명 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

배경 : Clostridium difficile에 의한 설사(Clostridium difficile associated diarrhea; CDAD)는 임상 경과가 다양하다. 최근에 유럽과 북미에서 C. difficile 감염의 발생률이 증가하고 고전적 치료에 잘 반응하지 않으며 이환률이 증가하였고, 이러한 원인이 새로운 균주의 탄생에 기인한다고 보고되었다. CDAD의 예후에 영향을 미치는 세균성 요인과 숙주 요인을 확인하기 위해 본 연구를 진행하였다. 재료 및 방법 : 2002년 8월부터 2003년 12월까지 CDAD가 진단된 20세 이상인 환자들을 대상으로 후향적 Cohort 연구를 하였다. 세균성 요인을 확인하기 위해 cdt A, cdtB, tcd A, tcd A rep 그리고 tcd B 유전자(binary toxin)를 확인하였다. 설사가 치료 시작 후 11일 이상 지속되거나, 2달 이내에 재발하거나, 수술 혹은 다른 시술이 필요한 경우, 사망한 경우 예후가 좋지 않은 것으로 정의하였다. 결과 : 총 115예에서 toxin을 생성하는 C. difficile가 동정되었으며, Toxin A와 toxin B 모두 양성인 균이 91예, toxin B만 양성인 균이 24예였다. Toxin A 생성 여부가 예후에 영향을 미치지 않았지만, 제산제를 사용한 환자에서 그렇지 않은 환자에 비해 toxin B만 양성인 균이 많이 동정되었다(P<0.05). 예후가 좋지 않은 경우는 39예(33.9%)였고 76예(66.1%)에서 예후는 양호하였다. 단변량 분석에서 70세 이상의 고령, 남성, 증상 발현 후 사용한 항생제의 개수 사용, 증상 발현 후 carbapenem, aminoglycoside, glycopeptide 사용, 당뇨 및 뇌졸중 병력이 있는 경우, 그리고 높은 Charlson index가 불량한 예후 인자로 확인되었다. 그러나 독립적인 예후 인자를 조사했을 때에는70세 이상의 고령(odds ratio=3.378, P=0.009), 증상 발현후 carbapenem 사용(odds ratio 7.210, P<0.001)이 예후에 중요한 영향을 미치는 요소로 확인되었다. 결론 : 70세 이상의 고령과 증상 발현 후 carbapenem 사용이 CDAD 독립적인 불량한 예후인자이다. Background : Clostridium difficile associated diarrhea (CDAD) has a wide range of clinical manifestations. The prognostic factors of CDAD are not fully understood. Materialsand Methods : A retrospective cohort study of 115 patients with CDAD from Aug. 2002 to Dec. 2003 was conducted to evaluate prognostic factors of CDAD. Bacteriologic factors were determined by detecting the binary toxin gene, tcd A, tcd A rep and tcd B gene. Poor prognosis was defined as diarrhea more than 10 days even with classic treatment, recurrence, death, and moribund discharge. Results : Approximately 79% of isolated strains were toxin A+/B+ strains and 21% were toxin A-/B+ strains. There was no difference in prognosis between toxin A+ and toxin A- strains. 39 (33.9%) cases showed poor prognosis and 76 (66.1%) cases showed good prognosis. Univariate analyses revealed that the poor prognostic factors were old age over 70 years old, male, the number of antibiotics used after onset of symptom, the administration of carbapenems, aminoglycosides, glycopeptides after onset of symptom, history of DM and stroke, and high Charlson comorbidity index. Multiple logistic regression analysis identified old age over 70 years old (odds ratio=3.378, P=0.009) and the administration of carbapenems after onset of symptom (odds ratio 7.210, P<0.001) as the independent poor prognostic factors. Conclusion : Old age over 70 and the administration of carbapenems after onset of symptom were the poor prognostic factors for CDAD caused by none-binary toxin producing strains.