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손미라 ( Son¸ Mira ),김신향 ( Kim¸ Sinhyang ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2021 정신간호학회지 Vol.30 No.1
Purpose: The purpose of this study was to explore the experience of self-awareness of nursing students through a short-term overseas language study. Methods: Study subjects were 10 nursing students, and collected data were analyzed with open coding, axial coding, selective coding, and process analysis based on Strauss and Corbin's grounded theory (1998). Results: In total, 23 sub-categories and 12 categories were generated. The 12 categories included "Longing for a bigger world", "Don't want to be intimidated", "Interest in English", "Tension about local classes", "Feeling of pushing the limit", "Getting along with natives", “Making Korean American University students a role model", "Self-observe confronting unfamiliarity", "Self-encourage about enduring hardships", "Self-expansion for a better self", "Recognize self-transformation", "Focusing on the reality". Nursing students' self-awareness experience through a short-term overseas language study was a process of solving the phenomenon of 'feeling of pushing the limit', and a derived core category was 'surpass the feeling of pushing the limit and take a step forward'. Conclusion: Study participants experienced self-awareness. These results will not only expand our understanding about self-awareness of nursing students and educators but will also provide information for developing a short-term overseas study program.
송우정,Mira Choi,Dong Hun Lee,Jae-Woo Kwon,Gun-Woo Kim,Myung Hwa Kim,Mi-Ae Kim,Min-Hye Kim,Byung-Keun Kim,Sujeong Kim,Joung Soo Kim,Jung Eun Kim,Ju Young Kim,Joo Hee Kim,Hyun Jung Kim,Hye One Kim,Hyo-Bin 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4
Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
Kim, Mirae,Li, Yongzeng,Peng, Di,Yeom, Eunseop,Kim, Kyung Chun Elsevier 2019 Experimental thermal and fluid science Vol.105 No.-
<P><B>Abstract</B></P> <P>When the circular jet impinges onto a cylinder, the three-dimensional (3D) curved wall jet was attached to the wall due to the Coanda effect and the flow separation was delayed with increasing Reynolds number and impinging angle. These interesting phenomena can be studied in depth through a variety of parameters and measurement methods. Time-resolved stereo PIV measurement was conducted to investigate the 3D flow characteristics with instantaneous velocity and vorticity fields. Pressure sensitive paint (PSP) method was used to examine the pressure distribution on the cylinder surface when a circular jet impinges on it. The effects of the impingement angle, Reynolds number, and diameter ratio between the jet nozzle and the cylinder (d/D) were examined at a fixed nozzle to wall distance ratio of two (H/d = 2). Experimental results show that the pressure gradient in the flow direction decreases and the separation is delayed when the Reynolds number and impingement angle are increased at the same distance ratio. As the diameter ratio decreases with the same impingement angle and Reynolds number, the maximum suction pressure increases, and the pressure gradient in the wall jet flow direction increases. The three-dimensional nature of the surface pressure distribution changes with the flow parameters, which are well explained with three-dimensional flow field measurements in the curved 3D wall jet due to the Coanda effect.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface pressure distribution was measured when a circular jet impinges on a cylinder. </LI> <LI> Effects of the impingement angle, Reynolds number, and diameter ratio were examined. </LI> <LI> Pressure gradient in flow direction decreases when the impingement angle increases. </LI> <LI> The three-dimensional nature of the surface pressure changes with the flow parameters. </LI> </UL> </P>
Kim, Hojeong,Kim, Changsoo,Seo, Sang Won,Na, Duk L.,Kim, Hee Jin,Kang, Mira,Shin, Hee-Young,Cho, Seong Kyung,Park, Sang eon,Lee, Jeongmin,Hwang, Jung Won,Jeon, Seun,Lee, Jong-Min,Kim, Geon Ha,Cho, Han Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.1
<B>ABSTRACT</B><B>Background:</B><P>There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants.</P><B>Methods:</B><P>We recruited cognitively normal participants (<I>n</I> = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders.</P><B>Results:</B><P>Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant.</P><B>Conclusions:</B><P>Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.</P>
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Mira Kim,Jiyoung Jeon,Jongouk Baek,Jaeyul Choi,Eun Ju Park,Jiyeon Song,Hyojeong Bang,Kwee-Hyun Suh,Young Hoon Kim,Jongmin Kim,Doran Kim,민경훈,Kwang-Ok Lee 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
The improvement of ginsenoside accumulation in Panax ginseng as a result of γ-irradiation
Kim, Dong Sub,Song, Mira,Kim, Sun-Hee,Jang, Duk-Soo,Kim, Jin-Baek,Ha, Bo-Keun,Kim, Sang Hoon,Lee, Kyung Jun,Kang, Si-Yong,Jeong, Il Yun The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.3
In this study, gamma rays were used to irradiate embryogenic calli induced from cotyledon explants of Panax ginseng Meyer. After the embryogenic calli were irradiated, they were transferred to adventitious roots using an induction medium; next, mutated adventitious root (MAR) lines with a high frequency of adventitious root formations were selected. Two MAR lines (MAR 5-2 and MAR 5-9) from the calli treated with 50 Gy of gamma rays were cultured on an $NH_4NO_3$-free Murashige and Skoog medium with indole-3-butyric acid 3 mg/L. The expression of genes related to ginsenoside biosynthesis was analyzed using reverse transcription polymerase chain reaction with RNA prepared from native ginseng (NG), non-irradiated adventitious root (NAR) and 2 MAR lines. The expression of the squalene epoxidase and dammarenediol synthase genes was increased in the MAR 5-2 line, whereas the phytosterol synthase was increased in the MAR 5-9 line. The content and pattern of major ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, and Rg1) were analyzed in the NG, NAR, and 2 MAR lines (MAR 5-2 and MAR 5-9) using TLC and HPLC. In the TLC analysis, the ginsenoside patterns in the NG, NAR, and 2 MAR lines were similar; in contrast, the MAR 5-9 line showed strong bands of primary ginsenosides. In the HPLC analysis, compared with the NG, one new type of ginsenoside was observed in the NAR and 2 MAR lines, and another new type of ginsenoside was observed in the 2 MAR lines irradiated with gamma rays. The ginsenoside content of the MAR 5-9 line was significantly greater in comparison to the NG.
Kim, Eun‐,Mi,Kim, Jaehi,Kim, Yun‐,Gon,Lee, Peter,Shin, Dong‐,Sik,Kim, Mira,Hahn, Ji‐,Sook,Lee, Yoon‐,Sik,Kim, Byung‐,Gee John Wiley Sons, Ltd. 2011 Journal of peptide science Vol.17 No.5
<P><B>Abstract</B></P><P>Identification of substrate specificity of kinases is crucial to understand the roles of the kinases in cellular signal transduction pathways. Here, we present an approach applicable for the discovery of substrate specificity of Ser/Thr kinases. The method, which is named as the ‘high‐throughput phosphorylation profiling (HTPP)’ method was developed on the basis of a fully randomized one‐bead one‐compound (OBOC) combinatorial ladder type peptide library and MALDI‐TOF MS. The OBOC ladder peptide library was constructed by the ‘split and pool’ method on a HiCore resin. The peptide library sequence was Ac‐Ala‐X‐X‐X‐Ser‐X‐X‐Ala‐BEBE‐PLL resin. The substrate specificity of murine PKA (cAMP‐dependent protein kinase A) and yeast Yak1 kinase was identified using this method. On the basis of the result, we identified Ifh1, which is a co‐activator for the transcription of ribosomal protein genes, as a novel substrate of Yak1 kinase. The putative Yak1‐dependent phosphorylation site of Ifh1 was verified by <I>in vitro</I> kinase assay. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.</P>
Effect of frost on phosphorescence for thermographic phosphor thermometry
Kim, Dong,Kim, Mirae,Kim, Kyung Chun IOP Pub 2017 Measurement science & technology Vol.28 No.12
<P>In this study, we analyzed phosphorescence lifetime and its accuracy by growing frost for thermographic phosphor thermometry in a low-temperature environment. Mg<SUB>4</SUB>FGeO<SUB>6</SUB>:Mn particles were coated on an aluminum plate and excited with a UV-LED to obtain phosphorescence signals. The surface temperature was maintained at −20, −15, −10 °C, and the phosphorescence signal was acquired as the frost grew for 3700 s. The lifetime was calculated and compared with the calibration curve under no-frost conditions. The error of the measured lifetime was within 0.7% of that in the no-frost conditions. A 2D surface temperature profile of the target plate was successfully obtained with the frost formation.</P>