Proportion And Characteristics Of Transient Nodules In A Retrospective Analysis Of Pulmonary Nodules

( Jin Yeong Yu ),( Su Young Chi ),( Hee Jung Ban ),( Yong Soo Kwon ),( In Jae Oh ),( Kyu Sik Kim ),( Yu Il Kim1 ),( Sung Chul Lim ),( Song Choi ),( Yun Hyeon Kim ),( Young Chul Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

포도호랑하늘소의 生態 및 加害特性에 關한 硏究

金奎眞,李在休,朴鍾大,申炫雨 全南大學校 農漁村開發硏究所 1988 農業科學技術硏究 Vol.23 No.-

포도호랑하늘소의 生態 및 加害特性을 究明코자 1983~1985. 3個年에 걸쳐 全南 山間地이며 울타리式 포도栽培團地인 谷城과 平野地이며 天井式 포도 栽培團地인 羅州에서 遽行하였다. 1. 포도호랑하늘소의 形態的인 特徵을 보면 成蟲은 암컷의 크기가 12.6mm, 숫컷 11.7mm, 용`14.8mm, 卵은 長徑 1.12mm, 短俓 0.44mm 1마리 雄成蟲 産卵數는 15~53個 抱卵數는 29~108個였다. 한편 各態別 期間은 卵基間 7~12日 幼蟲期 268~303日,용期 12~15일, 成蟲 24~41日程度였다. 2. 本蟲은 年 1回 發生하여 成蟲의 發生其間은 山間地인 谷城에서는 7月中間~9月中旬으로 그 最盛期는 8月 中旬頃이었으며, 平野地인 羅州에서는 8月中旬~9月中旬으로 그 最盛期는 9月上旬頃이었다. 3. 被害莖은 3年以上의 가지로서 直徑이 9014mm에서 많았다. 4. 品種에 다른 被害率은 거봉 34.7% Muscat Bailey A29.8% Dela ware 27.3%, Campbell Early 22.9%였다. 5. 越冬態의 蟲齡別 越冬率은 1齡 8.4% 2齡 75.4%, 3齡 12.7% 4齡 3.5%였다. 6. 포도원의 剪定後 剪定地를 放置한 경우에는 45.7% 除去한 경우는 7.6%의 被害率을 보였다. 7. 포도호랑하늘소의 幼蟲과 용에寄生하는 天敵으로서 주머니응애(Pediculoides ventrico년)寄生蟲(Odontobracon bicolar)이 調査되었으며 特히 주머니용애는 寄生率이 높았다. This study was carried out to investigate Bionomics and Damaged aspect on the Grape tiger longicorn Xylotrechus pyrrhoderus at Goksung, mountain area and Naju, field area from 1983 to1985. In size of each stage, female adult was 12.6mm male adult 11.7mm, pupa 14.8mm, egg length 1.22mm, width 0.44mm. Periods of egg was 7 to 12 days, larva 268 to 303 days, pupa 12 to 15 days, adult 24 to 41. days No. of eggs in ovary and laid was 29 to 108 and 15 to 53, respectively but was affected by environmental condition. Grape tiger longicorn have one generation under natural condition. In mountain area, adults emerged from mid-August to mid-September and peak was mid--August.In field area, adults emerged from mid-August to mid-September and peak was early-September. Rate of injury in grape vine stem was great above 3 years branch and damages by Grape varactics were 34.7% in Kyoho, 29.8% in Muscat Bailey A, 27.3% in Dela Ware. 22.9% in campbell Early, respectively. Overwintering larva was great in 2nd instar of 75.4%. Natural enemies of Grape tiger longicorn was investigated in the larva and pupa, Pediculodes ventricosus(Acarina) Odontabracor bicolar(Hymennoptera)

Inhibition of oxidative stress induced‑cytotoxicity by coptisine in V79‑4 Chinese hamster lung fibroblasts through the induction of Nrf‑2 mediated HO‑1 expression

Hyeon‑Gyun Jo,Cheol Park,이혜숙,Gi‑Young Kim,Young‑Sam Keum,Jin Won Hyun,Taeg Kyu Kwon,Yung Hyun Choi,Su Hyun Hong 한국유전학회 2021 Genes & Genomics Vol.43 No.1

Background Coptisine is a natural alkaloid compound and is known to have multiple benefcial efects including antioxidant activity. However, whether it can protect lung fbroblasts from oxidative damage has not been studied yet. Objectives To investigate the potential inhibitory efect of coptisine against oxidative stress in V79-4 lung fbroblast cells. Methods V79-4 cells were treated with H2O2 (1 mM) in the presence or absence of coptisine (50 µg/ml), N-acetyl cysteine (NAC, 10 mM) or zinc protoporphyrin IX (ZnPP, 10 µM) for the indicated times. The alleviating efects of coptisine on cytotoxicity, cell cycle arrest, apoptosis, reactive oxygen species (ROS) production, DNA damage, mitochondrial dynamics, and inhibition of ATP production against H2O2 were investigated. Western blot analysis was used to analyze the expression levels of specifc proteins. Results Coptisine inhibited H2O2-induced cytotoxicity and DNA damage by blocking abnormal ROS generation. H2O2 treatment caused cell cycle arrest at the G2/M phase accompanied by increased expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1 and decreased expression of cyclin B1 and cyclin A. However, these efects were attenuated in the presence of coptisine or NAC. Coptisine also prevented apoptosis by decreasing the rate of Bax/Bcl-2 expression in H2O2-stimulated cells and suppressing the loss of mitochondrial membrane potential and the cytosolic release of cytochrome c. In addition, the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was markedly promoted by coptisine in the presence of H2O2. However, zinc protoporphyrin IX, a potent inhibitor of HO-1, attenuated the ROS scavenging and anti-apoptotic efects of coptisine. Conclusions Based on current data, we suggest that coptisine can be used as a potential treatment for oxidative stress-related lung disease.

구강저에 발생한 단독형 신경섬유종

김용각,유현석,곽재근,김규영,정붕희 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Benign neural sheath neoplasms are not common in the maxillofacial region. These lesions can occur as solitary tumors, or they can affect many sites in the form of multiple neurofibromatosis. A solitary neurofibroma is seldom undergo sarcomatous transformation, since solitary neurofibroma is relatively radioresistant and its recurrence rate seems to be low, the treatment of choice is surgical excision. This case showed a solitary neurofibroma in the left side of the floor of mouth which occurred in a 33 - year -old female. The tumor was excised. And there is no evidence of disease. She is satisfied in function and esthetic aspect.

秦始皇陵 출토 병용의 服飾 硏究 : 胡服과의 관련성을 중심으로

김소현,조규화 한국의류학회 1993 한국의류학회지 Vol.17 No.1

This study intends to find out the correspondence of the costumes of the terracotta warriors at the tomb of Qin Shi Huang to the dress of nomadic people. The Chinese took the dress of nomadic people into their costumes so that they might practise shooting arrows from horse back in the Age Of Wars. The terracotta warriors at the tomb of Qin Sin Huang provide us with substantial evidence that Qin Dynasty inherited the system of wearing the dress of nomadic people from Zhao. Figures of calvarys wear the jackets of nomadic people, but figures of other warriors wear Han jackets. This means that the aim of taking the dress of nomadic people is to be convenient in practising shooting arrows from horse back. Nomadic people adjusted their jackets to left, because they road on a horse from left for being the tunga only on the left. But calvarys adjusted their jackets to right. In those days, China didn't have a tunga. So there was no necessity for riding from left. And Chinese were accustomed to adjusted their jackets to right. This is the reason why calvarys adjusted their jackets to right, though they wear the dress of nomadic people. Soldiers wear trousers. Some have puttee, some have their leg bounds. All the soldiers tightened their coats or jackets with belts which were inhereted from nomadic people. They wear either shoes or short boots. The figures are classified according to rank, espicially in their hats and armours. General wears a cap adorned with pheasant' feathers, officer wears an unadorned cap, and men are hatless or in turbans. Calvary's headgear looks like a p'ing-chin-tse which was correspondence to the headgear of nomadic people. Soldiers wear armours according to duty, and armours are differentiated by rank. From the state of terracotta warriors, I think that the warriors were made from BC 246 to BC 210 which is equal to the date of making the tomb of Qin Shi Huang. Then the date of making the terracotta warriors was between 60 and 100 years since the king Wu Ling of the state of Zhao took the dress of nomadic people.

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

안면비대칭 정도에 따른 정모 두부방사선사진관 3차원영상의 비교 연구

조홍규,김경근,황현식 전남대학교 치과대학 2001 구강과학 Vol.13 No.2

The purpose of this study was to find out the problems of P ­ A cephalometric measurements used in the facial asymmetry analysis and to show the necessity of using three ­ dimensional morphometry. Steel ball (1.2㎜ in diameter) were attached in twenty seven landmarks of symmetrical artificial human skull, and eighty seven different asymmetrical artificial human skulls were formed by enlarging gradually remus height, mandibular body length, and gonial angle of the hemiface. From the P ­ A cephalometry and three ­ dimensional morphometry of each skull types, three linear measurements (representing ramus height, mandibular body length, mandibular length) and two angle measurements (representing gonial angle, menton deviation) and two area measurements (representing mandibular area, lower facial area) were acquired and made into asymmetry index. Menton deviation itself was used as asymmetry index while left ­ right differences were used in the other measurements. These asymmetry index were compared with each other to show the different aspect of the seven asymmetry index according to the degree of actual facial asymmetry. Through the statistical analysis, following results were obtained. 1. When actual ramus height difference becomes large, menton deviation and lower facial area asymmetry index of P ­ A cephalometry were reduced significantly more than those of three ­ dimensional morphometry (p<0.001). 2. When actual mandibular body length difference becomes large, ramus height, lower facial area asymmetry index of P ­ A cephalometry were reduced significantly (p<0.001) while mandibular body length, mandibular length, gonial angle, and mandibular area asymmetry index of P ­ A cephalomentry were magnified significantly more than those of three ­ dimensional morphometry (p<0.01). 3. When actual gonial angle difference becomes large, gonial angle asymmetry index of P ­ A cephalometry was reduced significantly (p<0.001) while lower facial area, mandibular body length, and mandibular area asymmetry index were magnified significantly more than those of three ­ dimensional morphometry (p<0.01). 4. When the correlation between actual ramus height difference and seven asymmetry index of P ­ A cephalometry and three ­ dimensional morphometry was analysed, no difference between P ­ A cephalometry and three ­ dimensional morphometry was found (p<0.01). 5. When the correlation between actual mandibular body length difference and seven asymmetry index of P ­ A cephalometry and three ­ dimensional morphometry was analysed, significance was found in mandibular body length, mandibular length, menton deviation, mandibular area, and lower facial area (p<0.001) while significance was found only in gonial angle of three ­ dimensional morphometry (p<0.01). 6. When the correlation between actual gonial angle difference and seven asymmetry index of P ­ A cephalometry and three ­ dimensional morphometry was analysed, significance was found in gonial angle (p<0.001) while significance was found only in lower facial area of three ­ dimensional morphometry (p<0.01). The above results suggest that three ­ dimensional morphometry show to be necessary for the accurate facial asymmetry analysis.

설측브라켓 부착시 위치오차에 관한 연구

최준규,황현식,김종철 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.1

본 연구는 설측브라켓 부착시 부착방법에 따른 위치오차를 알아보기 위하여 시행되었다. 교정환자 20명의 초진시 석고모형을 연구대상으로 하여, 초진모형의 각 치면에 긴밀하게 브라켓을 부착하는 방법, 치아재배열을 시행한 후 치면에 긴밀하게 부착하는 방법 그리고 치아재배열을 시행하고 이상호선을 제작한 후 브라켓을 결찰하여 부착하는 passive bracketing의 3가지 방법으로 브라켓을 부착한 후 각 방법으로 부착된 브라켓의 위치오차를 측정 및 비교하여 다음과 같은 결과를 얻었다. 1. 각도오차 분석결과, 치아재배열을 시행하지 않은 경우 상악 제1소구치와 하악견치의 위치오차가 타 방법에 비하여 크게 나타났으며, passive bracketing을 시행하지 않은 경우 상악 중절치, 하악 제1·제2소구치에서 그 위치오차가 크게 나타났다. 2. 토크오차 분석결과, 치아재배열을 시행하지 않은 경우 하악 제2소구치의 위치오차가 타 방법에 비해 크게 나타났으며 passive bracketing을 시행하지 않은 경우 상악 전 치아와 하악 제1·제2소구치에서 그 위치오차가 크게 나타났다. 3. 회전오차 분석결과, passive bracketing을 시행하지 않은 경우 상악 중절치간, 하악 중절치간, 하악 측절치와 중절치사이 그리고 하악 견치와 측절치 사이에서 그 위치오차가 크게 나타났다. 4. 내외오차 분석결과, passive bracketing을 시행하지 않은 경우 상악 견치와 측절치 사이에서 위치오차가 타 방법에 비해 크게 나타났으며, passive bracketing을 시행하지 않은 경우 상악 중절치간, 측절치와 중절치 사이, 제1·제2소구치사이, 하악 측절치와 중절치 사이, 견치와 측절치 사이에서 그 위치오차가 크게 나타났다. 본 연구 결과는 설측교정술의 경우 브라켓 간접부착 술식을 사용하더라도 상당량의 위치오차가 나타나며, 이는 passive bracketing으로 줄일 수 있음을 시사하였다. The purpose of this study was to evaluate the positioning errors according to the method of bonding lingual brackets. Dental models of twenty orthodontic patients with malocclusion were selected for this study. The positioning errors were measured on each model that brackets were bonded to. Three different bonding methods were used. For the first method, the bracket was bonded intimately to the lingual surface of the model. For the second method, the bracket was bonded intimately to the lingual surface after setting up using articulator. The passive bracketing, bonding the bracket ligated first to ideal archwire, was used after setting up as the last method. The results were as follows: 1. The brackets bonded without setting up showed greater angulation errors in the upper 1st premolar and the lower canine than those in other bonding methods. The brackets bonded without passive bracketing showed greater positioning errors in upper central incisor, lower 1st and 2nd premolars. 2. The brackets bonded without setting up showed greater torque error in lower 2nd premolar than those in other bonding methods. The brackets bonded without passive bracketing showed greater torque errors in all upper teeth, lower 1st and 2nd premolars. 3. The brackets bonded without passive bracketing showed greater rotation errors between upper central incisors, lower central incisors, lower lateral and central incisor, lower canine and lateral incisor. 4. The brackets bonded without setting up showed greater in-out errors between upper canine and lateral incisor than those in other bonding methods. The brackets bonded without passive bracketing showed greater in-out errors between upper central incisors upper central and lateral incisors, upper 1st and 2nd premolars, lower lateral and central incisors, lower canine and lateral incisor. These results suggest that there is a large amount of positioning error in lingual brackets even by an indirect bonding technique, and it may be reduced by passive bracketing.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

월수함수 단일항전개를 이용한 추적 최적제어기 설계

안두수,오현철,김민형,이재춘,이명규 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

This paper presents the methode of optimal control theory and observer for time invariant system via Single Term Walsh Series. The algorithm of the optimal control theory is simulated by MATLAB.