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Kim, Jiyoon,Yang, Chansik,Kim, Eun Jin,Jang, Jungim,Kim, Se-Jong,Kang, So Min,Kim, Moon Gyo,Jung, Hosung,Park, Dongeun,Kim, Chungho The Company of Biologists Limited 2016 Journal of cell science Vol.129 No.10
<P>Vimentin, an intermediate filament protein induced during epithelialto- mesenchymal transition, is known to regulate cell migration and invasion. However, it is still unclear how vimentin controls such behaviors. In this study, we aimed to find a new integrin regulator by investigating the H-Ras-mediated integrin suppression mechanism. Through a proteomic screen using the integrin beta 3 cytoplasmic tail protein, we found that vimentin might work as an effector of H-Ras signaling. H-Ras converted filamentous vimentin into aggregates near the nucleus, where no integrin binding can occur. In addition, an increase in the amount of vimentin filaments accessible to the integrin beta 3 tail enhanced talin-induced integrin binding to its ligands by inducing integrin clustering. In contrast, the vimentin head domain, which was found to bind directly to the integrin beta 3 tail and compete with endogenous vimentin filaments for integrin binding, induced nuclear accumulation of vimentin filaments and reduced the amount of integrin-ligand binding. Finally, we found that expression of the vimentin head domain can reduce cell migration and metastasis. From these data, we suggest that filamentous vimentin underneath the plasma membrane is involved in increasing integrin adhesiveness, and thus regulation of the vimentin-integrin interaction might control cell adhesion.</P>
Kim, Jiyoon,Hong, Jongin,Park, Moonkyu,Zhe, Wu,Kim, Dongjin,Jang, Yu Jin,Kim, Dong Ha,No, Kwangsoo WILEY‐VCH Verlag 2011 Advanced Functional Materials Vol.21 No.22
<P><B>Abstract</B></P><P>A facile route is presented for the fabrication of spherical PbTiO<SUB>3</SUB> (PTO) nanodot arrays on platinized silicon substrates using PbO vapor phase reaction sputtering on micellar monolayer films of polystyrene‐<I>block</I>‐poly(ethylene oxide) (PS‐<I>b</I>‐PEO) loaded with TiO<SUB>2</SUB> sol–gel precursor. Short exposure to PbO transforms the amorphous TiO<SUB>2</SUB> into polycrystalline PTO, while keeping the inherent size and periodicity of TiO<SUB>2</SUB> nanodots. HRTEM images show that the spherical PTO nanodots, with an average size and height of 63 nm and 40 nm, respectively, are fixed on the Pt supported by residual carbon. XPS narrow scan spectra of Ti 2p and O 1s strongly verify the evolution of chemical identity and the reduction of the Ti‐O binding energy from TiO<SUB>2</SUB> to PTO. The amplitude and phase images of piezoelectric force microscopy (PFM) confirm a multidomain structure attributed by the crystalline orientation of the PTO nanodots. Furthermore, the discrete PTO nanodots show remarkable switching properties due to the low strain field induced by the small lateral size, and the absence of domain pinning effects by grain boundary.</P>
Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR
Kim, Jiyoon,Noh, Shin Hye,Piao, He,Kim, Dong Hee,Kim, Kuglae,Cha, Jeong Seok,Chung, Woo Young,Cho, Hyun‐,Soo,Kim, Joo Young,Lee, Min Goo John Wiley Sons A/S 2016 Traffic Vol.17 No.7
<P>Induction of endoplasmic reticulum (ER)‐to‐Golgi blockade or ER stress induces Golgi reassembly stacking protein (GRASP)‐mediated, Golgi‐independent unconventional cell‐surface trafficking of the folding‐deficient ΔF508‐cystic fibrosis transmembrane conductance regulator (CFTR). However, molecular mechanisms underlying this process remain elusive. Here, we show that phosphorylation‐dependent dissociation of GRASP homotypic complexes and subsequent relocalization of GRASP to the ER play a critical role in the unconventional secretion of CFTR. Immunolocalization analyses of mammalian cells revealed that the Golgi protein GRASP55 was redistributed to the ER by stimuli that induce unconventional secretion of ΔF508‐CFTR, such as induction of ER‐to‐Golgi blockade by the Arf1 mutant. Notably, the same stimuli also induced phosphorylation of regions near the C‐terminus of GRASP55 and dissociation of GRASP homomultimer complexes. Furthermore, phosphorylation‐mimicking mutations of GRASP55 induced the monomerization and ER relocalization of GRASP55, and these changes were nullified by phosphorylation‐inhibiting mutations. These results provide mechanistic insights into how GRASP accesses the ER‐retained ΔF508‐CFTR and mediates the ER stress‐induced unconventional secretion pathway.</P>
Bone Marrow Mononuclear Cells Have Neurovascular Tropism and Improve Diabetic Neuropathy
Kim, Hyongbum,Park, Jong-seon,Choi, Yong Jin,Kim, Mee-Ohk,Huh, Yang Hoon,Kim, Sung-Whan,Han, Ji Woong,Lee, JiYoon,Kim, Sinae,Houge, Mackenzie A.,Ii, Masaaki,Yoon, Young-sup Wiley (John WileySons) 2009 Stem Cells Vol.27 No.7
<P>Bone marrow-derived mononuclear cells (BMNCs) have been shown to effectively treat ischemic cardiovascular diseases. Because diabetic neuropathy (DN) is causally associated with impaired angiogenesis and deficiency of angiogenic and neurotrophic factors in the nerves, we investigated whether DN can be ameliorated by local injection of BMNCs. Severe peripheral neuropathy, characterized by a significant decrease in the motor and sensory nerve conduction velocities (NCVs), developed 12 weeks after the induction of diabetes with streptozotocin in rats. The injection of BMNCs restored motor and sensory NCVs to normal levels and significantly improved vascular density and blood flow in diabetic nerves over 4 weeks. Fluorescent microscopic observation revealed that DiI-labeled BMNCs preferentially engrafted in sciatic nerves. Whole-mount fluorescent imaging and confocal microscopic evaluation demonstrated that many of the BMNCs localized following the course of the vasa nervorum in close proximity to blood vessels without incorporation into vasa nervorum as endothelial cells at a detectable level. Real-time reverse transcription-polymerase chain reaction analysis showed that the levels of angiogenic and neurotrophic factors were significantly increased in the nerves by BMNC injection. Local transplantation of BMNCs improved experimental DN by augmenting angiogenesis and increasing angiogenic and neurotrophic factors in peripheral nerves. These findings suggest that BMNC transplantation may represent a novel therapeutic option for treating DN.</P>
Effects of a low-FODMAP enteral formula on diarrhea on patients in the intensive care unit
Eunjoo Bae,Jiyoon Kim,Jinyoung Jang,Junghyun Kim,Suyeon Kim,Youngeun Chang,MI YEON KIM,Mira Jeon,Seongsuk Kang,Jung Keun Lee,Tae Gon Kim 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.6
BACKGROUND/OBJECTIVES: A dietary restriction on the intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) has been reported to be effective in the treatment of gastrointestinal (GI) tract complications. Enteral nutrition (EN) is widely used for patients who cannot obtain their nutritional requirements orally, but many studies have reported EN complications, especially diarrhea, in up to 50% of patients. SUBJECTS/METHODS: We performed a single-center, non-randomized, controlled trial to determine the effects of a low-FODMAP enteral formula on GI complications in patients in intensive care units (ICUs). Patients in the ICU who needed EN (n = 66) were alternately assigned to the low-FODMAP group (n = 33) or the high-FODMAP group (n = 33). RESULTS: Anthropometric and biochemical parameters were measured, and stool assessment was performed using King"s Stool Chart. We excluded patients who received laxatives, GI motility agents, proton pump inhibitors, antifungal agents, and antibiotics other than β-lactams. There were no differences in GI symptoms during 7 days of intervention, including bowel sound, abdominal distension, and vomiting between the 2 groups. However, diarrhea was more frequent in the high-FODMAP group (7/33 patients) than the low- FODMAP group (1/33 patients) (P = 0.044). CONCLUSIONS: Our results suggest that a low-FODMAP enteral formula may be a practical therapeutic approach for patients who exhibit enteral formula complications. Our study warrants further randomized clinical trials and multicenter trials.
Inhibition of Autophagy Enhances the Characteristic of Chemically Derived Hepatic Progenitors (CdHs)
( Ha Yoon Kim ),( Myounghoi Kim ),( Soraya Salas-silva ),( Tae Hun Kim ),( Jiyoon Byeon ),( Michael Adisasmita ),( Min Kim ),( Ji Hyun Shin ),( Dong-ho Choi ) 대한간학회 2023 춘·추계 학술대회 (The Liver Week) Vol.2023 No.1