서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

적응 신경망 수신기를 이용한 DS/CDMA 다중사용자간섭(MAI) 제거

김재수,김창선,김성곤,변건식 동아대학교 2001 大學院論文集 Vol.26 No.-

The capacity of direct-sequence code-division multiple-access (DS/CDMA) systems is co-channel severely limited by multiple access interference (MAI) produced by the other users. To improve the capacity, joint-detection receivers and MAI cancellation techniques have been proposed.[1][2][3] This paper presents an adaptive neural network-based receiver that has the capacity of combating the 'near-far' problem and rejecting the multi-user interference in a multipath channel.[4] A comparative performance analysis of the conventional receiver and the adaptive neural network receiver is camel out using a Monte Carlo simulation. It is found that the new receiver performs extremely well in multipath and multiple access channels with a significant 'near-far' effect.

향기요법이 통증을 주소증으로 입원한 환자의 수면장애에 미치는 영향

박수곤 ( Soo Gon Park ),양미성 ( Mi Sung Yang ),김오영 ( Oh Young Kim ),조희근 ( Hee Guen Jo ),최진봉 ( Jin Bong Choi ),김선종 ( Sun Jong Kim ),설재욱 ( Jae Uk Sul ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :The purpose of this study is to investigate the effects of aroma therapy on sleep disorder patients with musculoskeletal pain. Methods :The 44 patients were divided into 2 groups: Experimental group(Exp. group) was treated with aroma therapy and control group was treated except aroma therapy. To evaluate the efficiency of aroma therapy, the Korean sleep scale A(Jin-Joo Oh, Mi-Soon Song, Sin-Mi Kim. 1998) and visual analogue scale(VAS) were applied before treatment and after 5 days treatment. Results :1. The Experimental group has improved statistical significance in sleep disorder score as compare to the control group. 2. The improvement of sleep disorder score of Exp.group has difference according to impression. 3. The improvement of sleep disorder has an effect on pain decrease. Conclusions :Aroma therapy has effects of improvement on sleep disorder with musculoskeletal pain.

여러가지 수복물의 polishing조건에 따른 치수 온도변화

김재곤,이승영,박종하,백병주,양종숙 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

수복물의 연마의 중요성에 대하여 많은 연구들이 이루어져 왔으며, 이는 수복물의 금속성질의 개선, 변연적합성의 증가 그리고 치태축적의 감소 등을 이유로 시행된다. 그러나 불행하게도 수복물에 대한 연마시 열의 발생으로 인하여 치수부위에 손상을 초래하므로 열의 발생을 최소화하려는 노력이 뒤따라야 할 것이다. 이에 본 연구에서는 수복물의 연마시 회전속도의 차이, 냉각제의 적용 유무, 여러 종류의 수복물의 차이, 간헐적인 연마와 연속적인 연마의 차이 그리고 잔존 상아질의 두께의 정도에 따른 치수내부에서의 열의 변화를 알아보기 위하여 발거된 구치에 5급 와동을 형성한 후 복합레진(Z100, 3M co), resin-mod-ified GLC(Dyract, Fuji II LC), 그리고 아말감(Degussa)등으로 충전하였으며, 다양한 조건에서의 연마를 시행, 치수내부에서의 열의 변화를 측정하여 다음과 같은 결과를 얻었다. 1. Amalgam을 건조한 상태에서 연마시 다른 재료에 비해 큰 치수내 온도 상승을 보였다.(P<0.05). 그러나 Z100, Dyract, Fuji II LC간에는 간헐적 수복물 연마와 연속적인 수복물 연마 모두 어떤 경우든 유의차가 없었다.(P>0.05). 2. 같은 조건으로 연마를 시행했을 때, 간헐적인 연마보다 연속적인 연마를 한 경우가 치수내 온도가 더 크게 상승하였다.(p<0.01). 3. 아말감과 Dyract에 있어서는 잔존 상아질의 차이에 따른 치수내 온도변화에 유의한 차이를 보였으나(P<0.01), Fuji II LC에 있어서는 유의성이 없었다(P>0.01). 4. 냉각제의 유무에는 관계없이 어떤 경우든 시간에 따른 온도 상승을 보였다. 그러나, 냉각제를 사용한 경우가 냉각제를 사용하지 않은 경우에 비해 온도 상승값이 훨씬 작았다.(P<0.01) The importance of finishing and polishing the restoration has been described by several authors. The final step provides for improved metallurgical properties, better marginal adaptation, reduced plaque accumulation. Unfortunately, finishing of the restorations can produce damage from temperature rises at the pulpal wall. The aim of this study was to determine the changes in temperature can be occurred during the use of finishing and polishing instruments under a variety of conditions. ; with or without a water coolant, intermittent or continuous operation, high or low rotation speed, remaining dentin thickness, and various restorative materials. Class V preparations were cut on extracted molars and restored with composite resin(Z 100), resin-modified glass ionomer cements(Dyract, Fuji II LC), and amalgam. Finishing was done with aluminum oxide coated disc(Sof-lex polishing disc, 3M, USA). The following results were obtained. 1. The rise of temperature during polishing of amalgam restorations was the highest among the all experimental groups except polishing with water coolant(P<0.05). However, there were no statictical differences in temperature rises between Z 100, Dyract and Fuji II LC(P>0.05). 2. The intrapulpal temperature was greatly influenced by the applied time, and intermittent polishing was showed significantly lower temperature rises than continuous polishing(p<0.01). 3. The intrapulpal temperature was increased according to the application of polishing regardless of using water coolant. However, polishing with water coolant showed significantly lower temperature in the pulp than not used water coolant(P<0.01).

담도폐쇄증 환아의 치과치료 : 증례보고

김재곤,양연미,백병주,이승익 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

Intra-& extra-hepatic duct system의 경화를 야기하는 Biliary atresia는 출생시 1:10,000의 발생빈도를 보이며, 5년 이하의 생존율을 나타내는 예후가 좋지 않은 질환이다. 담도폐쇄증의 원인은 아직 명확하지 않으나, 유전적인 요소나 발육성 원인으로 믿고 있다. 임상적 특징으로 두드러진 황달, 간비증대, 가려움증, 지방변, 황색종, 성장지연, 문맥압항진증, 출혈, 골연하증, 복수 그리고 호흡기계 감염 등을 나타낸다. 구강내 소견으로 녹색을 띄는 변색치아, 유치의 확장된 치수강과 치근관, 치아맹출지연, 법랑질 형성부전, 그리고 심한 치아 우식 등이다. 담도폐쇄증은 조기진단과 수술에 의해 사망률이 감소되고, 성장과 발달이 정상으로 돌아오며 생존율도 향상되었으나 여전히 그 원인과 치료에 대한 연구가 계속되어야 할 것이다. 이에 저자는 전북대학교 치과병원에 내원한 2명의 담도폐쇄증환아에 대해 임상, 방사선학적 특징 및 적합한 처치에 대하여 보고하고자 한다. Congenital biliary atresia with pregressive sclerosis of the intra-and extra-hepatic duct system occurs in 1:10,000 live births, and has a poor prognosis with an expected survival of less than 5 years. Etiology of biliary atresia is unclear, however, it is believed a genetic or developmental cause. The clinical characteristics include pronounced jaundice, hepatosplenomegaly, pruritus, steatorrhea, xanthomas, growth retardation, portal hypetension, bleedings, ascites and respiratory infections. Oral manifestations have seldom been reported in patients with biliary atresia, but there may be enamel hypoplasia, delayed tooth eruption, and green teeth. Early diagnosis and surgical intervention have decreased morbidity, returned growth and development to normal and improved the prognosis for survival. Authors report the clinical and radiologic characteristics, proper managements about two cases with biliary atresia.

불소적용시 법랑질과 상아질에서 불화칼슘형성의 차이에 관한 실험적 연구

김재곤,권선자,윤현두,안수현,백병주 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of this study was to compare the amount of calcium fluoride deposited on the enamel and dentin surface and to obtain information on the morphological change and crystallographic details of mineral deposition after 12,000ppm APF application in vitro. The bovine enamel and dentin blocks were randomly assigned to eight groups according to artificial caries lesion formation and difference of fluoride application time. The fluoride concentration and morphological characteristics on the treated enamel and dentin surface were investigated by using fluoride quantitative analysis and SEM. The powdered enamel and dentin of the intact bovine incisors were prepared for the X-ray diffraction analysis. The following results were obtained. 1. The amounts of KOH-soluble fluoride on the carious enamel and dentin surface after 24h APF application were higher than after only 5min APF application(P<0.05), but in the case of the sound enamel and dentin surface were similar after 5min and 24h application (P>0.05). The fluoride content was highly increased in the carious dentin as compared with sound dentin after APF application(P<0.05). 2. The caruous enamel surface after APF application, the demineralized enamel surface were recovered a more dense enamel surface and precipitation of crystal was observed a distintive surface layer of spherical globules of about 1 m diameter. In the case of the fluorided carious dentin surface, precipitation of calcium fluoride-like material was deposited both inside the dentinal tubules as well as in the intertubular regions. 3. The crystallographic structure of powdered enamel and dentin after 24h APF application had large crystallities of apatite and CaF2 diffraction peaks in the enamel as compared with dentin. The diffraction data collected from the 27.50-29.50(2) angular range of the powdered enamel, the (105) apatite, (225) apatite and (111) CaF2 peaks of the enamel crystallities were detected after 24h APF application.

전북지역 치과개원의의 열구전색제 사용실태에 관한 연구

김재곤,백병주 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.2

Since the introduction of pit and fissure sealants in the early 1970's, many studies have been published amply documenting the efficacy of these materials as caries-preventive agents. However, the acceptance of the technique by dentist has been questionable. This survey was investigated the attitudes toward and use of pit and fissure sealants by dentist in Chonbuk area. The results were as follows: 1. Utilization of pit and fissure sealants is very high. Only 15% of dentists never use pit and fissure sealants, whereas 85% generally use pit and fissure sealants. 2. Most dentists reported that their knowledge of pit and fissure sealants was gained through dental schools education. 3. Concern about difficult to sell' to patient, poor retention of pit and fissure sealants and unsubstantiated by research were given as the main reasons why pit and fissure sealants was not used. 4. Patient demands and various educate program were given as important factors that would lead to increase use of pit and fissure sealants.

단클론항체를 이용한 타액 내 Streptococcus mutans 수준의 측정

김추성,김재곤,양연미,백병주,이경열,김미아,임수민 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

Streptococcus mutans는 구강 내에 상존하는 치아우식증의 주요 원인균으로서 치면의 피막에 부착 후 glucan을 형성하여 세균의 군락을 이루며, 외부로부터 공급된 자당대사를 통하여 유기산을 생성함으로써 법랑질을 탈회시킨다. 치아우식 활성도의 평가를 위한 단클론항체를 이용한 방법은 진료실에서 빠른 시간 내에 간편하게 타액에 존재하는 Streptococcus mutans의 정량분석이 가능한 방법이다. 이 연구는 3세에서 6세 사이의 어린이 15명을 대상으로 자극성 타액을 채취하여 시판 중인 단클론항체를 이용한 Salivacheck Mutans, strip을 이용한 Dentocult-SM 그리고 MSB배지 배양법으로서 타액 내 Streptococcus mutans를 측정한 후 그 값을 우식경험치아수와 비교하여 상관관계를 알아보았다. Saliva-check Mutans를 이용한 방법은 Dentocult-SM과 MSB배지법과 통계학적으로 유의한 상관관계를 보였으나 (p<0.05), MSB배지법은 어린이의 우식경험치아수와 통계학적으로 유의한 결과를 나타내지 않았다 (p=0.34). Streptococcus mutans, one of the major causal agents of dental caries, is component of the dental plaque. It produces various organic acids such as lactic acid which is the end-product of glycolysis, and this leads to dental caries. A new system using species-specific monoclonal antibodies was developed to detect Streptococcus mutans in saliva. The system quickly detects salivary Streptococcus mutans in 30min and classifies the result into two levels. The purpose of this study was to investigate correlation between monoclonal antibody-based detecting system and selective medium-based detecting methods. Children's deft indices were also compared with Streptococcus mutans counts in MSB agar plate. Subjects consisted of 15 children in the age of 3 to 6 years. They were assigned to three groups: Group Ⅰ (deft index = 3), Group Ⅱ (deft index ≤ 3), Group Ⅲ (deft index ≥ 4). The results are as follows : 1. The rate of children with positive response was 13.3% and with negative response was 86.7% in the result of Saliva-check Mutans test kit. 2. There was a positive correlation between monoclonal antibody-based detecting system and selective medium-based detecting methods (p<0.05). 3. Streptococcus mutans counts in MSB agar plate were irrelevant to deft of children(p=0.34).

절제된 백서의 좌골 신경에서 절제 원위부의 변화에 따른 신경재생의 비교 실험연구

김정태,엄기일,김잉곤,류재만,이혜성 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

성숙 백서 좌골신경의 분지전 근위부에서 7㎜가량을 절제하여 신경 간격을 만든뒤 실라스틱도관 근위단에 절단된 신경의 근위부를 관통고정하고 원위부에는 아무것도 열결하지 않거나 좌골신경 절편, 종골건 절편, 안면신경 절편을 각각 관통고정시켜 제4주 및 8주에 신경 축색수를 대조군과 혹은 각 실험군끼리 비교하여 다음과 같은 결론을 얻었다. 1. 신경 절편을 연결헌 2,4군의 신경재생은 대조군과 거의 차이가 없었고(P>0.05) 아무것도 연결하지 않은 1군, 건절편을 연결한 3군에 비해 현격한 신경재생을 보였다.(P<0.01). 2. 신경 절편의공여부에 관계없이 2,4군의 실험군에서 각각 비슷한 신경재생을 보여 일단 신경이 손상되면 신경 성장인자가 손상된 신경단으로 부터 분비되며 종류에 관계없이 그 근위부의 신경 재생을 자극할 수 있음을 알 수 있었다. 3. 건절편을 연결한 3군의 실험군에서는 일부 신경재생이 일어나는 것으로 보아 여러가지 가능성을 제시할 수 있었다. 이상에서 같이 신경 재생에 대한 기전은 아직까지 밝혀지지 않고 많은 논란의 대상이 되고 있는 것이 사실이나 저자들은 이에 조금이라도 접근해보고자 본 실험을 시도하였고 많은 의문점이 제시되었으나 만족할 만한 결과를 얻었다. 앞으로 보다 더 세밀한 비교관찰과 많은 개체수를 이용한 실험이 필요하겠고 축색수 이외에도 수초의 두께, 수초와 축색의 비율, 유수 및 무수신경수의 비율등도 함께 비교하는 정확한 결과의 분석이 필요하리라 생각된다. An experimental model was presented for studying nerve regeneration over constant gaps of various distal stumps such as, empty tube(GroupⅠ), sciatic nerve segment(GroupⅡ), calcaneal tendon segment(Group Ⅲ), facial nerve segment(Group Ⅳ), to ascertain how the regenerating fibers of the proximal stump of the severed sciatic nerves of the rats are oriented and processed. In this experiment, the silastic tube was used as a guide to observe the sprouting of the regenerating fibers from proximal stump and then the regenerating fibers in the tubes were obtained and analyzed by light microcope, electron microscope and axon counts at 4 weeks and 8 weeks with the evoked action potential at 8 weeks. The results were as follows. 1. The axon counts of experimental group Ⅱ and Ⅳ with nerve segment stump were similar to those of their control groups(P>0.05) and were greater than those of experimental groupⅠ and Ⅲ(P<0.01). 2. The axon counts between the experimental group Ⅱ and Ⅳ were nearly indistinguishable and so nerve segments, irrespective of donor site in the same rat, induced the regenerating stimulus to their proximal stump of resected sciatic nerve. 3. In experimental group Ⅲ, the obtaining results of axon counts were not negligible, in spite of tendon stump, and the author could propose various possibilities. In conclusion, we could approach to the regenerating process of the nerve through the analysis of the above results but yet can not explain the exact mechanism. Anyway when the results are applied to the clinical situation, we would be helped much.

소아의 악골내 발생한 낭종의 외과적 처치

김재곤,김영진,김미라,백병주 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.1

악골의 낭종은 크게 치성과 비치성으로 구분되며 치성낭은 치성기관이나 그 잔존 세포성분과 관련되어 주로 골내에서 발생한다. 비치성낭종은 과거에는 태아의 발육중 상피의 봉입이나 융합선을 따라 존재하는 상피잔사가 증식하여 낭성변형을 일으킨다는 설이 유력하였으나 현재에는 이러한 태아의 발육 동안 상피의 봉입은 일어나지 않는 것으로 보고 있다. 함치성낭은 미맹출 치아와 관련되어 발생하고 상피의 전암 가능성이 있으므로 가능한 빨리 제거하도록 하며 조대술이나 적출술이 이용될 수 있고 간혹 원인치의 발거가 추천된다. 비구개낭은 가장 일반적인 비치성낭으로 상악 중절치 사이에 경계가 명확한 방사선 투과상으로 나타난다. 적출술과 조대술로 치료할 수 있으며 전암 가능성이나 재발은 드물다. 본 증례에서는 전북대학교 병원 소아치과에 내원한 아동의 악골내 발생한 낭종을 외과적으로 제거한 후 다음과 같은 결론을 얻었다. 1.함치성낭의 환아에서, 원인 치아를 보존하고 완전 적출술로 병소를 제거한 후 경과를 관찰한 바 영구치의 정상적인 맹출이 이루어졌다. 2.비구개낭을 치료시, 인접치아의 생활력에 대한 정확한 진단과 그에 따른 치료법의 선택으로 불필요한 근관치료를 피할 수 있다. 3.향후 비구개낭의 환아의 관련치에 대한 계속적인 관찰이 필요하리 사료된다. 4.악골내 방사선 투과성의 병소를 치료시, 정확한 감별진단과 적절한 치료법의 선택이 중요하다. The Dentigerous cyst is reported to be one of the most common lesions of the jaw. It is derived from reduced enamel epithelium that surrounds the crown of an unerupted tooth. Dentigerous cysts usually remains asymptomatic and presents as well-circumscribed radiolucencies surrounding the crown of a tooth. Most dentigerous cysts are treated by surgical enucleation or marsupialization of the cyst to allow eruption of the permanent tooth. The nasopalatine duct cysts derived trom the islands epithelium remaining after closure of the embryonic nasopalatine duct. The cyst presents as a well-circumscribed oval or heart-shaped radiolucency located in the midline of the anterior maxilla between the roots of the central incisors. Treatments is by surgical enycleation, employing a paltal approach. This report present two cases. One case was diagnosed with dentigerous cyst and treated by enucleation. 12Months later, affected second premolar was erupted normally. The other case was diagnosed with nasopalation duct cyst. Histological examination of the enucleated cyst confirmed a nasopalatine duct cyst. There was no recurrence during follow up period.