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肝吸蟲症 治療前後에 있어서 血淸 및 尿의 抗體價變動에 관한 比較硏究
金亨東,嚴基善,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3
The changes of IgG levels of sera and urine were observed with the enzyme-linked immunosorbent assay (ELISA) at before and after medication in human clonorchiasis. Sera and urine from 68 cases of confirmed clonorchiasis were tested at before and at 9 and 18 month after treatment with Distocide® (praziquantel). Group I (n=22) was cured after first medication and then followed up for 18 months. And Group Ⅲ (n=24) of patients with eggs in their feces after first medication showed egg reduction rate of 90%. Thirteen normal controls were parasite free healthy persons for clonorchiasis in non-endemic area. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 14.3㎍/㎖ and the results obtained were as follows: 1. When a serum dilution of 1:400 was used, the absorbance values (488 nm) were 1.122, 1.373 and 1.632 in groups Ⅰ,Ⅱ,Ⅲ respectively before medication. Antibody level decreased significantly at 9 months after medication showed 0.572, 0.749 and 1.155 in the respective group. Then the levels decreased slightly to 0.464, 0.516 and 1.107 at 18 months after medication. But the control group showed relatively constant absorbance values of 0.291 at before 0.301 and 0.286 respecively at 6 and 18 months. 2. Urine showed absorbance values of 0.484, 0.629 and 0.849 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. Then the values decreased about a half level revealed 0.261, 0.226 and 0.467 in the respective group at 18 months after medication. Control group showed relatively constant absorbance values 0.232 at before and 0.252 at 18 months. 3. The diameter of wheal size (mm) by intradermal test did not show substantial changes, i.e. 11.7, 13.3 and 12.7 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication; 11.7, 12.9, and 11.4 in the respective group at 18 months after medication. 4. The relation of the absorbance values between sera (y) and urine (x) made the regression equation: y=0.707X+0.908, and showed relatively high correlation (r=0.619, n=68, p<0.001) before medication; y=0.760X+0.387 with some correlation (r=0.582, n=68, p<0.001) at 18 months after medication. 5. The relation between the absorbance values of urine and log EPG (eggs per gram of feces)/100 revealed more or less irregular correlations, i.e.r=0.566(p<0.01), 0.661(p<0.001)and 0.384(p<0.10)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. 6. The relation between the absorbance values of urine and the wheal size (mm) by intradermal test showed low correlation, i,e, r=0.416(p<0.10), 0.416(p<0.10)and 0.421(p<0.05)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication.
일반 측방 두부규격 방사선사진과 측방 두부규격 전산화 방사선사진에서의 계측점의 신뢰도에 대한 비교 연구
김형돈,박창서,김기덕 大韓口腔顎顔面 放射線學會 1997 Imaging Science in Dentistry Vol.27 No.1
The purpose of this study was to compare & to find out the variability of head film measurements(landmarks identification) between Fuji computed radiographic cephalometry and conventional cephalometry. 28 Korean adults were selected. Lateral cephalometric FCR film and conventional cephalometric film of each subject was taken. Four investigators identified 24 cephalometric landmarks on lateral cephalometric FCR film and conventional cephalometric film. The comparable measurements between lateral cephalometric FCR film and conventional cephalometric film were statistically analysed. The results were as follows: 1. In FCR film & conventional film, coefficient of variation (C.V.) of 24 landmarks was taken horizontally & vertically. There is no significant difference of rank order of landmarks in C.V. between two films. 2. In comparison of significant differences of landmarks variability between FCR film & conventional film, horizontal value of coefficient of variation showed significant differences in four landmarks among twenty-four landmarks, but vertical value of coefficient of variation showed significant differences in sixteen landmarks among twenty-four landmarks. FCR film showed significantly less variability than conventional film in 17 subjects among 20(4+16) subjects that showed significant difference.
혈장 중 theophylline 분석법 확립 및 약동학적 연구
김형기,권준택,염윤기 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3
배경 및 목적 : 치료적 약물농도 모니터링이나 약물 상호작용연구에 활용할 수 있는 빠르고 간단한 혈중 theophylline의 분석방법을 확립한다. 재료 및 방법 : 표준 혈장시료에 1N HCl 100 ㎕를 첨가하고 내부 표준물질 7-(β-hydroxy-propyl) theophylline (50 ㎍/ml) 50 ㎕를 첨가한후 diethyl ether를 이용하여 추출한 후 질소기류하에서 건조하여 이동상으로 재용해한 후 C18 reverse-phase column에 주입하여 280 nm의 자외선파장에서 HPLC system을 이용하여 검출하였다. 표준 혈장시료를 이용하여 일내- 일간 정밀성과 정확성, 회수율, 단기, 장기 안정성 및 냉해동 안정성을 평가하여 분석방법을 검증하였다. 결과 : 최소검출농도는 0.1 ㎍/ml로 10 ㎍/ml의 농도까지 직선성을 관찰할 수 있었으며 일내- 일간 정밀성과 정확성, 회수율 및 단기, 장기 안정성 및 냉해동 안정성 모두 CV%가 10 % 이내로 분석방법을 확립하였다. 결론 : 본 실험결과 theophylline의 치료적 약물농도 모니터링 및 약물상호작용에 관련된 연구에 활용할 수 있는 빠르고 간단한 분석방법을 확립하였다.
김형기,권준택,염윤기 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3
The bioequivalence of generic fluoxetine tablet(Myungin Pharmaceutical Co.) to the fluoxetine tablet(Prozac^(ⓡ)), Lilly Korea Co.) as a reference drug. Single dose of 60 mg fluoxetine was administered to 24 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 72 hours and plasma concentration of fluoxetine was measured by well validated HPLC. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of fluoxetine is bioequivalent with the reference, both formulations in 60 mg tablet.