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Application of fracture mechanical assessment to in-wall shield ribs in ITER vacuum vessel
Kim, Yu-Gyeong,Kim, Hyun-Soo,Park, Chul-Kyu,Kim, Gwang-Ho,Moon, Ho-Kyu,Hong, Kwen-Hee,Chung, Woo-Ho,Lee, Hyeon-Gon,Sa, Jeong-Woo,Choi, Chang-Ho,Sim, Jae-Min,Chang, Yoon-Suk North-Holland 2017 Fusion engineering and design Vol.124 No.-
<P><B>Abstract</B></P> <P>In-wall shield ribs are installed between double walls of vacuum vessel and their role is to hold neutron shielding blocks. Since one of key issues on these structures is to sustain integrity during entire ITER operation without any in-service inspection or maintenance, fracture behavior shall be evaluated in design stage. In the present study, a weight function method was employed for crack initiation assessment. The most critical structure was selected as a representative one and its structural integrity was evaluated. In order to check validity of this method, an extended finite element method was adopted for bounding cases. As a result, not only structural safety but also quite conservatism were observed comparing to those of extended finite element analysis with similar tendency. It means that the weight function method could be a conservatively practical approach for fracture mechanical assessment of in-wall shield ribs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Structural analysis of IWS rib assembly was performed and verified via RCC-MR. </LI> <LI> Systematic crack initiation assessment was conducted by using weight function method. </LI> <LI> Conservatism of the weight function method was verified by detailed X-FEM analyses. </LI> </UL> </P>
Kim Ok-Hyeon,Lee Gyeong Yun,Kim Kyung Yong,Son Jong In,Jung Tae Woo,정지훈,Bang Joon Seok,김형춘,정윤희,Lee Hyun Jung 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Background Hypoxia is a pathological phenomenon of the central nervous system that occurs during ischemia and stroke, leading to brain cell damage. Astrocytes play an important role in maintaining homeostasis in the brain microenvironment under normal as well as in pathological conditions. 3-hydroxymorphinan (3-HM) is an active metabolite of dextromethorphan (DM) that is widely used in anti-cough remedies and is more potent and safer than DM in the treatment of neurological disorders. However, previous research has not examined whether 3-HM has a protective effect in ischemic condition. Objective In this study, we aimed to confirm the effect of 3-HM on hypoxia-induced astrocyte death. We also investigated the protective mechanism of 3-HM and its potential applicability in ischemia brain injury. Result For the in vitro hypoxic conditions, CoCl2, a hypoxia-mimetic agent, was added to mouse primary astrocytes. 200 μM of CoCl2 showed cytotoxicity, whereas pre-incubation with 3-HM attenuated cell death by CoCl2. Moreover, pretreatment with 3-HM dramatically reduced oxidative stress and mitochondrial damage by CoCl2. Further, 3-HM significantly reduced intracellular calcium influx induced by extracellular glutamate and finally modulated the glutamate released from the astrocytes. Conclusion Taken together, these results suggest that 3-HM has a potential to regulate glutamate release from the astrocytic cell death in hypoxic condition and could be used as a promising preventive or therapeutic agent for ischemic brain injury.
( Kim¸ Hyeon Gyeong ),( Jeong¸ Chang Geun ) 한국경영공학회 2023 한국경영공학회지 Vol.28 No.3
Purpose The purpose of this paper is to produce theoretical implications by presenting a response strategy to reduce turnover intention of Air Force pilots based on preceding research. Methods As such, a survey was conducted on Air Force pilots with at least 24 months of work experience under the Ministry of National Defense, 241 of which were targets of analysis. Results This paper finds that reduction in role ambiguity overload, financial job reward, and role achievement culture had a significant and positive (+) effect on job satisfaction, and power-oriented culture had a significant and negative (-) effect on job satisfaction. Conclusion Air Force pilots' working conditions were identified as a major factor of pilots' job satisfaction. This paper empirically verified operating mechanism of Air Force pilot management, and affirmed its effectiveness and validity of reward systems by verifying that job satisfaction is a partial mediator for working conditions and turnover intention.
Synergistic Effect of Minoxidil and Retinol on Hair Growth in Human Dermal Papilla Cells
( Hyeon Gyeong Yoo ),( In Young Chang ),( Se Rah Lee ),( Soon Jin Choi ),( Hyun Keol Pyo ),( Ji Yun Kim ),( Oh Sang Kwon ),( Jin Ho Chung ),( Kwang Hyun Cho ),( Hee Chul Eun ),( Kyu Han Kim ) 대한피부과학회 2005 초록집 Vol.43 No.20
Kim Hyojin,Yoon Yune-Jung,Kim Hyunmi,Cha Eun-Young,Lee Hye Suk,Kim Jeong-Han,Yi Kyu Yang,Lee Sunkyung,Cheon Hyae Gyeong,Yoo Sung-Eun,Lee Sang-Seop,Shin Jae-Gook,Liu Kwang-Hyeon The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.11
KR-33028 (N-[4-cyano-benzo[b]thiophene-2-carbonyl]guanidine) is a new cardioprotective agent for preventing ischemia-reperfusion injury. This study was performed to identify the metabolic pathway of KR-33028 in human liver microsomes and to compare its metabolism with that of cryopreserved human hepatocytes. Human liver microsomal incubation of KR-33028 in the presence of NADPH and UDPGA resulted in the formation of four metabolites, M1, M2, M3, and M4. M1 and M2 were identified as 5-hydroxy-KR-33028 and 7-hydroxy-KR-33028, respectively, on the basis of LC/MS/MS analysis with the synthesized authentic standard. M3 and M4 were suggested to be dihydroxy-KR-33028 and hydroxy-KR-33028-glucuronide, respectively. Metabolism of KR-33028 in cryopreserved human hepatocytes resulted in the formation of M1, M2, and M4. These data show a good correlation between major metabolites formed in human liver microsomes and cryopreserved human hepatocytes. In addition, KR33028 was found to inhibit moderately the metabolism of CYP1A2 substrates. Based on the results obtained metabolic pathway of KR-33028 is proposed.