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      • 백제 무령왕릉 및 송산리 5.6호분의 현황과 보존대책

        김광훈,최석원,정상만,서만철,이금배,이남석 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-

        무령왕릉을 비롯한 송산리 고분군의 5호분 및 6호분의 발굴이후의 변화상황, 고분구조의 벽체거동 상황 및 구조안전, 누수현상, 고분 내에 서식하는 조류문제, 고분내 습기 및 결로현상 제거를 위한 공기조화시설 등을 포함하는 종합정밀조사를 1996년 5월 1일 부터 1997년 4월 30일 까지 1년간 수행하였다. 무령왕릉 및 6호분 벽돌깨김 상황 조사결과 1972년과 l996년을 비교하여 보면 벽돌파손율이 각각 2.5배와 2.9배로 증가하고 있다. 1972년 상황은 약 1450년간 진행된 것이고 l996년의 상황은 불과 24년간 진행된 것임을 감안할 때 고분이 발굴된 이후 벽돌의 균열은 상당한 가속도로 진행되어 온 것이 사실이며 이대로 진행된다면 더욱 더 가속화될 것으로 판단된다. 고분벽체의 거동상태를 계측한 결과 우기에 지하수 유입에 의한 지반의 약화로 인하여 건기보다 2배 정도 거동하는 양상을 보인다. 한편, 무령왕릉 연도 입구의 호벽은 전실쪽으로의 거동이 0.43 mm/myr, 연도쪽으로 2.05 mm/myr의 거동을 보여 무령왕릉에서는 가장 심한 거동을 보이고 있다. 봉분내부의 토양층구조에 대한 지오레이다 영상단면을 분석한 결과 지중의 누수방지층이 심하게 균열되어 있는 것으로 판단된다. 직접누수와 지하수 형태로 유입된 침투수는 고분군 주위의 지반의 함수비를 증가시켜 지반의 지지력을 악화시키고 또한 고문내로 서서히 유입되어 고분내부의 습도를 100% 로 유지시키는 주된 원인이다. 이러한 높은 습도는 고분내의 남조류의 번식을 초래하였다. 이와 같이 고분군의 발굴후 인위적인 환경변화와 지속적인 강우침투 및 배수 불량의 영향은 고분군의 안정성에 상당한 위험을 초래하였으며, 현 상태는 각 고분에 대한 보강이 불가피한 것으로 판단된다. 고분 벽돌의 깨짐, 고분 벽체의 거동, 조류의 서식 등올 포함하여 송산리 고분군에서 발생되고 있는 보존상의 제반 문제점들은 일차적으로 누수 및 침투수에 의한 결과이다. 그러므로 무엇보다도 고분군 내부 및 고분 주변으로의 강우 및 지하수 침투를 막는 차수 대책이 시급한 것으로 판단된다. 또한 이미 발생한 변위가 더 이상, 진행되지 않도록 봉분하중 경감 빛 토압균형을 이루는 보강대책이 시급한 실정이다. The detail survey on the Songsanri tomb site including the Muryong royal tomb was carried out during the period from May 1, 1996 to April 30, 1997. A quantitative analysis was tried to find changes of tomb itself since the excavation. Main subjects of the survey are to find out the cause of infiltration of rain water and groundwater into the tomb and the tomb site, monitoring of the movement of tomb structure and safety, removal method of the algae inside the tomb, and air controlling system to solve high humidity condition and dew inside the tomb. We found that break rate of bricks inside the Murong royal tomb and the 6th tomb had been increased about 250 % and 290 % for just last 24 years from 1972 to 1996, respectively. The situation in 1996 is the result for just 24 years while the situation in 1972 was the result for about 1450 years. Status of breaking of bricks represents that a severe problem is undergoing. The wall movement of tombs is detecting in disadvantageous directions, especially in rainy season. The front wall of the Muryong royal tomb shows the biggest movement having a rate of 2.05 mm/myr toward the passage way. Georadar section of the shallow soil layer represents several faults in the artificial water-protection layer within soil layer. Rainwater flew through faults into the tomb and nearby ground and high water content in nearby ground resulted in low resistance and high humidity inside tombs. High humidity inside tomb made good living condition for algae with high temperature and moderate light source. Artificial change of the tomb environment since the excavation, infiltration of rain water and groundwater into the tombsite and bad drainage system had resulted in dangerous status for the tomb structure. Main cause for many problems including breaking of bricks, movement of tomb walls and algae living is infiltration of rainwater and groundwater into the tomb site. Therefore, protection of the tomb site from high water content should be carried out at fust. Waterproofing method includes a cover system over the tomsite using geotextile, clay layer and geomembrane. Decrease and balancing of soil weight above the tomb are also needed for the safety of tomb structures. Above mentioned preservation methods are suggested to give least changes to tomb site and to solve the most fundmental problems. Repairing should be planned in order and some special cares are needed for the safety of tombs in repairing work. Finally, a monitoring system measuring tilting of tomb walls, water content, groundwater level, temperature and humidity is required to monitor and to evaluate the repairing work.

      • KCI등재

        비누화 PC88A에 의한 NdCl₃와 SmCl₃용매추출의 화학모델

        이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.10

        A chemical model was developed to estimate equilibrium constant for the solvent extraction of Nd and Sm from chloride solution with saponified PC88A. The model could be employed to predict the distribution coefficient of metal from the initial extraction conditions. The model consisted of chemical equilibria, mass balance, charge balance and solvent extraction reaction. By applying the model to the experimental conditions and data, equilibrium constants for the solvent extraction of Nd and Sm were obtained. The effect of the saponification of PC88A on the extraction of Nd was explained in terms of the equilibrium constant obtained in this study and the change of equilibrium pH. The predicted distribution coefficients of Nd and Sm agreed well with those measured. (Received July 14, 2004)

      • 수술 전 진단된 충수돌기 점액류종 1례

        허광식,손현화,김동규,박찬국,김만우,김정용,기근홍 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

        Primary unruptured appendiceal mucocele is a rare disease. It is very difficult to diagnose preoperatively because of the rarity of classical symptoms and low incidence. Usually it is discovered incidentally during abdominal ultrasonography(US), computed tomography(CT), or appendectomy for acute appendicitis. If untreated, one type of mucoceles may rupture producing a potentially fatal entity known as pseudomyxoma peritonei, therefore preoperative diagnosis is very important. With the advent of colonoscopy, abdominal US and CT, it has been possible to preoperatively diagnose mucocele of appendix. We experienced a case of appendiceal mucocele in a 60 year-old woman who had symptoms of lower abdominal discomfort and right lower quadrant abdominal pain, and it was diagnosed preoperatively by colonoscopy, abdominal US and CT. So we present this case with review of literature.

      • KCI등재

        염산용액에서 PC88A에 의한 Sm의 용매추출

        이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.10

        Solvent extraction experiments of Sm were performed from chloride solution with PC88A and saponified PC88A. Solvent extraction reaction of Sm with PC88A and the corresponding equilibrium constant were evaluated from the experimental and ionic equilibria data as follows Sm^(3+)_(aq)+ 1.5H₂A_(2,org)= SmA_(3,org)+ 3H^(+)_(aq) , K = 0.33. The predicted distribution coefficients of Sm agreed well with the experimental results. The distribution coefficients of Sm with saponified PC88A and the values of equilibrium pH depended on the initial extraction conditions. When the concentration of PC88A was in excess of that of Sm, saponification of PC88A greatly enhanced the extraction of Sm. (Received June 21, 2004)

      • KCI등재

        염산용액에서 비누화 PC88A에 의한 용매추출로 Gd와 Sm의 분리

        이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.5

        Solvent extraction experiments have been performed to separate Gd and Sm from chloride solution with PC88A and saponified PC88A. The effects of extraction conditions on the distribution coefficients of Gd and Sm were investigated. The distribution coefficients of Gd were higher than those of Sm in the experimental ranges of experimental conditions of this study. A solvent extraction model was developed to predict the distribution coefficients of metals and separation factor between Gd and Sm from the initial extraction conditions. The measured distribution coefficients of Gd and Sm with PC88A and saponified PC88A showed good agreements with the predicted values. (Received March 3, 2005)

      • 폐암에 의한 Trousseau 증후군 치험 1예

        윤성욱,김예리,김석,유광하,정상만 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

        Trousseau's syndrome refers to an association of thrombosis with visceral malignancy. The thrombophlebitis is usually recurrent and migratory. An episode of thrombosis may precede clinical recognition of malignancy by weeks or months and in many cases, the underlying malignancy was occult. Patients with a recurrent deep venous thrombophlebitis without a known predisposing factors for hypercoagulable state deserves a consideration for underlying malignancy. We report a patients with lung cancer who initially demonstrates the clinical features of the Trousseau's syndrome.

      • Prodomain Processing of Recombinant Plasmepsin II and IV, the Aspartic Proteases of Plasmodium falciparum, Is Auto- and Trans-Catalytic

        Man Kim, Yong,Hyang Lee, Mi,Gwang Piao, Tae,Wha Lee, John,Ho Kim, Jong,Lee, SungGa,Min Choi, Kyung,Hua Jiang, Jing,Ue Kim, Tae,Park, Hyun Japanese Biochemical Society 2006 The Journal of biochemistry Vol.139 No.2

        <P>Prodomain processing of the four food vacuole plasmepsins (PMs), the malarial aspartic proteases, is prerequisite for their activity on hemoglobin degradation of the parasite Plasmodium falciparum. Although previous studies have suggested the involvement of a calpain-like PM convertase in the processing of PMs, the underlying mechanism of their processing remains to be clarified. Here, to investigate the mechanism by which food vacuole PM II and IV are processed, we used their wild-type and mutant proteins in which the catalytic Asp residue in two active-site motifs was mutated, as well as protease inhibitors. Autocatalytic processing of wild-type PM II and IV was inhibited only by an aspartic protease inhibitor pepstatin A. Unexpectedly, their proteolytic activities were inhibited not only by pepstatin A but also by calpain inhibitor ALLN. The active-site mutants of both PM II and IV showed neither autocatalytic processing nor proteolytic activities. However, the mutants of both PMs were efficiently processed upon incubation with their respective wild type proteins. Furthermore, the mutants of both PMs were processed upon incubation with each other's wild-type PM in both pepstatin A- and ALLN-sensitive manners. These results suggest that the processing of PM II and IV occurs via an intra- and inter-molecular autocatalytic event as well as via a transcatalytic event between them.</P>

      • SCISCIESCOPUS

        Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.

        Kim, Bo Hyun,Cho, Kyoung Im,Kim, Seong Man,Kim, Jee-Yeon,Choi, Bo Gwang,Kang, Ji Hyun,Jeon, Yun Kyung,Kim, Sang Soo,Kim, Seong-Jang,Kim, Yong Ki,Kim, In Joo Japan Endocrine Society 2012 Endocrine journal Vol.59 No.10

        <P>This study evaluated the effects of irbesartan and propranolol on thyroid hormone (TH)-induced cardiac functional and structural remodeling. A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks. Forty Sprague-Dawley rats were randomly divided into four groups (n = 10 each): control group, T(4) group (T(4) alone), T(4) plus irbesartan group (T(4)-Irb, 30 mg/kg), and T(4) plus propranolol group (T(4)-Pro, 0.5mg/mL of drinking water). Cardiac chamber size and functional parameters were measured by echocardiography and cardiomyocyte diameter. Heart rate (HR) and cardiac fibrosis were determined. T(4) alone showed significantly increased HR and cardiomyocyte width (25.0 1.77 vs. 18.8 0.84 μm, P < 0.001) with fibrosis, reduced left ventricle (LV) longitudinal strain (S(long); -16.0 6.27 vs. -22.7 5.19 %, P < 0.001) compared with control. When compared with T(4) alone, T(4)-Irb showed significantly improved LV S(long) (-21.4 1.84 vs. -16.0 6.27 %, P =0.017) and reduced cardiomyocyte width (21.0 1.0 vs. 25.0 1.77 μm, P =0.002) with comparable HR (458.4 24.3 vs. 486.6 30.1 bpm, P = 0.086). However, T(4)-Pro showed significantly reduced HR with improved LV S(long) without alteration of cardiomyocyte width and fibrosis compared with T(4) alone. In conclusion, renin-angiotensin system (RAS) blocking by irbesartan could significantly attenuate TH-induced cardiac structural and functional remodeling. However, HR reduction by propranolol could not alternate structural remodeling, which may implicate the RAS as having an important role in thyrotoxic cardiomyopathy beyond tachycardia.</P>

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