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Kim, Chun Gon,Castro-Aceituno, Veró,nica,Abbai, Ragavendran,Lee, Hyun A.,Simu, Shakina Yesmin,Han, Yaxi,Hurh, Joon,Kim, Yeon-Ju,Yang, Deok Chun Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.99 No.-
<P><B>Abstract</B></P> <P>Siberian ginseng (<I>Eleutherococcus senticosus</I>) was used for the synthesis of an ecofriendly silver nanoparticle (Sg-AgNP), which has exhibited antibacterial, antioxidant effect and lower cytotoxicity to normal cells in comparison to human cancer cells. Although, the potential anticancer activity of Sg-AgNP has not been determined. In this study, two cancer cell lines were used to evaluate the cytotoxicity and apoptotic effect of Sg-AgNP along with the determination of the role of the Caspase-3 / p38 MAPK pathways. Results shown that Sg-AgNP reduced the cell viability of colon cancer cells HT29 and lung cancer cells A549. The cytotoxic effect was higher than the effect exhibited by a commercial silver nanoparticle and Cisplatin. Reactive oxygen species were observed to be superior in both cell lines in the presence of Sg-AgNPs than c-AgNPs and Cisplatin. It was observed an activation of <I>MAPK14</I> gene and phosphorylation of p38 MAPK protein in both cell lines induced by Sg-AgNPs treatment. Furthermore, induction of morphological changes in the nucleus was done by Sg-AgNPs at 10 μg/mL in both cell lines. On the other hands, the activation of <I>CASP3</I> gene and Caspase-3 protein was observed in HT29 cells but only at protein level in A549 cells. These results, suggest that Sg-AgNPs anticancer potential activity might be linked to the induction of apoptosis though the generation of ROS by activation of the Caspase-3/p38 MAPK pathway.</P>
Outcomes of deceased donor liver transplantation from elderly donors
Kim Minjae,Hwang Shin,Ahn Chul-Soo,Kim Ki-Hun,Moon Deok-Bog,Ha Tae-Yong,Song Gi-Won,Jung Dong-Hwan,Park Gil-Chun,Yoon Young-In,Kang Woo-Hyoung,Cho Hwui-Dong,Na Byeong-Gon,Kim Sang Hoon,Lee Sung-Gyu 대한이식학회 2021 Korean Journal of Transplantation Vol.35 No.2
Background: Favorable outcomes achieved after deceased donor liver transplantation (DDLT) suggest that use of elderly donors may be an effective way to expand donor pool. Methods: This was a retrospective analysis of adult DDLT using elderly donors. It was a double-arm study that compared posttransplant outcomes to ascertain whether use of elderly donors (aged ≥76 years) has adverse effects on outcome of DDLT. Elderly donor study group included 14 donors aged ≥76 years and elderly donor control group comprised 39 donors aged 66–75 years. Results: Mean donor age of the study and control groups was 78.2±3.1 years and 68.9±2.7 years, respectively (P<0.001). Other clinical parameters were comparable between these two donor groups. The 1-, 3-, and 5-year graft survival rates in the elderly study group were 83.6%, 59.7%, and 59.7%, respectively, and those in the elderly control group were 79.4%, 68.1%, and 59.6%, respectively (P=0.97). The overall 1-, 3-, and 5-year survival rates after donation from elderly study group were 83.6%, 59.7%, and 59.7%, respectively, and those after donation from control group were 79.3%, 72.1%, and 64.1%, respectively (P=0.74). Regarding overall patient survival, univariate analysis identified pretransplant requirement for ventilator support (P=0.021) and pretransplant renal replacement therapy (P=0.025) as statistically significant risk factors; however, neither was significant on multivariate analysis. Conclusions: The results of this study suggest that using an elderly donor graft might not worsen the posttransplant outcomes significantly; thus, advanced age per se may not be an exclusion criterion for organ donation.
Kim, Chun-Gon,Kang, Jong-Pyo,Huo, Yue,Chokkalingam, Mohan,Kim, Yeon-Ju,Kim, Dong-Hyun,Yang, Deok-Chun Springer-Verlag 2018 Archives of microbiology Vol.200 No.7
<P>A novel bacterium, designated DCY114(T), was isolated from ginseng-cultivated soil in Gochang-gun, Republic of Korea. This isolate was assigned to the genus Paenibacillus and is closely related to Paenibacillus amylolyticus NRRL NRS-290(T) (98.3%), P. dongdonensis KUDC0114(T) (98.0%), P. tylopili MK2(T) (97.9%), P. tundrae A10b(T) (97.8%), and P. xylanexedens B22a(T) (97.5%) based on 16S rRNA gene sequence analysis. Strain DCY114(T) is a Gram-reaction positive, catalase and oxidase positive, facultatively aerobic rod that is motile by peritrichous flagella. Strain DCY114(T) produces siderophores and indole-3-acetic acid (IAA) and is able to solubilize phosphate as a plant growth-promoting bacterium. MK-7 was the diagnostic menaquinone. The major cellular fatty acids were anteiso-C-15:0, C-16:0, and C-18:0, and the major polar lipids were diphosphatidylglycerol (DPG), phosphatidylethanolamine (PE), and an unknown amino lipid (AL1,2). The genomic DNA G + C content was 46.0 mol%. Phenotypic and chemotaxonomic results also placed strain DCY114(T) within the genus Paenibacillus. DNA-DNA homology values between strain DCY114(T) and closely related reference strains were lower than 43%. The low DNA relatedness data in combination with phylogenetic and biochemical tests indicated that strain DCY114(T) could not be assigned to a recognized species. The results of this study support that the DCY114(T) strain is a novel species belonging to the genus Paenibacillus, for which the name Paenibacillus panacihumi is proposed. The type strain is DCY114(T) (= KCTC 33915(T) = JCM 32073(T)).</P>
Relationships between Creep Property and Oxidation Behavior of Alloy 617 for VHTR Components
Woo-Gon Kim(김우곤),Jae-Young Park(박재영),Sung-Deok Hong(홍성덕),Seon-Jin Kim(김선진),Yong Wan Kim(김용완) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
Relationships between creep property and oxidation behavior were investigated at 950℃, 900℃ and 850℃ in air and He environments for Alloy 617, which is considered as a prime candidate material for the VHTR components. The creep data were obtained with different stress levels at the three temperatures. Oxidation microstructure features such as surface oxide layer, internal oxidation and decarburization were observed each crept specimen. At 950℃ and 900℃, creep rupture time in the He environment was shorter than that in air one, and the thickness of the surface oxide layer was thicker than the air. The deterioration of creep resistance in He environment was due to thicker oxide-layer thickness, which reduced an effective area carrying creep load. On the other hand, at 850℃, creep rupture time was almost same regardless of both environments. The surface oxide-layer thickness was reduced with about 50% compared to the temperatures of 950℃ and 900℃. The temperature of 850℃ could be assumed as a boundary temperature which He effects disappeared. It was found that the relationships between the creep property and surface oxide-layer thickness were in accordance with in both environments.
( Sang-deok Ji ),( Jong-gon Son ),( Seong-wan Kim ),( Nam-suk Kim ),( Kee-young Kim ),( Hae-yong Kweon ),( Gyu-byeong Seong ),( Young-ho Koh ) 한국잠사학회 2017 International Journal of Industrial Entomology Vol.34 No.2
Cooked mature silkworms have received increasing attention as a new source of income for sericultural farms. Quality improvement of these worms as the end-product requires prevention of the following: inclusion of unfertilized silkworm eggs, mixing with impurities, producing undercooked or overcooked mature larvae, and mixing spewed silk substance. Preventing unfertilized eggs and impurities and reducing undercooked or overcooked mature larvae can be achieved by sericultural farms. However, the prevention of spewed silk substance requires the development of new techniques. This study developed new techniques for optimum cold storage temperature, soaking, and hydro-thermal treatment to minimize the spewing of mature larvae prior to steaming: when larvae mature after 7 days on the 5<sup>th</sup> instar, they should be soaked in water at room temperature of 25℃ immediately upon collection and stored at 8℃ for less than 3 days. They should be soaked in boiling water for approximately 10 s immediately before steaming to kill the larvae and cooked with steam. This method allows for the production of high-quality mature larvae without spewed silk substance. These new techniques will considerably improve the production of well-cooked quality mature larvae by minimizing silk substance spewed out from the larvae.