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난소암 환자에 대한 복합 화학요법 ( PAC Regimen ) 의 독성에 관한 연구
김두상(DS Kim),김문신(MS Kim),김용철(YC Kim),박형무(HM Park),유명숙(MS Yoo),신호문(HM Shin),김동명(DM Kim),조수현(SH Cho),조태승(TS Cho),환윤영(YY Hwang),심재철(JC Sim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.2
한양의대 산부인과학교실에서 1978년 10월부터 1982년 9월까지 PAC regimen(제1일에 adriamycin 50mg/㎡, 제2일에 cis-platinum 50mg/㎡, 제3~7일에 cyclophosphamide 150mg/ ㎡)으 로 화학치료를 받은 상피성난소암환자 16예를 대상으로 그 독성을 조사 분석하여 타 보고 자들의 성적과 비교 관찰한 바 다음과 같은 결론을 얻었다. 1. 혈액학적 독성은 총 16예중 10예(62.5%)에서 발생하였으며 혈소판 감소증은 3예 (18.8%), 백 혈구감소증 6예(37.5%), 빈혈 6예(37.5%)로 나타났으며 수혈은 1예(6.3%)에 실시하였다. 2. 신장에 대한 독성은 총 16예중 7예(43.8%)에서 각각 BUN증가 4예(25%) 혈청 creatinine 증 가 3예(18.8%)로 나타났으나, 전예가 경증이었다. 3. 가장 빈발하고 고통스러운 독성은 오심 구토로 전예에서 발생하였으며 perphenazine과 diazepam으로 어느정도 극복할 수 있었다. 4. 기타 말초신경독성은 5예(31.3%), 청력장애 1예(25%), 주관적인 시력장애 3예(18/8%), 간장 독성 1예(6.3%)였고 탈모증은 전예(100%)에서 발생하였다. The toxicity of PAC regimen was evaluated in 17 patients of ovarian epithelial carcinoma at the Edpartmane of Obstet. Nad Gynecol., Hanyang University Hospiatal from October, 1978 through september 1982. The PAC regimen consists of adriamycin 50mg/㎡ on the first day, cis-platinum 50mg/㎡ on the second day, and cyclophos-phanide 150mg/㎡ on the third to seventh day. It was repeated every 4 weeks. The results were as follow: 1. The hematologic toxicity occurred in 62.5%(10/16) of the patients, including thrombocytenia 18.8%(3/16), leukipenia 37.5%(6/16), and anemia 37.5%(6/16). For only one case, transfusion was require. 2. Nephrotoxicity occurred in 43.8%(7/160), including an elevation of BUN 25.0%(4/16) and an elevation of serum creatinine 18.8%(3/16). But all were in mild degree. 3. For the symptoms of gastrointestinal tract were nausea and vomiting which occurred in all cases and most distressing problems. All patients, however, were well tolerated with perphenazine and diazepam. 4. Peripheral neurotoxicity occurred in 31.3%(5/16), ototoxicity in 25.0%(1/4), blurred vision in 18.8%(3/16), hepatotoxicity in 6.3%(1/16) and alopecia in 100%.
불임환자의 치료를 위한 선택적 난관조영술과 비수술적 난관 재개통술에 대한 임상적 연구
김달수(DS Kim),김민관(MK Kim),신영우(YW Shin),조태승(TS Cho),배동한(DH Bae),김표년(PN Kim) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.3
Selective salpingography and non-surgical fallopian tube recanalization was performed in 18 patients with infertility and tubal obstruction documented with hysterosalpingography, in the Department of Obstetrics and Gynecology of Soonchunhyang University, College of Medicine, Chun-an hospital. In the 18 patients, 29 obstructed tubes were detected in previous hysterosalpingography. Recanalization of obstructed tube was successful in 24 (82.7%) of 29 tubes without serious complication. Four patients who had proximal tubal obstruction conceived without receiving any other therapy, and the average time from procedure to conception was 4.5 month. All pregnancies were intrauterine, The authors conclude that nonsurgical fallopian tube recanalization with selective salpingography provide more information than hysterosalpingography and is an effective treatment for infertility caused by proximal tubal obstruction.
김두상(DS Kim),조재윤(JY Cho),김병렬(BR Kim),김종혜(JH Kim) 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.12
24세 미혼여성에 발생된 자궁근종의 1례를 보고하는 바이다. A case of nearly double fist sized submucous and intramural leiomyoma in a 24 year old unmarried woman was reported and a brief review of literature on etioloty and abnormal uterine bleeding was made.
난소과립막세포 스테로이드호르몬 생성 및 증식에 대한 Mullerian Inhibiting substance의 효과
김장흡(JH Kim),제동성(DS Jae),김태응(TE Kim),신재인(JI Shin),김은중(EJ Kim),이진우(JW Lee),나종구(JG Na),김수평(SP Kim) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.12
Ovarian follicular growth is a consequence of granulosa cell proliferation, and steroid production by these cells appears to be a major determinant of the endocrine microenvironment of ovum maturation. The gonadotropins, FSH ad LH, regulate directly the growth and differentiation of the granulosa cells in the ovary, but there is evidence to suggest that the gonadotropins act partly through locally produced growth factors and that this interaction is complex. A number of growth factors, such as epidermal growth factor(EGF), insulin-like growth factor-I(IGF-I), and transforming growth factor-β(TGF-β) are produced in the ovarian follicle and might act in an autocrine and/or paracrine manner to directly control granulosa cell proliferation and differentiation. While it has been demonstrated that steroid hormones, gonadotropins and growth factors regulate proliferation and differentiation of ovarian follicles, little is known concerning the fators involved in the inhibition of ovarian function. Recently, Mullerian inhibiting substance(MIS), a non-steroidal testicular Sertoli cell product responsible for the regression of Mullerian duct in male embryo, has been shown to be produced by ovarian granulosa cells in adolescnet and ault females. Although the function of MIS in the ovary has not been fullydelineated, MIS appears to be a regulator of oocyte maturation and follicular development in the rat. In this study, in order to investigate the influence of MIS on steroidogenesis and proliferation of human granulosa cells, we performed culture of human granulosa cells. The cells were cultured for 2 to 12 days under two conditions, with and without MIS(20 ng/ml). Each condition was additionally defined by the presence and absence of EGF(20 ng/ml), FSH(10 ng/ml), or LH (10 ng/ml). Estradiol, progesterone, and testosterone were mearsured form the spent media by radioimmunoassay and the cell number was determined by trypsinizing the cells and counting them with a Coulter counter. The result were as follows: 1. There was about 6-fold increase in the final granulosa cell number when the culture were maintained for 12 days in Ham`s F-10 supplemented with 10% MIS-free female fetal calf serum(control). FSH and EGF caused a significant increase in granulosa cell number compared with the control but LH significantly suppressed cell number after 8 days in culture. 2. MIS caused a significant decrease in granulosa cell number compared with the control after 8 days in culture in the 20 ng/ml dose, and on day 12 in the 2 ng/ml dose(p
자궁내막증 발생에 있어서 유전적 요인: 자궁내막증의 발생과 HLA 항원과의 관계
김동호(DH Kim),김태철(TC Kim),허민(M Hur),이미경(MG Lee),박애자(AJ Park),김정구(JK Kim),김대원(DW Kim),최두석(DS Choi) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4
Objective: Many of previous reports have demonstrated a hereditary tendency to development of endometriosis and the incidence of the disease varies in different ethnic groups. However, the genetic background to these differences has not been clearly explained. Our investigation was performed to seek a possible association between certain HLA antigens and the development of the endometriosis. Methods: From May 1997 to the end of October 1998, 70 patients, 39 patients who have endometriosis [34 nonfamilial and 5 familial subjects] and 31 control subjects, were typed for HLA-A, B, C, and DR. To evaluate differences in HLA antigen frequencies between endometriosis and control subjects, X2 tests were performed. Analysis was performed on the entire sample of 39 as well as separatively for familial[n=5] and nonfamilial subjects[n=34]. A two-tailed P value was calculated for each X2 value. Fisher`s exact P value was calculated for small numbers. Results: Increased frequency of HLA-A24, B61, and DR15 antigen were found as compared the entire sample of 39 endometriosis to 31 control subjects [p〈0.05]. In turn, there was a reduced frequency of DR2 antigen in endometriosis. Also, increased frequency of HLA-B61 and DR3 antigen were found as compared 5 familial subjects to 31 control subjects[p〈0.05]. Conclusion: We suggest that the development of endometriosis may be associated with HLA antigens, specially A24, B61, DR15 and negatively associated with DR2, and that HLA-B61 and DR3 antigens may be associated with the development of the familial endometriosis. We think that HLA typing may be valuable in detecting those women with a tendency to develop endometriosis, and further study is needed.