정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

쇄석말뚝(CSP)의 압밀거동특성에 관한 실험적 연구

김유철,김병일,박용원 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

Crushed Stone Pile(CSP) is one of the ground improvement methods and is suitable for soft clays or loose silty sands. CSP has proven successful in increasing bearing capacity, reducing settlements, increasing time rate of consolidation. In this study several model tests were performed to evaluate the stress concentration ratio and the consolidation behaviour characteristics of CSP relevant to the area replacement ratio. Two rectangular model tanks(1.0m×1.0m×1.0× & 1.5m×1.5m×1.2m) are used and area replacement ration of 20%, 30%, 40%, are applied in the model tests. The results of model tests are compared with the model test results of SCP performed previously.

디지털 및 일반 측방두부규격방사선사진에서 측정 방법에 따른 계측치의 비교

김미자,허경회,이원진,허민석,이삼선,이진구,안병근,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : To compare cephalometric measurement between measuring methods in digital and conventional lateral cephalometric radiograph. Materials and Methods : Twenty digital and conventional lateral cephalometric radiographs were selected. In digital group, cephalometric measurements were performed manually using hardcopies and automatically using VCeph^(TM) program on the monitor. In conventional group, the same measurements were performed manually on conventional films, and for automatic measurement conventional films were digitized by scanner. All measurements were performed twice by 4 observers, and 24 cephalometric variables were calculated and the time spent for each measurement was recorded. The differences in measurements data and the time spent for each measurement were compared within each group. Intra-observer and inter-observer comparisons were performed. Results : In both groups, no statistically significant difference between manual and automatic measurements was observed and most of the variables didn’t show statistically significant differences between methods. The observer with less experience tended to show statistically significant differences of measurements between methods, and differences from other observers. The differences of measurements between methods in digital group were lesser than those of conventional group with statistical significance in 8 variables out of 24. With automatic method and in digital group, the spent time was shorter. Conclusion : With direct digital radiograph, automatic method using manually idenitified landmarks can be preferable in cephalometric analysis.

Fenton산화에 의한 쓰레기 埋立場 浸出水의 處理

김선희,이병대,김세정,이철희 嶺南大學校 工業技術硏究所 1995 工業技術硏究所論文集 Vol.23 No.1

This study was aimed to investigate treatment feasibility of leachate from landfill that was located in Bancheung-Dong Kyungbuk Talsung-Kun. From the analytical results of leachate, high concentration of organic and nonbiodegradable matters was contained. It could not be treated by biological process only thus required a combined treatment able to high rate COD removal efficiency. Two types of Fenton's oxidation were adapted in this study. The first one is pre treatment before biological treatment. The second one is post treatment after biological treatment. Thus, the optimal conditions in both methods were investigated. From the survey of treatment conditions, in case of pre treatment, the optimal condition was ?? 0.1, ?? 27.08, pH 3, temperature 30℃ and reaction time 2 hr. On the other hand, ?? 0.14, ?? 57.42, pH 3, temperature 30℃ and reaction time 1.25 hr was obtained for post treatment as optimal conditions. In the above optimal conditions, high COD removal efficiency was shown in pre and post treatment. Also it can be expected that nonbiodegradable matters are degraded and converted to biodegradable matters.

수도권 지역 개신교인, 불교인, 천주교인의 종교적 내재성(immanence) 비교 : 종교정향과 종교의식의 실증적 분석을 중심으로 An Empirical Analysis on religious orientation and religious attitudes

金東基,高炳哲 韓國宗敎敎育學會 2004 宗敎敎育學硏究 Vol.19 No.-

이 연구는 수도권 지역의 개신교, 불교, 천주교 신자들 간의 내재성 차이를 검증하여 신앙인들을 이해하고, 종교 간의 의식차이를 연구하는 데 중요한 기초 자료를 제공하는 것이 목적이다. 첫째, 변인들의 주요 항목들 간의 상관관계 분석 결과에서 세 종교 전체에서 보면, 신앙중요도는 종교적 내재성의 수용성과 현재성에서 유의미하게 상관성이 있고, 경계성에서는 상관이 유의미하지 않았다. 둘째, 종교적 내재성 정도에 따른 종교 간 비교를 위한 t검증 결과에서는 개신교가 경계성과 수용성에서 다른 종교와 큰 차이를 보였다. 셋째, 종교적 내재성과 종교정향의 정도가 종교의식에 미치는 영향에 대한 변량분석 결과는 세 종교 전체에서, 내재성 세 척도(수용성, 경계성, 현재성)의 거의 모두에서 유의미한 상호작용이 일어났다. 종교별로는 유의미한 변량분석 결과가 천주교가 가장 많았고, 그 다음이 개신교, 불교의 순으로 나타났다. 내재성 하위 척도별로는 수용성, 현재성, 경계성의 순이다. 종교정향 하위 척도별로는 추구적 정향,외적 정향, 내적 정향의 순으로 나타났다. The purpose of this study was to examine the effects of immanence in the Protestant, the Buddhist and the Catholic believers in the Seoul Metropolitan Area, as analyzing their religious orientations and religious attitudes. First, the results revealed that relationships(r) were significant among believing attitude, acceptance, present-orientation by the participants in 3 religions. But the relationship was not significant between believing attitude and boundary-leveling. Second, the results of t-test were significant between boundary-leveling and acceptance of religious immanence by the Protestant then other religions. Third, the result of ANOVA showed that the interaction effect of immanence scales(acceptance, present-orientation, boundary-leveling) and religious orientations(external, internal, quest) were significant to religious attitudes by participants in 3 religions. The Catholic were the most significant interactional effect; the Protestant were the second weaker significant level and the Buddhist were the third significant level. Acceptance scales were the most significant interactional effect; the present-orientation was the second weaker significant level and the boundary-leveling was the third significant level. Quest scales were the most significant interactional effect; the external scales was the second significant level and the internal scales was the third significant level.

원형 비강진 1예

김영조,박홍표,정병수,최규철 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pityriasis rotunda is an uncommon cutaneous disorder consisting of asymptomatic, strikingly circular, scaly lesions on the trunk and extremities, with the histologic appearance of ichthyosis vulgaris. A case of pityriasis rotunda in a 35-year-old woman in whom no diagnosable disorder could be demonstrated is presented.

소규모 도시의 생활폐기물 발생특성 : 동해시를 중심으로 For Donghae City

김승호,원철희,김병욱,임재명 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B

This research was performed to investigate the generation and physico-chemical characteristics of municipal solid wastes. The results were as follows: i) The generation rate and bulk density were 0.157 kg/cap/d and 147.8 g/L in residential zone, respectively. In non-residential zone, the generation and bulk density were 1.71 kg/cap/d and 85.6 g/L, respectively. Consequently, bulk density of non-residential zone was lower than that of residential zone. ii) The wastes consisted of 90% of combustibles and 10% of incombustibles in residential zone. And the wastes from non-residential zone was composed 85% of combustibles and 15% of incombustibles. iii) Water content was estimated at 47∼50% in residential zone and restaurants. In non-residential zone, except restaurants, water content was in the range of 10∼30%. Ash content was nearly 10% in overall zone.

메탈라스와 와이어메쉬로 횡구속된 철근 콘크리트 기둥의 내력 및 연성에 관한 연구

김병철,이우진,정덕우,윤승조,김성수,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Generally, transverse steel in reinforced concrete column serves the three-fold function of confining the compressed concrete, preventing lateral buckling of the longitudinal reinforcing steel, and acting as shear reinforcement. However, the amount of confining steel required in the form of rectangular hoops is still argument. This paper summarizes the results of an experimental program where 10 short columns with compressive strength 21MPa are designed with variable lateral confinements such as Metal Lath and Wire Mesh were tested under monotonic axial compression to failure. The columns were 300mm square and 750mm high. The purpose of this study is to investigate the ductility and strength of columns with variable lateral confinement. Test results indicate that specimen confined by metal lath and hoop, and wire mesh and hoop show 1.89 times ductility than NO.I specimen using hoop only. However, effect of lateral confinement by metal lath and wire mesh is how or same than NO.I specimen in maximum strength.

인터넷 의료상담에 관한 분석 및 연구

김영조,박홍표,정병수,최규철 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Telemedicine uses computer and telecommunication technologies to provide medical information and services. Telemedicine can be useful in any situation in which there is a physical barrier between the doctor and the patient. We analyzed medical consultations from Chosun University Hospital is home page (http://hosp.chosun.ac.kr) to find problems on the home page and to offer high quality medical information services. Methods : We collected 544 queries of medical consultation on our home page from May 1998 to May 1999. From medical consultation data on the internet web site of Chosun University Hospital, consulted documents were analyzed with regard to medical department, patients’ age, consultation by attorney, and dermatologic consultations. Results : The telemedicine system is a relatively satisfactory method to both patients and physicians due to easier access and almost rea1-time medical consultation through the world wide web. But several problems should be solved to provide a more effective and lawful telemedicine environment. Conclusion : As a consequence to analyzed medical consultations on our home page, there were several problems in our store-and-forwarding system. To establish an effective telemedicine system, we have to prepare protocols to receive sufficient information and patients have to send digital images to make help an accurate diagnosis. Also problems of liability, reimbursement and coordinated national policy need to be solved.

모반세포성 모반과 악성 흑색종의 CD44 발현에 관한 면역조직화학적 연구

김정수,김영조,최규철,정병수 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1