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Discovery of urinary metabolomic biomarkers for early detection of acute kidney injury
Won, A Jin,Kim, Siwon,Kim, Yoon Gyoon,Kim, Kyu-Bong,Choi, Wahn Soo,Kacew, Sam,Kim, Kyeong Seok,Jung, Jee H.,Lee, Byung Mu,Kim, Suhkmann,Kim, Hyung Sik The Royal Society of Chemistry 2016 Molecular bioSystems Vol.12 No.1
<P>The discovery of new biomarkers for early detection of drug-induced acute kidney injury (AKI) is clinically important. In this study, sensitive metabolomic biomarkers identified in the urine of rats were used to detect cisplatin-induced AKI. Cisplatin (10 mg kg(-1), i.p.) was administered to Sprague-Dawley rats, which were subsequently euthanized after 1, 3 or 5 days. In cisplatin-treated rats, mild histopathological alterations were noted at day 1, and these changes were severe at days 3 and 5. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at days 3 and 5. The levels of new urinary protein-based biomarkers, including kidney injury molecule-1 (KIM-1), glutathione S-transferase-alpha (GST-alpha), tissue inhibitor of metalloproteinase-1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, neutrophil, neutrophil gelatinase-associated lipocalin (NGAL), and osteopontin, were significantly elevated at days 3 and 5. Among urinary metabolites, trigonelline and 3-indoxylsulfate (3-IS) levels were significantly decreased in urine collected from cisplatin-treated rats prior to histological kidney damage. However, carbon tetrachloride (CCl4), a hepatotoxicant, did not affect these urinary biomarkers. Trigonelline is closely associated with GSH depletion and results in insufficient antioxidant capacity against cisplatin-induced AKI. The predominant cisplatin-induced AKI marker appeared to be reduced in urinary 3-IS levels. Because 3-IS is predominantly excreted via active secretion in proximal tubules, a decrease is indicative of tubular damage. Further, urinary excretion of 3-IS levels was markedly reduced in patients with AKI compared to normal subjects. The area under the curve receiver operating characteristics (AUC-ROC) for 3-IS was higher than for SCr, BUN, lactate dehydrogenase (LDH), total protein, and glucose. Therefore, low urinary or high serum 3-IS levels may be more useful for early detection of AKI than conventional biomarkers.</P>
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
김봉오,박제석,오명철,현재석,김재하,오창경,김수현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2
톳, 미역 및 다시마를 용매별로 추출하여 이들 추출물의 항돌연변이원성을 검색하였다. 톳 용매별 추출물의 MMS에 대한 항돌연변이 효과는 TA100 균주에서 헥산, 에탄올, 에칠에테르 추출물 순으로 높았고, TA102 균주에서 헥산, 에칠에테르, 에탄올 순으로 높았으나, 미역 및 다시마 추출물은 항돌연변이원성이 거의 없었다. ICR191에 대한 항돌연변이 효과는 시험된 모든 시료에 대한 에탄을 추출물이 높은 항돌연변이 효과를 나타내었고, 에칠에테르와 헥산 추출물은 물 추출물보다도 낮은 효과를 나타냈다. 그러나 톳 추출물은 시험된 모든 용매 추출물에서 60% 이상의 높은 항돌연변이 원성을 나타내어 ICR-191에 의해 유도되는 돌연변이 원성을 저해하는 물질이 수용성 및 비수용성에 걸쳐 다양함을 나타내었다. 한편, 미역, 다시마 및 톳 추출물의 sodium azide에 대한 항돌연변이원성은 없는 것으로 나타났다. Desmutagenic effects against methyl methanesulfonate(MMS)-, 2-methoxy-6-chloro-9-〔3-[2-chloroethyl〕aminopropylamino〕acridine(ICR191)- and sodium azide-induced mutations by the extracts from Hizikia fusiforme. Laminaria japonica and Undaria pinnatifida with different solvents were investigated. The solvent extracts from Hizikia fusiforme were the highest desmutagenic effect against MMS in n-hexane and against ICR191 in ethanol extract. but no against sodium azide in all solvent extracts tested. While the solvent extracts from Undaria pinnatifida and Laminaria japonica were the highest against ICR191 in ethanol extract. but no against sodium azide and MMS in all solvent extracts tested. Moreover. all the solvent extracts from Laminaria japonica were inhibited 60% or more ICR191-induced mutations.
소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과
김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-
Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.
확장 칼만 필터를 이용한 동적 전기 임피던스 단층촬영법
김봉석,김경연,김민찬,이윤준 濟州大學校 情報通信硏究所 2000 情報通信硏究所論文集 Vol.3 No.-
In electrical impedance tomography (EIT). the resistivity(impedance) distribution of the unknown object is estimated from boundary voltages induced by different current patterns with various reconstruction algorithms. In this paper. we propose a dynamic EIT reconstruction algorithm based on the extended Kalman filter(EKF). The reconstruction problem is formulated as dynamic equation which consists of the state equation and the observation equation and the unknown state is estimated recursively with the aid of the EKF. Computer simulations for the 16-channel synthetic data are provided to illustrate the reconstruction performance of the proposed algorithm.
동적 전기 임피던스 단층촬영법에서 전류주입방법에 따른 영상복원 성능 분석
김봉석,김경연 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2
Electrical impedance tomography(EIT) is a relatively new imaging modality in which the resistiviry distribution of an unknown object is estimated based on the known sets of injected currents and measured voltages on the surface of the object. In this paper. image reconstruction performance in dynamic EIT is analyzed according to the injected current patterns. In dynamic, the inverse problem is formulated as dynamic equation which consists of the state and the observation equations, and the unknown state (resistivity) is estimated recursively with the aid of the extended Kalman filter(EKF) In doing so. the generalized Tikhonov regularization technique is employed to mitigate the ill-posedness characteristics of the inverse problem.
운동 강도의 차이가 흰쥐의 혈액 성분과 적혈구의 형태에 미치는 영향
김부환,김종오,지용석,최대원,윤진환,정일규,김영욱,오봉석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4
This study was to investigate the effects on hematological indices and heinz body formation in various intensity, Male Sprague-Dawley rats were randomly divided into the control group, the low-intensity exercise group, nigh-intensity exercise group (n=7 in each group). Animals of the low-intensity exercise groups were put on exercise 30 min per 1 day, 5 days per week for 6-weeks. Animals of the high-intensity exercise groups were put on exercise 120 min per 1 day, 5 days per week for 6-weeks. Red blood cell count (RBC), hemoglobin (Hgb), hematocrit (Hct), mean ceil volume (MCV), mean hemoglobin corpuscular (MCH), mean hemoglobin corpuscular concentration (MCHC) were analyzed in automated hematology analyzer (ABX Hematology MICROS 60) from 10㎕ of whole blood. Erythrocyte morphology were evaluated in super vital (Brilliant cresyl blue stain) stained blood films. In the present results, Hg, MCHC in the high-intensity exercise group was significantly decreased compared with the different exercise intensity and the control group. MCV in the high-intensity exercise group was significantly increased compared with the different exercise intensity end the control group. Heinz body formation in the high-intensity exercise group was significantly increased compared with the different exercise intensity and the control group. In the present study, it can be suggested that intensity of exercise can influence hematological variables and heinz body formation. These findings suggest that high intensity exercise induces oxidative damage to erythrocyte.