정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

전측 시개전핵의 하행성 통각 조절계에 대한 중뇌수도주변회백질의 관여

이배환,김현,서영석,홍승길,안창일,김기석 한국심리학회 한국심리학회지 생물 및 생리 Vol.6 No.1

이 연구는 전측 시개전핵의 자극으로 인한 하행성 통각 억제 체계에 중뇌수도주변회백질이 관여하는가를 알아보기 위해 수행되었다. 펜토바비탈로 마취된 쥐의 꼬리튀기 반사를 사용하여 전측 시개전핵을 전기자극하고 중뇌수도주변회백질에 리도카인을 주입한 결과 전측 시개전핵의 자극으로 유발된 무통 효과가 억제되었다. 하올리브 수준의 복측 연수에 WGA-HRP를 주입하였을 때 중뇌수도주변회백질의 복외측 부위에 표지된(labeled) 뉴론이 집중적으로 관찰되었으며, 전측 시개전핵에서도 표지된 뉴론이 발견되었다. 이러한 결과는 전측 시개전핵의 하행성 통각 억제 체계에 최소한 부분적으로 중뇌수도주변회백질이 관여한다는 것을 시사한다. This study was conducted to determine whether the periaqueductal gray (PAG) is involved in descending pain inhibition system mediated by the anterior pretectal nucleus (APTN). Pain sensitivity was assessed using tail-flick test to radiant heat in the rat anaesthetized with pentobarbital. Microinjections of lidocaine into the PAG inhibited the analgesic effects of stimulating the APTN. After WGA-HRP was injected into the ventral medulla at the level of the inferior olivary nuclei, the labeled neurons were detected in the ventrolateral PAG and in the APTN. The results suggest that the PAG is at least partially involved in a descending antinociceptive pathway originating in the APTN.

알칼리용액으로 처리된 폐피혁 분이 석고-피혁 복합체의 물성에 미치는 영향

조헌영,서정목,전기석,이기환 공주대학교 생산기술연구소 2001 論文集 Vol.9 No.-

Gypsum material has strong compressive strength and excellent resistance against fire. But, these material has some demerits ; weak water-resistance, heavy specific gravity and low physical properties in flexural and tensile strengths. While, leather shaving dust(LSD) which is much produced from leather manufacturing company in waste has strong tear and tensile strengths, the properties of the high hygroscopic and the superior thermal insulation. In this research, gypsum-leather composites were made with gypsum and LSD. And the physical properties of those were tested. The optimum dosage of LSD for gypsum-leather composite was decided to 1~5%(w/w) of the gypsum. In that case, the composit which has compressive strength: 147~272 kg_(f)/cm^(2), flexural strength: 66~87kg_(f)/cm^(2), specific gravity: 1.11~1.29 is made.

피혁 분으로 변성된 석고계 재료의 물성

조헌영,서정목,전기석,이기환 공주대학교 생산기술연구소 2000 論文集 Vol.8 No.-

Gypsum materials have strong mechanical strengths and great resistance to fire. Also these one are very cheap because of the gypsum is a byproduct from chemical plants. But, these materials have some demerits ; weak water-resistance, heavy specific gravity and low physical properties in bending and tensile strengths. While, leather shaving dust(LSD) is very much produced from leather manufacturing process. The LSD is composed of collagen fibers which is a kind of protein. This one has strong tear and tensile strengths because of the collagen fibers are cross linked during the tanning process of leather. Also the dust has the properties of the high hygroscopic and the superior thermal insulation, but is not degraded any more in neutral condition such as gypsum slurry. In this paper, we have reinforced the physical properties of gypsum with LSD as a filler. From this research, it is decided that the optimum dosage of LSD to gypsum is below 5%(w/w) of the gypsum, and the specific gravity of LSD-gypsum mixture is reduced to 30% relative to gypsum alone.

Poly-(acrylic acid-co-methylacrylate)합성조건에 따른 시멘트계 재료의 물성

조헌영,서정목,이효진,이기환,김진만,맹학영 공주대학교 생산기술연구소 2000 論文集 Vol.8 No.-

The water soluble polymers based on polycarboxlates are come into the spot-light in the detergent fields of CaCO_3, Al(OH)_3 and leather industries. In this research, we synthesized molecular weights(Mn) by changing the concentrations of monomer(acrylic acid-methylacrylate mixture), chain transfer agent(butanethiol) and initiator(ammoniumpersulfate). We investigated the influences on the fluidities(the flow & the mini slump) and the setting times of cement material admixtured with the copolymers by the statistical method. The optimum synthesis formulation of the poly-(AA-co-MA) for cement materials is at the concentrations of monomer 50 M%, chain transfer agent 6.0 M% and initiator 2.0 M%. The number-average molecular weight of that was decided on 7,600 by the viscosity method.

구개열 아동 언어의 진단 평가

신효근,고승오,홍기환,서정환,고도흥,김현기 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

디지털 FWS간 허용 간섭 기준

이기환(Ki Hwan Lee),이주환(Joo Hwan Lee),서경환(Kyoung-Whoan Suh),송주빈(Ju Bin Song) 한국방송·미디어공학회 2008 방송공학회논문지 Vol.13 No.4

The method to determine allowable interference criteria is required due to new digital FWSs(Fixed Wireless Systems) adding to allowable frequency bands, besides current FWSs and digital FWSs. In this paper, we suggested a method to define allowable interference between digital FWSs. Types of interference for FWS were defined and channel characteristics were analyzed. Allowable interference criteria were analyzed using the suggested method for M-ary QAM modulations, which is typical modulation technique of digital FWS.

Gene Expression Profiling of Genotoxicity Induced by MNNG in TK6 Cell

Suh, Soo-Kyung,Kim, Tae-Gyun,Kim, Hyun-Ju,Koo, Ye-Mo,Lee, Woo-Sun,Jung, Ki-Kyung,Jeong, Youn-Kyoung,Kang, Jin-Seok,Kim, Joo-Hwan,Lee, Eun-Mi,Park, Sue-Nie,Kim, Seung-Hee,Jung, Hai-Kwan The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.2

Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death. In this study, we investigated to examine gene expression profiles and genotoxic response in TK6 cells treated with DNA damaging agents MNNG (N-methyl-N'-nitrosoguanidine) and hydrogen peroxide $(H_2O_2)$. We extracted total RNA in three independent experiments and hybridized cRNA probes with oligo DNA chip (Applied Biosystems Human Genome Survey Microarray). We analyzed raw signal data with R program and AVADIS software and identified a number of deregulated genes with more than 1.5 log-scale fold change and statistical significancy. We indentified 14 genes including G protein alpha 12 showing deregulation by MNNG. The deregulated genes by MNNG represent the biological pathway regarding MAP kinase signaling pathway. Hydrogen peroxide altered 188 genes including sulfiredoxins. These results show that MNNG and $H_2O_2$ have both uniquely regulated genes that provide the potential to serve as biomarkers of exposure to DNA damaging agents.

Effects of weaning and castration ages on growth performance, blood metabolites, and carcass characteristics in Hanwoo steers

( Hwan Lim ),( Jun Sang Ahn ),( Min Ji Kim ),( Gi Hwal Son ),( Joong Kook Park ),( Jae Yoon Shim ),( Il Young Kim ),( Ji Hyung Kim ),( Sung Myoun Cho ),( Eung Gi Kwon ),( Jong Suh Shin ),( Byung Ki Pa 한국축산학회(구 한국동물자원과학회) 2018 한국축산학회지 Vol.60 No.12

Background: Recently, as production costs have been increasing owing to rising feed prices worldwide, shortening the age of slaughter has been recognized as a way to increase farm income. In Korea, the raising period for Hanwoo steers is over 31 months with the delay of weaning and castration stated as one of the reasons for the increase in the raising period. Thus far, studies on age of weaning and castration have been conducted individually, and there have been no studies on the combined effects of weaning and castration ages on the growth performance and carcass characteristics in Hanwoo steers. Methods: Weaning ages were calculated at 80 or 130 days of age, and castration ages were calculated at 90 days and 180 days of age. Calves were allocated to one of the four treatment groups: W80C90 (weaning at 80 days of age and castration at 90 days of age), W80C180, W130C90, and W130C180. Results: For the entire experimental period, weaning and castration ages did not significantly affect growth performance of Hanwoo steers. In addition, weaning and castration ages did not affect the overall yield and quality traits of carcass in Hanwoo steers. Conclusion: Weaning and castration ages had small effects on growth performance and carcass characteristics in Hanwoo steers. Therefore, the early weaning and castration ages are recommended to reduce the slaughter age without any negative effects on meat quality grade.

Development of Quantltative Methodology for Assessing Environmental Impacts of Recycled Materials in Life Cycle Analysis

(Ki Suk Chung),(Jong ll Park),(In Suk Suh),(Jong Hwan Eun),(In Bum Lee),(Jong Shik Chung) 한국전과정평가학회 2000 한국전과정평가학회 정기총회 연구논문집 Vol.2000 No.0