http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성
홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2
Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
대두박에 대한 extrusion처리 및 formaldehyde처리가 젖소의 반추위내 in situ분해율에 미치는 영향
문여황,김기원,문점동,조광일,김병기,이성실,이상철 진주산업대학교 농업기술연구소 2001 農業技術硏究所報 Vol.14 No.-
This experiment was conducted to investigate the effect of temperature of extrusion processing on ruminal degradation characteristics of soybean meal. Four ruminally cannulated Holstein cows were employed to in situ trial and treatments were composed of soybean meals untreated(Control), extruded at 115, 130 and 155℃, and treated with 0.3% formaldehyde(HCHO). The nylon bags were suspended for 0, 3, 6, 9, 12 and 24 hours in the rumen, respectively. Animals fed the diet of 50 : 50 in concentrate and orchard grass hay at 110% of NRC(1988) requirements, and were freely access to water and mineral block. The regression equations for degradation characteristics and effective degradability(ED) of crude protein of soybean meals in the rumen were obtained as follows. Control P = 26.41 + 69.86(1-e^-0.041t) ; ED(k=0.05) = 57.89% 115℃ extrusion P = 3.39 + 44.76(1-e^-0.013t) ; ED(k=0.05) = 12.63% 130℃ extrusion P = 2.79 + 56.60(1-e^-0.015t) ; ED(k=0.05) = 15.85% 155℃ extrusion P = 1.71 + 31.48(1-e^-0.018t) ; ED(k=0.05) = 0.04% 0.3% HCHO P = 7.23 + 35.14(1-e^-0.015t) ; ED(k=0.05) = 15.34% where, P = Degradability during the time(t) suspended in the rumen, k = Passage rate at the rumen(%/hr/100). Ruminal degradabilities of dry matter, crude protein, organic matter and energy significantly (P<.01) decreased by extrusion or HCHO treatments, but did not affected by the temperature of extrusion processing. The ruminal degradation of soybean meals treated extrusion and formaldehyde, paticularly crude protein, was low beyond expectation.
학교체육 활성화 방안에 대한 연구(Ⅰ) : 강원대학교 교양체육 운영방법의 개선을 중심으로
이광재,문병용,노성규,박기동,홍관이,한상준,유옥재,엄기진,정청자,오수일,김윤래,박장평,부기원 江原大學校附設 體育科學硏究所 1986 江原大學校附設體育科學硏究所論文集 Vol.- No.11
Try to find a scheme for activation to College Physical Education, this Report informs the various kinds of Survey and process those were projected for improvement of management methods on Cultural Physical Education in Kang Weon National University. From experimentally carried out "Sports events Choosing System" not as usual be inforced "Total practical Skill System", Following Positive effects and sujestions were Presented; 1. "Sports events choosing system" gave birth to more students' interesting and more voluntary participation to the sports events they chose, and sports skill and instruction level was elevated due to charge of expert according to each sports events. This system would be managed continuously hereafter for it related to life sports. 2. This System needs to closed cooperations between College and Community, for the facilities of community are utilized by college. 3. To complete the plan for activation of college Physical Education, additionally, the successional study ; namely "autonomous extracurricular sports activity" should be excuted hereafter.
( Su Jin Moon ),( Cheol Jung Lee ),( Yong Yeon Cho ),( Jun Ki Min ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Rheumatoid arthritis (RA) is a systemic infi ammatory disease and mainly affects in the synovial joints. However, little information is available regarding the etiological mechanisms on the RA and natural compounds reducing RA symptom. Here, we investigated whether kaempferol, a natural compound abundantly found in editable plants, could target kinase domain of fi broblast growth factor (FGF) receptor (FGF-R), that is a well-known receptor tyrosine kinase implicated in RA pathogenesis. Methods: RA and osteoarthritis (OA) synovium tissues were used for immunohistofi uorescence assay and immunohistochemical staining. Mouse embryonic fi broblasts were used to investigate FGF-mediated cell migration study. Autoimmune arthritiswas induced by type II collagen (CII) immunization in DBA/1J mice. Kaempferol (2mg/ kg) was administered orally three times per week. The frequencies of IL-17-producing CD4+ T (Th17) cells and CD4+ CD25+ Foxp3+ regulatory T (Treg) cells were analyzed by fi ow cytometry. Results: Phosphorylation of the FGFR3 and RSK2 was highly detected in RA tissues compared with OA. KI-67, a cell proliferation marker, was higher in RA than that of OA. Cell migration induced by FGF was mediated through RSK2, and kaempferol inhibited FGF-induced cell migration by suppression of RSK2-mediated activities of the AP-1 and NF-κB and gene expression of COX-2. We found that active RSK2 positive cells were extensively co-stained with CD68 in RA synovium. Kaempferol inhibited FGF-induced synovial cell migration through RSK2-mediated signaling pathway. Kaempferol treatment suppressed arthritis severity in mice with autoimmune arthritis through suppression of Th17 and reciprocal induction of Treg cells in vivo. Infi ammation and joint destruction were signifi cantly suppressed in the joints of kaempferol- treated mice. Conclusions: Dual targeting of kaempferol on FGFR and RSK2 could be a novel therapeutic strategy in RA.
AMP-activated Protein Kinase 활성체인 Metformin의 모발 성장에 미치는 영향
문혜림 ( Hye-rim Moon ),박기영 ( Ki-young Park ),강현지 ( Hyun Ji Kang ),이우진 ( Woo Jin Lee ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),박경훈 ( Gyeong-hun Park ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.4
Background: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous roles in physiological conditions, and dysregulation of AMPK induces pathological processes and diseases. However, the role of AMPK and its activators have not yet been studied in the context of hair growth regulation. Objective: To investigate the effects of metformin on dermal papilla (DP) and outer root sheath (ORS) cells, as well as the role of the AMPK pathway in hair growth. Methods: We evaluated whether metformin, a well-known AMPK activator, had any beneficial effects on hair growth. In addition, to evaluate the molecular and cellular mechanisms that were involved, protein levels of AMPK and β-catenin were analyzed. Results: Metformin increased the cellular proliferation of human DP and ORS cells. Ki-67 expression was also significantly increased after metformin treatment in the ex vivo hair follicle organ culture. Furthermore, DP and ORS cells treated with metformin had a significant increase in AMPK phosphorylation, which in turn suppressed β-catenin degradation and enhanced its nuclear accumulation. Conclusion: We demonstrated that metformin promoted hair growth via the AMPK/β-catenin signaling pathway in vitro with DP and ORS cells. The hair-promoting effects of AMPK activators may potentially be used for the treatment of alopecia, and further investigation will be needed in the future. (Korean J Dermatol 2019;57(4):175∼ 181)
비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
RYU, Seung-Hee,KANG, Ki Mun,MOON, Soo Young,CHAI, Gyu Young,HONG, Joon Pio,CHO, Kyoung-Oh,KANG, Mun-Il,CHOI, Eun Kyung,LEE, Sang-wook Journal of Radiation Research Editorial Committee 2010 JOURNAL OF RADIATION RESEARCH Vol.51 No.5
<P>Concurrent chemotherapy with radiotherapy (CCRT) has been applied for the treatment of advanced stage of head and neck cancer patients. However CCRT is associated with several complications including mucositis, dermatitis, stomatitis, etc. This study was conducted to evaluate the therapeutic effect of systemically administrated recombinant human epidermal growth factor (rhEGF) in CCRT-induced oral mucositis in a mouse model. Oral mucositis was induced in male BALB/c mice through combination treatment with cisplatin (11 mg/kg, i.p.) and irradiation (17 Gy) of the head and neck area. rhEGF (1.0 mg/kg/day for consecutive 3 days) was administered systemically, and the therapeutic effect was determined by histological evaluation of the oral mucosa. To elucidate optimal dose of rhEGF on CCRT-induced mucositis, various concentrations (0.04–3 mg/kg) of rhEGF were injected for 3 days. Systemic rhEGF administration accelerated the recovery of body weight. Histologically, rhEGF-treated mice showed significantly increased epithelial cell layer thickness, basal cell number, and expression of Ki-67 compared to control mice. Most effective dose was 1 mg/kg among other doses tested. Systemic administration of 1 mg/kg of rhEGF reduces the severity of oral mucositis induced by CCRT in a mouse model, suggesting that rhEGF can be used for treating CCRT-induced mucositis during the cancer treatment.</P>
홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9
This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.