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Keun-Ok Jung,Kun-Young Park 한국식품영양과학회 1999 Preventive Nutrition and Food Science Vol.4 No.4
The anticarcinogenic effects of the methanol extracts from leek (buchu in Korean) kimchi and Korean cabbage kimchi were evaluated using cytotoxicity and transformation tests in C3H/10T1/2 cells. Various fractions of the 6-day fermented leek kimchi at 15℃, hexane, methanol soluble, dichloromethane, ethyl acetate, butanol and aqueous fraction, were also studied in the same system. The inhibitory effect of the leek kimchi (6-day fermented at 15℃, pH 4.29) was higher than that of the Korean cabbage kimchi (4-day fermented at 15℃, pH 4.21) on the cytotoxicity induced by 3-methylcholanthrane (MCA) in the C3H/10T1/2 cell system. While the MCA-treated culture (control) formed 21.0 foci of type Ⅱ plus Ⅲ in C3H/10T1/2 cells, 100㎍/ml of the methanol extract of the leek kimchi and that of the 4-day fermented Korean cabbage kimchi treated cultures reduced the formation of type Ⅱ plus Ⅲ foci to 7.4 and 11.3, respectively. Among the fractions of the leek kimchi, the dichloromethane fraction showed the highest inhibitory effect on MCA-induced cytotoxicity in C3H/10T1/2 cells. Fifty ㎍/ml of dichloromethane fraction from the leek kimchi suppressed the MCA-induced cytotoxicity hy 77%. On the transformation test using MCA, the dichloromethane fraction considerably reduced the formation of type Ⅱ plus Ⅲ foci, especially type Ⅲ foci. When 50㎍/ml of dichloromethane fraction from the leek kimchi was treated, the numbers of type Ⅲ foci mediated by MCA were decreased to 1.7 compared to 10 for the control. These results indicate that leek kimchi has stronger anticarcinogenic effects than Korean cabbage kimchi and that the dichloromethane fraction of the leek kimchi may contain the major compound(s) that suppress the carcinogenesis in the eukaryotic cells.
Effect of Kimchi and Its Ingredients on the Growth of Helicobacter pylori
Keun-Ok Jung,Jeung-Ha Kil,Kwang-Hyuk Kim,Kun-Young Park 한국식품영양과학회 2003 Preventive Nutrition and Food Science Vol.8 No.2
Effects of kimchi and its ingredients, vitamin C and β-sitosterol on the growth of Helicobacter pylori were investigated. Three kimchi variations were studied: a standard recipe (kimchi Ⅰ) and two functional variations for cancer prevention and treatment made with organically grown ingredients (kimch Ⅱ and Ⅲ). Methanol extracts and juices from kimchi Ⅰ and Ⅲ did not inhibit the growth of H. pylori. However, 10 mm and 12 mm inhibition zones were formed by methanol extract and juice from kimchi Ⅱ, which had higher concentrations of red pepper powder (RPP) than those of kimchi Ⅰ and Ⅲ. Among the major kimchi ingredients, methanol extracts of RPP, garlic and ginger substantially inhibited the growth of H. pylori. The maximal inhibition zone (30 mm) was attained with garlic treatment. Inhibitory effects of the RPP, garlic and the sub-ingredient mixture (prepared with radish, garlic, RPP, ginger, green onion, sugar and fermented anchovy juice) on H. pylori were decreased by lactic acid bacteria fermentation. Neither the fermented garlic nor the fermented sub-ingredient mixture inhibited the growth of H. pylori. But, the inhibition zone of fermented RPP was 12 mm, which was less than the 16 mm inhibition zone formed by the non-fermented RPP. Vitamin C and β-sitosterol which are known to be functional active compounds of kimchi also showed no inhibitory effect on the growth of H. pylori after 3 days of incubation. Further study is needed to determine why the inhibitory effect is removed or decreased by lactic acid fermentation, and to determine if fresh kimchi and lactic acid bacteria of kimchi can inhibit the growth of H. pylori.
Anticancer Effects of Leek Kimchi on Human Cancer Cells
Keun-Ok Jung,Kun-Young Park,Lloyd B. Bullerman 한국식품영양과학회 2002 Preventive Nutrition and Food Science Vol.7 No.3
The anticancer effects of leek (buchu in Korean) kimchi were evaluated in the human cancer cells: AGS gastric adenocarcinoma cells, HT-29 human colon adenocarcinoma cells and HL-60 leukemia cells. The leek kimchi (fermented for 6 days at 15℃) was fractionated into 7 groups: methanol extract, hexane extract, methanol soluble extract (MSE), dichloromethane (DCM) fraction (fr.), ethyl acetate fr., butanol fr. and aqueous fr. Most of the leek kimchi fractions inhibited the growth of AGS and HT-29 cancer cells in a dose dependent manner. In particular, the DCM fr. showed the highest inhibitory effect among the fractions. Treatment with the DCM fr. (0.1 mg/mL) reduced the survival rates of AGS and HT-29 cancer cells to 19% and 37% of the controls, respectively. Moreover the DCM fr. of the leek kimchi arrested G2/M phase in the cell cycle and induced apoptosis in HL- 60 human promyelocytic leukemia cells. These results indicate that the leek kimchi exerted an anticancer effect on those human cancer cells, and that the DCM fr. arrested G2/M phase in the cell cycle and induced apoptosis in the leukemia cells.
Jung, Sung-Jin,Lee, Byeong-Hyeon,Kim, Byung Kyu,Lim, Sang-Soon,Kim, Seong Keun,Kim, Dong-Ik,Won, Sung Ok,Park, Hyung-Ho,Kim, Jin-Sang,Baek, Seung-Hyub Elsevier 2018 Acta materialia Vol.150 No.-
<P><B>Abstract</B></P> <P>Precise control of carrier density is essential to synthesize high-performance thermoelectric materials. Doping by impurities is often frustrated in <I>n</I>-type Bi<SUB>2</SUB>Te<SUB>3</SUB> alloys by incomplete activation, bipolar doping, the formation of secondary phases, and prevailing intrinsic point defects such as vacancies. This weakens the reproducibility of synthesis processes and reduces the long-term reliability of material's performance, hence aging. Here, we explore an impurity-free doping technique to synthesize <I>n</I>-type bismuth tellurium selenides, combining a cold deformation and a hot extrusion. The cold deformation enables controlling the electron density in the range of ∼10<SUP>19</SUP>/cm<SUP>3</SUP> via the formation of intrinsic point defects, and the hot extrusion allows texturing the microstructure to enhance the electrical conductivity, hence a large power factor of >5 × 10<SUP>−3</SUP> W-m<SUP>−1</SUP>-K<SUP>−2</SUP>. We confirm that our process is very reproducible, and the properties of the samples are stable without aging even after thermal stresses. Using this method, we can decouple the relationship between bandgap, carrier density, and composition to improve the high-temperature thermoelectric property. Moreover, we demonstrate the fabrication of high-performance thermoelectric materials from low-graded, raw materials by modifying the degree of the mechanical deformation to reach an optimum carrier density. Our work provides a promising approach to synthesizing <I>n</I>-type thermoelectric materials in the reproducible and adaptable way.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Naringenin targets ERK 2 and suppresses UVB ‐induced photoaging
Jung, Sung Keun,Ha, Su Jeong,Jung, Chang Hwa,Kim, Yun Tai,Lee, Hoo‐,Keun,Kim, Myoung Ok,Lee, Mee‐,Hyun,Mottamal, Madhusoodanan,Bode, Ann M.,Lee, Ki Won,Dong, Zigang John Wiley and Sons Inc. 2016 Journal of Cellular and Molecular Medicine Vol.20 No.5
<P><B>Abstract</B></P><P>A number of natural phytochemicals have anti‐photoaging properties that appear to be mediated through the inhibition of matrix metalloproteinase‐1 (MMP‐1) expression, but their direct target molecule(s) and mechanism(s) remain unclear. We investigated the effect of naringenin, a major flavonoid found in citrus, on UVB‐induced MMP‐1 expression and identified its direct target. The HaCaT human skin keratinocyte cell line and 3‐dimensional (3‐D) human skin equivalent cultures were treated or not treated with naringenin for 1 hr before exposure to UVB. The mechanism and target(s) of naringenin were analysed by kinase assay and multiplex molecular assays. Dorsal skins of hairless mice were exposed to UVB 3 times per week, with a dose of irradiation that was increased weekly by 1 minimal erythema dose (MED; 45 mJ/cm<SUP>2</SUP>) to 4 MED over 15 weeks. Wrinkle formation, water loss and water content were then assessed. Naringenin suppressed UVB‐induced MMP‐1 expression and AP‐1 activity, and strongly suppressed UVB‐induced phosphorylation of Fos‐related antigen (FRA)‐1 at Ser265. Importantly, UVB irradiation‐induced FRA1 protein stability was reduced by treatment with naringenin, as well as with a mitogen‐activated protein kinase (MEK) inhibitor. Naringenin significantly suppressed UVB‐induced extracellular signal‐regulated kinase 2 (ERK2) activity and subsequently attenuated UVB‐induced phosphorylation of p90<SUP>RSK</SUP> by competitively binding with ATP. Constitutively active MEK (CA‐MEK) increased FRA1 phosphorylation and expression and also induced MMP‐1 expression, whereas dominant‐negative ERK2 (DN‐ERK2) had opposite effects. U0126, a MEK inhibitor, also decreased FRA1 phosphorylation and expression as well as MMP‐1 expression. The photoaging data obtained from mice clearly demonstrated that naringenin significantly inhibited UVB‐induced wrinkle formation, trans‐epidermal water loss and MMP‐13 expression. Naringenin exerts potent anti‐photoaging effects by suppressing ERK2 activity and decreasing FRA1 stability, followed by down‐regulation of AP‐1 transactivation and MMP‐1 expression.</P>