실혈성쇼크의 회복에 미치는 고장성욕액의 영향

南基鏞,廉哲鎬 朝鮮大學校 附設 醫學硏究所 1984 The Medical Journal of Chosun University Vol.9 No.1

This study was to investigate the effects of hypertonic saline solution on the recovery of hemorrhagic shock in rabbits, Infusions of hyperosmotic NaCl (2,400 mOsm/L) solution were given to the anesthetized rabbits in severe hemorrhagic hypotension by intravenous injection. Arterial pressure, heart rate, plasma osmolarity, plasma electrolyte, hematocrit and plasma volume were measured in rabbits during experiments. The results obtained were as follows : 1) Increase of arterial pressure and diminution of heart rate were observed after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion. 2) Plasma osmolarity and plasma sodium concentration increased slightly after infusions of hypertonic saline solution in hemorrhagic shock as compared with physiological saline solution infusion, and hematocrit diminished slightly in both groups. 3) Increase of plasma volume was observed after infusions of hypertonic saline solution in hemorrhagic shock. 4) Infusions of hypertonic NaCl showed almost no influence on hemodynamic factors in nonhemorrhagic state. 5) The effects of hypertonic NaCl infusions on hemorrhagic shock in rabbits were transient.

자동화학분석기 Hitachi 736-20과 Parallel^(�)의 비교 검토

김순기,김용남,박용성,이기문 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

비강 및 부비동에 발생한 반전성 유두종의 임상-병리조직학적 고찰

노용훈,이승학,전세영,김용기,나한조,최봉남,서재홍 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

정신분열병 환자 가족의 연성 신경학적 특성

김은남,장기용,강병조 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.1

연구목적 본 연구는 정선분열형 환자가족들의 연성 신경학적 징후를 살펴봄으로써 연성 신경학적 징후가 체질 표지(trait marker)로서의 의미가 있는지를 알아보기 위한 것이다. 연구방법 정신분열병 환자 가족군은 정신분열병 환자의 1차 인척 중 정신병에 이환되지 않은 자를 대상으로 하였다. 연성 신경학적 검사는 Buchanan과 Heinrich의 신경학적 평가척도의 한국어판을 이용하여, 가족군 20명과 정상대조군 20명에게 시행하였다. 연구결과 1) 연성 신경학적 평가척도의 총점은 정신분열병 환자 가족군이 13.55±6.12, 정상대조군은 3.55±2.46으로 두 군 간에 유의한 차이를 나타내었다(P<0.0001). 각 하위영역인 김각통합 영역, 운동조정 영역, 복합운동활동순서화 영역, 기타 영역에서 가족군이 정상대조군보다 유의하게 높은 점수를 나타내었다(P<0.05). 2) 정신분열병 환자 부모군과 형제군은 신경학적 평가척도의 총점에서 유의한 차이가 없었다. 하위영역에서는 감각통합 영역에서 두 군간에 유의한 차이를 나타내었다(P<0.05). Objective : This study was performed to assess Neurological soft sign(NSS) in schizophrenic's relatives and to know the relationship between NSS and trait marker. Method : The study sample of relatives consisted of 20 nonpsychotic subjects, each of whom was a biological parent or sibling of a proband meeting DSM-Ⅳ criteria for schizophrenia. The authors evaluated NSS using the structured tool for measuring neurological abnormalities, Neurological Evaluation Scale-Korean Version(NSE-K). A comparison of NSS score was made between 20 relatives and 20 normal controls. Results : 1) The schizophrenic's nonpsychotic relatives were significantly more impaired than normal controls on total scores(P<0.0001) and on scores of sensory integration, motor coordination, sequencing of complex motor acts and other areas(P<0.05). 2) There were statistically no difference in NSS total scores between schizophrenic's nonpsychotic parents and siblings. Schizophrenic's nonpsychotic parents were significantly more impaired than siblings on scores of sensory integration(P<0.05). Conculsions : These findings suggest that abnormal NSS may be one of possible trait markers in schizophrenia.

당뇨병 유발쥐혈청내 methylated amino acid의 함량 변화

김용기,유세근,남석우,이향우 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1

In order to investigate the relationship between methylated amino acids and diabetes, we investigated the changes of serum concentration of methylated amino acids in serum of the experimentally induced diabetic rats. The diabetic symptom was induced by injectly alloxan 100 mg/kg intraperitoneally. The serum content of N^G-monomethylarginine(MMA), N^G, N^G-dimethyl-arginine(DMA) and N^G, N^G-dimethylarginine(D'MA) were analyzed by HPLC. The results are as followings ① There was no change in serum content of MMA in the diabetic group. ② But it was observed that the amounts of DMA and D'MA were increased remarkably in the diabetic group. Specifically, D'MA content was increased about 7 times in comparision to that of the control group. ③ However, the concentration of trimethyllysine in RBC was decreased slightly in diabetic group but not significant statistically.

익수환아의 예후에 영향을 미치는 인자에 관한 연구

김용배,정대봉,조수형,조남수,박영봉,박상기,김춘호,양은석,문경래 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Drowning is the second most common cause of accidental death of children in Korea. But the study of near-drowning is very rare in Korea. The purpose of our study is to determine the factors that may influence survival on the basis of submersion time, consciousness state upon admission to hospital, the kinds of water, laboratory findings and neurological outcomes. The survey was performed by a retrospective cohort study on 28 near-drowning victims of less than 15 years of age who were admitted to the emergency room in the Chosun University Hospital between May 1988 & May 1997. The results were as follows :1)Sex distribution was 22 males and 6 females. 2) Submersion time was <5 minutes in 9 cases, 5-9 minutes in 6 cases, 10-14 minutes in 5cases, 15-19 minutes in 3 cases, ≥20 minutes in 5cases. 3) Comatose patients upon arrival were 6/7 cases in the death group(86%) and 2/21 cases in the improved group(10%). They had unfavorable outcomes(P<0.05). 4) The first PH value was mean 7.02±0.12 in the death group and mean 7.31±0.13 in the improved group. There was a statistically significant difference between the death and the improved group(P<0.05) 5) The patients who gad increased blood glucose concentration were all 7 cases in the death group and 12/22 cases in the improved group(54%). The mean blood glucose concentration was mean 424.7235.6㎎/㎗ in the death group and mean 140.182.7㎎/㎗ in the improved group. There was a statistically significant difference between the death and the improved group(P<0.05). 6) The patients who had pulmonary edema upon arrival were all 7 cases in the death group and 1/21 cases in the improved group(46%). They had unfavorable outcomes(P<0.05). 7) The patients who had been submerged more than 15 minutes were all 7 cases in the death group and 6/21 cases in the improved group(5%). They had unfavorable outcomes(P<0.05). We conclude that pediatric victims of near-drowning can be assigned to high or low likelihoods of unfavorable our outcomes with the use of five variables ; comatose mentation upon arrival decreased initial blood pH, increased initial blood glucose concentration, pulmonary edema, and maximum submersion time estimated longer than fiften minutes. This prediction rule may be useful if it can be validated in another cohort.

이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향

정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.

정신분열병 환자의 가족력 유무와 연성 신경학적 특성

김은남,장기용,강병조 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

본 연구는 정신분열병 환자들의 연성 신경학적 증상을 알아보고 또한 가족력 유무에 따른 연성 신경학적 증상의 차이를 살펴보기 위한 것이다. 1995년 7월부터 동년 10월까지 국립부곡정신병원에 입원치료중이며 DSM-IV 진단 기준에 의해 정신분열병으로 진단된 환자를 대상으로 하였다. 이중 병록지와 환자 가족의 정보를 근거로 하여 1차 인척 중에서 정신분열병의 기왕력이 있는 환자들을 가족력이 있는 환자군으로 분류하였다. Buchanan과 Heinrich의 신경학적 평가척도의 한국어판을 이용하여 가족력이있는 정신분열병 환자군20명, 가족력이 없는 정신분열병 환자군 20명 그리고 정상대조군 20명 사이의 연성 신경학적 이상소견을 비교하였다. 이 연구의 결과는 다음과 같다. 1) 연성 신경학적 평가척도의 총점은 정신분열병 환자군은 23.93±6.66, 정상대조군은 3.55±2.46으로 두 군간에 유의한 차이를 나타내었다(P<0.0001). 정신분열병 환자군은 감각통합 영역, 운동조정 영역, 복합활동순서화 영역, 그리고 기타 영역에서 정상대조군 보다 유의하게 높은 점수를 나타내었다(P<0.0001) 2) 연성 신경학적 이상 소견은 정신분열병 환자의 가족력의 유무와 유의한 상관관계는 없었다. 가족력이 있는 환자들이 신경학적 평가척도의 모든 영역에서 가족력이 없는 환자들보다 평균 점수가 높게 나타났으나 통계적으로 유의한 차이는 없었다. 이상의 결과에서 정상대조군보다 정신분열병 환자군에서 연성 신경학적 이상소견이 많이 나타났다. 이는 생물학적 표지로서의 연성 신경학적 증상의 중요성을 보여준다고 할 수 있다. 그러나 가족력 유무에 따른 연성 신경학적 이상 소견에 유의한 차이가 없었으므로 이 생물학적 표지가 trait marker인지 state marker인지는 좀더 연구를 해 보아야 할 것 같다. This study was performed to assess neurologic soft sign(NSS) in schizophrenics and to know the relationship between NSS and family history of schizophrenia. All Patients were hospitalized in Bugok National hospital during the period from July, 1995 to October, 1995 and diagnosed as schizophrenia based on DSM-IV criteria. Schizophrenics were classified as familial schizophrenics if at least one first-degree relative had a clear history of schizophrenia, based on review of any medical records and reports of family informants. The authors evaluated NSS using the structured tool for measuring neurological abnormalities, Neurological Evaluation Scale-Korean Version(NSE-K). A comparison of NSS score was made among three groups subjects consisting of 20 familial schizophrenics, 20 non-familial schizophrenics and 20 normal controls. The results were as follows : 1) the schizophrenics were significantly more impaired than normal controls on total scores of sensory integration, motor coordination, sequencing of complex motor acts and other areas(P<0.0001). 2) NSS scores were not correlated with family history of schizophrenia. Mean item scores of familial schizophrenics were higher than non-familial schizophrenics but there were statistically no differences between two groups. these findings suggest that abnormal NSS may be one of possible biological markers of schizophrenics. But there were statistically no differences in NSS scores between familial schizophrenics and non-familial schizophrenics. therefore, A further study is needed to investigate whether NSS is a trait marker of schizophrenics.

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

통풍 환자에서 Allopurinol 약제의 과민증후군 : 1례 보고 A Case Report

이승구,하기용,이남기,김성태 최신의학사 1994 最新醫學 Vol.37 No.9