http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김지연,김동재,Kim, Jiyeon,Kim, Dongjae 한국데이터정보과학회 2013 한국데이터정보과학회지 Vol.24 No.6
임상시험에서 적당한 크기의 표본 수 결정은 통계적으로 유의한 연구결과의 도출과 연구수행의 효율적인 비용을 산출하기 위해서 중요한 사항 중의 하나이다. 기존의 비열등성 시험에서 표본 수 계산방법에는 t 검정법을 이용한 모수적 방법이 있고, Wilcoxon 순위합 검정을 이용하여 Wang 등 (2003)이 제안한 표본 수 계산방법을 Kim과 Kim (2007)이 비열등성 시험에 확장시켜 적용하여 제시한 비모수적 방법이 있다. 본 논문에서는 Orban과 Wolfe (1982)가 제안한 선형위치통계량의 검정법에 Kim (1994)이 계산한 검정력의 결과를 이용한 표본 수 계산 방법을 제안하고, 그에 따른 표본 수 계산결과를 기존에 제시된 표본 수 계산 결과와 비교하였다. 그 결과 기존의 방법들보다 본 논문에서 제안하는 방법으로 계산한 경우의 표본 수가 가장 작게 나왔다. 따라서 모집단에 대해서 구체적인 분포함수를 가정하기 힘든 경우 모수적 방법을 이용하게 되면 검정력이 떨어지거나 유의수준을 제어하지 못하는 문제점을 보완하고, 모수적 방법에 비해 표본 수가 크게 나와 시간이나 비용 면에서 효율적이지 않았던 Wilcoxon 순위합 검정을 이용한 방법의 단점을 보완할 수 있는 방법으로 본 논문에서 제시한 위치 (placement)를 이용한 표본 수 계산이 이용될 수 있다. In clinical research, sample size determination is one of the most important things. There are parametric method using t-test and non-parametric method suggested by Kim and Kim (2007) based on Wilcoxon's rank sum test for determining sample size in non-inferiority trials. In this paper, we propose sample size calculation method based on placements method suggested by Orban and Wolfe (1982) and using the power calculated by Kim (1994) in non-inferiority trials. We also compare proposed sample size with that using Kim and Kim (2007)'s formula and that of t-test for parametric methods. As the result, sample size calculated by proposed method based on placements is the smallest. Therefore, proposed method based on placements is better than parametric methods in case that it's hard to assume specific distribution function for population and also more efficient in terms of time and cost than method based on Wilcoxon's rank sum test.
Comparative Analysis of Human Epidermal and Peripheral Blood γδ T Cell Cytokine Profiles
( Kwangmi Kim1 ),( Jiyeon Han ),( Tae Ryong Lee ),( Dong Wook Shin ),( Hak Chang ),( A Ri Cho ),( Soon Jin Choi ),( Seong Jin Jo ),( Ohsang Kwon ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.3
Background: Human epidermal γδ T cells are known to play crucial roles in the defense and homeostasis of the skin. However, their precise mechanism of action in skin inflammation remains less clear. Objective: In this study, we analyzed the cytokine expression profile of human epidermal γδ T cells and compared it to that of peripheral blood γδ T cells to investigate the specific activity of epidermal γδ T cells in modulating skin inflammation. Methods: We isolated γδ T cells from epidermal tissue or peripheral blood obtained from healthy volunteers. Isolated γδ T cells were stimulated using immobilized anti-CD3 antibody and interleukin-2 plus phytohaemagglutinin, and were then analyzed using a cytokine array kit. Results: Both epidermal and peripheral blood γδ T cells produced comparable levels of granulocyte-macrophage colony-stimulating factor, I-309, interferon-γ, macrophage migration inhibitory factor, macrophage inflammatory protein-1α, and chemokine (C-C) ligand 5. The epidermal γδ T cells produced significantly higher levels of interleukin-4, -8, -13, and macrophage inflammatory protein-1β than the peripheral blood γδ T cells did. Notably, the epidermal γδ T cells produced several hundred-fold higher levels of interleukin- 13 than interleukin-4. Conclusion: These results suggest that the epidermal γδ T cells have a stronger potential to participate in the Th2-type response than the peripheral blood γδ T cells do. Furthermore, epidermal γδ T cells might play an important role in the pathogenesis of Th2-dominant skin diseases because of their active production of interleukin-13. (Ann Dermatol 26(3) 308∼313, 2014)
A library of TAL effector nucleases spanning the human genome
Kim, Yongsub,Kweon, Jiyeon,Kim, Annie,Chon, Jae Kyung,Yoo, Ji Yeon,Kim, Hye Joo,Kim, Sojung,Lee, Choongil,Jeong, Euihwan,Chung, Eugene,Kim, Doyoung,Lee, Mi Seon,Go, Eun Mi,Song, Hye Jung,Kim, Hwangbeo Nature Publishing Group, a division of Macmillan P 2013 Nature biotechnology Vol.31 No.3
Transcription activator–like (TAL) effector nucleases (TALENs) can be readily engineered to bind specific genomic loci, enabling the introduction of precise genetic modifications such as gene knockouts and additions. Here we present a genome-scale collection of TALENs for efficient and scalable gene targeting in human cells. We chose target sites that did not have highly similar sequences elsewhere in the genome to avoid off-target mutations and assembled TALEN plasmids for 18,740 protein-coding genes using a high-throughput Golden-Gate cloning system. A pilot test involving 124 genes showed that all TALENs were active and disrupted their target genes at high frequencies, although two of these TALENs became active only after their target sites were partially demethylated using an inhibitor of DNA methyltransferase. We used our TALEN library to generate single- and double-gene-knockout cells in which NF-κB signaling pathways were disrupted. Compared with cells treated with short interfering RNAs, these cells showed unambiguous suppression of signal transduction.
Insoo Kim,Kikyoung Yi,이주희,Kyumin Kim,Soyoung Youn,서수연,Jiyeon Kim,Jung mun choi,정석훈 대한수면학회 2019 sleep medicine research Vol.10 No.2
Sleep Med Res > Volume 10(2); 2019 > Article Original Article Sleep Medicine Research (SMR) 2019; 10(2): 83-89. Published online: Dec 31, 2019 DOI: https://doi.org/10.17241/smr.2019.00451 Dysfunctional Beliefs about Sleep in Cancer Patients Can Mediate the Effect of Fear of Progression on Insomnia Insoo Kim, MD1, Kikyoung Yi, MD2, Joohee Lee, MD1, Kyumin Kim, MD1, Soyoung Youn, MD1, Sooyeon Suh, PhD3, Jiyeon Kim, PhD4, Jung Mun Choi, BA1, Seockhoon Chung, MD, PhD1 1Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 2Department of Psychiatry, Yongin Mental Health, Yongin, Korea 3Department of Psychology, Sungshin Women’s University, Seoul, Korea 4Department of Art Therapy, Hanyang Cyber University, Seoul, Korea Correspondence: Seockhoon Chung, MD, PhD, Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, 86 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea, Tel +82-2-3010-3411, Fax +82-2-485-8381, E-mail schung@amc.seoul.kr Received Oct 21, 2019 Revised Nov 1, 2019 Accepted Nov 5, 2019 Copyright© 2019 The Korean Society of Sleep Medicine Abstract Background and Objective The role of the dysfunctional belief about sleep is important for the development of insomnia among cancer patients. This study intended to investigate whether dysfunctional belief about sleep mediates the relationship between fear of progression and insomnia in cancer patients. Methods Three hundred and thirty-seven cancer patients participated in our study. Dysfunctional belief about sleep, severity of insomnia, depression, fear of progression, and anxiety were measured using the following questionnaires: Cancer-related Dysfunctional Beliefs about Sleep (C-DBS); Insomnia Severity Index (ISI); Patient Health Questionnaire-9 (PHQ-9); Fear of Progression (FoP); and the state subcategory of State and Trait Anxiety Inventory (STAI). Path analysis was used to clarify the relationships among the variables. Since C-DBS consists of two items, i.e., Q1-immune & Q2-recurrence, we implemented an additional path analysis including these variables separately. Results C-DBS mediated the effect of FoP (β = 0.36, p < 0.001) and patient sex (β = 0.13, p = 0.009) on ISI. PHQ-9 (β = 0.32, p < 0.001) and STAI (β = -0.09, p = 0.071) had a direct influence on ISI scores. In our second path analysis, Q1-immune item mediated the effect of FoP (β = 0.19, p < 0.001) on ISI, and Q2-recurrence item mediated the effect of FoP (β = 0.23, p < 0.001) and patient sex (β = 0.09, p = 0.019) on ISI. Conclusions Our path analysis model indicated that C-DBS mediates the effect of FoP and patient sex on ISI. Our second path analysis results suggested that there could be an internal process of Q1 and Q2 item. Efforts to reduce dysfunctional beliefs should be considered as well as management of fear of progression for better sleep of cancer patients.
Indications of strong neutral impurity scattering in Ba(Sn,Sb)O3single crystals
Kim, Hyung Joon,Kim, Jiyeon,Kim, Tai Hoon,Lee, Woong-Jhae,Jeon, Byung-Gu,Park, Ju-Young,Choi, Woo Seok,Jeong, Da Woon,Lee, Suk Ho,Yu, Jaejun,Noh, Tae Won,Kim, Kee Hoon American Physical Society 2013 Physical review. B, Condensed matter and materials Vol.88 No.12