발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

자기회귀 모델을 이용한 팔운동 근전신호의 기능분리

南文鉉,金正鉉,金洛敎 建國大學校 附設 産業技術硏究所 1992 논문집 Vol.17 No.-

본 연구에서는 AR 모델을 이용한 인간의 팔운동 근전신호의 기능분리에 관한 방법을 제시하였다. 4가지 기능의 팔운동 시에 근전신호의 특성을 잘 나타낼수 있는 매개변수를 공분산범과 연속적 최소제곱 알고리즘을 이용하여 각 기능에 대한 모델의 매개변수와 적정차수를 결정하였다. 또한 팔 기능을 분류하기 위한 신뢰구간은 총합제곱오차의 평균과 표준차로 결정하였다. AR 모델의 오차를 이용하여 각 운동에 대한 기능분리를 실행한 결과 차수가 4차일 때 가장 높은 인식률을 얻을 수 있었으며, 차수가 증가할수록 인식률은 감소하였다. 따라서 본 연구의 결과는 의용생체공학이나 재활공학에 응용할 수 있으리라 기대한다. In this thesis, general method using autoregressive model in the functional separation of the myoelectric signal of human arm movements are suggested. Covariance method and sequential least squares algorithm were used to determine the model parameters and the order of signal model to describe four arm movement patterns; the forearm flexion and extension, the wrist pronation and supination. The confidence interval to classify the functions of arm movement was defined by the mean and standard deviation of total squares error. With the error signals of autoregressive(AR) model, the result showed that the highest success tate was obtained in the case of 4th order, and success rate was decreased with increase of order. This technique might be applied to biomedical-and rehabilitation-engineering.

페루프 극점의 견실성 해석

남부희,이정문 江原大學校 産業技術硏究所 1991 産業技術硏究 Vol.11 No.-

This paper deals with the robustness of closed-loop poles of a linear time-invariant system with uncertain parameters. A new method is presented to calculate the perturbation of a pole -located region due to parameter uncertainties. A method to calculate allowable bounds on parameter uncertainties is also presented to retain closed-loop poles in a specified region. Based on Lyapunov equations and norm operations, they provide useful measures on the robustness of closed -loop poles. An example is given to illustrate proposed methods.

箱子桁의 壓縮플랜지 挫屈에 대한 模型實驗解析

鄭熺孝,南文熙 慶尙大學校 1986 論文集 Vol.25 No.2

As box girder is the structure constituted by thin plates, security of the structure is greatly influenced by the collapse on compressional flange. The collapses of flange bring about stress concentration at upper sides of web, morever, if in case of the imperfect plate they were increased, tensile stress would occur at the middle point of upper flange and develop collapse failure at upper sides of web and projections of upper flange. The ratio a/b(both side-lengths of plate) of the collapse is decided by the distance of diaphragm, when load is increased up critical load the ratio a/b approaches 0.70. Designing the box girder, engineers must take into the influences of side stress that imperfects of flange and eccentric load arouse.

화상처리를 이용한 물체의 운동 파라미터 추정

정남채,문용선,박종안 조선대학교 생산기술연구소 1996 生産技術硏究 Vol.18 No.2

In case a robot works in space of gravity-free state, it is difficult to estimate object motion parameters because of control problem of itself and moving objects. The nature and parameters of short term motion can be estimated continuously with the goal of understanding motion through the image processing. This paper proposes a method which solves correspondence of feature points when we estimate object motion parameter from image information of freely moving objects in space of gravity-free state. Replacing the inertial coordinate system with the camera coordinate system which is equipped within a space robot, computer simulation results are investigated to be able to analyze a problem of correspond points from image information, and to obtain sequence of angular velocity ω which determine a motion of object.

플라비아닌산을 이용한 클로르프마진의 용매추출 분광광도법

정문모,남수자,이미나,이지연,허문회,안문규 慶星大學校 1998 論文集 Vol.19 No.2

철근콘크리트 T형교의 내하력 증진

남문희,정희효,이관희,박준용 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

Even though there are a lot of methods of promotion of load resistance for reinforced concrete T-beam bridge, the methods have been faults respectively. In this study, we will convert simple supported T-beam into continuous T-beam for promotion of load resistance and cancel joint. This method is decidedly superior to another method in maintenance, construction, economics and external appearance.

경사 슬래브교의 지간/폭, 경사각에 따른 응력 상관성

남문희,정희효,이관희,이수경 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

Skewed slab bridge have designed a width beam, stress of skewed slab bridge is quite different in according with skew and width /length. Especially in case that we analyse skewed slab bridge as a width beam, stress of right angle direction against axis of bridge is not analysed. In this study we will present the stress of transverse axis to longitudinal axis of bridge according to skew and width/length.

초등학생의 음주예방교육 요구

문정순,송경애,박선남,김한숙 대한간호학회 아동간호학회 2003 Child Health Nursing Research Vol.9 No.2

Pisolithus tinctorius菌에 의해 형성된 소나무류 外生菌根의 形態的 比較

文美蘭,吳光仁,鄭南澈 全南大學校 農業科學技術硏究所 1999 農業科學技術硏究 Vol.34 No.-

Pisolithus tinctorius菌을 곰솔(Pinus thunbergii), 소나무(P. densifora), 리기다소나무(P. rigida), 테에다소나무(P. taeda), 리기테다소나무(P. rigitaeda), 버지니아소나무(P. virginiana)에 人工接種하여 수종간 균근의 發達, 菌根型의 特異性, 外部形態的 特徵을 調査하였다. P. tinctorius菌이 接種된 소나무류의 菌根型은 線型(linear type), 頂端型(apical type), 棍棒型(clavate type), 塊根型(nodular type), 二次分枝型(dichotomy type), 念珠型(bead type), 長二次分枝型(long dichotomy type), 不均衡 二次分枝型(unbalanced dichotomy type), 二重二次分枝型(double dichotomy type), 不均衡二重二次分枝型(unbalanced double dichotomy type), 不均衡半二重二次分枝型(unbalanced semi-double dichotomy type), 珊瑚型(coralloid type)으로 識別되었다. 곰솔, 리기테다소나무의 均套표면은 노란색 Felt 형의 뚜렷한 菌套를 형성하였다. 그러나 리기다소나무, 소나무, 테다소나무, 버지니아소나무의 菌套表面은 부착 菌絲의 형성이 전혀 없는 매끄럽고 윤기있어 보이는 황갈색 velvety형 均套를 나타냈다. 소나무, 리기다소나무, 테다소나무, 버지니아소나무는 線型, 頂端型, 二次分枝型, 念珠型, 長二次分枝型들과 같은 단순한 형태들이 주로 나타났지만, 곰솔과 리기테다소나무는 二次分枝型, 變形들인 長二次分枝型, 不均衡二次分枝型, 二重二次分枝型, 不均衡二重二次分枝型, 不均衡半二重二次分枝型들이 많이 나타났고 안정형인 珊瑚型으로 發達하였다. The morphological characteristics of ectomycorrhizae in the seedlings of 6 different pines(Pinus. thunbergii, P. densiflora, P. rigida, P. teada, P. rigiteada and P. virginiana), inoculated with ectomycorrhizal fungi, Pisolithus tinctorius(Pers.) Coker & Couch, were analyzed. The types of ectomycorrhizal short roots among 6 pines could be categorized into 12 types; linear, apical, clavate, nodular, dichotomy, bead, long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, unbalanced semi-double dichotomy, and coralloid types. Whereas the sheaths of seedlings of P. thunbergii and P. rigiteada were covered with a mycellium bed of light yellowish white, those of the other pines were covered with the smooth and blight bed of yellowish brown without attached mycellium. The five major types(i.e, linear, apical, dichotomy, bead, and long dichotomy types) of the 12 types classified in this study were for P.densiflora, P.rigida,P.teada,and P.virginiana,respectively. However, P. thunbergii, and P. rigiteada of long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, and unbalanced semi-double dichotomy types were the major types, which were developed into a stable type such as coralloid type.