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강정훈,이은태,이도훈 경희대학교 산학협력기술연구원 2000 산학협력기술연구논문집 Vol.6 No.-
The most common cause of bridge failure stems from floods. The scouring of bridge foundation is the most common cause of flood damsge to bridges. The need to minimize future flood damage to the nation's bridges requires that additional attention be devoted to developing and implementing improved procedures for designing and inspecting bridges for scour. Statistically, we can expect thousands of bridges to experience floods on the order of magnitude of 100-year flood or greater each year. Because it is not economically feasible to construct all bridges to resist all conceivable floods or to install scour countermeasures at all existing bridges to ensure absolute invulnerability from scour damage, some risks of failure may have to be accepted from future floods. However, every bridge over a stream, whether existing or under design, should be assessed as to its vulnerability to floods in order to determine the prudent measure to be taken. The added cost of making a bridge less vulnerable to scour is small when compared to the total cost of a failure which can easily be two or three times the cost of the bridge itself. Moreover, the need to ensure public safety and to minimize the adverse effects resulting from bridge closures requires our best efforts to improve the state-of-practice for designing and maintaining bridge foundation to resist the efforts of scour.
강한솔,정수현,황은진,이정주,노승용 서울여자대학교 여성연구소 2011 여성연구논총 Vol.26 No.-
People are getting more interested in their “quality of life” as they achieved certain level of economic development. Governments pay great attention on well-being and happiness of people as well and try to find the best way to improve citizens' quality of life. However, South Korea is still on 27th out of 39 OECD and G20 countries in quality of life index, which means that there are great needs to improve Koreans' quality of life. Moreover, it is expected that Korean women's quality of life might be worse than this in its patriarchal environments. In fact, there are few research regarding Korean women's quality of life and it is unknown what personal and social factors affect Korean women's quality of life and how we can improve it. This research attempts to find out factors related to Korean women's quality of life through the surveys of 536 Korean women. The results show that quality of life is most influenced by factors such as self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. In addition, happiness of Korean womem is greatly affected by various factors such as mental health, interpersonal relationship, self-respect, self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. Among various factors related to quality of life and happiness of Korean women, scores of self-respect, self-fulfillment, and interpersonal relationship are high, while scores regarding income are relatively low. Key words:Quality of Life, Happiness, Maslow
고속액체크로마토그래피에 의한 나프록센 광학이성질체의 분리 및 품질관리
정수진,진전성,이은주,이은실,강종성 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
Enantiomeric separation of naproxen is necessary in drug evaluation processes as the pharmacological activity of naproxen resides mainly in the (S)-enantiomer, The enantioseparation of naproxen was carried out with three different stationary phases. The methods were validated with the terms of linearity, intraday and interday precision, accuracy, selectivity and recovery. Among the selected stationary phases, ChiroSil DMB column with hexane : t-butylmethylether : acetic acid (60:40:0.1, v/v/v) as mobile phase showed the best enantioseparation of the naproxen in the commercial preparations. The wavelength for detection was 270 nm and flow rate was 2.0 mL/min. The contents of (S)-naproxen in the commercial preparations were 92.7 - 98.3%, indicating that all tested preparations were satisfactory to current regulation. However, the contents of (R)-naproxen as impurity in the commercial preparations were varied from 0.08% to 1.08%.
Benzo(a)pyrene에 의한 돌연변이원성과 지질과산화에 미치는 d-Limonene과 Cineole의 억제 효과에 대한 비교연구
강은미,박성배,김상건,정기화 德成女子大學校 藥學硏究所 1993 藥學論文誌 Vol.4 No.1
It has been reported that d-limonene inhibits chemical-induced rat mammary cancer by the mechanism of increases in detoxification enzymes such as glutathione S-transferases and that cineole fails to exhibit significant suppressive effect on chemical-induced carcinogenesis. The present study was designed to compare the effects of d-limonene and cineole on the benzo(a)pyrene (BP)-induced mutagenicity, BP metabolism and lipid peroxidation. Modified Ames assay was employed to evaluate the inhibitory effect of d-limonene and cineole on the BP-induced mutagenicity. The number of revertant-bearing wells was decreased by 44∼77% in the presence of both BP and d-limonene compared with that of BP alone whereas cineole decreased the number of revertant-bearing wells by 28∼45% at the concentrations between 2㎛ and 2mM. d-Limonene suppressed BP metabolism by 16, 54 and 67% at 1, 10 and 100 mM, respectively while cineole inhibited the metabolism by 16, 26 and 55% at the same concentrations. The EC_50 values for d-limonene and cineole in inhibiting lipid peroxidation were 2.0 mM and 16 mM respectively, as assayed by thiobarbituric acid method. The present study showed that d-limonene and cineole have common antimutagenic effects although d-limonene appeared to be more effective than cineole in suppressing mutation and lipid peroxidation. The results suggest that the antimutagenic effects of d-limonene and cineole may be associated with alternation in enzyme activities and with inhibition of lipid peroxidation.
청소년 문화축제참여가 자아정체성과 사회공존지수에 미치는 영향
정명수,송은미,이강욱,정진영 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-
This study aims to examine the influence of the participation in the festivals on the development of the self identity and the influence of the emotional outlooks based on the participation in the festivals and the emotional outlooks produced by the interaction with others on the development of the self identity with the young people who participated in the 2004 Yeosu International Youth Festival as the subjects. Putting these findings together, it is shown that the participation of the adolescents in cultural festivals has a positive influence on the development of their self-identity, and, in particular, it is also shown that the emotional outlooks produced by the participation in cultural festivals and the emotional outlooks obtained through the interaction with others have a positive influence on the self-identity of the adolescents. Accordingly, it is necessary to study those programs producing no oppositions and the methods of participation for the development of the self-identity of the adolescents, and it is also necessary to develop natural programs and incentives to smooth the complex and diverse interactions among the participants.
뚜렷한 입체 선택성을 갖는 알릴 디올의 고리 카보네이트와 아세토니드의 Wacker 산화 반응 연구
강석구,정경윤,정재욱,남궁은영,김태현 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1
Palldium(Ⅱ) 촉매 하에서의 말단 알릴 디올의 고리 카보네이트와 아세토니드의 산화반응은 anti-Markovnikov hydation에 의해 알데히드 또는 α,β-불포화 알데히드 만이 생성되었다. 치환된 알릴 디올의 분자내 이중 결합의 반응으로는 (E)-알릴 디올의 경우에 β-케토 생성물을, 반면에 (Z)-알릴디올의 경우엔 α-케토 생성물을 얻을 수 있었다. 치환된 알릴 디올의 고리 카보네이트와 아세토니드에서는 각각 β-케토 화합물과 α,β-케토 화합물 들이 생성되었다. Palladium(Ⅱ)-Catalyzed oxidation of acetonides or cyclic carbonates of terminal allylic diols afforded aldehydes or α,β-unsaturated aldehydes as the sole products, resulting of anti-Markovnikov hydation. For the internal olefins of the substituted allylic diols, (E)-allylic diol provied β-keto-product, whereas (Z)-allylic diol affored α-keto-product. The acetonides and cyclic carbonates of the substituted allylic diols yielded β-keto-products and α,β-unsaturated ketones, respectively.