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( Yewon Kang ),( Eun-jung Jo ),( Jung Seop Eom ),( Mi-hyun Kim ),( Kwangha Lee ),( Ki Uk Kim ),( Hye-kyung Park ),( Min Ki Lee ),( Jeongha Mok ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.1
Background: This study compared the treatment outcomes of patients with multidrug-resistant tuberculosis (MDRTB) before and after the implementation of public-private mix (PPM). Factors affecting treatment success were also investigated. Methods: Data from culture-confirmed pulmonary MDR-TB patients who commenced MDR-TB treatment at Pusan National University Hospital between January 2003 and December 2017 were retrospectively reviewed. Patients were divided into two groups in terms of PPM status: pre-PPM period, patients who commenced MDR-TB treatment between 2003 and 2010; and post-PPM period, patients treated between 2011 and 2017. Results: A total of 176 patients were included (64 and 112 in the pre- and post-PPM periods, respectively). 36.9% of the patients were resistant to a fluoroquinolone or a second-line injectable drug, or both. The overall treatment success rate was 72.7%. The success rate of post-PPM patients was higher than that of pre-PPM patients (79.5% vs. 60.9%, p=0.008). Also, loss to follow-up was lower in the post-PPM period (5.4% vs. 15.6%, p=0.023). In multivariate regression analysis, age ≥65 years, body mass index ≤18.5 kg/m<sup>2</sup>, previous TB treatment, bilateral lung involvement, and extensively drug-resistant (XDR)- or pre-XDR-TB were associated with poorer treatment outcomes. However, the use of bedaquiline or delamanid for ≥1 month increased the treatment success. Conclusion: The treatment success rate in MDR-TB patients was higher in the post-PPM period than in the pre-PPM period, particularly because of the low rate of loss to follow-up. To ensure comprehensive patient-centered PPM in South Korea, investment and other support must be adequate.
( Yewon Kang ),( Kwangha Lee ),( Eun-jung Jo ),( Jung Seop Eom ),( Jeongha Mok ),( Mi-hyun Kim ),( Ki Uk Kim ),( Hye- Kyung Park ),( Min Ki Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: There are few data regarding effect of early tracheostomy on clinical outcomes in our country. Our study aimed to investigate effect of early tracheostomy on clinical outcomes (including long-term mortality) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ≥ 96 hrs). Methods: Data were obtained retrospectively from 575 patients, (69.4% male; median age 68 years) who hospitalized at a medical intensive care unit (ICU) of a single university-affiliated tertiary care hospital over 9 years (between March 2008 and February 2017). Early tracheostomy was defined as ≤ 10 days after translaryngeal intubation. Results: Their hospital and one-year cumulative mortality rate after ICU admission were 38.6 % (n=222) and 61.2 % (n=352), respectively. Also, one hundred forty-three patients (24.9%) underwent early tracheostomy, while others classified with late (n=115, 20.0 %) or no tracheostomy group (n=317, 55.1%). When total patients were divided two groups (early versus late or no tracheostomy), there were no significant differences of Acute Physiology and Chronic Health Evaluation II [median 22 interquartile range (16-25) vs 19 (15-25), p=0.172] and Sequential Organ Failure Assessment scores [7 (5-10) vs 6 (4-9), p=0.737] on ICU admission between both groups. However, early tracheostomy group showed higher medical costs during hospital stay [26,609 (17,634-44,066) vs 21,536 (13,974- 36,509) USD, p=0.013], ICU rehabilitation (46.2 vs 20.1%, p<0.001) and lower hospital mortality (21.7 vs 44.2% p<0.001). In stepwise multivariable Cox-proportional hazard model, early tracheostomy [Hazard ratio 1.550 (95% Confidence interval 1.197-2.006), p=0.011] was associated with one-year survival improvement. Conclusions: In our study, early tracheostomy group showed higher total hospital cost during hospital stay. Also, early tracheostomy was associated with higher hospital and one-year survival improvement.
The review of the clinical usefulness and price of currently listed drugs in South Korea
CHO Jung Sook,KIM Jung Ock,PARK Eun Yeong,LIM Min Kyoung,LEE Jin Hee,LEE Jong Hwan,SUNG Ye Na,YOON Sang-heon,NA Yewon,KIM Ji Yeon,LEE Seung Yeon,LEE Sook Hyun,LEE Yeun Hee,SO Soo Mi,KIM Byung Soo,LEE 대한약학회 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1
외팔보 및 양단고정보 형태의 압전 발전시스템 발전량 비교
김선중(Sun Jung Kim),송예원(Yewon Song),황성주(Sung Joo Hwang),안정환(Jung Hwan Ahn),김정훈(Jeong Hun Kim),성태현(Tae Hyun Sung) 한국소음진동공학회 2015 한국소음진동공학회 학술대회논문집 Vol.2015 No.4
In this study, we compared a cantilever piezoelectric energy harvester with a fixed-fixed piezoelectric energy harvester and analyzed the output powers of two harvesters. In two harvesting systems, the same piezoelectric material was used for giving identical condition. In order to exert input energy, we fell steel balls on the piezoelectric harvester. The weights of steel balls were 2g and 4g. The cantilever piezoelectric energy harvester generated the maximum power of 6.494 mW with a 4g steel ball and the fixed-fixed piezoelectric energy harvester produced the maximum power of 8.934 mW. The fixed-fixed piezoelectric energy harvester produced higher maximum power than the cantilever one in all cases. The results shows that 33-mode is more dominant than 31-mode.
Yewon Kang,Sae-Hoon Kim,So-Young Park,Bo Young Park,Ji-Hyang Lee,Jin An,Ha-Kyeong Won,Woo-Jung Song,Hyouk-Soo Kwon,조유숙,Hee Bom Moon,Ju Hyun Shim,양민석,김태범 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.3
Purpose: The incidence of drug-induced liver injury (DILI) has been increasing; however, few algorithms are available to identify DILI in electronic health records (EHRs). We aimed to identify and evaluate DILI with an appropriate screening algorithm. Methods: We collected data from 3 university hospitals between June 2015 and May 2016 using our newly developed algorithm for identifying DILI. Among patients with alanine transferase (ALT) ≤ 120 IU/L and total bilirubin (TB) ≤ 2.4 mg/dL in blood test results within 48 hours of admission, those who either had 1) ALT > 120 IU/L and TB > 2.4 mg/dL or 2) ALT > 200 IU/L at least once during hospitalization were identified. After excluding patients with liver disease-related diagnosis at discharge, medical records were retrospectively reviewed to evaluate epidemiological characteristics of DILI. Results: The total number of inpatients was 256,598, of whom 1,100 (0.43%) were selected by the algorithm as suspected DILI. Subsequently, 365 cases (0.14% of total inpatients, 95% confidence interval, 0.13–0.16) were identified as DILI, yielding a positive predictive value of 33.1%. Antibiotics (n = 214, 47.2%) were the major class of causative drug followed by chemotherapeutic agents (n = 87, 19.2%). The most common causative drug was piperacillin-tazobactam (n = 38, 8.4%); the incidence of DILI by individual agent was highest for methotrexate (19.4 cases/1,000 patients administered the drug). Common reasons for excluding suspected DILI cases were ischemic hepatitis and postoperative liver dysfunction. Conclusions: Using our EHR-based algorithm, we identified that approximately 0.14% of patients developed DILI during hospitalization. Further studies are needed to modify criteria for more accurate identification of DILI.
Yewon Cheong,Ji Seung Jung,Won Jae Lee,Jun Bong Lee,Jang Won Yoon 한국예방수의학회 2020 예방수의학회지 Vol.44 No.1
Salmonella is one of the most important bacterial pathogens responsible for many zoonotic food-related infectious diseases. Quantitative detection of the foodborne Salmonella contamination in various food sources is therefore critical for preventing the related disease outbreaks. In this study, we developed and evaluated a reliable real-time polymerase chain reaction (RT-PCR) assay to detect the Salmonella contamination quantitatively. The experimental results showed that our invA gene-specific quantitative RT-PCR (qRT-PCR) assay provides a strong correlation between the Cq values and the direct plate counts of Salmonella species in the artificially formulated samples. Further study may be necessary to identify more accurate correlation and equation that can apply to Salmonella spp.
Yewon Park,WonTae Jung,양은솔,Kyu-Yeol Nam,Woo-Ri Bong,Jaehee Kim,Kyu Yeon Kim,SeungHwan Lee,Joo-Youn Cho,Jang-Hee Hong,JaeWoo Kim 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.1
UI026 is an expectorant and antitussive agent which is a new combination of Pelargonium sidoides extract and Coptis extract. The bioactive compounds of Pelargonium sidoides and Coptisextracts were identified as epicatechin and berberine, respectively. This study evaluated the effect of food on the pharmacokinetics (PKs) and safety of UI026. A randomized, openlabel, single-dose, 2-treatment, parallel study in 12 healthy male subjects was performed. Subjects received a single oral dose of UI026 (27 mL of syrup) under a fed or fasted condition according to their randomly assigned treatment. Blood samples for the PK analysis were obtained up to 24 hours post-dose for berberine and 12 hours post-dose for epicatechin. The PK parameters were calculated by non-compartmental analysis. In the fed condition, the mean maximum plasma concentration (C max ) and mean area under the plasma concentrationtime curve from time zero to the last observed time point (AUC last ) for berberine were approximately 33% and 67% lower, respectively, compared with the fasted condition, both showing statistically significant difference. For epicatechin, the mean C max and mean AUC lastwere about 29% and 45% lower, respectively, compared to the fasting condition, neither of which showed a statistically significant difference. There were no drug-related adverse events. This finding suggests that food affects the systemic exposure and bioavailability of berberine and epicatechin.