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척추 전이성 종양의 수술적 치료 : 삶의 질에 대한 평가를 중심으로 focused in evaluation of life quality
양준영,이준규,홍의표,안성환,이정범 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
목적 : 척추에 발생한 전이성 종양 환자들을 대상으로, 수술적 치료를 시행한 환자에 있어서, 술후 생존 기간과 생존 기간 내 동통, 신경학적 증상, 일상 생활 능력 등의 평가를 통한 수술적 치료의 결과에 대하여 보고하고자 한다 . 연구대상 및 방법 : 1996년부터 1999년까지 본원에서 전이성 종양으로 수술적 치료를 받았던 환자중 추시가 가능했던 13례의 환자를 대상으로 하였으며 술 후 생존 기간 및 술 전 및 술 후 추시 중의 동통 양상 및 신경학적 증상의 호전여부, 일상 생활 수행 능력을 분석하였다 . 결과 : 전례에서 술 전 동통을 호소하였으며, 1례에서만 단독 보행이 가능하였고, 1례에서는 앉는 것만 가능하였으며, 11례에서는 앉지도 못하였다. 술 후 평가에서는 전례에서 동통이 감소하였으며, 술전에 신경학적 증상이 보였던 환자 중 75%에서 신경학적 증상이 호전이 나타났으며, 대상환자 중 92%에서 자가 보행이 가능하거나, 앉는 것이 가능하게 되었다. 사망한 환자의 술후 생존기간은 평균 11.2 개월이었다. 결론 : 수술적 치료를 받은 척추의 전이성 골종양 환자에서 술 후 신경학적 증상의 호전, 동통의 감소 및 보행 능력의 호전을 볼 수가 있었다. 따라서 척추의 전이성 종양 환자에 있어, 수술의 적응증이 된다면 수술적 치료를 적극적으로 시행하는 것이 환자의 삶의 질을 향상시킬 수 있다고 사료된다. To evaluate the clinical results of surgical treatment in metastatic spinal tumor patients. Thirteen patients of spinal metastatic tumor, treated by surgical methods, in this hospital from 1996 to 1999, were included in this study. We analysed pre and post operative pain, neurologic symptom and life quality. Preoperatively, all patients complained of pain and one case do could self walking, one case could do self sitting, and eleven patients were bed-ridden states. Postoperatively, pain was subsided in all cases. Neurologic symptom recovered in 75% of patients who had had preoperative neurologic symptoms. Postoperatively, patients walk or sit without assistance in 92% of cases. Mean postoperative span of survival was 11.2 months. Surgical treatment of spinal metastatic tumor improved the neurologic status and reduced pain. So, we conclude that if indicated, surgical treatment seems to achieve better results than conservative treatment in spinal metastatic tumor patient.
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Bum-Keun Kim,Jun-Soo Lee,Yong-Jin Cho,Dong-June Park 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4
Corn and rice starches were physically modified by planetary mill. While native starches showed high peak viscosities (1,001 and 563 cp), it decreased largely (42 and 20 cp for rice and corn starch, respectively) after 2 hr of physical modification. When two starches were co-ground, peak viscosities decreased more largely than single ground one only in 30 min, indicating the pasting properties could be easily changed by co-grinding. Especially, the higher the amount of corn starch, the viscosity decreased more largely, which means that paste stability could be controlled also by changing the ratio of corn and rice starch. Mean particle size increased with physical modification time since particles became spread because of shear force. There were also changes in surface morphology after physical modification. Fluid property, such as mean time to avalanche (MTA), was improved (from 6.16±0.47 and 8.37±1.23 sec to 5.47±0.78 and 5.26±1.37 sec for rice and corn starch, respectively) by physical modification. Pasting property, such as swelling power, was also improved by physical modification. These mean that native starches can be applied to both conventional powder and new paste-food industry more efficiently by physical modification.
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Bum-Keun Kim,Jun-Soo Lee,Ju-Kyoung Oh,Dong-June Park 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
Resveratrol-loaded poly(ε-caprolactone) (PCL) nanoparticles were prepared by oil in water (O/W) emulsion solvent evaporation method. The morphology of the nanoparticles was evaluated using atomic force microscope (AFM), in which well-shaped and rigid nanoparticles were prepared. The mean particle size of nanoparticles prepared using only dichloromethane (DCM) (523.5±36.7 ㎚) was larger than that prepared with a mixture of DCM and either ethanol (EtOH) (494.5±29.2 ㎚) or acetone (493.5±6.9 ㎚). The encapsulation efficiency of nanoparticles prepared only with DCM as dispersed phase (78.3±7.7%) was the highest of those prepared with solvent mixtures. An increase in the molecular weight of PCL led to an increase in encapsulation efficiency (from 78.3±7.7 to 91.4±3.2%). Pluronic F-127 produced the smallest mean size (523.5±36.7 ㎚) with the narrowest particle size distribution. These results show that dispersed phase, molecular weight of wall materials, emulsion stabilizer could be important factors to affect the properties of nanoparticles.
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History of Acquired Immune Deficiency Syndrome in Korea
Kim June Myung,Kim Nam Joong,Choi Jun Yong,Chin Bum Sik 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.2
The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. A total of 12,522 infected individuals have been reported up to 2015, of which 2,020 died. The male to female ratio was 15.4:1, and 34.2% of them were under 30 years old. The infection route was homosexual and bisexual contact in 60.1% of cases and heterosexual contact in 34.6% of cases. Candidiasis, Pneumocystis pneumonia, tuberculosis were common as a AIDS (acquired immune deficiency syndrome)-defining illness. But with the introduction of antiretroviral therapy in the late 1990s, non-AIDS defining illnesses such as metabolic complications, cardiovascular diseases, bone diseases, and neuropsychiatric disorders such as neurocognitive dysfunction, depression, and anxiety are emerging as new health problems. The management policy switched its focus from regulating and monitoring of HIV-infected persons to ensuring access to treatment and promotion of voluntary HIV testing in high-risk groups. Also as the age of the infected persons increases, a need for various supports such as social rehabilitation, life counseling, and welfare has emerged.
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최석훈,Bum Sik Chin,Sang Hoon Han,Han Sung Lee,Chang Oh Kim,Su Jin Jeong,Hee Kyung Choi,Myung Soo Kim,Jun Yong Choi,Young Goo Song,June Myung Kim 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.6
Background : The aim of the present study was to assess the contribution of a QuantiFERON-TB Gold In-Tube test (QFT-IT) in differentiating active tuberculosis (TB) from latent tuberculosis infection (LTBI) by quantifying interferon-γ levels. Materials and Methods : We retrospectively reviewed clinical records of 314 patients older than 15 years who had performed QFT-IT between July 2006 and August 2007 at a tertiary care teaching hospital. Results : Subjects with active TB (n=81, culture confirmed active TB in 40 subjects) and LTBI (n=76) were included. Mean±SD IFN-γ levels were 4.96±3.98 IU/mL (range -0.08-10) for all subjects with active TB, 4.54±4.05 IU/mL (range -0.08-10) for culture confirmed active TB, and 4.11±3.57 IU/mL (range 0.35-10) for subjects with LTBI. The quantitative results of QFT-IT on IFN-γ levels between all the subjects with active TB and those with LTBI were not statistically significant (P=0.16). The result was similar when compared between those with culture confirmed active TB and those with LTBI, showing little statistical significance (P=0.554). Conclusion : The production of IFN-γ measured by QFT-IT showed no correlation between its level and the activity of Mycobacterium tuberculosis infection. These results suggest that measuring IFN-γ using QFT-IT might not be useful for distinguishing active TB from LTBI. Background : The aim of the present study was to assess the contribution of a QuantiFERON-TB Gold In-Tube test (QFT-IT) in differentiating active tuberculosis (TB) from latent tuberculosis infection (LTBI) by quantifying interferon-γ levels. Materials and Methods : We retrospectively reviewed clinical records of 314 patients older than 15 years who had performed QFT-IT between July 2006 and August 2007 at a tertiary care teaching hospital. Results : Subjects with active TB (n=81, culture confirmed active TB in 40 subjects) and LTBI (n=76) were included. Mean±SD IFN-γ levels were 4.96±3.98 IU/mL (range -0.08-10) for all subjects with active TB, 4.54±4.05 IU/mL (range -0.08-10) for culture confirmed active TB, and 4.11±3.57 IU/mL (range 0.35-10) for subjects with LTBI. The quantitative results of QFT-IT on IFN-γ levels between all the subjects with active TB and those with LTBI were not statistically significant (P=0.16). The result was similar when compared between those with culture confirmed active TB and those with LTBI, showing little statistical significance (P=0.554). Conclusion : The production of IFN-γ measured by QFT-IT showed no correlation between its level and the activity of Mycobacterium tuberculosis infection. These results suggest that measuring IFN-γ using QFT-IT might not be useful for distinguishing active TB from LTBI.
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