FDM에서 경사면의 표면과 면적오차법의 관계에 대한 연구

전재억,정진서,황영모,김수광,김준안,계중읍,하만경 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-

In any rapid prototyping process, the layer by layer building process introduces an area error between the staircase and the surface line specified by the computer-aided design model. This affects the dimensional accuracy as well as the surface finish for different part build orientations. This paper describes a methodology for computing the area error for any orientation of the part built by the fused deposition modelling system. This technique can be applied to determine the best build orientation of the part, based on the minimum area error. This technique is verified by comparing the results with the experimental measurements of the area error of the parts built at different orientations.

Annual Case Volume and One-Year Mortality for Endovascular Treatment in Acute Ischemic Stroke

Kim Jun Yup,Kang Jihoon,Kim Beom Joon,Kim Seong-Eun,Kim Do Yeon,Lee Keon-Joo,Park Hong-Kyun,Cho Yong-Jin,박종무,Lee Kyung Bok,Cha Jae-Kwan,Lee Ji Sung,Lee Juneyoung,Yang Ki Hwa,Hong Ock Ran,Shin Ji Hyeon 대한의학회 2022 Journal of Korean medical science Vol.37 No.36

Background: The association between endovascular treatment (EVT) case volume per hospital and clinical outcomes has been reported, but the exact volume threshold has not been determined. This study aimed to examine the case volume threshold in this context. Methods: National audit data on the quality of acute stroke care in patients admitted via emergency department, within 7 days of onset, in hospitals that treated ≥ 10 stroke cases during the audit period were analyzed. Ischemic stroke cases treated with EVT during the last three audits (2013, 2014, and 2016) were selected for the analysis. Annual EVT case volume per hospital was estimated and analyzed as a continuous and a categorical variable (in quartiles). The primary outcome measure was 1-year mortality as a surrogate of 3-month functional outcome. As post-hoc sensitivity analysis, replication of the study results was examined using the 2018 audit data. Results: We analyzed 1,746 ischemic stroke cases treated with EVT in 120 acute care hospitals. The median annual EVT case volume was 12.0 cases per hospital, and mortality rates at 1 month, 3 months, and 1 year were 12.7%, 16.6%, and 23.3%, respectively. Q3 and Q4 had 33% lower odds of 1-year mortality than Q1. Adjustments were made for predetermined confounders. Annual EVT case volume cut-off value for 1-year mortality was 15 cases per year (P < 0.02). The same cut-off value was replicated in the sensitivity analysis. Conclusion: Annual EVT case volume was associated with 1-year mortality. The volume threshold per hospital was 15 cases per year.

In-hospital mortality of atrial fibrillation-associated acute ischemic stroke in the intensive care unit

Kim Do Yeon,Kang Jihoon,Jeong Han-Gil,Park Chan-Young,Kim Jun Yup,Kim Beom Joon,Han Moon-Ku,Bae Hee-Joon,Kim Baik Kyun 대한신경집중치료학회 2022 대한신경집중치료학회지 Vol.15 No.2

Background: Although atrial fibrillation (AF)-associated acute ischemic stroke (AIS) is on the rise, is devastating, and life-threatening, there is limited data on the clinical course and in-hospital mortality of patients treated in the intensive care unit (ICU). This study aimed to describe the clinical course and factors associated with in-hospital mortality in AF-associated AIS patients admitted to the ICU.Methods: This study was a retrospective analysis of a prospective nationwide multicenter cohort including non-valvular AF-AIS patients receiving ICU care admitted to 14 stroke centers in South Korea from 2017 to 2020. In-hospital outcomes, including in-hospital mortality and neurological deterioration (ND) have been described.Result: Amongst 2,487 AF-associated AIS patients, 259 (10.4%) were treated in the ICU. In-hospital mortality and ND occurred in 8.5% and 17.0% of the patients, respectively. Higher rates of initial National Institute for Health Stroke Scale scores, symptomatic steno-occlusive lesions, and CHA₂DS₂-VASc (Congestive Heart Failure, Hypertension, Age ≥75 [Doubled], Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack [Doubled], Vascular Disease, Age 65–74, Female) scores were found in those with in-hospital mortality. The CHA₂DS₂-VASc score after admission increased the risk of in-hospital mortality (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.00–2.18) were associated with in-hospital mortality. Antithrombotic use within 48 hours was related to decreased in-hospital mortality (OR, 0.26; 95% CI, 0.10–0.67).Conclusion: ICU care in AF-associated AIS is common, and the establishment of optimal treatment strategies in the ICU may be needed.

Acute Stroke Care in Korea in 2013–2014: National Averages and Disparities

Jun Yup Kim,Keon-Joo Lee,Jihoon Kang,Beom Joon Kim,김성은,Hyunji Oh,Hong-Kyun Park,Yong Jin Cho,Jong-Moo Park,Kwang-Yeol Park,Kyung Bok Lee,Soo Joo Lee,Tackeun Kim,Ji Sung Lee,Juneyoung Lee,Ki Hwa Yang,A 대한의학회 2020 Journal of Korean medical science Vol.35 No.20

Background: This study aimed to describe the current status of acute stroke care in Korea and explore disparities among hospitals and regions. Methods: The 2013 and 2014 national stroke audit data and the national health insurance claims data were linked and used for this study. Stroke patients hospitalized via emergency rooms within 7 days of stroke onset were selected. Results: A total of 19,608 patients treated in 216 hospitals were analyzed. Among them 76% had ischemic stroke; 15%, intracerebral hemorrhage (ICH); and 9%, subarachnoid hemorrhage (SAH). Of the hospitals, 31% provided inpatient stroke unit care. Ambulances were used in 56% of cases, and the median interval from onset to arrival was 4.5 hours. One-quarter of patients were referred from other hospitals. Intravenous thrombolysis (IVT) and endovascular treatment (EVT) rates were 11% and 4%, respectively. Three-quarters of the analyzed hospitals provided IVT and/or EVT, whereas 47% of hospitals providing IVT and 67% of hospitals providing EVT had less than one case per month. Decompressive surgery was performed on 28% of ICH patients, and clipping and coiling were performed in 17.2% and 14.3% of SAH patients, respectively. There were noticeable regional disparities between the various interventions, ambulance use, arrival time, and stroke unit availability. Conclusion: This study describes the current status of acute stroke care in Korea. Despite quite acceptable quality of stroke care, it suggests regional and hospital disparities. Expansion of stroke units, stroke center certification or accreditation, and connections between stroke centers and emergency medical services are highly recommended.

Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke

Kim Jun Yup,Lee Keon-Joo,Kang Jihoon,Kim Beom Joon,Han Moon-Ku,강규식,Park Jong-Moo,Park Tai Hwan,Park Hong-Kyun,Cho Yong-Jin,Hong Keun-Sik,Lee Kyung Bok,Jang Myung Suk,Lee Ji Sung,Lee Juneyoung,Bae Hee- 대한의학회 2022 Journal of Korean medical science Vol.37 No.13

Background: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. Methods: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. Results: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, eversmokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. Conclusion: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.

Performance of Human Skin Detection in Images According to Color Spaces

Kim Jun-Yup,Do Yong-Tae 한국정보기술응용학회 2005 한국정보기술응용학회학술대회 Vol.2005 No.1

Applications of genome-scale metabolic network model in metabolic engineering.

Kim, Byoungjin,Kim, Won Jun,Kim, Dong In,Lee, Sang Yup Published by Stockton Press on behalf of the Socie 2015 Journal of industrial microbiology & biotechnology Vol.42 No.3

<P>Genome-scale metabolic network model (GEM) is a fundamental framework in systems metabolic engineering. GEM is built upon extensive experimental data and literature information on gene annotation and function, metabolites and enzymes so that it contains all known metabolic reactions within an organism. Constraint-based analysis of GEM enables the identification of phenotypic properties of an organism and hypothesis-driven engineering of cellular functions to achieve objectives. Along with the advances in omics, high-throughput technology and computational algorithms, the scope and applications of GEM have substantially expanded. In particular, various computational algorithms have been developed to predict beneficial gene deletion and amplification targets and used to guide the strain development process for the efficient production of industrially important chemicals. Furthermore, an Escherichia coli GEM was integrated with a pathway prediction algorithm and used to evaluate all possible routes for the production of a list of commodity chemicals in E. coli. Combined with the wealth of experimental data produced by high-throughput techniques, much effort has been exerted to add more biological contexts into GEM through the integration of omics data and regulatory network information for the mechanistic understanding and improved prediction capabilities. In this paper, we review the recent developments and applications of GEM focusing on the GEM-based computational algorithms available for microbial metabolic engineering.</P>

Expression of Transcripts in Marmoset Oocytes Retrieved during Follicle Isolation Without Gonadotropin Induction

Kim, Yoon Young,Kang, Byeong-Cheol,Yun, Jun Won,Ahn, Jae Hun,Kim, Yong Jin,Kim, Hoon,Rosenwaks, Zev,Ku, Seung-Yup MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.5

<P>The in vitro maturation of oocytes is frequently used as an assisted reproductive technique (ART), and has been successfully established in humans and rodents. To overcome the limitations of ART, novel procedures for the in vitro maturation of early follicles are emerging. During the follicle isolation procedure, the unintended rupture of each follicle leads to a release of extra oocytes. Such oocytes, which are obtained during follicle isolation from marmosets, can be used for early maturation studies. Marmoset (<I>Callithrix jacchus</I>), which is classified as a new-world monkey, is a novel model that has been employed in reproductive biomedical research, as its reproductive physiology is similar to that of humans in several aspects. The ovaries of female marmosets were collected, and the excess oocytes present during follicle isolation were retrieved without pre-gonadotropin induction. Each oocyte was matured in vitro for 48 h in the presence of various concentrations of human chorionic gonadotropin (hCG) and epidermal growth factor (EGF), and the maturity of oocytes and optimal maturation conditions were evaluated. Each oocyte was individually reverse-transcribed, and the expression of mRNAs and microRNAs (miRs) were analyzed. Concentrations of hCG significantly affected the maturation rate of oocytes [the number of metaphase II (MII) oocytes]. The expression of <I>BMP15</I> and <I>ZP1</I> was highest when the oocytes were matured using 100 IU/L of hCG without pre-treatment with gonadotropins, and that of <I>Cja-mir-27a</I> was highest when cultured with follicle stimulating hormone. These results suggest that these up-regulated miRs affect the maturation of oocytes. Interactions with other protein networks were analyzed, and a strong association of BMP15 and ZP1 with sperm binding receptor (ACR), anti-Müllerian hormone (AMH), and AMH receptor was demonstrated, which is related to the proliferation of granulosa cells. Collectively, on the basis of these results, the authors propose optimal maturation conditions of excess oocytes of marmoset without in vivo gonadotropin treatment, and demonstrated the roles of miRs in early oocyte maturation at the single-cell level in marmosets.</P>

Methionine Sulfoxide Reductase B3-Targeted <i>In Utero</i> Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss

Kim, Min-A,Cho, Hyun-Ju,Bae, Seung-Hyun,Lee, Byeonghyeon,Oh, Se-Kyung,Kwon, Tae-Jun,Ryoo, Zae-Young,Kim, Hwa-Young,Cho, Jin-Ho,Kim, Un-Kyung,Lee, Kyu-Yup Mary Ann Liebert 2016 ANTIOXIDANTS AND REDOX SIGNALING Vol.24 No.11

Chemotherapy Outcome of Recurred Ovarian cancer Patients who had Olaparib Maintenance Therapy

( Yup Kim ),( Jun Sik Park ),( Yong Jae Lee ),( Kyung Jin Eoh ),( Sung Hoon Kim ),( Sang Wun Kim ),( Young Tae Kim ),( Jung Yun Lee ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Olaparibis PARP inhibitor approved for the use of maintenance therapy in BRCA positive, recurrent and platinum-sensitive ovarian cancer. Little is known about the chemotherapeutic response after the patients whose cancer recurred after the Olaparibmaintenance. This study investigates outcome of recurrent ovarian cancer after Olaparibmaintenance therapy. Methods: Retrospectivechart review of 52 patients who underwent Olaparibmaintenance therapy in Severance hospital from Oct.2017 to Jul.2019 was done. Age, BRCA mutation, family history of gynecological cancer, previous chemotherapy history, Olaparibadministration period, detection date of disease progression, and current regimen of chemotherapy and status was collected. Results: Diseaseprogressed in 15 patients. Of those diseaseprogressed, 1 died immediately after progression. 14 survived and continued chemotherapy, but method varied. 2 patients undergone debulking surgery before chemotherapy. 1 died after 1year1 month,the other survived 1 year 5 months. 1 patient started chemotherapy after radiotherapy, and this patient’s overall survival was 7 months. 1 patient enrolled in the study regimen containing prexasertib,and this patient survives until now, for 7 months. Other 9 patients started platinum-based chemotherapy right after the progression. Their regimen varied. 3 patients undergone platinum-based chemotherapy with pegylated doxorubicin, 2 with gemcitabine, 4 withdocetaxel and one with belotecan. Among 3 with pegylated doxorubicin, overall survival was 3month, 6month, 10month each. With gemcitabine, overall survival was 2year 8months, 10month each. Of 4 patients with docetaxel, overall survival was 1 month, 6 months,9 months, and 1 year and 10 months. With Belotecan,overall survival was 4 months.(Figure 1) Medianprogression free survival was 8 months.(Figure 2) Conclusion: After KFDA approved Olaparibmaintenance therapy, majority of BRCA positive platinum-senstivierecurrent ovarian cancer patients take olaparibas maintenance therapy after successful second line chemotherapy. Recurrence is rare until now, but the number of recurrences after olaparibis bound to increase. Careful inspection is needed for patients of such case, to establish the best way of management.