P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

Evaluation of Agronomic Stability of North Korean Rice Varieties using Statistical Models

O-Young Jeong,Jeom-Ho Lee,Ha-Cheol Hong,Eung-Gi Jeong,Jin-Soo Paek,Chang-Ihn Yang,Yong-Hee Jeon,Myeong-Ki Kim,Kyu-Seong Lee,Sae-Jun Yang,Young-Tae Lee 韓國作物學會 2008 한국작물학회지 Vol.53 No.1

This experiment was carried out to evaluate the agronomic stability of North Korean rice varieties using the statistical model developed by Grafius, Finlay, and Ever hart. The lowest yearly variation based on coefficients of variation was found in Hannam 29 for number of panicles per hill, in Sijoong 9 for number of grains per panicle, in Pyeongyang 3 for ripened grain ratio, in Sijoong 16 for 1,000 grain weight, and in Yeomju 1 for grain yield. By Grafius's model, Pyeongbook 3, Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups show stable for 3 years. Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups were found to be highly stable as analyzed by both Finlay and Wilkinson's model and Everhart & Russell's model. With reference to three models, Weonsan 66 was highly stable for 3 years with showing more yield than Odaebyeo in early maturing groups while Seohaechalbyeo was highly stable for 3 years with showing high yield than Hwaseongbyeo in medium maturing groups above 5~;t~;ha-1 of milled rice respectively.

Evaluation of Agronomic Stability of North Korean Rice Varieties using Statistical Models

Jeong, O-Young,Lee, Jeom-Ho,Hong, Ha-Cheol,Jeong, Eung-Gi,Paek, Jin-Soo,Yang, Chang-Ihn,Jeon, Yong-Hee,Kim, Myeong-Ki,Lee, Kyu-Seong,Yang, Sae-Jun,Lee, Young-Tae The Korean Society of Crop Science 2008 한국작물학회지 Vol.53 No.1

This experiment was carried out to evaluate the agronomic stability of North Korean rice varieties using the statistical model developed by Grafius, Finlay, and Ever hart. The lowest yearly variation based on coefficients of variation was found in Hannam 29 for number of panicles per hill, in Sijoong 9 for number of grains per panicle, in Pyeongyang 3 for ripened grain ratio, in Sijoong 16 for 1,000 grain weight, and in Yeomju 1 for grain yield. By Grafius's model, Pyeongbook 3, Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups show stable for 3 years. Weonsan 66 in early maturing groups and Seohaechalbyeo in medium maturing groups were found to be highly stable as analyzed by both Finlay and Wilkinson's model and Everhart & Russell's model. With reference to three models, Weonsan 66 was highly stable for 3 years with showing more yield than Odaebyeo in early maturing groups while Seohaechalbyeo was highly stable for 3 years with showing high yield than Hwaseongbyeo in medium maturing groups above $5\;t\;ha^{-1}$ of milled rice respectively.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

자연환경방사선에 의한 피폭선량(유효선량당량)의 종합적 해석연구

전재식,채하석,이병영,김현창,이동준,김도성,엄두하 충남대학교 기초과학연구소 1990 연구논문집 Vol.10 No.-

자연환경방사선의 세 가지 주요 요소인 지각방사선, 우주선 전리성분 및 라돈과 그 자핵종이 주는 선량을 측정, 해석하였는 바 18개월간에 걸쳐 대전, 수원, 경산 지역에 대하여 수행하고 이를 종합하여 유효선량당량으로 평가하였다. 지각방사선과 우주선 전리성분 측정을 위하여 3"∮×3" Nal(Tl) 섬광검출기와 휴대형 다중파고분석기를 이용한 감마선 분광분석 및 ^7LiF PTEE disk TLD에 의한 적산선량측정을 병행하였고, 공기중 라돈농도의 측정은 CR-39 고체비적검출기를 내장한 라돈컵을 설계제작하여 사용하였으며 비적수 라돈농도 교정인자는 스웨덴 국립방사선 방호연구소의 표준 라돈 챔버내에서 조사하여 결정하였다. 세 지역의 가연방사선에 의한 유효선량당량에는 약간의 수치적 차이는 있었으나 본질적 차이는 찾아볼 수 없었으며 지역 측정치의 분산가중 평균치는 지각방사선 (463±3)uSvㆍy^-1[(52.9±0.3)nSvㆍh^-1], 우주선 전리성분 (287±15)uSvㆍy^-1[(32.8±1.7)nSvㆍy^-1]로 외부 피폭이 (775±9)uSvㆍy^-1[(88.5±1.0)nSvㆍy^-1]였으며 라돈과 그 자핵종에 의한 내부피폭은 (1973±298)uSvㆍy^-1[(225.2±34.0)nSvㆍy^-1]였다. 따라서 자연황경방사선에 의한 여간 총 선량당량은 (2762±296)uSvㆍy^-1[(315.3±34.0)nSvㆍh^-1]로 평가되었는데 이 값들은 UN보고서^(11)에 나온 “정상적 자연방사선 지역”의 값과 비교할 만한 타당한 값으로 나타났다. Assessment of effective dose equivalent from natural environmental radiation that consists of terrestrial gamma­ray, ionizing component of cosmic­ray and alpha­rays of atmospheric radon and its decay products has been carried out for 18 months in Daejeon, Suwon and Kyungsan areas. A 3"∮×3"cylindrical Nal(Ti) scintillation detector in association with portable multichannel analyser and ^7LiF PTFE disk TLDs were used for the measurement of terrestrial gamma­ray and cosmic­ray ionizing component, while self­designed radon­cups with CR-39 SSNTD attached to the inside bottom were used for the integral measurement of at­mospheric radon concentration. Determination of calibration factor for converting track density of CR-39 detector to radon concentration was made by irradiation of radon­cups in the standard radon chamber of Swedish National Institute of Radiation Protection. Although resultant effective dose equivalents of three different measurment points show minor numerical differences, no essential discripancy between the places was found. The variance weighted means of the annual effective dose equivalents of each component of radiation from the tree places came out to be: (463±3)uSvㆍy^-1[(52.9±0.3)nSvㆍy^-1] for terrestrial gamma­ray, (287±15)uSvㆍy^-1[(32.8±1.7)nSvㆍy^-1] for ionizing component of cosmic­ray and (1973±298)uSvㆍy^-1[(225.2±34.0)nSvㆍy^-1] for internal exposure of radon and its decay products. Consequent total effective dose equivalent turned out to be (2762±298)uSvㆍy^-1[(315.3±34.0)nSvㆍy^-1], which if reasonably comparable with that appeared in UNSCEAR Report^[11]as per caput annual effective dose equivalent in “areas of normal back ground radiation.”

排球競技에서 中央攻擊과 左右攻擊이 勝敗에 미치는 影響

河永俊,金明鎭 仁荷大學校 스포츠科學硏究所 1991 論文集 Vol.3 No.-

The purpose of this study was to investigate the effect of the center and side attack on the win and lose, gain and lose point, gain and lose set. The subjects were 68 games in 7th president cup volleyball tournament. The attack style was divided into two(the side and center) attack. The result of attack was divided into 11 sections as follows; (side-SSPP, SSSP, SEPP, SRTP, SAVP, canter- CSPP, CSSP, CEPP, CESP, CRTP, CACP). Regression and t-test were used for analysis of the data. The results were obtained as follows : 1. Win team is significance difference mean more than lose team in CSPP, CSSP, SSPP, but CEPP, SEPP are less than lose team. 2. The effect order of the gain point is SSPP, CEPP, CESP, CSPP, SEPP. 3. The effect order of the gain set are SSPP, CEPP, CSSP, SEPP, BETP, CSPP, CESP, SSSP 4. The effect order of the lost point are CSSP, SSPP, CESP, BETP. 5. The effect order of the lost set are CSSP, SSSP, SSPP, SESP. 6. The effect order of the ranting are CEPP, SSSP, CSSP.

HPGe 검출기에 의한 지각방사선의 핵분광학적 연구

전재식,채하석,진응국,이철영,조혁,하정우 충남대학교 기초과학연구소 1992 연구논문집 Vol.12 No.-

고순도 Ge(HPGe) 검출장치를 사용한 현장측정을 통하여 지각방사선에 대한 핵분광학적 연구를 수행하였는바 지각방사선장의 핵분광학적 특성차이를 규명하기 위하여 지면의 자연방사성 핵종분포가 대표적 전형인 충남대학교 캠퍼스내 미경작 개활지 잔디밭과, 우라늄 함량이 높은 곳으로 알려진 괴산군 덕평리 지역 등 특이한 두 지역을 측정지점으로 선택하였다. 환산선량의 비교확인을 위하여 HPGe 분광측정은 3″ø×3″원통형 NaI(T1) 섬광검출기에 의한 분광측정과 동시에 수행하였으며 본 연구에 사용된 HPGe 검출기에 대한 스펙트럼-선량율 환산인자 G(E)는 감마선속이 검출기 축에 수직 입사하는 것으로 가정하고 Monte Carlo 방법으로 씨뮬레이션한 감응스펙트럼들을 사용하여 산출하였다. 이 G(E)를 사용하여 산출된 선량율(D˙_Ge)은, 이미 기준기급 전리함과의 비교 교정을 통하여 스펙트럼-선량 환산체계가 확립된 바 있는 NaI(T1) 검출기로 구한 선량율(D˙_NaI)과 만족스러운 일치를 보였으며 D˙_Ge와 D˙_NaI 사이의 상관계수는 +0.9988, 회귀 방정식의 기울기는 1.001을 나타내었다. 측정한 스펙트럼에서는 미미한 크기의 ^137Cs 감마선 피크가 확인되었으나 1960년대에 수행되었던 대기권 핵실험의 영향이나 Chernobyl 원전사고의 영향은 관측되지 않았다. Study of terrestrial gamma-rays was carried out by means of in-situ spectrometry using high purity germanium (HPGe) detector system. Two distinguishable fields of measurements, namely, uncultivated flat lawns in CNU campus where the distribution of natural radionuclides in the ground in known to be quite typical and well-known uranium rich area of Dukpyung-ri in Gwoesan-kun were selected in order to specify the difference in spectrometric characteristics of the fields. In-situ HPGe spectromety was accompanied by scintillation spectrometry with 3″ø×3″cylindrical NaI(T1) detector for comparative confirmation of derived dose rates from the spectra measured. Spectrum-dose rate conversion operator, G(E), of our particular HPGe detector was calculated using response spectra simulated by Monte Carlo method with an assumption of gamma-ray beams incident vertically to the detector axis. Resultant dose rates (D˙_Ge) showed satisfactory agreement with those obtained by NaI(T1) spectrometry and corresponding G(E) operation (D˙_NaI) of which system has been well-established through intercalibration with a reference ion chamber. Correlation coefficient and the slope of regression equation between D˙_Ge and D˙_NaI came out to be +0.9988 and 1.001, respectively. Though traceable height of ^137Cs gamma-ray peak was identified on the field spectrum, ground contamination of fission products released from atmospheric nuclear test performed in 1960s and possibly from Chernobyl accident was not observed as of today.

소집단 학습자 구성 방법에 따른 체육 학습 효과

하영준,김연갑 인하대학교 스포츠과학연구소 2000 論文集 Vol.12 No.-

Today, the learning with small groups is a popular style of pedagogy in the field of so called "open education" which is being concerned in the elementary and middle school. Despite many researches on the effects on learning with small groups had been implemented, there has not been any consensus of decision yet, which is the most important factor in .the pedagogy with small groups, Therefore the main purpose of this study is to find the way to organize the small groups which is the most essential part in learning with small groups, comparing the effects on physical learning of the elementary school student by the way of forming small groups(homogeneous and heterogeneous groups), in the field of physical teaching-learning, which is one of the learning styles in small groups, coming from "Spectrum of teaching style" developed by Mosston. For the experimentation, 95 students(50 bys and 45 girls) in their forth grade are selected from 2 classes in "C" elementary school located in In-Cheon and are divided into 2 groups, that is to say, homogeneous(small group by each levels) and heterogeneous(small group by mixed levels) group. Then these two sample groups are instructed to dribble and pass the ball in the simple basketball and soccer game respectively, three times a week, through the regular physical class for 12 weeks. Meanwhile a pre-test is implemented in the first second week and final test in the eleventh twelfth week. The following results can be achieved from this research; First, there was no big difference between the homogeneous and heterogeneous group, once the same contents and circumstances had been provided to the small group.(P>0.05) Second, organizing homogeneous and heterogeneous group from the whole group made no big different effects in learning(P>0.05), however, as a result of comparing the learning effects on the boy group and girl group by levels(high, intermediate, low), significant difference was observed in the high level soccer group of boy(P>0.05) and dribbling and passing group of girl(P>0.05), and no significant difference was caught from the remaining learning effects by the event, gender and small groups(high, intermediate, low) Therefore, the average comparison showed that homogeneous group in the high level students, heterogeneous in the intermediate and low are tend to get better learning effects. Consequently, the above-mentioned research makes a meaningful way to the efficient management on the learning with small group of the "open education" which is most concerned recently. Especially, it shows that the learning ability of the student, the characteristics of the learning subject and the external conditions for the class are the main factor in the way of forming groups and gives a hint of necessity of the flexible grouping to the things given. It will also be helpful to form small groups in the course by level, which is the basis of seventh education course.

운동학습 귀인에 대한 피드백 유형별의 앞구르기 학습효과 분석

하영준,김진규 仁荷大學校 스포츠科學硏究所 2001 論文集 Vol.13 No.-

The purpose of the study is to clarify the effect of feedbacks(non-feedback, positive feedback and negative feedback) on middle school girls' forward rolling learning by attribution factors(ability, efforts, luck, colleagues and difficulty). 465 girls of P and Y middle schools in Incheon were selected as the experiment target by simple random sampling. A survey on attribution of motor learning was conducted first. Subjects were classified into 3 groups who had a same attribution and who had similar past leaming abilities. During the total of 3 trials, every learner received feedbacks after each trials and after 3 times of trials, every was measured by the survey as well. The mean and the standard deviation was computed as measuring source. To verify the hypothesis, pearson's correlation and Anova, the subordinate program of SPSS, were used and Scheffe was used as a posthumous verification and the result is as follows; 1. Raising the level of attributions to the factor of difficulty and the other factors was significant in improving forward rolling. (p<.05) 2. As an attribution, as for difficulty factor, providing a positive feedback was more efficient than not providing it(p<.05), and as for the other factors, not providing feedback was more efficient than providing positive feedbacks (p<.05) 3. The improvement rate was the lowest in students who take the learning attribution as an ability factor, and other groups showed similar improvement rates (p<.05).

만성 발 뒤꿈치 통증의 원인 및 검사

하상호,이준영 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S