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Jun Seop Yun,Hyeeun Song,Nam Hee Kim,So Young Cha,Kyu Ho Hwang,Jae Eun Lee,Cheol-Hee Jeong,Sang Hyun Song,Seonghun Kim,조은애산드라,김현실,육종인 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosphorylation by GSK-3β constitutes a critical event for viral replication, the molecular mechanism underlying N phosphorylation is not well understood. In this study, we found the putative alpha-helix L/FxxxL/AxxRL motif known as the GSK-3 interacting domain (GID), found in many endogenous GSK-3β binding proteins, such as Axins, FRATs, WWOX, and GSKIP. Indeed, N interacts with GSK-3β similarly to Axin, and Leu to Glu substitution of the GID abolished the interaction, with loss of N phosphorylation. The N phosphorylation is also required for its structural loading in a virus-like particle (VLP). Compared to other coronaviruses, N of Sarbecovirus lineage including bat RaTG13 harbors a CDK1-primed phosphorylation site and Gly-rich linker for enhanced phosphorylation by GSK-3β. Furthermore, we found that the S202R mutant found in Delta and R203K/G204R mutant found in the Omicron variant allow increased abundance and hyper-phosphorylation of N. Our observations suggest that GID and mutations for increased phosphorylation in N may have contributed to the evolution of variants.
( Han Jun Bae ),( Ji Hyun Son ),( Yun Kyeong Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yun Nyun Kim ),( Kwon Bae Kim ) 대한내과학회 2011 대한내과학회 추계학술발표논문집 Vol.2011 No.1
Background: Anemia was known as a powerful and independent predictor of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). The development of anemia during hospitalization for acute myocardial infarction was frequent and was associated with an increased long-term mortality. It has been reported that a decline of hemoglobin concentration during intensive care unit stay in ACS patients without bleeding events was powerful predictor of clinical ischemic events. However there were limited datas available if the decreased hemoglobin level is related to major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI) in ACS patients. Methods: We retrospectively enrolled 211 patients from March 2003 through October 2009. The inclusion criteria was patients diagnosed stable angina or ACS and underwent PCI. Patients were free of blood cell transfusion or bleeding events after PCI. All patients had been checked hemoglobin level 1 day and 2 days after PCI. The 1-year incidences of MACE, including death, myocardial infarction (MI), target vessel revascularization (TVR) and stent thrombosis (ST) were evaluated in all patients included. Statistical analysis was performed using SPSS 18.0. The association between hemoglobin changes and MACE was analyzed with ANOVA. Results: Participated patients were composed of 167 males and mean age was 60.31±10.72. Number of patients diagnosed stable angina were 63, unstable angina were 53, non-ST segment elevation myocardial infarction were 47, and ST segment elevation MI were 42. Initial hemoglobin level was 12.0 to 17.7 g/dL (mean value 13.64±1.19). Hemoglobin change was from -4.1 to +1.8 g/dL 24 hours after PCI and from -4.0 to +1.8 g/dL 48 hours after PCI. Hemoglobin change on 1day after PCI had no significant relation with mortality, subsequent MI, TVR, and ST (p=NS). And hemoglobin on 2day after PCI also had no relation with mortality, subsequent MI, TVR, ST (p=NS). Conclusions: In patients underwent PCI, hemoglobin change day 1 and day 2 after PCI was not related to MACE in stable angina and ACS patients. Therefore routine hemoglobin follow-up after PCI is not needed if patient has low risk of bleeding.
Jun, Indong,Chung, Yong-Woo,Heo, Yun-Hoe,Han, Hyung-Seop,Park, Jimin,Jeong, Hongsoo,Lee, Hyunjung,Lee, Yu Bin,Kim, Yu-Chan,Seok, Hyun-Kwang,Shin, Heungsoo,Jeon, Hojeong American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.5
<P>Developing an artificial extracellular matrix that closely mimics the native tissue microenvironment is important for use as both a cell culture platform for controlling cell fate and an in vitro model system for investigating the role of the cellular microenvironment. Electrospinning, one of the methods for fabricating structures that mimic the native ECM, is a promising technique for creating fibrous platforms. It is well-known that align or randomly distributed electrospun fibers provide cellular contact guidance in a single pattern. However, native tissues have hierarchical structures, i.e., topographies on the micro- and nanoscales, rather than a single structure. Thus, we fabricated randomly distributed nanofibrous (720 +/- 80 nm in diameter) platforms via a conventional electrospinning process, and then we generated microscale grooves using a femtosecond laser ablation process to develop engineered fibrous platforms with patterned hierarchical topographies. The engineered fibrous platforms can regulate cellular adhesive morphology, proliferation, and distinct distribution of focal adhesion proteins. Furthermore, confluent myoblasts cultured on the engineered fibrous platforms revealed that the direction of myotube assembly can be controlled. These results indicate that our engineered fibrous platforms may be useful tools in investigating the roles of nano- and microscale topographies in the communication between cells and ECM.</P>
Does oil price rise necessarily reduce export?: Focused on Korean exports
( Yun Seop Hwang ),( Young Jun Choi ) 한국생산성학회 2012 生産性論集 Vol.26 No.4
This paper analyzes the effects of oil price change on the value of exports of Korea. The general convention is that the effect of oil price raise is leading to reducing the exports. The change in oil price is related to the change of production costs as well as changes in macroeconomic indices, such as price level and interest rate. Those changes in production costs and macroeconomic indices may affect the performance of exports. However, we found that the oil price increase is not necessarily reducing the exports based on Korean industrial exports data. Rather, in our analysis, the rise of oil price lowers the real interest rate and thus the increase in oil price leads to an increase in the value of Korean exports. It is also found that oil price affects the export directly and indirectly through the real interest rate.
Design of SIMT Architecture-based Reconfigurable Image Signal Processor
Yun-Seop Hwang,Kwang-Yeob Lee,Jun-Mo Jeong 한국정보통신학회 2015 2016 INTERNATIONAL CONFERENCE Vol.7 No.1
This paper proposes SIMT architecture-based reconfigurable Image Signal Processor (ISP). Conventional ISP commonly has the hard-wired image processing algorithm of which the processing speed is fast, but one problem of these conventional ISP is that they cannot apply various image processing algorithms. On the other hand, as the image quality required by various devices is gradually increasing and the image processing algorithms are becoming diversified, the burden of calculations in the main processor such as CPU or GPGPU is growing bigger. To solve these problems, an ISP was designed in this paper which can reduce the burden of the main processor by applying the SIMT structure which is based on instructions, can apply various image processing algorithms, and allows parallel processing. The proposed ISP was verified with a VC-707 board equipped with Virtex-7 FPGA and showed about 2.4 times higher processing speed compared to the DSP which performs a similar role as ISP.