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Paclitaxel and Cisplatin Combination Chemotherapy in Pretreated Breast Cancer
Joo Hyuk Sohn,Yong Tai Kim,Sun Young Rha,Nae Choon Yoo,Jae Kyung Roh,Byung Soo Kim,Chang Ok Suh,Gwi Eon Kim,Woo Ick Jang,Hyun Cheol Chung 대한암학회 2003 Cancer Research and Treatment Vol.35 No.3
Purpose: A single institute trial of combination chemotherapy,with paclitaxel and cisplatin, in patientswith m etastatic breast cancer, having failed previouscombination chemotherapy, was performed.Materials and Methods: Patients were only eligible forthis study if there disease had progressed, followingtreatment with previous chemotherapy, in either anadjuvant or a m etastatic setting. Paclitaxel 175 m g/m2was administered as a 3-hour continuous infusion onday 1, and cisplatin 80 mg/m2 was administered for 2hours on day 2, with adequate hydration. This wasrepeated every 3 w eeks, and continued until one ofthe following events occurred: disease progression,unacceptable adverse effect or treatment refusal bythe patient. Intercurrent palliative radiotherapy, or concurrenthormonal therapy, was permitted, dependingon each patient's status. All the endpoints were evaluatedunder the principle of intention to treat analysis.Results: A total of 24 patients entered the study, and18 had at least one m easurable lesion, but 6 did not.The objective response rate of the 18 patients was 50%(9/18). Two were complete responses and seven showedpartial responses. The median response duration, progressionfree and overall survival were 5.3 months(range, 4~18), 6 months (95% CI, 5~7) and 12 months(95% CI, 7~17), respectively. 67% of the planned dosewas administered. Out of a total 135 cycles administered,about 20% of cycles showed grade 3 or 4leukopenia and 7% showed grade 3 thrombocytopenia.Two patients suffered from pneumonia, and one experiencedneutropenic fever. Mucositis, greater thangrade 3, existed in three cases. No treatment relateddeaths were reported.Conclusion: The combination chemotherapy, withpaclitaxel and cisplatin, was active in the treatment ofmetastatic breast cancer patients having failed previouschemotherapy. (Cancer Res Treat. 2003;35:267-273)
Lee, Young Joo,Lee, Chang Geol,Cho, Byoung Chul,Kim, Gwi Eon,Choi, Hye Jin,Choi, Eun Chang,Sohn, Joo Hyuk,Kim, Joo-Hang Wiley Subscription Services, Inc., A Wiley Company 2010 Head & neck Vol.32 No.2
<B>Background.</B><P>In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5-fluorouracil (5-FU) and cisplatin has increased acute toxicities as well as survival. Once-weekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we investigated CRT using weekly administration of 5-FU–cisplatin in locally advanced head and neck cancer.</P><B>Methods.</B><P>In a single-arm, phase II study, CRT included radiation (70.0 Gy/35 fr) and weekly 5-FU (750 mg/m<SUP>2</SUP>) and cisplatin (20 mg/m<SUP>2</SUP>).</P><B>Results.</B><P>Thirty-two patients completed planned radiation. Thirteen (41%) achieved complete response, and 16 (50%) partial response. Twelve patients (38%) experienced acute grade 3 toxicities. Grade 3 mucositis, which was the most common toxicity, developed in 5 (16%) patients. The survival rates at 1 and 2 years were 81% and 76%, respectively. The progression-free survival rates at 1 and 2 years were 69% and 66%, respectively.</P><B>Conclusions.</B><P>We demonstrated weekly 5-FU-cisplatin with conventional radiotherapy was efficacious and feasible with high compliance rate in locally advanced head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2010</P>
Assessing South Korea's Compliance with Global Norms on Development Cooperation
Jiyoung Hong(Jiyoung Hong),Heon Joo Jung(Heon Joo Jung),Hyuk-Sang Sohn(Hyuk-Sang Sohn),Geonwoo Park(Geonwoo Park) 한국학술연구원 2022 Korea Observer Vol.53 No.4
Over the last f ive decades, the UN and OECD/DAC have strongly urged member states to comply with global aid norms to improve aid effectiveness. To what extent are the global aid norms actually put in practice in countries that have pledged themselves to comply with these norms? Norm life cycle theory explains the internalization of global norms as legalization, institution-building, and official policies at the national level. This study supplements the norm lifecycle theory by subdividing the process of norm internalization into the policy formation stage and the post-implementation stage at the national level and empirically examines it by employing five criteria: ODA/GNI ratio; aid to LDCs; the ratio of grant to loan; aid-untying; and fragmentation. The results show that some aid norms are well accepted and implemented at both stages while other norms are neither addressed in official aid policies nor put into practice.
( Hyuk Lee ),( Jung Ho Park ),( Dong Il Park ),( Hong Joo Kim ),( Yong Kyun Cho ),( Chong Il Sohn ),( Woo Kyu Jeon ),( Byung Ik Kim ),( Seoung Wan Chae ) 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
Background/Aims Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between mucosal mast cells and intestinal permeability remains unclear. The objective of this study was to evaluate the correlation among intestinal permeability, tryptase activity and mucosal mast cell count. Methods Rectal biopsies from 16 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 7 normal subjects were assessed for tryptase activity and macromolecular permeability using horseradish peroxidase in Ussing chambers. In addition, mucosal mast cell levels were immunohistochemically quantified via image analysis. Results Rectal biopsy of tissues from IBS-D patients showed significantly increased permeability compared with those from normal controls (0.644±0.08 and 0.06 ± 0.00 ng/2 hr/mm2, P<0.01). Tryptase activity was also substantially higher in rectal biopsy samples from IBS-D patients than those from normal controls (0.86 ± 0.18 and 0.28 ± 0.04 mU/mg protein, P<0.05). Mucosal mast cell counts were not significantly different between the 2 groups (P>0.05). However, correlation analysis revealed that only mucosal mast cell count was significantly correlated with intestinal permeability in IBS-D patients (r =0.558, P<0.05). Conclusions This study demonstrated a positive correlation between the number of mucosal mast cells and intestinal permeability, suggesting that mucosal mast cells play an important role for increased intestinal permeability in patients with IBS-D.
A Critical Analysis of Multilateral Aid of Middle Power States
Hyuk-Sang Sohn(손혁상),Joo Hee Kim(김주희) 한국정치학회 2017 한국정치학회보 Vol.51 No.3
개발협력의 양자원조와 다자원조의 효과성에 대한 논쟁은 여전히 중요한 주제로 남아있다. 힘이 우선시 되는 국제정치 질서 하에서 대다수의 중견국들은 지정학적 한계를 극복하고 국가의 이익을 추구하기 위해 다자적 접근을 전략적으로 활용하고 있다. 본 연구는 한국을 포함한 중견국들의 다자원조의 주요한 특성을 파악하는데 주목적이 있다. 이러한 과정 중에 중견국이 공적개발원조에 있어 다자적 접근을 양자적 접근보다 더 선호하는지, 그러한 경향은 어떻게 나타나는지 밝혀내고자 한다. 또한 중견국의 특징이라 할 수 있는 새로운 원조형태인 다자적 양자(multi-bi) 원조가 다자와 양자원조의 특징을 모호하게 하는 경향이 있다는 점에서 다자적 양자원조의 새로운 모습을 분석하고자 한다. 새천년개발목표에서 지속가능한발전으로 국제개발협력의 패러다임이 변화하고 있는 시점에서 본 연구는 중견국들이 다자적 원조를 통해 스스로의 영향력을 행사하기 위한 노력을 경주하고 있다는 점을 보여주고자 한다. In development cooperation, there has been a long-standing debate on the effectiveness of multilateral versus bilateral aid. Many middle-power countries have utilized multilateral approaches strategically to overcome geopolitical restrictions and advance their national causes in the world powers-centered order. This study aims to identify the key characteristics of middle power countries’ multilateral aid, including the case of South Korea. By doing so, we attempt to discover whether, and to what extent, a middle power prefers the multilateral approach of ODA to a bilateral one. This study will also analyze the emerging pattern of multi-bi aid of middle powers. The multi-bi aid tends to blur the clear distinction between multilateral and bilateral assistance. At the moment of a big transformation in the international development paradigm from Millennium Development Goals (MDGs) to Sustainable Development Goals (SDGs), this study attempts to show that the middle power countries have made substantial efforts to enhance their influence in the world through the means of multilateral aid support.
The Prevalence of and Factors Associated with Influenza Vaccination in Patients with Asthma in Korea
( Sang Hyuk Kim ),( Sungmin Zo ),( Hwasik Jung ),( Saerom Kim ),( Ho Joo Yoon ),( Jang Won Sohn ),( Tae-hyung Kim ),( Sang-heon Kim ),( Ji-yong Moon ),( Dong Won Park ),( Tai Sun Park ),( Hye Yun Park 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Patients with asthma are at high risk of hospitalization and death from influenza infection, which Results in an additional burden on the medical system. However, despite the crucial role of influenza vaccination in preventing influenza infection and its complication, detailed epidemiologic data regarding influenza vaccination among patients with asthma is lacking. This study aimed to investigate the rate of influenza vaccination and factors associated with the vaccination in patients with asthma using nationally representative survey data. Methods Among 72,843 participants of the Korea National Health and Nutrition Examination Survey between 2010 and 2019, 760 patients with self-reported physician-diagnosed asthma were included in this study. The outcome was the influenza vaccination rate assessed by questionnaire. Logistic regression analysis was performed to evaluate factors associated with not being vaccinated in patients with asthma. Results The overall influenza vaccination rate was 63.7% in patients with asthma and there was no significant change in the vaccination rate (range 58.7%-70.0%) during the study period. In multivariable logistic regression analysis, younger age (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 1.07-1.16, p < 0.001), lower income (aOR 2.76, 95% CI 0.77-3.80, p = 0.040), and the presence of respiratory symptoms (aOR 2.56, 95% CI 1.22-5.36, p = 0.012) were associated with the increased odds of being unvaccinated for influenza. Conclusion The vaccination rate in patients with asthma was stable, ranging from approximately 60% to 70% between 2010 and 2019 in Korea. As patients with younger age, lower income, or respiratory symptoms might be non-adherent to influenza vaccination, more attention is needed in these patients to increase the influenza vaccination rate. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, Information and Communications Technologies (MSIT) (NRF-2020R1F1A1070468 and NRF-2021M3E5D1A01015176).
( Woo Hyuk Choi ),( Hong Joo Kim ),( Jung Ho Park ),( Dong Il Park ),( Yong Kyun Cho ),( Chong Il Sohn ),( Woo Kyu Jeon ),( Byung Ik Kim ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: There has been no report concerning the predictive capability of each scoring system for the complications of liver cirrhosis, such as variceal bleeding and hepatic encephalopathy. The aim of the present study was to evaluate the any predictive capability of each scoring systems, especially those which measure the dynamic changes of residual liver functions over time (△scores), in a large cohort of patients admitted to a tertiary-care institution with or without complications of liver cirrhosis. Methods: We retrospectively studied 128 patients with liver cirrhosis (92 males, 36 females, median age 53 years, range 28~80) admitted to our institution from March 2004 to April 2006. Seventy three patients (57.0%, group 1) admitted due to the complications of cirrhosis (variceal bleeding and encephalopathy), and 55 patients (43.0%, group 2) admitted due to the causes unrelated to complications of cirrhosis (such as acute pyelonephritis). We calculated the model for end stage liver disease (MELD), MELD-Sodium (MELD-Na), and Child-Turcotte-Pugh (CTP) scores on admission, and at 3 and 6 months prior to admission. Results: The relative risk of complications for the patients group with △MELD/3 months ≥2, △MELD-Na/3 months ≥2 and △CTP/3 months ≥1 was 2.61 (95% CI 1.57~4.34, p<0.01). 1.93 (95% CI 1.27~2.92, p<0.01), and 3.52 (95% CI 1.87~6.60, p<0.01), respectively. The area under receiver operating characteristic (ROC) curve of △MELD /3 months, △MELD-Na/3 months, and △CTP/3 months for the occurrence of cirrhotic complications were 0.758, 0.711, and 0.711, respectively. Higher △MELD/3 months (≥2), △MELD-Na/3 months (≥2), and △CTP/3 months (≥1) were all associated with decreased survival. Conclusions: △MELD/3 months, △MELD-Na/3 months, and △CTP/3 months were clinically useful parameters predicting the occurrence of cirrhotic complications, such as variceal bleeding and hepatic encephalopathy.