http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Screening and Compound Isolation from Natural Plants for Anti-allergic Activity
( Jong Phil Bak ),( Jong Bo Kim ),( Jong Hyuk Park ),( Yoon Jung Yang ),( In Su Kim ),( Eui Su Choung ),( Se Chan Kang ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Drug discovery for the treatment of allergic disease is an important field in human health. Natural plants and medicinal herbs used commercially in Korea were screened for degranulation inhibitory activities of 164 plant species in the RBL-2H3 cell line, and their activities were investigated using the β-hexosaminidase release assay; 34 species were active. Lactuca indica var. laciniata had the highest degranulation inhibitory activity, and Plantago asiatica, Cimicifuga heracleifolia, Poncirus trifoliata, Lycopus ramosissimus, Quercus mongolica, Anemarrhena asphodeloides, Eugenia caryophyllata, and Curcuma longa exhibited degranulation inhibitory capacity higher than 50% at 125 μg/mL. One compound was isolated by activity-guided fractionation and isolation from methanol (MeOH) extract of A. asphodeloides, which has not yet been identified as constituent for anti-allergic and atopic effects. The structure of isolated compound was elucidated on the basis of NMR and Mass spectrometric data as nyasol, which was highly effective at very low dose (70.98±1.57% at 50 μg/mL). These results demonstrate that natural products and contained compounds may be useful in the therapy of allergic diseases, such as atopic dermatitis and asthma.
박종필 ( Jong Phil Bak ),손정현 ( Jeong Hyun Son ),김용민 ( Yong Min Kim ),이은용 ( Eun Yong Lee ),임강현 ( Kang Hyun Leem ),김이화 ( Ee Hwa Kim ) 경락경혈학회 2011 Korean Journal of Acupuncture Vol.28 No.4
목적: 본 연구는 감초의 염증에 대한 효과를 연구하였다. 감초의 에탄올 그리고 물로 추출한 두 가지의 약침액을 이용하여 쥐의 대식세포에서 유래한 RAW264.7 세포에 대한 염증 억제효과를 확인하였다. 방법: Inducible nitric oxide synthase(iNOS), cyclooxygenase-2(COX-2)를 포함한 염증성 단백질의 발현과 extracellular signal-regulated kinase 1/2(ERK1/2) 그리고 phosphorylated ERK1/2 의 발현을 Western blot 으로 확인하였고, PGE2의 발현은 ELISA 로 확인하였다. 결과: RAW264.7 세포에 감초의 물 혹은 에탄올 추출 약침액을 투여한 결과 투여된 농도에 따라 LPS로 유도된 NO의 생성이 억제되었으며 iNOS, COX-2, 그리고 인산화 ERK1/2 의 발현도 감소되었다. 결론: 본 실험 결과, 적작약의 물 그리고 에탄올 추출 약침액에 대하여 항염증성 효과가 있음을 확인하였다.
Michael B. Ye,Jong Phil Bak,Chi Sun An,Hai Lan Jin,김종문,Hyuk Jung Kweon,박표잠,김영준,임병우,최동국 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5
β-Glucan is known to have anti-inflammatory properties, and several studies have demonstrated the beneficial effects of dietary β-glucan on inflammatory bowel disease (IBD). However, it is unknown how β-glucan mediates its protective effects on IBD. Therefore, we used a well-established mouse model for IBD, interleukin (IL)-10^(–/–) mice, to explore the protective effects of β-glucan on IBD-like symptoms caused by IL-10 deficiency. The mice were divided into two groups: IL-10^(–/–) and IL-10^(–/–) + β-glucan treatment groups. IL-10^(–/–) mice treated with dietary β-glucan exhibited less inflammation within the colon. The levels of immunoglobulins A and E were lower in the serum, spleen, mesenteric lymph nodes, and Peyer's patches in the IL-10^(–/–) mice compared with the IL-10^(–/–) + β-glucan mice. Also, the expression of pro-inflammatory cytokines was lower in the IL-10^(–/–) + β-glucan mice compared with the IL-10^(–/–) mice. Histological analysis also revealed that administration of dietary β-glucan in IL-10^(–/–) mice reduced colonic tissue damage. Finally, the expression of the pro-inflammatory cytokine tissue necrosis factor-α was significantly lower with dietary β-glucan treatment in IL-10^(–/–) mice. In conclusion, dietary β-glucan reduces the inflammation associated with IBD caused by IL-10 deficiency.
Suppression of Inflammatory Macrophage Responese by Glycyrrhiza Uralensis Herbal Acupuncture Extract
박종필,손정현,김용민,이은용,임강현,김이화,Bak, Jong-Phil,Son, Jeong-Hyun,Kim, Yong-Min,Lee, Eun-Yong,Leem, Kang-Hyun,Kim, Ee-Hwa Society for Meridian and Acupoint 2011 Korean Journal of Acupuncture Vol.27 No.3
목적 : 본 연구는 감초의 염증에 대한 효과를 연구하였다. 감초의 에탄올 그리고 물로 추출한 두 가지의 약침액을 이용하여 쥐의 대식세포에서 유래한 RAW264.7 세포에 대한 염증 억제효과를 확인하였다. 방법 : Inducible nitric oxide synthase(iNOS), cyclooxygenase-2(COX-2)를 포함한 염증성 단백질의 발현과 extracellular signal-regulated kinase 1/2(ERK1/2) 그리고 phosphorylated ERK1/2 의 발현을 Western blot 으로 확인하였고, PGE2의 발현은 ELISA 로 확인하였다. 결과 : RAW264.7 세포에 감초의 물 혹은 에탄올 추출 약침액을 투여한 결과 투여된 농도에 따라 LPS로 유도된 NO의 생성이 억제되었으며 iNOS, COX-2, 그리고 인산화 ERK1/2 의 발현도 감소되었다. 결론 : 본 실험 결과, 적작약의 물 그리고 에탄올 추출 약침액에 대하여 항염증성 효과가 있음을 확인하였다.
팔물탕의 항산화 효과와 자외선으로 유도된 각질형성세포 손상에 대한 보호효과
김태연,박종필,Kim, Tae-Yeon,Bak, Jong-Phil 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3
Objective : In this paper, we investigated the anti-oxidative capacities and protective effects of water extract of palmul-tang (PMT) against Ultraviolet B(UVB)-induced oxidative damage in human keratinocytes(HaCaT). Method : To evaluate the anti-oxidative activities of PMT, we measured scavenging activities on 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical, hydroxyl radical, hydrogen peroxide, superoxide anion, lipid peroxidation and reducing power of PMT. To give an oxidative stress to HaCaT cells, UVB was irradiated with $40mJ/cm^2$ to HaCaT cells. To detect the protective effects of PMT against UVB, we measured cell viability, apoptotic bodies and reactive oxygen species(ROS) generation. Results : PMT showed the anti-oxidative activities by scavenging DPPH radical, hydroxyl radical, hydrogen peroxide, superoxide anion, lipid peroxidation. Also PMT showed high reducing values. The UVB-induced oxidative conditions led to the cell apoptosis. However, treatment with PMT reduced oxidative stress conditions, including inhibition of cell apoptosis and expression of ROS. Conclusion : PMT had anti-oxidative activities and exhibited protective effects against UVB on HaCaT cells. PMT would be useful for the development of cosmetics treating UVB-induced skin aging.
Luong, Truc Thanh,Kim, Eun-Hye,Bak, Jong Phil,Nguyen, Cuong Thach,Choi, Sangdun,Briles, David E.,Pyo, Suhkneung,Rhee, Dong-Kwon American Society for Microbiology 2015 Infection and immunity Vol.83 No.1
<P>Alcohol impairs the host immune system, rendering the host more vulnerable to infection. Therefore, alcoholics are at increased risk of acquiring serious bacterial infections caused by <I>Streptococcus pneumoniae</I>, including pneumonia. Nevertheless, how alcohol affects pneumococcal virulence remains unclear. Here, we showed that the <I>S. pneumoniae</I> type 2 D39 strain is ethanol tolerant and that alcohol upregulates alcohol dehydrogenase E (AdhE) and potentiates pneumolysin (Ply). Hemolytic activity, colonization, and virulence of <I>S. pneumoniae</I>, as well as host cell myeloperoxidase activity, proinflammatory cytokine secretion, and inflammation, were significantly attenuated in <I>adhE</I> mutant bacteria (Δ<I>adhE</I> strain) compared to D39 wild-type bacteria. Therefore, AdhE might act as a pneumococcal virulence factor. Moreover, in the presence of ethanol, <I>S. pneumoniae</I> AdhE produced acetaldehyde and NADH, which subsequently led Rex (redox-sensing transcriptional repressor) to dissociate from the <I>adhE</I> promoter. An increase in AdhE level under the ethanol condition conferred an increase in Ply and H<SUB>2</SUB>O<SUB>2</SUB> levels. Consistently, <I>S. pneumoniae</I> D39 caused higher cytotoxicity to RAW 264.7 cells than the Δ<I>adhE</I> strain under the ethanol stress condition, and ethanol-fed mice (alcoholic mice) were more susceptible to infection with the D39 wild-type bacteria than with the Δ<I>adhE</I> strain. Taken together, these data indicate that AdhE increases Ply under the ethanol stress condition, thus potentiating pneumococcal virulence.</P>