자궁적출술 후 통증에 Gabapentin 의 진통효과

최종호,김창성,김은성,유건희,이윤기,문동언,윤건중 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.6

인지질말과 콜레스테롤을 포함한 인지질막의 수용액에서의 산화반응 속도에 관한 연구

康順姬,朴鐘倫,金健,盧貞銀 梨花女子大學校 韓國生活科學硏究院 1988 韓國生活科學硏究院 論叢 Vol.42 No.-

생체막의 중요 성분중의 하나인 지질의 산화반응에 대한 연구로 모델 생체막인 인지질 이중층막을 제조한 후 pH 7.5 완충용액에서 KMnO_4로 산화시킬 때의 속도는 근사 일차 속도식으로 나타났다. PC 이중층막의 산화반응 속도 상수를 25℃에서 40℃ 온도 구간에서 얻어낸 결과 급격한 속도 상승 증가 현상이 PC 이중층막의 상전이 온도 구간에서 관측되었다. 그리고 PC에 콜레스테롤 10mol% 포함한 혼합 이중층막의 산화 속도 상수는 PC 이중층막의 산화속도 상수보다 모든 온도구간에서 크게 나타났다. The kinetics of oxidation of phosphatidyl choline(PC)and PC-cholesterol-reconstituted vesicle on water has been studied at 20°, 25°, 30°, 35°, and 40℃. The oxidation was initiated by KMnO_4 in pH 7.5 Tris-buffer aqueous solution and the product was measured by UV absorption at 230nm. The kinetics of oxidation of PC-vesicle and PC-cholesterol-reconstituted vesicle by KMnO_4 was pseudo-first order reaction. The oxidationof PC-cholesterol reconstituted vesicle was faster than that of PC vesicle. The highest difference of rate constants of PC vesicle was observed in the range of the phase transition temperature (35∼40℃) of PC-vesicle.

무도수련에서 형(形)의 의미

박순진,허건식,윤종대 龍仁大學校 武道硏究所 1998 武道硏究所誌 Vol.9 No.1

Various Katas have characteristics that the orders and methods of attack and defense was designed under agreement. Practicing Katas makes it possible to learn principles of various techniques and to acquire the techniques. These Katas are used for fair judgement and fair criteria to referee in game. Complex techniques have been analyzed and organized to have competitive martial arts from martial arts for training. Since various Kata have its technical implication with representing Kata of various train purposed martial arts, it should neither be criticized nor be modified with ease. Therefore Kata should be carefully studied with maintaining original factors and with organizing Kata for new technique.

성인 IgA 신병증의 임상적 고찰

김영학,권용은,허경무,윤채중,김종인,김건영,배학연,정종훈 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

당뇨병성 합병증을 가진 환자에서 혈중 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

연구 배경 : 고혈당성에 의한 산화환원반응 이상(가저산소증)이 조절 되지않는 당뇨병의 특징으로 혈관과 신경 기능에 대한 진성 저산소증의 효과와 유사하며, 당뇨 합병증의 병태생리에 중요한 역할을 한다. 고혈당이 있는 인슐린 비의존형 당뇨병 환자에서 인슐린 수준이 정상이듯이, 빈혈이 있는 당뇨병 환자에서 EPO의 농도는 실제 혈색소 농도의 감소비율과 차이가 있을 것이라 추측된다. Friedman 등은 당뇨병성 합병증 원인 인자로 가저산소증(pseudohypoxia) 또는 저산소증(hypoxia)을 제기하였고 이런 인자들이 EPO의 상대적 또는 절대적 결핍에 의한 것임을 보고하였다. 방법 : EPO-Trac^(TM 125)I RIA kit을 이용하여 방사면역측정법으로 EPO 수준을 검사하였다. 전혈 3㎖을 5-10㎖ 시험관에 정맥 채혈하였으며, 용혈과 장기간의 보존을 위하여 원심분리를 즉시 시행하여 혈청을 영하 200C에서 냉동 보관 후 일괄적으로 검사 결과를 얻었다. 결과 : 1996년 9월부터 1997년 2월까지 조선대학교 부속병원 내과에 입원한 2형 당뇨병 환자 63례를 대상으로 하여 다음과 같은 결과를 얻었다. 1) 당뇨병성 합병증이 없는 군과 있는 군간의 혈색소, 혈중 EPO농도의 차이는 유의한 차이가 있었으며 혈색소의 감소율보다 혈중 EPO의 감소율이 더 높았다. 2) 당뇨병성 망막증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으나 혈중 EPO농도는 유의한 차이가 있었다. 증식성군에서만 혈중 EPO의 감소비율이 혈색소에 비해 높았다. 3) 당뇨병성 신증의 유무에 따른 혈색소, 혈중 EPO농도는 유의한 차이가 있었고 혈색소 감소율에 비해 EPO농도의 감소율이 높았다. 신증의 중증도에 따른 혈색소, EPO의 차이는 미세알부민뇨군을 제외하고는 유의한 차이를 보였고 혈색소 감소율에 비해 EPO의 감소율이 더높았다. 4) 당뇨병성 신경병증의 유무에 따른 혈색소 농도의 차이는 유의한 차이가 없었으며 EPO농도는 유의한 차이를 보였다. 혈색소와 EPO의 감소비율은 비슷하였다. 신경병증의 중등도에 따른 혈색소와 EPO농도의 변화는 유의한 차이가 없었으나 stage 3에서는 혈색소감소율보다 EPO감소율이 더높았다. 결론 : 당뇨병성 합병증을 가진 환자에서 빈혈의 정도는 대부분 혈청 EPO치의 절대적 감소에 의함을 간접적으로 밝혀낼 수 있었으며 차후 더 많은 대상으로 비교 분석이 필요하리라 사료된다. Background: Hyperglycemic-induced redox(pseudohypoxia) imbalance is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural functions and plays an important role on the pathogenesis of diabetic complications. As is true for apparently "normal" insulin levels typically found in NIDDM even in the presence of hyperglycemia, a "normal" erythropoietin level in an anemic diabetic subject may be disproportionally low for the actual red cell mass. Therefore, Friedman et al suggested that pseudohypoxia or hypoxia as an etiological factor of diabetic complications are due to absolute or relative erythropoietin deficiency Method: EPO-TracTM 125I RIA kit was used for the quantitative determination of erythropoietin(EPO) in serum by radioimmunoassay. An adequate sample of blood (3ml whole blood) was collected aseptically by venipuncture in a 5~10ml glass tube to yield a minimum of 400 L of serum per assay. The serum was promptly removed from the clot by centrifugation in order to avoid hemolysis. Then to increase its storage time it was frozen at -200C in a nonself defrosting freezer. Finally, tests were undertaken simultaneously Results We studied 63 cases with diabetes mellitus, who were admitted to Chosun University Hospital from September, 1996 to February, 1997 at the Department of Internal Medicine. We defined the control group, as diabetic patients who did not have anemia(<13mg/dl), diabetic complications(retinopathy, nephropathy, neuropathy) and the remainders were defined as the experimental group(we excluded anemic patients, who had secondary causes of anemia and diabetic patients with end stage renal disease)Data were as follow 1) The relationship of Hb and the 24hr urine protein between diabetic patients with and without complications significantly differed(p=0.02, < 0.001 respectively), but the Hb level was poorly related between diabetic patients with and without retinopathy(except in preproliferative, proliferative subgroups) and neuropathy. 2) Subgroups of patients with diabetic complications had higher 24hr urine protein than patients without diabetic complications, except stage I diabetic neuropathy 3) The EPO level was significantly different between diabetic patients with and without complications. 4) The correlation between EPO and Hb was significantly different, especially in diabetic patients with retinopathy and nephropathy according to severity of diabetic complications, compared with patients who did not have diabetic complications such as retinopathy and nephropathy. Conclusion: We know that anemia induced by diabetic complications is due to relative EPO deficiency than absolute EPO deficiency, and further evaluation and studies are needed on many cases in the future

당뇨병성 합병증을 가진 환자에서 혈증 Erythropoietin 농도

김동규,유기동,허광식,김상용,윤성호,조영신,권용은,김태원,김건영,정종훈,배학연 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

Two-dimensional Supramolecular Structures by Hydrogen and Halogen Interactions

Jong Keon Yoon,Howon Kim,Kyung-Hoon Chung,Se-Jong Kahng 한국진공학회 2010 한국진공학회 학술발표회초록집 Vol.38 No.-

Achieving chiral resolution in self-assembled supramolecular structures through kinetic pathways

Yoon, Jong Keon,Son, Won-joon,Kim, Howon,Chung, Kyung-Hoon,Han, Seungwu,Kahng, Se-Jong IOP Pub 2011 Nanotechnology Vol.22 No.27

<P>Chiral phase transitions were studied in a self-assembled 2,6-dibromoanthraquinones supramolecular system prepared on Au(111) using scanning tunneling microscopy. As the molecules were deposited at about 150 K, they formed heterochiral chevron structures (a racemate) consisting of two alternating prochiral molecular rows. When the as-deposited sample was warmed to 300 K followed by cooling to 80 K, phase-separated homochiral structures (a conglomerate), as well as the chevron structures, were observed. We propose molecular models for the structures that are in good agreement with <I>ab initio</I> studies and can be explained by hydrogen bonds and halogen bonds. We found that heterochiral chevron structures were more stable than homochiral structures due to two additional <img SRC='http://ej.iop.org/images/0957-4484/22/27/275705/nano388856ieqn1.gif' ALIGN='MIDDLE' ALT='\mathrm {O} \cdots \mathrm {Br} '/> halogen bonds per molecule. We considered kinetic pathways for the phase transitions that were made possible via a disordered liquid phase entropically stabilized at 300 K. We show how chiral resolution can be achieved by exploiting kinetic paths allowed in supramolecular systems. </P>

Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections

Jong Hui Suh,Jeong-Seob Yoon,Hwan Wook Kim,Keon Hyon Jo 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.6

Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this repair mechanisms are well-balanced and adequately functional cellular components of the aortic wall, including endothelial cells, smooth muscle cells (SMCs), inflammatory cells, and adventitial fibroblasts. Adventitial fibroblasts naturally produce aortic extracellular matrix (ECM), and, when aortic wall is injured, they can be transformed into SMCs, which in turn are involved in aortic remodeling. We postulated the hypothesis that adventitial fibroblasts in patients with TAAD may have defects in ECM production and SMC transformation. Materials and Methods: Adventitial fibroblasts were procured from the adventitial layer of fresh aortic tissues of patients with TAAD (Group I) and of multi-organ donors (Group II), and 4-passage cell culture was performed prior to the experiment. To assess ECM production, cells were treated with TNF-α (50 pM) and the expression of MMP-2 / MMP-3 was analyzed using western blot technique. To assess SMC transformation capacity, cells were treated with TGF-β1 and expression of SM α-actin, SM-MHC, Ki-67 and SM calponin was evaluated using western blot technique. Fibroblasts were then treated with TGF-β1 (10 pM) for up to 10 days with TGF-β1 supplementation every 2 days, and the proportion of transformed SMC in the cell line was measured using immunofluorescence assay for fibroblast surface antigen every 2 days. Results: MMP-3 expression was significantly lower in group I than in group II. TGF-β1-stimulated adventitial fibroblasts in group I expressed less SM α-actin, SM-MHC, and Ki-67 than in group II. SM-calponin expression was not different between the two groups. Presence of fibroblast was observed on immunofluorescence assay after more than 6 days of TGF-β1 treatment in group I, while most fibroblasts were transformed to SMC within 4 days in group II. Conclusion: ECM production and SMC transformation are compromised in adventitial fibroblasts from patients with TAAD. This result suggests that functional restoration of adventitial fibroblasts could well be a novel approach for the prevention and treatment of TAAD.

선천적으로 후두개가 없는 환자에서의 기관내 삽관

윤건중,김종렬 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.2

A 27-yr old female patient who had a lumbar herniated nucleus pulposus was scheduled to undergo a laminectomy. In the past history, she has suffered from frequent upper respiratory infection and muffled voice. When we tried to intubate the patient for general anesthesia by routine method, we could not find the epiglottis and vocal cord. Fortunately we could intubate sucessfully through the folds were composed of hypertrophied aryepiglottic muscle and arytenoid cartilage between the tongue base and pharynx. In the postoperative period, we made observation of anatomical structure around the vocal cord by fiberoptic laryngoscope. We confirmed a congenital absence of epiglottis, hypertrophy of aryepiglottic fold and arytenoid region, elongated larynx and a large false vocal cord. (Korean J Anesthesiol 1997; 32: 302∼305)