치아 우식증의 조기 진단을 위한 QLF-D 개발

박형주,김종수,유승훈,신지선 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

QLF-D system composed with DSLR(digital single-lens reflex) camera, and the images of natural enamel caries and artificial caries was developed from 2 days to 14 days captured by QLF-D system. The correlation between lesion depth of the polarized microscope and luminosity ratio of QLF-D image was analyzed and the results were summarized as follows: 1. The Pearson correlation value between the lesion depth of polarized microscope images and luminosity ratio of QLF-D images was 0.969(p<0.01). 2. From Regression analysis of lesion depth from polarized image by demineralized period, the equation was y = 8.67x - 1.16(p<0.05). 3. From Regression analysis of luminosity ratio from QLF-D image by demineralized period, the equation was y = 3.53x + 6.42(p<0.05). From the results, QLF-D system can detect the enamel caries at the very early stage and can monitor the progression of demineralization and remineralization. For the convenient use of QLF-D system in the laboratory, the image analysing software was needed to analyze of interest site of enamel caries lesion. 저자는 DSLR(digital single-lens reflex) 카메라를 이용한 QLF-D 시스템을 고안하여, 사람의 유구치에 자연 발생된 법 랑질 초기 우식증을 관찰하고, 유구치 법랑질 시편을 대상으로 2일부터 14일까지 인공 탈회시킨 후 탈회 기간에 따른 상관관 계를 편광 현미경 소견과 비교 분석한 결과 다음과 같은 결과를 얻었다. 1. 탈회 기간에 따른 편광 현미경 상의 병소 깊이와 QLF-D 영상의 광밀도 값 비율 간의 피어슨 상관 계수는 0.969였다 (p<0.01). 2. 편광현미경에서 측정된 병소 깊이의 탈회 기간에 대한 회귀분석 결과 y=8.67x-1.16의 회귀 방정식이 산출되었다 (p<0.05). 3. QLF-D 영상에서 측정된 광도값 비율의 탈회 기간에 대한 회귀분석 결과 y=3.53x+6.42의 회귀 방정식이 산출되었다 (p<0.05).

면직물과 면/닥섬유 혼방직물의 질감이미지와 선호도 평가

신주동, 김여원, 최종명 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

The purpose of this study was to examine the subjective evaluation of texture images and preferences for cotton and cotton/mulberry blended fabrics in order to suggest the fabric planning for environment-friendly fashion products. Fifty male and female university students evaluated the texture images and preferences of cotton and cotton/mulberry blended fabrics dyed with natural indigo dye. For statistical analysis, frequency, mean, factor analysis, t-test, F-test and Pearson correlation. The results were as follows: The texture images of cotton and cotton/mulberry blended fabrics were classified into 4 factors: 'stiffness', 'elasticity', 'weight', and 'smoothness'. They evaluated significant differences according to the fiber content in the texture images for the fabrics. Also, there were partially significant differences by the gender in the texture images for the fabrics. Female students were more sensitive than males for the 'stiffness' and 'elasticity' factor. They were more preferred cotton fabrics than cotton/mulberry blended fabrics in terms of tactile and purchase preferences. The preferences of tactile were no different according to the gender, but there was significant difference according to the gender in terms of purchase preference.

매복된 상악 전치부의 자가이식 치험례

김신,음종혁,이애련,서수정,김주미,김주영,황보민 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.2

The autotransplantation procedure were performed for the cases with impacted maxillary anterior teeth, which were thought unrealistic by the treatment with surgical exposure and orthodontic traction into the arches. The results were as follow : 1. As the treatment with autotransplantation is the last resort, the case indicated should be selected cautiously by adequate case analysis. 2. In order to reduce postoperative complication, damages to periodontal ligaments and adjacent bony structures should be minimized by conservative surgical procedures. 3. After autotransplantation procedures, postoperative endodonic treatment and continuous follow-up check with clinical and radiographic examination should be followed. Although the autotransplantation procedure is not the treatment of choice in most cases, it was thought to be a good alternative in certain cases when orthodontic treatment is unrealistic with continuous study to overcome the handicaps.

수종 식물추출물의 항히스타민작용

이신웅,이윤주,손종근 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

The antihistaminic action of eighteen herbal medicines was investigated by the radioligand binding and functional assays. The hexane fractions of Trichosanthis radix, Mori cortex radicis and Evodiac fructus dose-dependently inhibited [³H]mepyramine binding to H, receptor in guinea-pig brain homogenates and histamine-induced contraction of isolated guinea-pig ileum. Antihistaminic action of the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus was more potent than their antimuscarinic action evaluated from the inhibition of [³H]QNB binding and carbachol response. The ethyl acetate and chloroform fractions from Scutcllariae radix also inhibited histamine-induced contraction, but antihistaminic potencies of these fractions were almost identical with their antimuscarinic potencies. The hexane fractions of Mori cortex radicis and Evodiae fructus inhibited selectively the increase of histamine-induced cutaneous vascular permeability in the rat dorsal skins. However, the ethyl acetate fraction from Scutellariae radix inhibited eqipotently the effects of histamine and serotonin on the vascular permeability. These results demonstrate that the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus have the selective histamine H₁ receptor blocking activity.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

PCR을 이용한 Rat 기관지 세척액에서의 Pneumocystis carinii DNA의 검출 : 기초실험 A pilot study

김주옥,홍석철,한표성,이종진,김선영,이영하,신대환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

Background: Pneumocystis carinii (PC) is a opportunistic pathogen causing serious pneumonia (Pneumocystis carinii pneumonia : PCP) in immunosuppressed patients including AIDS. Laboratory diagnosis of PCP is dependent on microscopic demonstration of the PC by using cytochemical staining or by immunocytochemical staining with monoclonal antibodies. However, these staining methods are not highly sensitive. The development of the polymerase chain reaction (PCR) has made it possible to detect very small numbers of pathogens in clinical specimens. To establish the usefulness of PCR for detection of PC DNA, We performed PCR as a pilot study. Methods: PCP was induced on Spraque-Dawley rats with prednisolone 5mg IM twice a week. Bronchial lavages, impression smears, and permanent sections were performed from the 3rd week to 7th week of cortisonized rats. PC DNA was extracted with bead beater / 10% CTAB method. Results: Impression smears showed PC cyst after the 4th week (100%, 28/28 rats), and permanent sections showed 27/28 rats. Control rats showed some PC cysts (2/7). PCR result was positive only one case among the 6th week rats (1/7), But positive 6 cases at the 7th week rats, (6/7). Among control rats. 2 cases were positive (2/7). ??This data is a pilot study for the PC DNA detection using a PCR. PCP were successfully cortisonized rats. If adequate bronchial washing technique will be used, PCR can be a sensitive for PC DNA detection.

광도와 온도가 가시광선 중합형 치과용 레진의 중합에 주는 영향

이종근,최주열,임범순,신현철 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.4

본 연구에서는 2종의 다이메타크릴레이트 치과용 레진 (urethane dimethacylate, UDMA와 bisphenol A glycerolate dimethacylate, Bis-GMA)이 광중합 반응하는 과정에서 변화되는 물성을 동역학분석법 (dynamic mechanical analysis, DMA)으로 관찰하였다. 광중합에 사용한 가시광선 (λ=400-500 nm)의 광도는 20 mW/㎠에서 70, 120, 300 및 600 mW/㎠로 변화시켜 그에 따른 저장탄성율 (storage modulus, G')과 손실탄성율 (loss modulus, G")의 변화를 측정하였고, 측정온도도 25 ℃에서 37, 50 및 60 ℃로 변화시켜 온도가 중합과정에 주는 영향을 관찰하였다. 광조사 시간은 모든 시편에 대하여 측정 시작 직후 30초로 일정하게 하였다. 각 조건에서 측정한 G' 과 tan δ (=G"/G') 결과를 이용하여 겔화 (gelation)와 유리화 (vitrification) 전이시점 (transition point)을 결정하였으며, 이를 이용하여 TTIT (Time-Temperature-Intensity-Transformation) 중합 도표를 작성하였다. 이 중합도표를 보면 광도 변화가 온도 변화보다 중합반응에 더 민감하게 영향을 주었으며, 특히 광도는 겔화보다 유리화에 훨씬 크게 영향을 주는 것을 알 수 있었다.

Capsaicin과 Paradol이 구강내 유해자극에 의한 개구반사와 신경흥분 전달에 미치는 영향

최동주,신일영,김중수,이종흔 대한구강생물학회 1988 International Journal of Oral Biology Vol.12 No.2

This study was performed to elucidate the analgesic mechanism of paradol and to compare effects of paradol with those of dihidrocapscaicin(DHC). Rabbits(2-2.5kg both sexes) were anesthetized with pentobarbital sodium(30mg/kg I.V.), and cannulated in trachea and external jugular vein. To observe effects on jaw opening reflex, inferior alveolar nerve(IAN) of both sides were exposed for drug application, and wire electrodes were inserted in anterior belly of digastric muscle for recording of EMGs of anterior belly of digastric muscle(dEMG) and in oral mucosa covering mental foramen for applying noxious stimulation. dEMGs evoked by noxious stimulation with double intensity of threshold for digastric EMG were recorded in magnetic tape recorder. To observe effects on action potential, saphenous nerve were exposed, and three tissue pools were made from surrounding tissue. The most distal pool was used for applying stimulation, the most proximal one for recording of action potentials, and the other on for drug application. Action potentials evoked by 200 folds intensity of threshold for most sensitive fiber were recorded in magnetic tape recorder. One side of IAN and saphenous nerves were used for DHC or paradol applications, the other side of nerves for control experiments(only vehicle application). Vehicle consisted of 10% Tween 80, 10% ethanol and 80% physiological saline(v/v), and drugs were solubilized in vehicle for 1.5% concentration(w/v). dEMGs and action potentials were recorded before drug application, immediate after 30 minutes drug application, at 30 and 60 minutes after drug had been washed out. DHC application on IAN could not influence on dEMG, but paradol application decreased the amplitude of dEMG. In action potential experiments, DHC decreased amplitude and conduction velocity of only C fiber, while paradol did those of C-fiber and Aδ-fiber.

시판 양말의 내구성에 관한 연구

김종은,박은희,신연주,이운희 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

This study was purposed to investigate the durability of mens socks. We purchased samples which were four kinds of cotton 100%, wool 100%, wool/nylon 65/35%, acryl/polyester/nylon 70/20/10% at several department store in Daegu city, then measured abrasion strength and bursting strength at 65, 75, 84, 95% relative humidity. The results were summarized as follows. 1. Durability of socks decreased in propotion as relative humidity increased. 2. The greatest durability of socks was acryl/polyester/nylon 70/20/10%, the least was wool 100%. 3. Abrasion strength of socks was distinguisedly decreased at high relative humidity environment which was more than 84%.

트리암시놀론아세토나이드 함유 구강점막 필름제의 제제설계 및 평가

이계주,박종범,신광현,이덕근,황성주 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

To design and evaluate the double-layered mucoadhesive film preparation for the treatment of aphthous stomatitis, the film consisting of an adhesive layer containing triamcinolone acetonide and impermeable protective layer was prepared by a solvent-casting evaporation technique and subsequent drying. The polymers, Polycarbophil®, Carbopol®, CMC and gelatin, swell appoximately 2 times its volume in 30 minutes when added to water. In vitro adhesive time was longer than 8hrs and adhesive force was 177-482g/㎤. The diffusion rate of triamcinolone acetonide from film was faster than that of commercial tablet but slower than that of the film. the effect of plasticizer on the protective layer showed that the more amount of plasticizer, the greater elongation, the lesser tensile strength. The stability of drug in the film revealed that no significant reduction in the content of triamcinolone acetonide during a period of six months at room temperature and 40℃ 75% RH. Drug deposit amount permeated through hsmster cheek pouch mucosa from film was greater than that of control film and tablet. In human oral mucosa, adhesive time was between 2.38∼2.83hrs. The adhesive feeling to the human muoscal membrane of sample was better than compared with commercial film and tablet.