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Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules
( Jiyoung Ahn ),( Yusung Choi ),( Eric Lawrence Simpson ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.2
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. In contrast to biologics, small molecules are similar to conventional pharmacologic chemical agents used as drugs and are generally prepared by chemical synthesis. Unlike biologics, these drugs often are taken orally or formulated for topical use. The purpose of this review is to summarize the efficacy and safety of the current topical and systemic new therapies in AD by reviewing recently published papers on therapies currently in phase 2 or 3 clinical trials. In this review, it is important to note the characteristics of the study population, the primary endpoints, and whether or not there was concomitant topical therapy allowed. These study design elements may significantly alter the results of studies and should be taken into account. Targeted therapy help push AD treatment into a new era of personalized medicine. (Ann Dermatol 33(2) 101 ∼107, 2021)
Facial erythema in patients with atopic dermatitis treated with dupilumab
( Jiyoung Ahn ),( Dong Heon Lee ),( Chan Ho Na ),( Dong Hyun Shim ),( Yu Sung Choi ),( Hye Jung Jung ),( Eric L. Simpson ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1
Background: The development of an eczematous rash on face and neck, which was not described in phase 3 clinical trials, is being reported in the literature in patients treated with dupilumab. Little is known regarding the causes or features of the facial dermatitis. Objectives: We conducted surveys of 162 severe AD patients treated with dupilumab to describe its clinical features, morphology, and etiology. Methods: A multicenter prospective cohort study was conducted from January 1, 2020, to December 31, 2020. A total of 162 patients under dupilumab treatment were asked to complete a questionnaire and patients were evaluated by dermatologists. Results: Out of all 162 patients, 84.6 percent had pre-existing facial dermatitis PRIOR to dupilumab therapy. 121 (88.3 %) patients of them got better after the treatment, 9 (6.6 %) patients of them had no change after the treatment, but 7 (4.3 %) patients of them got worse after the treatment. Out of 25 patients who had not pre-existing facial dermatitis PRIOR to the therapy, 6 (3.7 %) patients of total experienced new-onset facial erythema after the treatment. A large proportion of the patients in both groups had a history of TCS use. Conclusion: In severe AD patients treated with dupilumab, additional or new-onset development of an eczematous rash on face and neck after dupilumab treatment did not frequently occur. Although the mechanisms of this adverse event remains unclear, the possibility of topical corticosteroids withdrawal cannot be excluded.
FC 1-1 : Facial erythema in patients with atopic dermatitis treated with dupilumab
( Jiyoung Ahn ),( Dong Heon Lee ),( Chan Ho Na ),( Dong Hyun Shim ),( Yu Sung Choi ),( Hye Jung Jung ),( Eric L. Simpson ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: The development of an eczematous rash on face and neck, which was not described in phase 3 clinical trials, is being reported in the literature in patients treated with dupilumab. Little is known regarding the causes or features of the facial dermatitis. Objectives: We conducted surveys of 162 severe AD patients treated with dupilumab to describe its clinical features, morphology, and etiology. Methods: A multicenter prospective cohort study was conducted from January 1, 2020, to December 31, 2020. A total of 162 patients under dupilumab treatment were asked to complete a questionnaire and patients were evaluated by dermatologists. Results: Out of all 162 patients, 84.6 percent had pre-existing facial dermatitis PRIOR to dupilumab therapy. 121 (88.3 %) patients of them got better after the treatment, 9 (6.6 %) patients of them had no change after the treatment, but 7 (4.3 %) patients of them got worse after the treatment. Out of 25 patients who had not pre-existing facial dermatitis PRIOR to the therapy, 6 (3.7 %) patients of total experienced new-onset facial erythema after the treatment. A large proportion of the patients in both groups had a history of TCS use. Conclusion: In severe AD patients treated with dupilumab, additional or new-onset development of an eczematous rash on face and neck after dupilumab treatment did not frequently occur. Although the mechanisms of this adverse event remains unclear, the possibility of topical corticosteroids withdrawal cannot be excluded.
Correlation of atopic dermatitis with measurement tools in Korean patients: a retrospective study
( Jiyoung Ahn ),( Jae In Lee ),( Eric L. Simpson ),( Dong Heon Lee ),( Dong Hyek Jang ),( Jooyoon Bae ),( Hyejung Jung ),( Miyoun Park ),( Seongjun Seo ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease adversely affecting the patient’s quality of life (QOL). Current research is focussed on developing diagnostic tools for assessing its severity and possible treatment outcomes. The results of a clinical study with dupilumab have been published. Objectives: To determine a correlation between the AD patient’s assessment tools and to identify the precision of assessment tools which reflected the improvement in QOL of AD patients who were treated with dupilumab. Methods: We conducted a retrospective study on AD patients who were administered dupilumab from September 2018 to February 2019 in the department of dermatology at National Medical Center. We correlated the Eczema Area Severity Index (EASI), Numeric Rating Scale (NRS), Patient-Oriented Eczema Measure (POEM) and Dermatologic Life Quality Index (DLQI) at 0 and 16 weeks of dupilumab treatment. Results: Overall 64 patients were included in our study. The EASI and DLQI scores failed to show any correlation. POEM and DLQI showed maximum correlation (r = 0.54), followed by NRS and DLQI (r = 0.51). In addition, POEM and NRS (r = 0.59) and EASI and NRS (r = 0.3) were correlated, whereas EASI and POEM showed no correlation (r = 0.19). The changes in POEM assessment showed maximum correlation with changes in DLQI (r = 0.6), followed by a correlation with changes in EASI. Conclusion: POEM is a useful assessment tool that evaluates skin lesions and subjective symptoms.