Decolonization of Methicillin resistant Staphylococcus aureus: Role in the Neonatal Intensive Care Unit

Jiwon Koh,In-Gyu Song,Sae Yun Kim,Younghwa Jung,Seung Han Shin,Ee Kyung Kim,Han Suk Kim,Jung Hwan Choi,이주영 대한신생아학회 2016 Neonatal medicine Vol.23 No.2

Purpose: We aimed to assess the incidence of methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection in a neonatal intensive care unit (NICU) by using various decolonization methods and to evaluate their efficacy. Methods: Medical records of all neonates who were admitted to the NICU of Seoul National University Children's Hospital were retrospectively reviewed. Surveillance culture were obtained for all neonates in the NICU 48 hours after admission. Three periods with different decolonization methods were compared; Period 1 was without any decolonization measures (July 1, 2009 to August 26, 2010). In period 2, intranasal mupirocin and chlorhexidine gluconate bathing were administered to MRSA-colonized neonates (August 27, 2010 to September 6, 2011). In period 3, only chlorhexidine bathing was performed for MRSA-colonized infants (September 7, 2011 to August 31, 2012). Results: A total of 1,378 infants were admitted to the NICU during the study period. Baseline demographic and clinical characteristics were similar among the 3 periods. The incidence of MRSA colonization per 1,000 patient-days was 6.27 for period 1, 7.02 for period 2, and 6.29 for period 3; however, these values were not significantly different. The incidence of MRSA infection was highest in period 3, with 0.69 cases per 1,000 patient-days; however, this finding was not significant. The MRSA infection/colonization ratio also did not differ significantly among the 3 study periods. Conclusion: Decolonization of MRSA in the NICU with the application of chlorhexidine gluconate bathing alone or in combination with intranasal mupirocin were not effective in decreasing the incidence of MRSA colonization and infection.

Rheumatoid Factor Positivity is Associated with Lower Bone Mass in Korean Male Health Examinees without Clinically Apparent Arthritis

( Jiwon Hwang ),( Joong Kyong Ahn ),( Jaejoon Lee ),( Eun-mi Koh ),( Hoon-suk Cha ) 대한류마티스학회 2019 대한류마티스학회지 Vol.26 No.1

Objective. This cross-sectional study aimed to investigate the association between rheumatoid factor (RF) positivity and bone mineral density (BMD) in male Korean subjects without any history of joint disease. Methods. Of 84,344 males who had undergone a comprehensive health checkup program in 2012, 1,390 male health examinees were recruited, whose BMD and RF results were available. A RF titer ≥20 IU/mL was considered positive. BMD was measured at lumbar spine (L1∼L4) or hip (femoral neck and total hip) by dual-energy X-ray absorptiometry. Results. The association between RF positivity and BMD was assessed by multiple linear regression analysis. The mean age was 52.7±10.9 years (range 19∼88 years), and RF was detected in 64 subjects (4.6%). Demographics and laboratory data were not different between RF-positive and -negative subjects except hepatitis B surface antigen (HBsAg), which was more frequently seen in RF-positive subjects (15.6% vs. 4.3%, p=0.001). RF-positive subjects had significantly lower BMD compared to RF-negative subjects in lumbar spine but not in total hip regardless of the existence of HBsAg (1.17±0.16 g/㎠ vs. 1.10±0.18 g/㎠, p=0.002 in total subjects; 1.17±0.16 g/㎠ vs. 1.10±0.18 g/㎠, p=0.004 in HBsAg-negative subjects). After adjusting for multiple confounders, RF positivity was negatively associated with lumbar spine BMD (B=-0.088 and standard error=0.035, p=0.011). Conclusion. Our results show that the presence of RF could have an unfavorable impact on bone density in apparently normal males. Additional studies to elucidate the osteoimmunological mechanism of rheumatoid factor are warranted. (J Rheum Dis 2019;26:31-40)

Tuning Cage Dimension in Clathrate Hydrates for Hydrogen Multiple Occupancy

Koh, Dong-Yeun,Kang, Hyery,Jeon, Jiwon,Ahn, Yun-Ho,Park, Youngjune,Kim, Hyungjun,Lee, Huen American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.6

<P>As hydrogen molecules enter the clathrate hydrate body, the ubiquitous dodecahedral cavity (5<SUP>12</SUP>) is too small to allow anything but single occupancy thermodynamically. The possibility that H<SUB>2</SUB> double occupancy can occur in the dodecahedral cavity has been suggested and is still under debate. Here we uncover the unique feature of multiple occupancy of the hydrogen molecule in a dodecahedral cavity as induced by tuning the cage dimensions. The guest promoter population in the hydrate matrix spontaneously controls the degree of molecular hydrogen storage by tuning the cage dimensions. Our analysis combined with computational study reveals that only ∼1% expansion (∼3% in volume) of the cage dimensions is sufficient to provide thermodynamically stable room for double occupancy in the dodecahedral cavity. The findings in this research provide a strategy for doubling the hydrogen population in dodecahedral cavities in structure II hydrates.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-6/jp410632q/production/images/medium/jp-2013-10632q_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp410632q'>ACS Electronic Supporting Info</A></P>

Gastric inverted hyperplastic polyp with inflammatory myofibroblastic tumor-like stroma, mimicking GI stromal tumor

Elsevier 2019 Gastrointestinal endoscopy Vol.89 No.2

Effect of Single-BaseMutation on Activity and Foldingof 10-23 Deoxyribozyme Studied by Three-Color Single-Molecule ALEXFRET

Jung, Jiwon,Han, Kyu Young,Koh, Hye Ran,Lee, Jihyun,Choi, Yoon Mi,Kim, Christine,Kim, Seong Keun AmericanChemical Society 2012 The journal of physical chemistry. B, Condensed ma Vol.116 No.9

<P>We investigated the effect of single-base mutation onthe RNA-cleavingactivity and ion-induced folding of 10-23 deoxyribozyme at the single-moleculelevel by 3-color ALEX FRET (alternating laser excitation fluorescenceresonance energy transfer). We found that substitution or deletionof a single base in the active region of the enzyme leads to a differentfolding pathway and enzymatic activity for all three mutants studied,but the severity of the effect was dependent on the type of mutationand the mutation site. We suggest that mutation of even a single basemay result in a considerably different ionic and hydrogen-bondinginteractions. Structural changes of 10-23 deoxyribozyme as it successivelybinds with Mg<SUP>2+</SUP> and the substrate were also unambiguouslyidentified by the current single-molecule-detection method.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcbfk/2012/jpcbfk.2012.116.issue-9/jp2117196/production/images/medium/jp-2011-117196_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp2117196'>ACS Electronic Supporting Info</A></P>

시각장애인을 위한 장애물 회피 및 목적지 안내 시스템

고인석(Inseok Koh),김지원(Jiwon Kim),조희승(Heeseung Jo),Eric T. Matson 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.6

Acute Respiratory Failure due to Alveolar Hemorrhage after Exposure to Organic Dust

Sun Mi Choi,Jiwon Koh,Sang-Min Lee,Jinwoo Lee 대한중환자의학회 2016 Acute and Critical Care Vol.31 No.2

Diffuse alveolar hemorrhage (DAH) is associated with severe outcomes. We report a case of acute respiratory failure that required mechanical ventilation and was clinically and pathologically diagnosed as DAH related to exposure to organic dust. A 39-year-old man, who had visited a warehouse to grade beans for purchase, was referred to our hospital for impending respiratory failure. His initial radiographic examinations revealed diffuse bilateral ground-glass opacities in his lungs and bronchoalveolar lavage resulted in progressively bloodier returns, which is characteristic of DAH. He underwent bedside open lung biopsy of his right lower lobe in the intensive care unit. Biopsy results revealed DAH and organization with accumulation of hemosiderin-laden macrophages and a few fibroblastic foci. The patient was treated with empirical antibiotics and high-dose corticosteroids and successfully weaned from mechanical ventilation. DAH might be considered in the differential diagnosis of patients with acute respiratory failure after exposure to organic particles.

Sonographic evaluation of bladder wall thickness in women with lower urinary tract dysfunction

( Un Ju Shin ),( Jihye Koh ),( Jiwon Song ),( Soyun Park ),( Eun Joo Park ),( Chung-hoon Kim ),( Sung Hoon Kim ),( Byung Moon Kang ),( Hee Dong Chae ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3

Objective To investigate the correlation between bladder wall thickness (BWT) measured by ultrasonography and lower urinary tract dysfunction (LUTD) in patients with lower urinary tract symptoms (LUTS). Methods Forty-eight women with LUTS who underwent urodynamic study and BWT by ultrasonography as outpatients were studied. We assessed LUTS during a medical examination by interview. The thinnest part of the bladder wall was measured by a transabdominal ultrasonography. We excluded patients who had visited another hospital previously because we did not know what treatment they had received, including medications, behavioral therapy, or other treatments. We constructed receiver operating characteristic (ROC) curves for diagnosis of LUTD and also determined reliable BWT criteria by calculating the area under the curve. Statistical analyses were performed using the Kolmogorov-Smirnov method and Student's t-test. Results The mean age, body mass index, and duration of symptoms were 59.9±9.7 years, 26.06±3.4 kg/㎡, and 53.4±38.2 months, respectively. Urodynamic study parameters (Valsalva leak point pressure, maximal urethral closure pressure, functional length, and postvoid residual volume) were lower in patients with BWT <3 mm; however, these differences were not significant. Patients with BWT ≥3 mm developed a hypoactive bladder (P=0.009) and intrinsic sphincter deficiency (ISD) (P=0.001) at a significantly higher rate. According to the ROC analysis, the best BWT cut-off value was 3 mm for overactive bladder diagnosis. Conclusion Women with LUTD showed higher BWT values (≥3 mm), especially patients with hypoactive bladder and ISD. Sonographic evaluation of BWT is an easy, fast, and noninvasive method for possible diagnostic tool for LUTD.

Surgical Management of Residual or Recurred Hibernoma of the Neck

Kim Young Chul,Koh Jiwon,Kwon Seong Keun 대한후두음성언어의학회 2023 대한후두음성언어의학회지 Vol.34 No.2

A 16-year-old girl was incidentally found to have a mediastinal lipogenic mass, which was confirmed as a hibernoma on biopsy. Mediastinal mass excision with full sternotomy was performed, and follow-up chest computed tomography at postoperative 1 year revealed a residual or recurred mass at the left neck (level VI). Consequently, left level-VI neck dissection was performed, and the biopsy also confirmed hibernoma. During neck dissection, an electromyography tube was used to monitor the recurrent laryngeal nerve, and complete removal was achieved without damage to the vagus nerve, carotid vessels, or thyroid gland. When managing cervical lipogenic tumors, clinical suspicion is necessary, followed by radiological and pathological evaluations to differentiate malignancies. If a hibernoma is suspected, en bloc resection of the tumor is crucial to prevent hemorrhage and recurrence. Cervical hibernoma can cause symptoms such as dysphagia, weight loss, and exertional dyspnea owing to its mass effect. Surgeons should be cautious during tumor removal to protect the recurrent laryngeal nerve. We successfully removed the residual or recurred hibernoma in the neck without complications.

Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study

( Hee Seung Hong ),( Jiwon Baek ),( Jae Chul Park ),( Ho-su Lee ),( Dohoon Park ),( A-ran Yoon ),( Soo Jung Park ),( Sung Noh Hong ),( Seong-joon Koh ),( Chang Kyun Lee ),( Bo-in Lee ),( Sung Wook Hwa 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6

Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene. We aimed to investigate the clinical and genetic characteristics of Korean patients diagnosed with CEAS. Methods: From July 2018 to July 2021, we performed Sanger sequencing of the SLCO2A1 gene in 46 patients with chronic intestinal ulcers. CEAS was confirmed based on known SLCO2A1 mutations. We summarized the clinical characteristics of patients with confirmed CEAS. Results: Fourteen out of 46 patients (30.4%) had genetically confirmed CEAS, and two SLCO2A1 variants were detected (splicing site variant c.940+1G>A and nonsense mutation [p.R603X] in SLCO2A1). Twelve patients (85.7%) were females and the median age at diagnosis of CEAS was 44.5 years. All patients presented with abdominal pain, and 13 patients (92.9%) presented with anemia (median hemoglobin, 9.6 g/dL). Ten patients (71.4%) had hypoalbuminemia (median, 2.7 g/dL). The most commonly involved site was the ileum (13/14, 92.9%). Manifestations of primary hypertrophic osteoarthropathy (PHO), such as digital clubbing, pachydermia, and periostosis were observed in five patients (28.6%) and two male patients and one female patient satisfied all major PHO diagnostic criteria. Conclusions: The clinical and genetic characteristics of Korean patients with confirmed CEAS were similar to those reported in the literature. CEAS should be considered in the differential diagnosis for patients with unexplained chronic nonspecific ulcers of the small intestine. (Gut Liver 2022;16:942-951)