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Suh Jinyoung,김도희,Kim Su-Jung,Cho Nam-Chul,Lee Yeon-Hwa,Jang Jeong-Hoon,서영준 대한암예방학회 2022 Journal of cancer prevention Vol.27 No.1
Cancer-associated fibroblasts (CAFs) represent a major component of the tumor microenvironment and interplay with cancer cells by secreting cytokines, growth factors and extracellular matrix proteins. When estrogen receptor-negative breast cancer MDAMB-231 cells were treated with the CAF-conditioned medium (CAF-CM), Akt and STAT3 involved in cell proliferation and survival were activated through phosphorylation. CAFs secrete fibroblast growth factor 2 (FGF2), thereby stimulating breast cancer cell progression. Akt activation induced by CAF-CM in MDA-MB-231 cells was abolished when FGF2-neutralizing antibody was added. Treatment of MDA-MB-231 cells directly with FGF2 enhanced the phosphorylation of Akt and the FGF receptor (FGFR) substrate, FRS2α. These events were abrogated by siRNA-mediated silencing of FGFR1. In a xenograft mouse model, co-injection of MDAMB-231 cells with activated fibroblasts expressing FGF2 dramatically enhanced activation of Akt. Stable knockdown of FGFR1 blunted Akt phosphorylation in xenograft tumors. MDA-MB-231 cells co-cultured with CAFs or directly stimulated with FGF2 exhibited enhanced nuclear localization of FGFR1. Notably, FGF2 stimulation produced reactive oxygen species (ROS) accumulation in MDA-MB-231 cells, and FGF2-induced nuclear accumulation of FGFR1 was abrogated by the ROS scavenging agent, N-acetylcysteine.
Suh, Jinyoung,Kim, Do-Hee,Surh, Young-Joon Elsevier 2018 Archives of biochemistry and biophysics Vol.643 No.-
<P><B>Abstract</B></P> <P>Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs produce a variety of cytokines, growth factors and extracellular matrix proteins, thereby stimulating tumor progression. CAFs are distinct from normal fibroblasts for their overexpression of α-smooth muscle actin. Recent studies suggest that CAFs play an important role in proliferation and migration of cancer cells through cross-talk with them. Resveratrol (<I>trans</I>-3,4′5,-trihydroxystilbene), a phytoalexin present in grapes, has been reported to possess chemopreventive and chemotherapeutic activities. In the present study, we examined the effects of resveratrol on CAF-induced migration, invasion and self-renewal activity of breast cancer cells. Resveratrol inhibited proliferation, migration and invasion of human breast cancer cells treated with CAF-conditioned media (CAF-CM). Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9. In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Further, resveratrol abrogated stemness properties and reduced the expression of self-renewal signaling molecules in stem-like breast cancer cells. Taken together, the present study provides insights into the role of resveratrol in tumor microenvironment with focus on interaction between cancer cells and the hosting niche.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Resveratrol inhibited proliferation, migration and invasion of human breast cancer cells treated with CAF conditioned media. </LI> <LI> Resveratrol suppressed the expression of cyclin D1, c-Myc, MMP-2, MMP-9 and Sox-2 in breast cancer cells stimulated with CAFs. </LI> <LI> Resveratrol inhibited activation of Akt and STAT3 induced in human breast cancer cells stimulated with CAF conditioned media. </LI> <LI> Resveratrol abrogated the expression of self-renewal signaling molecules in stem-like breast cancer cells. </LI> </UL> </P>
Suh, Jinyoung,Kim, Do-Hee,Kim, Eun-Hee,Park, Sin-Aye,Park, Jong-Min,Jang, Jeong-Hoon,Kim, Su-Jung,Na, Hye-Kyung,Kim, Nam-Doo,Kim, Nam-Jung,Suh, Young Ger,Surh, Young-Joon Elsevier 2018 Cancer letters Vol.424 No.-
<P><B>Abstract</B></P> <P>15-Deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> (15d-PGJ<SUB>2</SUB>), one of the terminal products of cyclooxygenase-2-catalized arachidonic acid metabolism, has been shown to stimulate breast cancer cell proliferation and migration through Akt activation, but the underlying mechanisms remain poorly understood. In the present study, we investigated the effects of 15d-PGJ<SUB>2</SUB> on the activity of PTEN, the inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt axis, in human breast cancer (MCF-7) cells. Since the α,β-unsaturated carbonyl moiety in the cyclopentenone ring of 15d-PGJ<SUB>2</SUB> is electrophilic, we hypothesized that 15d-PGJ<SUB>2</SUB>-induced Akt phosphorylation might result from the covalent modification and subsequent inactivation of PTEN that has several critical cysteine residues. When treated to MCF-7 cells, 15d-PGJ<SUB>2</SUB> bound to PTEN, and this was abolished in the presence of the thiol-reducing agent dithiothreitol. A mass spectrometric analysis by using recombinant and endogenous PTEN protein revealed that the cysteine 136 residue (Cys<SUP>136</SUP>) of PTEN is covalently modified upon treatment with 15d-PGJ<SUB>2</SUB>. Notably, the ability of 15d-PGJ<SUB>2</SUB> to covalently bind to PTEN as well as to induce Akt phosphorylation was abolished in the cells expressing a mutant form of PTEN in which Cys<SUP>136</SUP> was replaced by serine (C136S-PTEN). The present study demonstrates for the first time that electrophilic 15d-PGJ<SUB>2</SUB> directly binds to cysteine 136 of PTEN and provides new insight into PTEN loss in cancer progression associated with chronic inflammation. These observations suggest that 15d-PGJ<SUB>2</SUB> can undergo nucleophilic addition to PTEN, presumably at Cys<SUP>136</SUP>, thereby inactivating this tumor suppressor protein with concomitant Akt activation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PTEN is inactivated through covalent modification by 15-deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> in breast cancer MCF-7 cells. </LI> <LI> 15-Deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> directly binds to the cysteine 136 residue of the recombinant PTEN. </LI> <LI> PTEN interaction with 15-deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> stimulates Akt phosphorylation. </LI> <LI> 15-Deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> stimulates growth of MDA-MB-231 cells when inoculated to the athymic nude mice. </LI> </UL> </P>
( Jinyoung Suh ),( Yeonju Hong ) 한국감성과학회 2022 춘계학술대회 Vol.2022 No.-
The five basic human senses: sight, hearing, smell, taste, and touch are directly related to human survival. Humans use all five senses to perceive the world, protect themselves from danger, and communicate with each other. As the sensory systems function simultaneously, not one at a time, humans are able to perceive an object more clearly and deeply. While traditional cross-modal association studies focus on the associations between sensory systems, we took a different approach. In this study, an initial study was conducted to cross-experience scent and music by connecting the vapor pressure, determining speed in scent, and the frequency, determining speed of sound, with a simple formula. As a result of this study, 136 chemical fragrance components and piano notes were matched, and a new perfumery method was developed to create scent from music.
비정형 텍스트 감성 분석을 통한 효율적인 제품 설계 방법론
박진영(Jinyoung Park),정면규(Myeongyu Jeong),서효원(Hyowon Suh) (사)한국CDE학회 2016 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2016 No.동계
In the Product Design stage, it is essential to analyze the customer’s needs. And, to analyze them we have to summarize the customer’s opinions. But, it is very difficult because the product reviews is unstructured text. So, In this thesis, we propose an Effective Product Design Methodology based on Sentiment Analysis of Unstructured Text. We will use Latent Semantic Analysis to search the latent relations of the features. And, to define the initial sentiment values, we will use the SentiWordNet. We will define the features and sentiment words. Also, we will represent the patterns in the unstructured text.
Kang, Jinyoung,Yang, Jaemoon,Lee, Jaewon,Oh, Seung Jae,Moon, Seyoung,Lee, Hong Jae,Lee, Sang Cheon,Son, Joo-Hiuk,Kim, Donghyun,Lee, Kwangyeol,Suh, Jin-Suck,Huh, Yong-Min,Haam, Seungjoo Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.19
<P>We fabricated <I>de novo</I> biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux<SUP>®</SUP> and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.</P> <P>Graphic Abstract</P><P>De novo smart calcium-phosphate gold nanocomposites as superior surface plasmon resonants are developed for localized photothermal and systemic treatment of epithelial cancer. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b822835c'> </P>
노인 류마티스 관절염 환자에서의 요양급여심사기준 변경에 따른 TNF-α 억제제 약물사용양상
윤진영 ( Jinyoung Youn ),김시인 ( Siin Kim ),서혜선 ( Hae Sun Suh ) 한국보건경제정책학회 2016 보건경제와 정책연구 Vol.22 No.4
In January 2014, there was a change in the reimbursement criteria of TNF-α inhibitor (TNFi) for RA patients. The new reimbursement criteria require DAS28 of a patient to assess disease activity, while previous reimbursement criteria required laboratory data and several subjective assessments. We examined the effect of a change in reimbursement criteria on the utilization of TNFi in RA patients. Data sources were 2013-2014 Aged Patient Sample data of Health Insurance Review and Assessment. Monthly trends in prescription and consumption of TNFi were estimated using segmented regression of interrupted time series. The consumption of TNFi was measured in terms of Daily Defined Dose per 1,000 RA patients per day. Subgroup analysis was conducted by the types of institution. There were increased baseline trends in prescription and consumption of TNFi, which were not significant. In subgroup analysis, tertiary hospital showed a significant increase in prescription and consumption immediately after the change in reimbursement criteria, while general hospital, hospital, and clinic showed a significant decrease in prescription and consumption. These trends were consistent throughout one year after the change in reimbursement criteria. This study shows that the change in reimbursement criteria of TNFi in RA patients had little impact on the overall utilization of TNFi. However, the change in reimbursement criteria significantly affected the pattern of TNFi utilization by the types of institution. Further research is needed to examine whether this change improved the accessibility to TNFi in RA patients.
제품 설계를 위한 제품 특징 기반 고객 리뷰 텍스트 처리 및 의미론적 분석 방법론
박진영(Jinyoung Park),정면규(Myeongyu Jeong),서효원(Hyowon Suh) (사)한국CDE학회 2015 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2015 No.하계
When engineers design the product, it is essential to consider both function and performance of the product. Also, it must be clearly understood about what functions do customers prefer and what level of performance they need. Product reviews are the representative writings including these contexts about the customer needs. Since product reviews includes customer’s opinion about product feature, it is the vital elements to analyze the customer’s needs. Previous researches for analyzing customer reviews are mostly about the classification of the reviews’ polarity. In view of product design, it is more important to consider the information about how much they prefer the product feature. Therefore we propose a methodology of text processing and semantic analysis based on product feature for applying to product design. First, we analyze the sentences with the methodology of text processing and semantic analysis. And then, we extract the product features about the function and performance of product. And in this paper, to verify the suggested methodology, we collects the customer reviews about the tire. After extracting product feature and sentiment word with the collected reviews, we construct new algorithm which calculates sentiment value of product feature by using SentiWordNet.