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Ho Yeop Lee,Byeong Chang Sim,Ha Thi Nga,Ji Sun Moon,Jingwen Tian,Nguyen Thi Linh,Sang Hyeon Ju,Dong Wook Choi,Daiki Setoyama,이현승 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.6
Background: An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood. In this study, we aimed to provide a comprehensive understanding of the metabolite changes that occur when patients with GD transition from hyperthyroidism to euthyroidism with methimazole treatment. Methods: Eighteen patients (mean age, 38.6±14.7 years; 66.7% female) with newly diagnosed or relapsed GD attending the endocrinology outpatient clinics in a single institution were recruited between January 2019 and July 2020. All subjects were treated with methimazole to achieve euthyroidism. We explored metabolomics by performing liquid chromatography-mass spectrometry analysis of plasma samples of these patients and then performed multivariate statistical analysis of the metabolomics data. Results: Two hundred metabolites were measured before and after 12 weeks of methimazole treatment in patients with GD. The levels of 61 metabolites, including palmitic acid (C16:0) and oleic acid (C18:1), were elevated in methimazole-naïve patients with GD, and these levels were decreased by methimazole treatment. The levels of another 15 metabolites, including glycine and creatinine,were increased after recovery of euthyroidism upon methimazole treatment in patients with GD. Pathway analysis of metabolomics data showed that hyperthyroidism was closely related to aminoacyl-transfer ribonucleic acid biosynthesis and branched-chain aminoacid biosynthesis pathways. Conclusion: In this study, significant variations of plasma metabolomic patterns that occur during the transition from hyperthyroidism to euthyroidism were detected in patients with GD via untargeted metabolomics analysis.
Devil or God: Image Transformation of Chinese Mythology Character “Nezha”(1927-2019)
Xuezheng Shen(심학정),Jingwen Li(이정문),Yunzhuo Zhang(장원탁),Shanshan Liu(유산산),Jangsun Hong(홍장선),Jongyoon Lee(이종윤) 한국만화애니메이션학회 2020 만화애니메이션연구 Vol.- No.58
중국 신화는 전 세계 문화 콘텐츠 산업에 풍부한 영감의 원천을 제공한다. Nezha(哪吒), 쑨우콩(孙悟空), 뮬란(花木兰)등 일부 중국 전통 캐릭터는 이미 널리 알려져 있다. 콘텐츠 제작자들은 반복적으로 각색하고 재창작하여 서로 다른 이미지를 다양한 형태로 중국, 일본, 미국 등 국가에게 퍼져나갔다. 그 중에서도 Nezha는 중국 본토의 신이 아니지만 가장 영향력 있는 신화 캐릭터다. 본 연구는 2019년 개봉된 인기 애니메이션 영화〈나타지마동강세〉를 시작으로 지난 100년 동안 서로 다른 작품에 등장한 50여개의 다른 이미지들을 연구 표본으로 삼았다. 본 연구는 이미지 분석 방법을 통해 이미지 변화의 이유관계를 서로 연결하기 위해 4개의 역사적 단계로 나누고 세계로부터 다문화주의의 영향을 받는 신화적 원형으로서 변화된 Nezha(哪吒)를 탐구한다. 마지막으로, 트랜드 미디어 스토리텔링에서 신화적 원형의 이미지는 문화적 유인과 문화적 활동가들로 인해 사회문화와 대중의 인지에 다원적인 변화를 수반한다고 보았다. Chinese mythology provides an inexhaustible source of inspiration for cultural content industries around the world. For instance, content producers are familiar with Nezha, Sun wukong, Mulan, and other traditional Chinese characters. These have subsquently been repeatedly adapted, recreated, and spread in different forms in China, Japan, the United States, and other countries. Among them, Nezha is the most influential mythical character, although he isn"t a native Chinese god. Starting from the most popular animated film 〈Nezha: Birth of the Devil〉in 2019, this paper sorts out 50 different Nezha"s images, which have appeared in various works over the past 100 years, as a research sample. Through the method of image analysis, this paper divides them into four historical stages to interpret the reason for image transformation. This paper explores "transformed" Nezha as a mythological archetype affected by multiculturalism from the world. Finally, the study concludes that the image of the mythical archetype in the transmedia storytelling will be accompanied by multiple changes in social culture and audience recognition because of the cultural attractors and cultural activators.
Dongxu Tang,Ki-Ju Lee,Jingwen Xu,Hyung-Bong Lim,K. Park,조원승 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.3
Alumina-reinforced zirconia composites containing 0 to 30 vol% of alumina were fabricated by sintering at 1550°C for 2h in air. The effect of the Al2O3 content on the mechanical properties and microstructure of 3Y-TZP ceramics was investigated. Al2O3 acted as an inhibitor of the grain growth of 3Y-TZP. As the alumina content increased, the fracture mode changed gradually from the transgranular mode to the inter-granular mode and the Young’s modulus and hardness increased. The biaxial flexural strength also showed a slight increase with an increase in Al2O3 content, due to the grain size refinement of the ZrO2 matrix,while the fracture toughness, which was investigated by the SEVNB method, showed a contrary ten-dency. The decrement of the fracture toughness can be explained by the increase in the critical transforma-tion stress, the decrease in the volume fraction of the transformable t-ZrO2 and the increase in the tensile residual stress.
Hu, Liqin,Zhou, Tingting,Feng, Jingwen,Jin, Hua,Tao, Yun,Luo, Dan,Mei, Surong,Lee, Yong-Ill Elsevier 2018 Journal of Electroanalytical Chemistry Vol.813 No.-
<P><B>Abstract</B></P> <P>Azithromycin (AZM) is a widely used macrolide antibiotic to treat infections caused by bacteria. Considering the side-effect to human health, a rapid and selective electrochemiluminescence (ECL) sensor was fabricated on the basis of molecularly imprinted polymer (MIP) modified carbon paste electrode as a recognition element. We systematically optimized the factors influencing the processes on the extraction and determination for AZM, including the amount of MIP power and paraffin oil, extraction solution, extraction time and the pH of Ru(bpy)<SUB>3</SUB> <SUP>2+</SUP> solution. Under the optimal condition, the wide linear range was observed from 1.0 × 10<SUP>−10</SUP> to 4.0 × 10<SUP>−7</SUP> mol L<SUP>−1</SUP>, and the limit of detection (LOD) was low as 2.3 × 10<SUP>−11</SUP> mol L<SUP>−1</SUP> (S/N = 3). The spiked recoveries of AZM in urine and blood samples were from 98.4% to 113.5% with RSD changing from 3.7% to 13.2%, respectively. The results of AZM determination by this proposed sensor were in accordance with that of high-performance liquid chromatography–tandem mass spectrometry method. Thus, the developed MIP-based ECL sensor will have a great potential application in rapid and sensitive determination of trace AZM in complex biological samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ECL sensor </LI> <LI> MIP modified CP electrode </LI> <LI> Trace AZM determined in biological samples </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Li, Hai,Dong, Bin,Park, Sahng Wook,Lee, Hyun-Sook,Chen, Wei,Liu, Jingwen American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.42
<P>PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of LDLR and triggers its intracellular degradation. <I>PCSK9</I> and <I>LDLR</I> are coordinately regulated at the transcriptional level by sterols through their promoter-imbedded sterol response elements (SRE) and co-induced by statins. Identification of regulatory networks modulating <I>PCSK9</I> transcription is important for developing selective repressors of PCSK9 to improve statin efficacy by prolonging the up-regulation of LDLR. Interestingly, the plant-derived hypocholesterolemic compound berberine (BBR) up-regulates LDLR expression while down-regulating PCSK9. In our investigations to define mechanisms underlying the transcriptional suppression of <I>PCSK9</I> by BBR in HepG2 cells, we have identified a highly conserved hepatocyte nuclear factor 1 (HNF1) binding site residing 28 bp upstream from SRE as a critical sequence motif for <I>PCSK9</I> transcription and its regulation by BBR. Mutation of the HNF1 site reduced <I>PCSK9</I> promoter activity >90%. A battery of functional assays identified HNF1α as the predominant trans-activator for <I>PCSK9</I> gene working through this sequence motif. We further provide evidence suggesting that HNF1 site works cooperatively with SRE as HNF1 mutation significantly attenuated the activity of nuclear SREBP2 to transactivate <I>PCSK9</I> promoter. Finally, we show that a coordinate modest reduction of HNF1α and nuclear SREBP2 by BBR led to a strong suppression of <I>PCSK9</I> transcription through these two critical regulatory sequences. This is the first described example of SREBP pairing with HNF1 to control an important regulatory pathway in cholesterol homeostasis. This work also provides a mechanism for how BBR suppresses <I>PCSK9</I> transcription.</P>
Ultra precision polishing of Si3N4 ceramics using magnetorheological fluids and diamond abrasives
Dong-Woo Kim,조명우,이정원,신영재,Ki-Ju Lee,Jingwen Xu,Seung-Yong Shin,조원승 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.3
Si3N4 ceramics were prepared by hot-pressing at 1800℃ for 2 h. Firstly, the microstructure and mechanical properties of Si3N4 ceramics with sintering aids of 8 mol% Y2O3+ 6mol% Al2O3 were investigated. The Si3N4 ceramics showed excellent mechanical properties. Grain bridging and pullout were observed during the Vickers indentation crack propagation, implying that they are possible toughening mechanisms for Si3N4 ceramics. The secondary phase was identified as Y10Al2Si3O18N4 (YAlSiON), which was formed by the reaction with the sintering aids, Si3N4, and SiO2. Secondly, ultra precision polishing experiments for Si3N4 ceramics were performed using magnetorheological fluids (MR fluids) and diamond slurries. A series of experiments were performed under various polishing conditions by changing the current intensity and spindle speed for a given time period of 10 minutes. The machined surfaces were observed using a SEM and surface profiler to investigate the surface integrity changes. As a result, a very fine surface roughness of Ra = 1.012 nm was obtained within 10 minutes when the electric current was 2 A and the wheel speed was 300 rpm. Also, it was observed that the MR polishing method can provide excellent surface roughness compared with the existing lapping methods.