고콜레스테롤혈증 치료제로서 3-치환 4,5-헥사메칠렌피라졸 유도체의 합성

최영희,김진일,장영동 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-

A series of 6-[2-(3-substituted 4, 5-hexamethylenepyrazo-1-yl)ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones were synthesized from 3-substituted 4, 5-hexamethylenepyrazole in 7 steps as potential antihypercholesterolemic agents.

크론병의 임상적 고찰

정희원,박재갑,이건욱,최국진,김진복 대한대장항문학회 1992 Annals of Coloproctolgy Vol.8 No.2

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

Vancomycin-Resistant Enterococci (VRE) 빈도, 검사법 및 감염관리 대책에 관한 전국 병원 설문조사

정희진,김우주,최선주,이경원,최강원,박승철 대한감염학회 2001 감염 Vol.33 No.2

Background : Vancomcyin-resistant enterococci (VRE) have been an important nosocomial pathogen in the 1990s. Recently, VRE have become an emerging nosocomial pathogen in Korea, but there have been no nationwide study about the status of VRE in Korea. This nationwide questionnaire survey was aimed to determine the prevalence of VRE, the appropriateness of detection method fur VRE, and to evaluate the infection control program in hospitals of various size in Korea. Methods : During 4 weeks (September 1 to October 1, 1999), a questionnaire surveillance study was conducted. We had sent the questionnaire to 200 large hospitals in Korea, which were distributed nationwide. Questionnaire included the prevalence of VRE within the hospital, the detection method for VRE, method of enterococci isolation, antibiotics-susceptibility test and infection control method of VRE. Results : The response rate to questionnaire was 42%. The species identification of enterococci was capable in 62.3% but the accurate enterococcal speciation were capable in 18%. Appropriate antibiotic-sus-ceptibility test were produced only in 6.5%. Total 746 VRE were detected in 42 hospitals during 1-year despite of low sensitivity of detection methods. VRE was noted in 54.4% of hospitals at least. The isolation programme of VRE infected patients was presented in 20.3%, regular surveillance of VRE in high-risk pop ulation was produced only in 16.5%. Conclusion : The prevalence of enterococci among microorganisms isolated from clinical specimens were increased up to 27.7% in Korea. VRE has been emerged in many big cities as well as in Seoul. The microbiological methods that include the speciation of enterococcal isolates, antimicrobial susceptibility test, and VRE detection appeared to be inappropriate in many hospitals. And, proper control and prevention methods were presented in a few hospitals. Education and training about accurate detection of VRE as well as proper infection control programs for VRE are urgently needed. (Korean J Infect Dis 33:78~87, 2001)

Ga_2Se_3 및 Ga_2Se_3 : Ni^2+ 單結晶의 光學的 Energy Gap의 溫度依存性 Ni^2+ single crystals

김진희,이상열,최성휴 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

Optical absorption properties of Ga_2Se_3 and Ga_2Se_3:Ni^2+ single crystals grown by the Bridgman method were investigated over the temperature range from 21 K to 296 K (or 292 K). The crystal structure of these compounds determined by X-ray diffraction analysis was α-type, cubic structure, and lattice constant a_o=5.410 A for Ga_2Se_3 single crystal, and a_o=5.408 A for Ga_2Se_3:Ni^2+ single crystal. It is confirmed from the optical absorption spectrum that Ga_2Se_3 single crystal has an allowed direct transition and the temperature dependence of the direct band gap of these compounds is well satisfied with Varshni equation. The constants of Varshni equation have the values of E_g(0)=2.093 eV, α=-5x10^-4 eV/K, β-488 K for Ga_2Se_3 single crystal, and E_g(0)=1.438 eV, α=2.63x10^-4 eV/K, β=-609K for Ga_2Se_3:Ni^2+(1mole%) single crystal, respectively.

DCJTB를 도핑시킨 단층 Alq₃소자에서 Two-color filter를 사용한 발광영역의 결정

채우리,채희백,최성진 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

A doping layer of thickness 2 nm of DCJTB(guest) was dopoed 1 % and varied its location 5nm each from the anode to the cathode in a single layer Alq(60 nm, host) OLED in order to investigate the region of charge recombination and light emission. Major emission peak was located 20 nm from the anode and the emission region was shown to be spread through the whole layer of Alq. We also investigate a method to determine the recombination zone with two-color filter from TEL

紫雲英裁培沓에서 窒素와 石灰의 施用이 紫雲英의 腐熟과 벼 生育에 미치는 影響

윤봉기,김희권,최형국,박인진 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.2

녹비작물로서 자운영을 재배한 논에 수포를 재배할 때 시용한 자운영의 부숙촉진방법을 구명하기 위하여 자운영의 개화 성기와 결실기에 자각 예취하여 시용하고 질소 0, 30, 60, 질소 30+석회 1000, 석회 1000㎏/㏊의 5가지 부숙촉진 처리로 2000년부터 2년동안 포장시험한 결과는 다음과 같다. 1. 자운영의 개화성기 생육은 초장 44.5㎝, 생초수량 23.88Mg/㏊였으며 결실기에는 초장43.6㎝, 생초수량 19.53Mg ㏊^(-1)이였다. 무기성분 함량은 자운영 개화성기에 T-N 2.6%. T-C 78.6%, P₂O_(5) 0.57%, K₂O 2.73%였으며 결실기에는 T-N 2.3%, T-C 82.8%, P₂O_(5) 0.53%. K₂O 2.15%였다. 2. 개화성기에 시용한 자운영의 부숙정도는 경운후 10일에 82.5~86.8%로 급증하여 이후 완 만한 경향을 보였으며 결실기의 부숙정도는 경운후 10일에 62.2~67.1%로 개화성기보다 낮았다. 부숙처리에 따라서는 개화성기에 예취하여 시용하고 부숙처리한 시험구중 석회 1,000㎏/㏊처리에서 최고의 부숙정도를 보였으며 결실기 처리구에서는 질소 30+석회 1,000㎏/㏊ 처리구에서 높은 부숙도를 의였다. 3. 벼의 생육은 출수기의 초장은 102.0~l12.4㎝, 수확기의 간장은 76.6~84.2㎝, 수장 17.9~20.0㎝로 개화성기의 부숙 처리에서 초장. 간장, 수장이 큰 편이었다. 벼의 수량은 4.89~5.33Mg/㏊로 자운영 개화성기의 부숙촉진 무처리(5.01 Mg/㏊)에 비하여 석회 1,000㎏ ㏊처리에서 4% 증수되었고 결실기의 부숙촉진 처리에서는 무처리 (5.25Mg/㏊)에 비하여 질소 30+석회 1,000㎏ ㏊^(-1)처리에서 1%증수되었으나 기타 처리에서는 1~2%감수되었다. 4. 시험후 토양의 화학성은 pH 5.4~6.0. OM 12.5~13.5g/㎏, CEC 12.4~14.5c㏖/㎏, Ava. P₂O_(5) 38~56㎎/㎏으로 자운영 부숙촉진 처리에저 Ava. P₂O_(5), Ava. SiO₂, CEC, 치환성 K의 함량이 많은 편이었다. The experiment was conducted to find out quick decomposition method of applied milk vetch at rice paddy soil. Decomposition methods were 5 treatments of N fertilizer 0, 30, 60, N 30+Lime 1000 and Lime 1000 ㎏/㏊ at paddy field applied flowering and bearing stage of milk vetch. It was summerized as follows; At flowering stage of milk vetch, the content of T-N, T-C, P₂O_(5), K₂O in milk vetch plant was 2.6, 78.6, 0.57, 2.73% respectively. plant height was 44.5 ㎝. green yield was 23.88 Mg/㏊. At bearing stage of milk vetch, the content of T-N, T-C, P₂O_(5), K₂O in milk vetch was 2.3, 82.8, 0.53, 2.15% respectively. Plant height was 43.6 ㎝. Green yield was 19.53 Mg/㏊. Decomposition rate of milk vetch at 10 days after application at the flowering stage was 82.5~86.8% and that of bearing stage was 62.2~67.1%. When milk vetch was cut at flowering stage, decomposition rate of milk vetch treated lime 1000 ㎏/㏊ was more than any other treatment. When milk vetch was cut at bearing stage, decomposition rate of milk vetch treated N 30+lime 1000 ㎏/㏊ was highest. Plant height of rice was 102.0~112.4 ㎝ at heading stage and stem height was 76.6~84.2 ㎝, panicle length 17.9~20.0 ㎝ at harvesting stage. Plant height, stem height, panicle length of decomposition treatment plot was trend to longer when milk vetch was cut at flowering stage. When milk vetch was cut at flowering stage, rice yield of lime 1000 ㎏/ ㏊ applied plot increased 4% more than that of control (5.01 Mg/ha). When milk vetch was cut at bearing stage, N30+lime 1000 ㎏/㏊ applied plot was increased 1% than that of control (5.25 Mg/ha). But the rice yield other plot decreased 1~2% than that of control. Chemical properties of soil after experiment were pH 5.4~6.0, OM 12.5~13.5 g/㎏, CEC 12.4~14.5 c㏖/㎏. The content of Av. P₂O_(5), Av. SiO₂, CEC, Exch. K in soil applied milk vetch was more than that of control.

표고버섯의 저장성 연장에 관한 연구

박철,윤희진,신완철,최석영 울산대학교 2006 생활과학논문집 Vol.7 No.2

저농도의 산소를 함유한 기체조성(G108)과 고농도의 이산화탄소를 함유한 기체조성(G604)을 이용하여 표고버섯의 저장성 연장 효과를 평가하였다. 표고버섯을 실온(22°C)과 냉장저장(4°C)으로 나누어 저장하면서 중량감소율, pH 변화, 색도(L값), PPO 활성, 유리아미노산 함량을 측정하였다. 실온저장 대조군은 7일 경과 후 중량이 6.3%까지 감소하였으나, G108군과 G604군은 각각 3.0%, 3.2% 감소하였다. pH는 실온저장 대조군에서는 저장 3일째 급격히 감소하다가 7일에는 크게 상승하였다. 반면에 G108과 G604군에서는 pH 변화가 3일까지 변화가 없다가 7일에는 감소하였다. L값은 실온저장 3일에 대조군이 46.4인 반면, G108과 G6O4군은 7일에 각각 76.1, 76.6이었다. 냉장저장 시 대조군의 중량은 7일부터 감소하기 시작하여 35일에는 39.0%까지 감소하였으나, G108과 G6O4군에서는 42일까지 각각 3.1%, 3.0% 감소하였다. 대조군의 pH는 저장 21일까지 크게 감소하다가 증가하기 시작하여 저장 35일째에는 크게 상승하였다. 반면에 G108과 G604군에서는 저장 42일까지 pH변화가 거의 일어나지 않았다. 냉장저장 시 대조군의 L값은 14일 경과 후 큰 폭으로 떨어졌지만, G108군과 G6O4군은 42일까지 별로 감소하지 않았다. PPO 활성은 대조군에서는14일부터는 크게 증가하였으나 G108과 G604 모두 저장 42일까지 거의 증가하지 않았다또한 유리 아미노산 함량도 대조군에서는 크게 감소하였으나 기체치환군에서는 그 감소율이 크게 지연되었다. 이상의 결과로 표고버섯의 저장 시 기체치환으로 버섯의 호흡을 억제함으로써 버섯의 저장성을 연장시킬 수 있음을 알 수 있었다. 실온저장 시 대조군은 1일부터 각종 품질 변화가 일어나는 반면에, 기체치환저장은 3일까지 변화가 일어나지 않았으며, 냉장저장 시에는 대조군이 3일경부터 품질 변화가 일어나는데, 기체치환저장은 14일까지 품질의 큰 변화가 없음을 알 수 있었다. The prolongation of shelf-life of oak mushroom(Lentius edodes) using low oxygen concentration(G108) and high carbon dioxide concentration(G604) was evaluated. The weight loss, pH change, colour(L value), PPO activities and free amino acid contents were measured during 7 days at 22"C or during 42 days at 4'c storage. During 22"C storage the weight loss rate of control was 6.3% at 7 days, but that of G108 and G6O4 were 3.0% and3.2% at 7 days respectively. The pH of control was decreased at 3 days, but increased thereafter, However The pH of G108 and G6O4 were not changed during 3 days and were decreased thereafter. The colour (L value) of control was 46.4 at 3 days, but that of G108and G604 were 76.1, 76.6 during 7 days respectively. During 4"C storage the weigh loss rate of control was 39.0% at 35 days, but that of G108 and G6O4 were little changed during 42 days. The pH of control was decreased at 21 days, but increased after 35 days. The pH of G108 and G604 were not changed during 42 days. The colour (L value) of control was highly decreased at 14 days, but that of G108 and G6O4 were little changed during 42 days. Also, PPO activities of control were continually increased from 14 days, that of G108 and G6O4 however were little changed during 42 days. The contents of free amino acids of control were decreased continuously, but their decreasing rate was delayed in the groups of modified atmosphere packaging. These results suggested that the shelf-life of oak mushroom was prolonged by inhibiting the respiration of that using the modified atmosphere packaging. During 22'c storage the qualities of control were not changed at 1 days, but that of G108 and G6O4 were not changed during 3 days. Also during 4f storage the qualities of control were not changed at 3 days, but that of G108and G6O4 were not changed during 14 days.

茶 침출조건에 따른 Catechin, 무기질 및 Vitamin C 함량 변화

이순재,김미지,윤연희,박규영,최원경,방진숙,부용출 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-

본 연구에서는 실제 상용하고 있는 각 차음료가 온도, 시간 및 추출 횟수에 따른 성분의 함량의 차이를 관찰코져 시판되고 있는 한국산 녹차, 우롱차 및 홍차를 대상으로 추출방법을 달리한 후 茶浸出液중의 주요성분인 catechin, vitamin C 및 여러가지 무기질의 함량을 측정하여 다음과 같은 결과를 얻었다. 1. 차침출온도에 따른 침출액중의 catechin과 vitamin C 함량의 차이를 볼 때 온도가 높을수록 많이 추출되었다. 2. 같은 온도라는 침출시간에 따른 차이를 관찰한 결과 시간이 길수록 침출액중의 catechin과 vitamin C의 함량이 증가되었다. 3. 녹차는 우려낸 횟수에 따른 catechin의 함량 차이는 처음에 비하여 2회 추출시약 51%, 3회추출시는 71% 감소하였다. 4. 차의 각 무기원소에 따른 함량을 비교시 Mg은 우롱차가 가장 높고 K, Mn은 녹차가, Zn, Cu 그리고 Fe는 홍차가 가장 높게 나타났다. 5. 녹차, 우롱차의 경우 대체로 무기질의 침출정도가 온도가 높을수록 오히려 감소하는 경향을 나타내었고 홍차는 Mg, K을 제외하고 모두 증가하였다. 6. 각 침출액중의 대부분의 무기질 함량은 추출횟수가 증가할수록 감소하였다. 7. 시료로 사용한 녹차, 우롱차, 홍차의 vitamin C 함량은 녹차, 우롱차, 홍차의 순으로 높게 나타났다. 8. 녹차를 추출한 횟수에 따른 vitamin C 함량은 1회에 비해 2회 추출시 약 36%, 3회 추출시 약 62% 감소되었다. 9. 5g의 녹차를 80℃에서 2분간 침출한 액중에서는 catechin은 100ml당 0.34g, Mg은 2.229mg, Ca은 0.365mg, K은 39.77mg, Zn은 0.037mg, Cu은 0.010mg, Fe는 0.001mg, Mn은 0.581mg이며, vitamin C는 9.65mg이 함유되어 있었다. This study was to compare the ingredients which are contained in usual Korean teas in-depednence on leaching temperature, time and number. The main contents i.e. catechin, vi-tamin C and other minerals extracted from Korean commercial green tea, oolong tea and black tea were measured. The resluts are as follows; According to extracting temperature, the higher temperature made catechin and vitamin C extracted more. For the same leaching temperature, the longer time the more catechin and vitamin C. In case of extracting number, the contents of catechin was decreased a-bout 50% and 70% at second time and third, respectively in comparasion to the first time. For minerals from teas, management(Mg) was most in oolong tea, potassium(K)and manganease(Mn) and in green tea and iron(FEe) was in black tea respectively. Most min-erals from greentea and oolong tea were extracted less as leaching temperature was in-creased. But in black tea minerals other than Mg and K were more at increased tempera-ture. Most minerals in extractions were decreased as leaching number was increased. The content of vitamin C in the experimental samples(tea) was most in green tea, next in oo-long tea and third in black tea. In comparasion with the first extraction vitamin C was de-creased about 35% and 60% at 2nd and 3rd leach, respectively.