Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의

이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)

A NOVEL FUNCTIONAL MATERIAL OF Ag-S$i_3N_4$ NANOSTRUCTURED COMPOSITE

Zhu, Zhu, Yi-Hun,Zhu, Zhu, Hong-Jie,Han, Han, Jin-Yi,Hu, Li-Ming 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1

$Ag-Si_3N_4$ nanostrutured composite has been investigated. The results show that it exhibits some novel properties such as strong piezpelectricity and high dielectricity. It can be constituted a battery using graphite and aluminum as the positive and the negative electrodes, respectively. The origins of these properties have been discussed.

Synthesis and Antiproliferative Activity of 1,4-Bis(dimethylamino)- 9,10-anthraquinone Derivatives against P388 Mouse Leukemic Tumor Cells

Guang-Zhu Jin,Hai-Shan Jin,Li-Li Jin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

A series of 2-substituted-1,4-bis(dimethylamino)-9,10-anthraquinone derivatives were synthesized and their in vitro antiproliferative activities against p388 mouse leukemic tumor cells were evaluated. In addition, the effect of substituents on the phenyl ring was investigated. Among the derivatives tested, seven showed a high antiproliferative effect and three showed a moderate effect. In addition, introduction of a series of substituted phenyl groups into 1,4-bis(dimethylamino)-9,10-anthraquinone at 2-position were shown to enhance its antiproliferative activity. The antiproliferative activity also increased upon substitution of the benzene ring by an electron donating group such as an amine or methoxyl group.

中日韓における形態素「~族」の比較研究

김금주(金錦珠)(Jin, Jin-Zhu) 한일일어일문학회 2012 한일어문논집 Vol.16 No.-

형태소 “족”은 “공통적인 특성을 가진 특정 사람”을 가리키는 의미에서 한중일 세 나라 언어로 공통된다. 본고에서는 형태소 “족”의 어의 “족”어의 중일한 비교 대조를 시도했다. 중국의 “족”어는 일본어와 한국어에 비해 외래어가 극소하고 그 95%가 한자로 표기되어 있다 특히“일족”라는 파생어를 생성하고있는 것도 한국어, 일본어와는 다르다. 일본어에 있어서 “족”어는 중국어와 한국어에 비해 당시의 인기 소설이나 잡지, 텔레비전 드라마의 제목에서 온 것이 많다. 또한 “족”어은 종종 마이너스의 어감을 띠고 있다. 일본에서는 “족”은 “계”로 대체되는 현상이 눈에 띄고, 일본어의 “족”어의 생성 메커니즘은 한중에 비해 쇠퇴의 길로 들어섰다 중국어와 일본어에 비해 한국어의 “족”어는 동물 이름으로 명명된 것이 많다. 또한 외래어 수용시“단축 + 합성” 형식의 다용, 한국산 영어가 범람함으로 말미암아 난해한 말이 많다. “족”어에는 한중일의 동의어가 많지만 그것은 인터넷의 보급이 “족”어의 전파에 박차를 가하고 있는 것이나 공통적인 생각, 행동 양식을 보이고 있는 이른바 “신·신 인류”가 세나라에 존재하는것에 기인하고 있다.

A Study on the Development of Wind and Wave Model of Typhoon

Jin Guo-Zhu,Song Chae-Uk,Seol Dong-Il Korean Institute of Navigation and Port Research 2004 한국항해항만학회지 Vol.28 No.9

In this paper, after analyzing other models with their advantages and disadvantages, we proposed a simple parametric model for calculating wind speed & direction and wave height & direction at any location around the typhoon at sea. The proposed wind-field model of typhoon is asymmetric, and consists of a circular symmetric wind-field caused by the pressure gradient of stationary typhoon and a moving wind-field caused by the movement of typhoon. By verifying this model through observed data, we found that it is accurate enough to develop the simulation software for training students and seafarers so as to take appropriate actions while being faced with the typhoon at sea.

Thermal Stability and Fracture Toughness of Epoxy Resins Modified with Epoxidized Castor Oil and Al₂O₃ Nanoparticles

Zhu, Lin,Jin, Fan-Long,Park, Soo-Jin Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8

This study examined the effects of the epoxidized castor oil (ECO) and $Al_2O_3$ content on the thermal stability and fracture toughness of the diglycidylether of bisphenol-A (DGEBA)/ECO/$Al_2O_3$ ternary composites using a range of techniques. The thermal stability of the composites was decreased by the addition of ECO and $Al_2O_3$ nanoparticles. The fracture toughness of the composites was improved significantly by the addition of ECO and $Al_2O_3$ nanoparticles. The composite containing 3 wt % $Al_2O_3$ nanoparticles showed the maximum flexural strength. Scanning electron microscopy (SEM) revealed tortuous cracks in the DGEBA/ECO/$Al_2O_3$ composites, which prevented deformation and crack propagation.

A Study on the Impact of Transformational Leadership on ESG Performance in SMEs

Zhu Jin,Huang, Fei 대한경영정보학회 2023 경영과 정보연구 Vol.42 No.1

With recent economic and social developments and scientific and technological advances, human society has made tremendous strides. Alongside the accomplishments, however, people have gradually realized that severe environmental and social problems accompany economic development and that non-financial factors such as the environment and corporate governance have become moral risks that cannot be ignored. As the fundamental unit of human economic activity and the primary social organization, enterprises are the backbone of sustainable development. ESG is a sustainable development concept that integrates environmental, social, and corporate governance. It emphasizes that enterprise development activities should pursue not only economic indicators but also consider environmental, social, and governance dimensions to achieve sustainable development of human society. ESG is the concrete manifestation of the "sustainable development concept" in the business world, serving as a guide and instrument for corporations to practice sustainable development. This paper examines, from a strategic management perspective, whether transformational leadership influences the ESG performance of corporations, whether organizational innovation mediates the relationship between transformational leadership and ESG performance, and the moderating effect of organizational ethical culture on transformational leadership and organizational innovation. The results of an analysis of 350 Chinese businesses indicate that transformational leadership has a positive effect on ESG performance, and that organizational innovation partially mediates the relationship between transformational leadership and corporate ESG performance. Furthermore, organizational ethical culture moderates the direct relationship between transformational leadership and organizational innovation and moderates the role of organizational innovation as a mediator between transformational leadership and ESG performance. This study provides valuable research on the relationship between leadership and ESG performance.

Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance.

Zhu, Jianhua,Jeong, Jae Cheol,Zhu, Yanmei,Sokolchik, Irina,Miyazaki, Saori,Zhu, Jian-Kang,Hasegawa, Paul M,Bohnert, Hans J,Shi, Huazhong,Yun, Dae-Jin,Bressan, Ray A National Academy of Sciences 2008 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.105 No.12

<P>Histone modification in chromatin is one of the key control points in gene regulation in eukaryotic cells. Protein complexes composed of histone acetyltransferase or deacetylase, WD40 repeat protein, and many other components have been implicated in this process. Here, we report the identification and functional characterization of HOS15, a WD40-repeat protein crucial for repression of genes associated with abiotic stress tolerance through histone deacetylation in Arabidopsis. HOS15 shares high sequence similarity with human transducin-beta like protein (TBL), a component of a repressor protein complex involved in histone deacetylation. Mutation of the HOS15 gene renders mutant plants hypersensitive to freezing temperatures. HOS15 is localized in the nucleus and specifically interacts with histone H4. The level of acetylated histone H4 is higher in the hos15 mutant than in WT plants. Moreover, the stress inducible RD29A promoter is hyperinduced and associated with a substantially higher level of acetylated histone H4 in the hos15 mutant under cold stress conditions. Our results suggest a critical role for gene activation/repression by histone acetylation/deacetylation in plant acclimation and tolerance to cold stress.</P>

Cat NPC2, a Newly Identified Allergen, With High Cross-Reactivity to Can f 7

Zhu Dan-Xuan,Li Lin,Xu Zhi-Qiang,Zhang Cheng,Zhang Jin-Song,Sun Jin-Lyu,Wei Ji-Fu 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.1

Purpose: Pet-derived allergens are the common indoor inhalant allergens. Among them, cat and dog allergens constitute more than 80% of animal allergic patients, which greatly affect the quality-of-life of patients and increase the burden of social health care. The aim of this study was to identify Cat-Niemann pick type C2 (NPC2) protein, a homologue of Can f 7, as a new allergen. Methods: Cat-NPC2 complementary DNA (cDNA) was cloned and optimized for amplification and expression in Escherichia coli. Then, recombinant Cat-NPC2 (rCat-NPC2) was purified by Ni2+ affinity chromatography. The allergenicity was assessed by enzyme-linked immunosorbent assay (ELISA), western blot and basophil activation test (BAT). Based on the sequence similarity, the cross-reactivity between Cat-NPC2 and Can f 7 was investigated by inhibition ELISA. Circular dichroism spectroscopy and homology modeling were used to characterize the structure of Cat-NPC2. Results: The cDNA sequence of Cat-NPC2 was cloned with a 450-bp open reading frame coding for 149 amino acids (GenBank MN_737596). The condon-optimized NPC2 gene was subcloned and expressed in E. coli with a molecular weight of 18.9 kDa. The native Cat-NPC2 was detected in cat dander extracts. The allergenicity determined by ELISA, western blot and BAT suggested at least 14.5% cat-allergic patients displayed high specific immunoglobulin E (IgE) recognition of Cat-NPC2. The predicted structure of Cat-NPC2 was found to consist of 7 β-strands arranged in 2 β-sheets. An ELISA based assay showed that rCat-NPC2 bound to cholesterol in a dose dependent manner. Based on the structure and sequence similarities, IgE cross-reactivity was demonstrated between Cat-NPC2 and Can f 7/Der f 2. Conclusions: In the study, a novel cat allergen, belonging to the NPC2 protein family, was identified and characterized at both molecular and immunological levels. The study will offer a deeper understanding of cat allergens and improve a component-resolved diagnosis in pet allergy.