Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

水稻의 基肥 水準과 栽植密度가 生育 및 收量에 미치는 影響

安元燮,金鎭雨,崔周鎬 진주산업대학교 1987 論文集 Vol.25 No.-

1986年 4月부터 10月까지 晋州農林專門大學 實習團場에서 供試品種 東津(Dong jin)을 N의 基肥 水準 및 栽植 密度에 미치는 影響에 관하여 試驗한 結果를 要約하면 다음과 같다. 1. 分蘗數는 N 18㎏區가 높았고 72株區가 가장 많았다. 2. 穗長은 N 18㎏區와 72株區 다른區에 비하여 약간 길었다. 3. 粒數는 N 18㎏區가 가장 많았으며 栽植密度間에는 高度의 有意性이 認定되었다. 4. 登熟比率은 基??水準間에 有意性이 認定되었고 72株區가 높았으며 N 18㎏區가 가장 낮았다. 5. 千粒量은 施肥量間에 有意性이 認定되었으나 栽植 密度間에는 차가 거의 없었다. 6. 收量은 栽植 密度間에는 有意性이 認定되었으며 施肥量에는 認定되지 않았지만 N 18㎏區에서 약간 높은 傾向을 보였다. This experiment was conducted in the experimental field of Chinju National Agricultural and Forestry Junior College from April to October, 1986. The purpose of this experiment was to investigate the effect of basic nitrogen, fertilization level and planting density on the growth and yield of rice cultivar, Dong jin,. The results obtained are as follows : 1. The number of tilers was largest at the level 18㎏ N ad in the spacing of 72 plants. 2. The panicle lengh was a little longer then any other group at the level of 18㎏ N and in the spacing of 72 plants. 3. The grain number was largest at the level of 18㎏ N and highly significant difference in the grain number was confirmed among the different planting density. 4. The percentage of ripeness showed significant differences among the levels of basic fertilization. It was high in the spacing of 72 plants and lowest at the level of 18㎏ N. 5. The 1000 grain weght revealed a significant difference among the fertilization levels, but it showed little difference among the plant density. 6. The difference of yield showed significance among the planting density, but it showed little significance among the levels of fertilization. Only the yield of 18㎏ N level tended to be a little large.

LPCD법에 의한 Tin박막의 전계 에미터 어레이 제작

조경제,이상윤,류정탁,김연보,이진호 大邱大學校 科學技術硏究所 2001 科學技術硏究 Vol.8 No.2

Using low pressure chemical vapor deposition (LPCVD), TiN thin films as field emitter array were fabricated. In this Work, a method was transfered to a substrate and the wet-etching of the silicon substrate instead of fabricated method of mold shape was using in generally but we have fabricated gated field emitter tips as using mold shape of the new method that using a side wall space structure. Following sequences such as LPCVD method of a gate electrod and gate oxide on a silicon substrate and defesited BPSG thin film as a high temperature was flowed by the mold shape of a sharpen, the TiN as a materials of emitter tips was deposited after was bounded by anodic bonding and the wet-etching of the silicon substrate by using KOII solution, the last have fabricated a gated field emitter arrays of a sharpen. These emitters were estmated by scanning electron microscopy and X-ray diffraction.

터널 콘크리트 벽체의 건전도 평가에 대한 연속 웨이브릿(Wavelet)의 적용

추진호,조성호,강태호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2

터널 라이닝의 두께와 강성(stiffness)의 평가에 웨이브릿(wavelet)을 이용하여 신호 해석의 극대화와 터널의 건전도 평가에 있어서 직접적인 수직 균열의 유무, 위치, 다양한 반사면의 탐지에 관한 웨이브릿해석의 적용성을 평가하였다. 기존의 탄성파 해석은 시간 혹은 주파수의 한 영역에서만 해석이 이루어져 왔으나, Wavelet 해석은 신호처리에 있어서 시간-주파수 영역을 동시에 살펴보면서 해석을 할 수 있다. 본 연구에서는 콘크리트의 두께와 강성 균열을 평가하기 위하여 탄성파 기법의 하나인 충격반향 시험법에 대하여 Wavelet 해석을 시행하였다. 유한요소법의 하나인 ABAQUS를 이용한 수치해석과 실규모 현장시험체에서 시행한 실측 데이터 해석에 연속 Wavelet을 적용하여 보았으며, 그 결과 구조물 내에 존재하는 균열의 존재 여부와 균열의 위치를 확인하는데 Wavelet 기법이 매우 효과적이며, 향상된 신뢰성을 제공함을 확인하였다. The feasibility of the continuous wavelet analysis was evaluated for the nondestructive assessment of the structural integrity of a tunnel concrete liner. The conventional approach to analyze the signal of the wave propagation is focused on just one domain of time or frequency, while the wavelet analysis analyzes both domains of time and frequency. This study introduced the continuous wavelet analysis to interpret and analyze the stress-wave signal in both frequency and time domains for the better identification of the vertical cracks in the tunnel concrete liner. The synthetic stress-wave signals from ABAQUS were used to establish the methodology to employ the wavelet analysis, and later the real measurements at the real-scale tunnel concrete liner were analyzed. As a result, it was concluded that the continuous wavelet analysis is a reliable and effective tool to identify the vertical cracks in the tunnel concrete liner.

SECKEL 증후군 환자의 증례보고

김추성,김재곤,백병주,양연미,정진우 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

Seckel 증후군은 상염색체 열성 유전질환으로 태내에서의 성장지연에 따른 출생 후의 소인증, 심한 소두증을 나타내며, 큰눈과 돌출된 코, 후퇴된 하악을 동반한 새 모양의 안모가 특징적이다. 다른 임상증상으로는 관절의 결함, 내반족, 드문드문 난 모발, 비뇨생식기의 이형성, 정신지체, 혈액학적 이상 등이 나타날 수 있다. Seckel 증후군의 구강 내 소견으로는 부정교합, 법랑질 저형성증, 일부 치아의 선천적 결손, 우상치 등이 나타날 수 있다. 본 증례는 Seckel 증후군을 보이는 두 증례에서 발육부전, 새 모양의 안모, 비뇨기과적 기형, 치아의 저형성과 부정교합 등 다양한 전신증상과 구강 내 증상들을 보였기에 이를 보고하는 바이다. Seckel syndrome is an autosomal recessive disorder characterized by intrauterine growth retardation and post-natally by dwarfism, severe microcephaly, bird-headed profile with receding chin, prominent nose, joint defects, clubfoot, sparse hair, malformation of genitourinary tract and rectum, mental retardation and hematological disorders. There is also a reduction in the number of blood cells. Dental anomalies of Seckel syndrome are crowded teeth with malocclusion, enamel hypoplasia, absence of some teeth and taurodontism. This report described the oral and maxillofacial manifestations of children associated with Seckel syndrome. Children with Seckel syndrome have several dental and skeletal irregularities. The purpose of this study was to report the dental and medical characteristics of the patient and review the literatures of Seckel syndrome.

水稻의 生育時期에 따른 잎 損傷이 收量에 미치는 影響

金鎭雨,安元燮,金正洙,崔周鎬 진주산업대학교 1985 論文集 Vol.23 No.-

本 硏究는 水稻의 葉身損傷 時期및 程度가 收量과 玄米中의 無構質 含量에 미치는 影響을 究明하기 위하여 1985年 4月부터 1985年 10月동안에 걸쳐서 葉身損傷 時期를 8月2日, 8月12日, 8月22日로 하고 損傷程度는 止葉을 포함한 上位4枚의 葉을 完全切葉, 半切葉, 半折返으로 水稻의 收量 玄米의 無構質 含量을 調査한 것으로서 그 結果를 要約하면 다음과 같다. 1. 登熟比率과 精玄比率은 葉身의 處理時期가 늦을수록 높았고 損傷程度에서는 공히 半折返區에서 高度의 有意性이 認定되었다. 2. 玄米重量및 正租收量은 處理時期가 늦은 半折返區에서 가장 높았다. 3. 秕重과 重層未은 處理時期와 損傷程度間에 高度의 有意性이 認定되었지만 稈長, 穗長, 穗數, 粒數 및 玄米千粒重에서는 有意性이 認定되지 않았다. 4. 玄米의 無構質 含量은 T-N K_2O는 完全切葉區에서 半切葉區, 半折返區보다 약간 높았고 P_2O_5 CaO MgO SiO_2는 공히 半切葉區에서 完全切葉區와 半折返區보다 높았다. 處理時期로는 T-N性分은 時期가 가장늦은 8月22日區에서 약간 높았고 P_2O_5 CaO MgO K_2O는 공히 處理時期가 가장 빠른 8月 2日區에서 많았다. SiO_2만은 8月 12日區에서 多少 높았다. This experiment was conducted to find out the degree and time of leafblade in jury of rice affects on yield and quality of rice grain. The investigation was complied from April, 1985 to October, 1985. To investigate the yield of rice and quality of rice grain. The leaves were injured by the three Types of treatments like full cutting, half cutting and bending the each 4 leaves locatea in the top portion of rice including flag leaf at three different time August 2, August 12 and August 22. According to the analysis of the date collected in this experiment, the main result obtained was a follows; 1. The later the treatment, the more the percent of ripeness and the percentage of hulled and unhulled rice increased. And the degree of injury showed high significance in bending plot. 2. Brown rice weight and winnowed rice yield showed the highest rate in late treatment of bending plot. 3. Empty grains weight and rice screenings weight showed high significance between the treatment time and degree of injury but not in culm length, panicle length, panicle number per plant, number of grains per spikelet and brown rice 1,000 grain weight. 4. The result of an analysis of the quality of rice grain showed that full cutting plot produced greater quantity than half cutting plot and bending plot in the content of T-N, K_2O. But in the content of p_2O_5, CaO, MgO, SiO_2, half cutting plot showed greater quantity than full cutting plot and bending plot. On the other hand as for the treatment time the ingredient of the T-N showed a little higher rate in the plot of August 22 with latest treatment time. But the ingredient of the P_2O_5, CaO, MgC, K_2O showed high rate in the plot of August 2 with the earliest treatment time. But only SiO_2 showed a little higher rate in the plot of August 12.

化學肥料 및 有機質肥料에 Zeolite 合施用으로 土壤內 重金屬 含量이 옥수수 生育에 미치는 影響

金鎭雨,李宗玉,崔周鎬 진주산업대학교 농업기술연구소 2000 農業技術硏究所報 Vol.13 No.-

This research was carried out to investigate how the growth of corn was affected by the heavy metal contents of treatments in plant by analyzing chemical of properties between the growth stages of corn and heavy metal contents in soils collected from chemical fertilizer and organic fertilizer of mixtures with zeolite The results obtained were summarized as follows. 1. The contents of heavy metals such as Zn, Pb, Cu, Cd and As in soil treatments were high compared with no-fertilizer by early growth stages, but harvest time of treatments in soil was low. 2. The contents of heavy metals in organic fertilizer of treatments in soil were low compared with chemical fertilizer by harvest time. 3. The contents of heavy metals activity of treatments in soil were decreased because of depending on amount of application of zeolite. 4. The final showed contents of heavy metals in all treatments of plant decreased on the contary no-fertilizer especially in the organic fertilizer+zeolite because of amount increased of application of zeolite.

Chemical-Looping Combustion을 위한 금속산화물 매체들의 산화 환원 반응특성

이진배,송영욱,박주식,최상일,김영호,양현수 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2

Chemical-looping combustion has been focused as a very promising combustion technology from the viewpoint of high energy efficiency, easy separation of CO_(2) and no formation of NO_(x). The key of this combustion technology is to develop oxygen carrier mediums with high oxygen capacity, and high machanical and thermal stability. In this study, various kinds of mediums were prepared by the combination of active metal oxides, such as NiO, CoO, Fe_(2)O_(3) or NiO-Fe_(2)O_(3), with YSZ(yttria stabilized zirconia) as a binder. The redox reactions on the mediums were also carried out by using the thermogravimetric reactor. The redox reaction rates on a NiO/YSZ medium were found to be most superior in comparison with those of other mediums. In addition, durability of the medium was also found to be appropriate for UC. For the purpose of high redox reaction rates, the optimum reaction temperatures of reduction and oxidation on a NiO/YSZ medium were observed as 600℃ and l000℃, respectively.

慶北 永川郡 大勝池에서 採集한 淡水魚의 吸蟲類 肝吸蟲 被囊幼蟲 奇生狀의 變動

李鎭植,文柱煥,鄭東一,崔東翊 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.3

1990年 4月부터 同年 9月까지 慶北 永川郡 大勝池(사근다리못)에서 採集되는 各種 淡水魚에서 肝吸蟲 被囊幼蟲의 寄生狀을 調査하여 1980年 同貯水池에서 調査한 成績과 比較한 바 採集魚種과 寄生狀의 差異를 觀察하였으므로 報告하는 바이다. 1980년 大勝池에서 採集된 魚種은 붕어(Carassius carassius), 강준치(Erythroculter erythropterus), 버들치(Moroco oxycepharus), 납지리(Paracheilognathus rhombea), 참붕어(Pseudorasbora parva), 참중고기(Sarcocheilichthys sinensis)의 6種이었으나 1990年에는 붕어, 파랑볼우럭(Lepomis macrorchirus), 참붕어의 3種만이 採集되었다. 1980年에 採集한 淡氷魚에서의 肝吸蟲 被囊幼蟲의 寄生率과 寄生程度는 강준치 25.0%, 5.4개, 납지리 13.0%, 0.5개, 참붕어 71.1%, 24.4개, 참중고기 46.7%, 5.8개였고, 1990年에는 참붕어에서만 25.0%, 7.7개로 檢出되었다. 以上의 成績으로 미루어 보아 大勝池는 지난 10年間 生態界가 變化하였고 그간에 移植된 파랑볼우럭이 生態界變化에 多少의 影響을 미친 것으로 생각된다. From April to September, 1990, fresh-water fish were collected in Daesong pond and examined for the presence of Clonorchis sinensis metacercaria in order to compare the infestation with C. sinensis metacercaria with that in 1980. Six species of fresh-water fish, Carassius carassius, the crusian carp, Erythroculter erythropterus, the white fish, Moroco oxycepharus, the fat minnow, Paracheilognathus rhombea, the flat bitterling, Pseudorasbora parva, the southern top-mouthed minnow, and Sarcocheilichthys sinensis, the oily shiner, had been collected in the pond in 1980. In 1990, however, only 3 species of fresh-water fish, C. carassius, P. parva and Lepomis macrorchirus, the blue gill, were collected. The rates and intensity of infestation with C. sinensis had been 71.1% and 24.4 cysts per gram of flesh in P. parva, followed by 46.7% and 5.8 in S. sinensis, 25.0% and 5.4 in E. erythropterus, 13.0% and 0.5 in P. rhombea in 1980. The metacercaria were demonstrated from P. parva alone, with the rate 27.3% and the intensity 7.7, in 1990. In the light of these results, it is likely that L. macrorchirus caused the ecosystem of the pond to be changed.

Coloring기법을 이용한 향상된 5-셀 PNPSF 테스트 알고리즘

장주석,윤태진 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

State-of-the-art memory chips are designed with spare rows and columns for reconfiguration purposes. After a memory chip is reconfigured, Physically adjacent cells may no longer have consecutive logical addresses. In this paper, we present new test algorithms to detect 5-cell Physical neighborhood pattern sensitive faults in dynamic RAMs, even if the logical and physical addresses are different and the physical-to-logical address mapping is not available. These algorithms have test length of O(N[log_2N][log_3N]^2) for N-bit RAMs, and also detect other faults such as stuck-at and coupling faults. The algorithms depend on the 3-coloring algorithm that trichromatically colors all the triplets among a group on n object in at most [log_3N]^2 coloring steps and 2-coloring algorithm that differently colors all the pairs among a group of n object in at most [log_2N] coloring step.