Surgery and Metronomic Chemotherapy in a Pet Rabbit (Oryctolagus cuniculus) with Mammary Gland Adenocarcinoma

Jihee Hong,Jeong-Min Lee,Ji-Young Lee,Han-Joon Lee,Dong-Kwan Lee,Joong-Hyun Song,Kun-Ho Song The Korean Society of Veterinary Clinics 2023 한국임상수의학회지 Vol.40 No.6

An 8-year-old female pet rabbit presented at the veterinary clinic for mammary gland palpation due to the presence of a mass. Upon physical examination, a mass was identified in the left fourth mammary gland. Abdominal ultrasonography revealed a 3 × 2 cm mass in the right uterus and general thickening of the endometrium, suggesting uterine sinusitis. Multiple pulmonary nodules suspected to be metastatic lesions were identified on chest radiography. Surgery was performed to mastectomy and ovariohysterectomy (OHE). The histopathological examination of the tumor revealed mammary gland adenocarcinoma (simple-type) with multiple nodules consisting of the proliferation of tumor cells forming tubules containing secretory materials, cellular debris, and solid nests with a central area of necrosis. Metronomic chemotherapy was performed with cyclophosphamide and lomustine (CCNU) based on the histopathological findings. The quality of life has been well maintained, with no specific clinical symptoms observed for 8 months after metronomic chemotherapy. To the best of authors' knowledge, this study is the first to examine the effects of metronomic chemotherapy with cyclophosphamide and lomustine in a pet rabbit.

Assessment of radiographic left atrial dimension and C-reactive protein in dogs with myxomatous mitral valve disease

Jihee Hong,Han-Joon Lee,Dong-Kwan Lee,Kun-Ho Song 한국동물위생학회 2024 韓國家畜衛生學會誌 Vol.47 No.1

Radiographic left atrial dimension (RLAD) is a valuable metric for assessing left atrial enlargement in dogs. While there have been studies on the use of RLAD and the increase in C-reactive protein (CRP) levels based on heart disease stages, there has been no prior research on the correlation between RLAD and CRP. In this study, the objective was to investigate the relationship between the rise in RLAD as myxomatous mitral valve disease (MMVD) stages advance and the increase in CRP levels with MMVD stage progression. In this study, a total of 30 small-breed dogs were included as subjects. These dogs were diagnosed with MMVD at the American College of Veterinary Internal Medicine (ACVIM) stage B1 or B2, or stage C, based on a comprehensive assessment including physical examination, thoracic radiography, and echocardiography. Measurements of VHS and RLAD were compared to assess any significant differences. There were significant differences in RLAD between dogs with MMVD ACVIM stage B1 and those with stage C. The monocytes and CRP levels showed significant differences between ACVIM stage B1, B2 and ACVIM C. Additionally, a significant correlation was observed between the RLAD and VHS measurements. This underscores the notable association between MMVD stage advancement and elevated monocyte and CRP levels. The RLAD scores exhibited a significant difference among dogs with ACVIM stages B1, B2, and C, and significant variations were also observed in monocyte and CRP levels. These results suggest that monocyte and CRP levels may be a valuable diagnostic indicator for heart disease in dogs during the diagnostic evaluation.

자살사고를 가진 성인의 불안정 성인애착이 자살취약성에 미치는 영향: 우울성향의 매개효과

홍지희 ( Jihee Hong ),안명희 ( Myunghee Christine Ahn ) 서강대학교 학생생활상담연구소 2016 人間理解 Vol.37 No.2

본 연구는 불안정 성인애착, 우울성향, 그리고 자살취약성의 관련성을 알아보고자 하였다. 구체적으로 자살사고를 가진 성인의 불안애착과 회피애착이 관계욕구좌절로 측정한 자살취약성에 영향을 미치는 과정을 확인하고 이 과정을 의존적, 자기비판적 우울성향이 매개하는지 탐색하였다. 서울·경기 지역에 거주하며, 한 달에 한 번 이상 자살관련 사고를 한다고 보고한 초기 성인기 남녀 278명의 자기보고식 설문자료를 SPSS 18.0과 AMOS 18.0 프로그램을 사용하여 분석하였다. 본 연구결과 의존적 우울성향과 자기비판적 우울성향은 각기 다른 양상으로 불안애착과 회피애착이 자살취약성에 미치는 영향을 매개하는 것으로 나타났다. 불안애착 수준이 높을수록 의존적 우울성향이 증가했고, 의존적 우울성향이 증가할수록 자살취약성은 감소하였다. 한편, 불안애착과 회피애착 수준이 높을수록 자기비판적 우울성향이 증가했고, 자기비판적 우울성향이 증가할수록 자살취약성이 높아졌다. 본 연구 결과를 바탕으로 연구의 의의, 후속연구를 위한 제언, 상담적 함의를 논의하였다. The present study investigated the role of depressive tendency in the relationship between insecure adult attachment and suicidal vulnerability among young adults with suicidal ideation. Results from self-report questionnaires based on a sample of 278 young adults in the Seoul/Gyeonggi area with reported suicidal ideation were analyzed using SPSS 18.0 and AMOS 18.0. Results from structural equation modeling indicated that the effect of insecure adult attachment on suicidal vulnerability was partially mediated by depressive tendency. First, anxious attachment significantly increased the level of dependent depressive tendency, but the increase in dependent depressive tendency significantly decreased suicidal vulnerability. On the other hand, anxious attachment and avoidant attachment significantly increased the level of self-critical depressive tendency. In turn, the increase in self-critical depressive tendency significantly increased suicidal vulnerability. Differential findings regarding dependent depressive tendency and self-critical depressive tendency add to the extant literature on depressive tendency, insecure adult attachment, and suicidal risk. Implications of the present findings as well as suggestions for future study were discussed.

Metastatic intestinal adenocarcinoma with osseous metaplasia in two Domestic Korean Shorthair cats

Jae-Ha Jung,Na-Yon Kim,Yeseul Yang,Dansong Seo,Goeun Choi,Hyunki Hong,Taeseong Moon,Hyeong-Mok Kim,Jihee Han,Jihee Hong,Yongbaek Kim 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.5

Two Domestic Korean Shorthair cats presented with dyschezia and vomiting. Computed tomography revealed a colonic mass with calcification and lymph node metastasis in case 1, and a small intestinal mass with disseminated mesenteric metastasis and calcification in case 2. Histopathology revealed intestinal adenocarcinoma with osseous metaplasia. Case 1 died two months after surgery from distant metastasis; and case 2 showed no metastasis for five months but presented with anorexia, euthanized seven months after diagnosis. Metastatic intestinal adenocarcinoma with bone formation should be considered as differential diagnosis for calcification on imaging, and lymph node metastasis at diagnosis may indicate poor prognosis.

FCT 7 : Evaluation of a novel thread-lift in the improvement of nasolabial folds & cheek laxity

( Jihee Kim ),( Hee Su Kim ),( Jung Min Bae ),( Jimyung Seo ),( Hong Sun Jang ),( Mi Ryung Rho ),( Byung Ho Oh ),( Kyung Ae Nam ),( Kee Yang Chung ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Since the use of the first barbed sutures for facial rejuvenation in 1990s, various products have been introduced based on different principles. There have been many published reports showing its effectiveness but majority relies on subjective improvement parameters assessed by practitioners or patients. Objectives: To evaluate the effectiveness of a novel monodirectionally barbed polydioxanone face-lifting thread by various objective measuring tools such as ultrasonography and 3-dimensional imaging. Methods: A single center, uncontrolled, open labeled, non-randomized trial was designed. Twenty three volunteers underwent a single thread-lifting. Ultrasonographic analysis and 3-dimensional imaging were performed before the procedure and one month after. Results: Among the 23 volunteers, 22 were females and one was a male. Average age of the enrolled volunteers were 60.2±6.8 years. Ultrasonographic measurement of the dermal thickness showed statistically significant increase and three dimensional measurements showed decreased volume and area around the nasolabial fold and jowl. All patients were satisfied with the outcomes after the single thread-lift procedure. Conclusion: In this study, we evaluated the outcomes of a thread-lift using three-dimensional imaging and ultrasonography. Thread-lift using a newly developed monodirectionally barbed polydioxanone thread was found to be convenient and effective to treat the aging features of the face.

Immobilization of Copper Hexacyanoferrate on Highly Porous Al2O3 Ceramic Foam for Remediation of Radioactive Cs Contaminated Water

Jihee Song,Chaerin Park,Hye-Jin Hong 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

Copper hexacyanoferrate (Cu-HCF), which is a type of Prussian Blue analogue (PBA), possesses a specific lattice structure that allows it to selectively and effectively adsorb cesium with a high capacity. However, its powdery form presents difficulties in terms of recovery when introduced into aqueous environments, and its dispersion in water has the potential to impede sunlight penetration, possibly affecting aquatic ecosystems. To address this, sponge-type aluminum oxide, referred to as alumina foam (AF), was employed as a supporting material. The synthesis was achieved through a dip-coating method, involving the coating of aluminum oxide foam with copper oxide, followed by a reaction with potassium hexacyanoferrate (KHCF), resulting in the in-situ formation of Cu-HCF. Notably, Copper oxide remained chemically stable, which led to the application of 1, 3, 5-benzenetricarboxylic acid (H3BTC) to facilitate its conversion into Cu-HCF. This was necessary to ensure the proper transformation of copper oxide into Cu-HCF on the AF in the presence of KHCF. The synthesis of Cu-HCF from copper oxide using H3BTC was verified through X-ray diffraction (XRD) analysis. The manufactured adsorbent material, referred to as AF@CuHCF, was characterized using Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). These analyses revealed the presence of the characteristic C≡N bond at 2,100 cm-1, confirming the existence of Cu-HCF within the AF@CuHCF, accounting for approximately 3.24% of its composition. AF@CuHCF exhibited a maximum adsorption capacity of 34.74 mg/g and demonstrated selective cesium adsorption even in the presence of competing ions such as Na+, K+, Mg2+, and Ca2+. Consequently, AF@CuHCF effectively validated its capabilities to selectively and efficiently adsorb cesium from Cs-contaminating wastewater.

Pre-treatment neutrophil-to-lymphocyte ratio is associated with improved overall survival in patients with gynecological cancer treated with immunotherapy

( Jihee Jung ),( Joonyoung Hong ),( Joseph J. Noh ),( Chel Hun Choi ),( Tae-joong Kim ),( Jeong-won Lee ),( Yoo-young Lee ),( Byoung-gie Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: The purpose of this study was to determine whether the pretreatment neutrophil-lymphocyte ratio at the time of initiation of immune checkpoint inhibitors (ICIs) in patients with recurrent gynecological cancer has an effect on progression free survival (PFS) and overall survival (OS). Methods: A retrospective, single-center cohort study was conducted using data between March 1, 2002, and February 18, 2021 at Samsung Comprehensive Cancer Center, Seoul. We identified patients who received ICIs for recurrent gynecological cancer (ovarian, endometrial, cervical, and other cancers). The absolute serum neutrophil and lymphocyte ratio (NLR) was calculated from the complete blood count laboratory results performed before the first cycle of ICIs. Based on the median value of the NLR ratio, analysis was performed by dividing into 2 groups as high or low NLR. Results: Among 250 patients, 207 patients were included in the analysis, excluding patients with unknown pre-treatment NLR ratio or follow-up loss. 103 patients were assigned to the group with a low NLR, and 104 patients were assigned to the group with a high NLR ratio. There were statistically significant differences between the two groups in terms of body weight, BMI, prior radiation therapy, ECOG, total number of ICIs, and prior antibiotics use before ICIs (p<0.05). In the univariate analysis according to NLR, the Kaplan-Meier curve showed significantly longer overall survival (OS) in patients with low NLR compared with high NLR (p=0.17). In Cox multivariable analysis, NLR, ECOG, and total number of ICIs were found to affect Especially, low NLR group demonstrated survival gain about 3 times compared to the high group (HR 3.26; 95% CI 1.89 5.62; p<0.001). Conclusion: Pre-treatment high NLR showed significant improved. OS in patients with ICIs for recurrent gynecological cancer. It is thought that pretreatment NLR can be used as a predictive marker to predict survival after ICIs in patients with recurrent gynecological cancer.

P087 Active cosmetic ingredient delivery system using biodegradable microneedle patch in melasma patients

( Jihee Kim ),( Young In Lee ),( Sungsik Shin ),( Jung U Shin ),( Jung Dong Kim ),( Hong Kee Kim ),( Dohyeon Jeong ),( Juyeop Shin ),( Jung Hyun Bae ),( Kwang Hoon Lee ),( Ju Hee Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Biodegradable microneedle is a recently developed method to deliver pharmaceutical components into the skin, and is expected to yield better clinical outcome compared to topical application. Objectives: To evaluate the efficacy of the hyaluronic acid (HA)-based microneedle patches containing ascorbic acid, tranexamic acid, niacin amide and resveratrol on melamsa patients. Methods: A twelve week, randomized, double blind study was performed. Twenty four Korean patients with mild to moderate melasma, according to Melasma Area and Severity Scale (MASI) were enrolled and completed the study. Patients used two different types of patches on each side of the designated area every other day for 8 weeks. Patients were requested for an additional 12-week follow up visit. Pigmentary improvements were assessed subjectively with MASI, patient satisfaction score, and photographic analysis. Additionally, quantitative analysis was performed with mexameter and corneometer (Courage & Khazaka, Cologne, Germany). Results: No patient complained of irritation or other side effects regarding the use of microneedle patch. Compared to control area without microneedle and active ingredients only, microneedle patch applied area showed statistically significant clinical improvement in degree of pigmentation. Conclusion: Results indicates that microneedle patch with active ingredients can be used safely and effectively for melasma treatment.

제품 서비스화(Product Servitization) 동향 및 분석

류지희(Jihee Ryu),임호순(Hosun Rhim),박광태(Kwangtae Park),김홍일(Hong-il Kim) 한국경영과학회 2009 한국경영과학회 학술대회논문집 Vol.2009 No.5

서비스 산업화가 진행됨에 따라 제품에서 서비스가 차지하는 비중과 중요성은 높아지고 있으며 이러한 현상은 전통적 제조기업의 역할을 변화시키고 있다. 본 연구에서는 전통적 제조기업이 서비스를 제공하고 나아가 새로운 비즈니스를 창출하는 현상을 설명하기 위하여 제품과 서비스의 변화를 분석하고 서비스화에 대한 이론적 배경과 연구동향을 살펴보았다. 이를 바탕으로 제품 서비스화(product servitization)의 관점에서 제조기업의 서비스화를 나타내기 위하여 시장, 제품-서비스-지식 통합시스템, 가치사슬 구성원의 핵심역량으로 구성된 개념적 모형을 제시하고 서비스화 이론을 뒷받침하는 기업사례를 모형에 적용하여 분석한다.

간호학과생과 응급구조학과생의 PTSD에 대한 태도와 지식

홍선우(Hong, Sun-Woo),방경숙(Bang, Kyung-Sook),방활란(Bang, Hwal Lan),임지희(Lim, Jihee) 한국간호교육학회 2020 한국간호교육학회지 Vol.26 No.4

Purpose: This study aimed to identify attitude and knowledge level on post-traumatic stress disorder (PTSD) among nursing and paramedic students. Methods: A questionnaire survey was conducted from December 1st to 20th in 2019. A total of 210 students participated from two universities in Korea. Data were analyzed using descriptive statistics, t-tests and one-way analysis of variance. Results: Students were positive about the governments spending on PTSD treatment (91.4%), and professional training (92.4%). PTSD patients were considered to be more dangerous (68.1%) and violent (42.4%) than the general population. There were no significant differences in attitude and general knowledge on PTSD between nursing and paramedic students. However, general knowledge on PTSD differed according to education experience on PTSD (t=2.04, p=.043). Knowledge scores for PTSD treatment differed significantly according to the academic major (t=2.02, p=.044), and education experience on PTSD (t=2.87, p=.005). Conclusions: The results of this study indicate nursing and paramedic students lack knowledge on PTSD. Therefore, developing curriculum regarding PTSD-related contents in undergraduate and continuing education in both departments is needed to provide better quality health care to people with PTSD.