DIFFERENCES OF WEIGHTED COMPOSITION OPERATORS ON BERGMAN SPACES INDUCED BY DOUBLING WEIGHTS

Jiale Chen 대한수학회 2023 대한수학회보 Vol.60 No.5

We characterize the boundedness and compactness of differences of weighted composition operators acting from weighted Bergman spaces $A^p_{\omega}$ to Lebesgue spaces $L^q(d\mu)$ for all $0<p,q<\infty$, where $\omega$ is a radial weight on the unit disk admitting a two-sided doubling condition.

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Dong Jiale,Wang Wenzhi,Zhou Wei,Zhang Siming,Li Meng,Li Ning,Pan Guoqing,Zhang Xianzuo,Bai Jiaxiang,Zhu Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

Preparation and Characterization of a pH-responsive Polymer that Interacts with Microbial Transglutaminase during Affinity Precipitation

Sipeng Li,Jialing Chen,Xuanjun Zhang,Zhaoyang Ding,Xuejun Cao 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.1

Microbial transglutaminase (MTG) has been widely used in the food and pharmaceuticals industries. In this study, MTG was purified using affinity precipitation with an affinity polymer (PMMDN-T), which was synthesized using a pH-responsive polymer (PMMDN) coupled with L-thyroxin as an affinity ligand. Interactions between MTG and PMMDN-T were investigated using turbidimetric titration, zeta potential measurements, and low-field nuclear magnetic resonance (LF-NMR). We found different behaviors, architectures, and phase states of pH-dependent interactions between MTG and PMMDN-T interactions. Binding energetics between MTG and PMMDN-T were determined by isothermal titration calorimetry (ITC). The isoelectric point (pI) of the affinity polymer was 4.65 and was recovered with 96.7% efficiency after recycling the polymer three times. The optimal adsorption condition was 0.02 mol/L phosphate buffer (pH 6.0) with 1.0 mol/L NaCl at 30.0°C and a ligand density of 50.0 μmol/g. The maximum elution recoveries of total MTG were 98.44% (protein) with 92.19% (activity) using 0.02 mol/L pH 10.0 Gly-NaOH as the eluent.

Design of Mixture Proportion of Engineered Cementitious Composites Based on Desert Sand

Dan Wang,Jialing Che,Chen Liu,Haifeng Liu 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.7

Engineered Cementitious Composites are a type of advanced building materials, which have excellent ductility and can significantly enhance structural resistance. However, the expensive material cost of ECC limits its engineering applications. This study investigated the potential of replacing commonly used silica (river) sand and imported PVA fibers with the local desert sand and PVA fibers, aiming at reducing the preparation cost of ECC and improving its economic benefits and sustainability. The mixture proportion was first optimized to obtain favorable strength and ductile enhancement, using a combination of single-factor test and theoretical calculation which mentioned the slurry coating thickness of fibers and desert sand. The potential of desert sand in preparing ECC was experimentally evaluated by comparing the uniaxial tension (compression) properties and microstructures of desert sand-based ECC (DS-ECC) and those of ordinary ECC. The results indicate that optimized DS-ECC can achieve satisfactory performance even when 100% fine aggregates are replaced by desert sand. It has comparable uniaxial tensile (compression) strengths to ordinary ECC but a significantly improved tensile ductility, with the ultimate tensile strain of about 5 − 8% and 3% at 7d and 28d curing ages, respectively. Meanwhile, the utilization of desert sand and local PVA fibers alone in ECC can substantially deliver a reduction of about 20 − 30% in material cost and an improvement in environmental impact.

The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy

Xiaodong Wu,Jiale Qin,Tao Shen,Weidong Fei,Lili Chen,Xing Xie,Weiguo Lu 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4

Objective: To assess the outcomes and toxic effects of 5-day actinomycin D (Act-D) salvagetherapy and to explore the predictors of Act-D resistance in patients with low-risk gestationaltrophoblastic neoplasia (GTN)who failed 5-day methotrexate (MTX) chemotherapy. Methods: This retrospective study analyzed patients with low-risk GTN administered Act-Dsalvage therapy after failing MTX chemotherapy at Women's Hospital, School of MedicineZhejiang University between January 2000 and December 2015. The clinical parameters ofthese patients were collected and analyzed. Results: The final analysis included 89 cases. Of these, 73 cases (82.02%) responded tosalvage Act-D. The remaining 16 resistant cases were switched to etoposide, MTX, Act-D/cyclophosphamide, and vincristine chemotherapy and achieved complete remission. Serumhuman chorionic gonadotrophin levels before Act-D salvage therapy (hCGAct-D)in the Act-D resistant cases were significantly higher than those in the Act-D responders (median 605 vs. 103 IU/L, p=0.009). However, the range of hCGAct-D values in Act-D responders was wider thanthat in Act-D-resistant cases (5.76–16,664 IU/L vs. 11.43–6,732 IU/L). Thus, assigning a generalcut-off value was difficult considering the individual setting. Except for 2 cases requiring othersalvage regimens due to Act-D toxicity, 97.80% of cases (89/91) tolerated the toxicity. During atleast 1-year follow-up, the survival rate was 100.00% and no case developed recurrence. Conclusion: Based on the good therapeutic effect and tolerable toxicity, we recommendAct-D salvage therapy for all patients with low-risk GTN who fail primary MTX chemotherapy. The higher serum hCG levels before Act-D salvage therapy may be associated with resistanceto this treatment.

Mechanical Performances of Concrete Produced with Desert Sand After Elevated Temperature

Haifeng Liu,Xiaolong Chen,Jialing Che,Ning Liu,Minghu Zhang 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.4

Currently, fire in building is one of the most serious disasters. With the increase of basic construction items in western China, ordinary medium sand resource no longer met with the need of engineering. Compressive strength experiments of concrete produced with desert sand after elevated temperature were carried out in this paper. The effects of desert sand replacement rate (DSRR), temperature and cooling regime on the mechanical performances of concrete produced with desert sand were analyzed. XRD and SEM experiments were also conducted to study the microstructure of concrete produced with desert sand after elevated temperature. Experimental results showed that the cubic compressive strength of concrete produced with desert sand increased firstly, and then declined with temperature. Whereas, the prismatic compressive strength and elasticity modulus of concrete produced with desert sand under static compression declined with temperature. With the enhancement of DSRR, the elasticity modulus under static compression, cubic compressive strength and prismatic compressive strength of concrete produced with desert sand after elevated temperature increased firstly, and then declined, the maximum value of which was reached when DSRR amounted to 40%. Regression models were established to predict the mechanical performances of concrete produced with desert sand after elevated temperature, which were in good agreement with experimental results.

Initial Report on the Oriented-precipitation of T1-Phase in Creep-Aged Al-Cu-Li Single Crystal

Wei Hu,Jiqiang Chen,Shuang Han,Jinjun Xu,Jiale Miao,Ting Xing,Renguo Guan 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5

In this work, the precipitation behavior of the T1-phase on each {111}Al habit plane was characterized by transmissionelectron microscopy (TEM), which was observed along two < 110 > Al zone axes in an Al-Cu-Li single crystal during creepaging. The results indicate that the oriented-precipitation of T1-phase in the Al-Cu-Li single crystal was originally determinedduring creep aging. The number densities of the T1-phase on the habit planes of (111)Al and (1−11)Al is noticeablyhigher than those of the T1-phase on the habit planes of (−111)Al and (11−1)Al in the same Al-Cu-Li single crystal when theexternal stress is loaded along the direction close to [111]Al orientation. It implies that the T1-phase tends to preferentiallyprecipitate on the habit planes that are perpendicular to the loading direction during creep aging. This work provides theinitial experimental evidence of the oriented-precipitation of the T1-phase in Al-Cu-Li alloy, and proposes the possibilityof regulating the precipitation distribution of the T1-phase.

Hepatocellular carcinoma prediction model performance decreases with long-term antiviral therapy in chronic hepatitis B patients

Xiaoning Wu,Xiaoqian Xu,Jialing Zhou,Yameng Sun,Huiguo Ding,Wen Xie,Guofeng Chen,Anlin Ma,Hongxin Piao,Bingqiong Wang,Shuyan Chen,Tongtong Meng,Xiaojuan Ou,Hwai-I Yang,Jidong Jia,Yuanyuan Kong,Hong Yo 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3

Background/Aims: Existing hepatocellular carcinoma (HCC) prediction models are derived mainly from pretreatment or early on-treatment parameters. We reassessed the dynamic changes in the performance of 17 HCC models in patients with chronic hepatitis B (CHB) during long-term antiviral therapy (AVT). Methods: Among 987 CHB patients administered long-term entecavir therapy, 660 patients had 8 years of follow-up data. Model scores were calculated using on-treatment values at 2.5, 3, 3.5, 4, 4.5, and 5 years of AVT to predict threeyear HCC occurrence. Model performance was assessed with the area under the receiver operating curve (AUROC). The original model cutoffs to distinguish different levels of HCC risk were evaluated by the log-rank test. Results: The AUROCs of the 17 HCC models varied from 0.51 to 0.78 when using on-treatment scores from years 2.5 to 5. Models with a cirrhosis variable showed numerically higher AUROCs (pooled at 0.65–0.73 for treated, untreated, or mixed treatment models) than models without (treated or mixed models: 0.61–0.68; untreated models: 0.51–0.59). Stratification into low, intermediate, and high-risk levels using the original cutoff values could no longer reflect the true HCC incidence using scores after 3.5 years of AVT for models without cirrhosis and after 4 years of AVT for models with cirrhosis. Conclusions: The performance of existing HCC prediction models, especially models without the cirrhosis variable, decreased in CHB patients on long-term AVT. The optimization of existing models or the development of novel models for better HCC prediction during long-term AVT is warranted.

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

Dai Xiaofeng,Wu Jiale,Lu Lianghui,Chen Yuyu 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.5

Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

One-Step Hydrothermal Deposition of Ag-Doped g-C3N4-TiO2 Nanocomposites on Cotton Fabric Surface with Enhanced Photocatalytic Activity

Wenjun Li,Hui Zhang,Pei Chen,Jiale Yao,Xiangzhi Dong 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2

In this study, Ag-doped g-C3N4-TiO2 nanocomposite photocatalysts were deposited on the surface of cotton fabric by a simpleone-step hydrothermal method. The structure features of as-modified cotton fabric were examined by a series of characterizationtechniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction(XRD) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV–Vis diffuse reflectance spectroscopy (DRS) andphotoluminescence spectroscopy (PL). The experimental results showed that highly dispersed Ag nanoparticles were dopedinto g-C3N4-TiO2 nanocomposites which were evenly coated on the fabric surface. The introduction of Ag nanoparticles intog-C3N4-TiO2 composites could significantly improve the photodegradation rate of methyl orange (MO) dye under visiblelight irradiation. Importantly, the doping site of Ag nanoparticles had a significant influence on the photocatalytic activityof Ag-doped g-C3N4-TiO2 nanocomposites. Compared with the g-C3N4-TiO2 coated cotton fabric, the Ag-doped g-C3N4-TiO2 coated cotton fabric displayed excellent photocatalytic properties for the photodegradation of MO dyes because of thenarrowed band gap and the faster separation and transfer of photoinduced charge carriers. The substrate of cotton fabric hadlittle influence on the active radicals produced by the Ag-doped g-C3N4-TiO2 nanocomposites. In addition, the as-modifiedcotton fabric exhibited good reusability and stability after five recycles for the photodegradation of MO dyes.